15 results on '"Donaire, David"'
Search Results
2. Influence of the Urban Exposome on Birth Weight
- Author
-
Nieuwenhuijsen, Mark J., Agier, Lydiane, Basagana, Xavier, Urquiza, Jose, Tamayo-Uria, Ibon, Giorgis-Allemand, Lise, Robinson, Oliver, Siroux, Valerie, Maitre, Lea, de Castro, Montserrat, Valentin, Antonia, Donaire, David, Dadvand, Payam, Aasvang, Gunn Marit, Krog, Norun Hjertager, Schwarze, Per E., Chatzi, Leda, Grazuleviciene, Regina, Andrusaityte, Sandra, Dedele, Audrius, McEachan, Rosie, Wright, John, West, Jane, Ibarluzea, Jesus, Ballester, Ferran, Vrijheid, Martine, and Slama, Remy
- Subjects
Weather -- Health aspects ,Air pollution -- Health aspects ,Environmental toxicology -- Health aspects ,Type 2 diabetes -- Health aspects ,Pregnant women -- Health aspects ,Algorithms ,Traffic engineering ,Pollution ,Health ,Environmental issues ,Health ,European Union -- Evaluation - Abstract
Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life. Objective: We evaluated the association of the urban exposome with birth weight. Methods: We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the DeletionSubstitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure- byexposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for co exposures. Results: The most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis. Conclusion: This investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures. https://doi.org/10.1289/EHP3971, Introduction The exposome is defined as the totality of environmental exposures from conception onwards (Wild 2005, 2012). This definition aims to provide a holistic view of environmental exposures and their [...]
- Published
- 2019
- Full Text
- View/download PDF
3. Symptoms timeline and outcomes in amyotrophic lateral sclerosis using artificial intelligence.
- Author
-
Segura, Tomás, Medrano, Ignacio H., Collazo, Sergio, Maté, Claudia, Sguera, Carlo, Del Rio-Bermudez, Carlos, Casero, Hugo, Salcedo, Ignacio, García-García, Jorge, Alcahut-Rodríguez, Cristian, Savana Research Group, Aquino, José, Casadevall, David, Donaire, David, Marin-Corral, Judith, Menke, Sebastian, Polo, Natalia, and Taberna, Miren
- Subjects
AMYOTROPHIC lateral sclerosis ,NATURAL language processing ,MOTOR neuron diseases ,ARTIFICIAL intelligence ,SYMPTOMS ,DELAYED diagnosis - Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative motor neuron disease. Although an early diagnosis is crucial to provide adequate care and improve survival, patients with ALS experience a significant diagnostic delay. This study aimed to use real-world data to describe the clinical profile and timing between symptom onset, diagnosis, and relevant outcomes in ALS. Retrospective and multicenter study in 5 representative hospitals and Primary Care services in the SESCAM Healthcare Network (Castilla-La Mancha, Spain). Using Natural Language Processing (NLP), the clinical information in electronic health records of all patients with ALS was extracted between January 2014 and December 2018. From a source population of all individuals attended in the participating hospitals, 250 ALS patients were identified (61.6% male, mean age 64.7 years). Of these, 64% had spinal and 36% bulbar ALS. For most defining symptoms, including dyspnea, dysarthria, dysphagia and fasciculations, the overall diagnostic delay from symptom onset was 11 (6–18) months. Prior to diagnosis, only 38.8% of patients had visited the neurologist. In a median post-diagnosis follow-up of 25 months, 52% underwent gastrostomy, 64% non-invasive ventilation, 16.4% tracheostomy, and 87.6% riluzole treatment; these were more commonly reported (all Ps < 0.05) and showed greater probability of occurrence (all Ps < 0.03) in bulbar ALS. Our results highlight the diagnostic delay in ALS and revealed differences in the clinical characteristics and occurrence of major disease-specific events across ALS subtypes. NLP holds great promise for its application in the wider context of rare neurological diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. A Case of Flexural Exanthema as a Presenting Sign for COVID-19
- Author
-
Oliveira, Raquel, Gonçalo, Margarida, Faria, Carlos, Donaire, David, Barbosa, Benilde, Cardoso, José Carlos, Julião, Maria José, Moura, José, and Carvalho, Armando
- Subjects
SARS-CoV-2 ,Exantema ,Infecções por Coronavírus ,COVID-19 ,Exanthema ,Coronavirus Infections - Published
- 2020
5. Case of Flexural Exanthema as a Presenting Sign for COVID-19
- Author
-
Oliveira,Raquel, Gonçalo,Margarida, Faria,Carlos, Donaire,David, Barbosa,Benilde, Cardoso,José Carlos, Julião,Maria José, Moura,José, and Carvalho,Armando
- Subjects
SARS-CoV-2 ,COVID-19 ,Exanthema ,Coronavirus Infections - Abstract
We report a case of a 84-year-old male hospitalized for bacterial pneumonia who, during hospitalization, developed a flexural exanthema in parallel with a positive swab for SARS-CoV-2. Supportive therapy was instituted, the rash disappeared in 7 days and the patient fully recovered. At the same time, two other cases of SARS-CoV-2 infection occurred in the same ward. Histopathology and immunohistochemistry of a skin biopsy showed a scarce predominantly perivascular lymphocytic infiltration in the upper dermis, predominantly by CD4+ T cells, a slight epidermotropism, spongiosis and focal parakeratosis, compatible with a viral exanthema or a maculopapular drug eruption. Patch testing with possible culprit drugs were negative. We seek to add value in understanding all the manifestations of SARS-CoV-2 infection and to draw attention to the importance of early identification of skin manifestations in association with COVID-19.
- Published
- 2020
6. Achenbach’s syndrome
- Author
-
Gomes, João Filipe, primary, Mendes, Jorge, additional, Donaire, David, additional, and Ferreira, Mafalda, additional
- Published
- 2020
- Full Text
- View/download PDF
7. Leiomyosarcoma of Inferior Vena Cava in an Immunocompetent Young-adult Female Patient.
- Author
-
Gomes, Joao Filipe, Vieira, Ines, Mendes, Jorge, Donaire, David, and Almeida, Rui
- Published
- 2022
- Full Text
- View/download PDF
8. Physiologic Response to Maximal Cycle Ergometry in Individuals with Down Syndrome: 1082: June 5 10:15 AM - 10:30 AM
- Author
-
Guerra, Míriam, Garrido, Eduardo, Martin, Carme, Giné-Garriga, Maria, Martínez, Eloïsa, Donaire, David, and Fernhall, Bo
- Published
- 2010
- Full Text
- View/download PDF
9. Um Caso de Exantema Flexural como Sinal de Apresentação de COVID-19.
- Author
-
Oliveira, Raquel, Gonçalo, Margarida, Faria, Carlos, Donaire, David, Barbosa, Benilde, Carlos Cardoso, José, Julião, Maria José, Moura, José, and Carvalho, Armando
- Published
- 2020
- Full Text
- View/download PDF
10. Diversity, distribution and conservation of the terrestrial reptiles of Oman (Sauropsida, Squamata)
- Author
-
Carranza, Salvador, primary, Xipell, Meritxell, additional, Tarroso, Pedro, additional, Gardner, Andrew, additional, Arnold, Edwin Nicholas, additional, Robinson, Michael D., additional, Simó-Riudalbas, Marc, additional, Vasconcelos, Raquel, additional, de Pous, Philip, additional, Amat, Fèlix, additional, Šmíd, Jiří, additional, Sindaco, Roberto, additional, Metallinou, Margarita, additional, Els, Johannes, additional, Pleguezuelos, Juan Manuel, additional, Machado, Luis, additional, Donaire, David, additional, Martínez, Gabriel, additional, Garcia-Porta, Joan, additional, Mazuch, Tomáš, additional, Wilms, Thomas, additional, Gebhart, Jürgen, additional, Aznar, Javier, additional, Gallego, Javier, additional, Zwanzig, Bernd-Michael, additional, Fernández-Guiberteau, Daniel, additional, Papenfuss, Theodore, additional, Al Saadi, Saleh, additional, Alghafri, Ali, additional, Khalifa, Sultan, additional, Al Farqani, Hamed, additional, Bait Bilal, Salim, additional, Alazri, Iman Sulaiman, additional, Al Adhoobi, Aziza Saud, additional, Al Omairi, Zeyana Salim, additional, Al Shariani, Mohammed, additional, Al Kiyumi, Ali, additional, Al Sariri, Thuraya, additional, Al Shukaili, Ahmed Said, additional, and Al Akhzami, Suleiman Nasser, additional
- Published
- 2018
- Full Text
- View/download PDF
11. Validation of the Regicor Short Physical Activity Questionnaire for the Adult Population
- Author
-
Molina, Luis, primary, Sarmiento, Manuel, additional, Peñafiel, Judith, additional, Donaire, David, additional, Garcia-Aymerich, Judith, additional, Gomez, Miquel, additional, Ble, Mireia, additional, Ruiz, Sonia, additional, Frances, Albert, additional, Schröder, Helmut, additional, Marrugat, Jaume, additional, and Elosua, Roberto, additional
- Published
- 2017
- Full Text
- View/download PDF
12. Biogeography and contemporary climatic differentiation among Moroccan Salamandra algira
- Author
-
Beukema, Wouter, Pous, Philip de, Donaire, David, Escoriza, Daniel, Bogaerts, Sergé, Toxopeus, Albertus G., Bie, Cornelis A. J. M. de, Rocha, Jorge, Carranza, Salvador, Generalitat de Catalunya, and Ministerio de Educación y Ciencia (España)
- Subjects
Viviparity ,Phylogeography ,Morocco ,Species distribution modelling ,MAXENT ,Mitochondrial DNA - Abstract
The opening of the Gibraltar land bridge occurred at the end of the Messinian Salinity Crisis approximately 5.3 Mya, and was one of the main causes of vicariance between European and north-west African amphibians, resulting in the origin of several new species. However, little is currently known about the causes for post-Messinian amphibian differentiation in the Maghreb, although it is acknowledged that the Pleistocene glaciations probably had considerable influence on several species. The current study uses both species distribution modelling (MAXENT) and information from a total of 694 bp of mitochondrial data (351 from cytochrome b and 342 from 12S rRNA) from 36 representatives of all three recognized subspecies of Moroccan Salamandra to infer the phylogeny and biogeography of Salamandra algira tingitana, which is characterized by both viviparous and ovoviviparous populations. According to the results, the split between S. a. tingitana and S. a. algira from the Rif and Middle Atlas mountains took place approximately 1.6 Mya, and could have been caused by a shift towards a colder and drier climate that occurred during the upper Pliocene, which may have resulted in the isolation of Salamandra at increasingly higher altitudes, or in other climatically favourable areas. Several lineages within S. a. tingitana originated during the Pleistocene climatic oscillations, one of which gave rise to the viviparous populations north of the Oued Martil. It is suggested that the origin of viviparity in S. a. tingitana occurred during the last 600 000 years. In order to further understand the origin of the unique viviparous population of S. algira from North Africa, predictive distribution models of the viviparous and ovoviviparous populations of S. a. tingitana were created using MAXENT to assess environmental differences. Niche divergence was subsequently determined using Schoener's D and Warren et al.'s I niche similarity metrics. Predictive modelling and niche divergence analyses revealed significant environmental differences between the two reproductive types, which could have influenced the transition from ovoviviparity to viviparity. © 2010 The Linnean Society of London, Biological Journal of the Linnean Society., The mtDNA work was funded by grant CGL2009-11663/BOS from the Ministerio de Educación y Ciencia, Spain. S.C. is a member of the Grup de Recerca Emergent of the Generalitat de Catalunya: 2009SGR1462.
- Published
- 2010
13. Biogeography of the White-Bellied Carpet Viper Echis leucogaster Roman, 1972 in Morocco, a study combining mitochondrial DNA data and ecological niche modeling
- Author
-
Escoriza, Daniel, Metallinou, Margarita, Donaire, David, Amat, Fèlix, and Carranza, Salvador
- Subjects
Patrons biogeogràfics ,Subtropical snakes ,Biogeographic patterns ,Saharan discontinuity ,Discontinuitat sahariana ,Serps subtropicals - Abstract
14 páginas, 4 figuras, 3 tablas., [EN]: In northwest Africa some species from Sahelian origin appear with relict populations and apparently isolated by the extreme aridity of the Sahara desert. However very tolerant to aridity species could maintain continuous populations as might be the case for Echis leucogaster as indicated by results from genetic analysis and bioclimatic models., [CA]: Al nord-oest d'àfrica apareixen un grup d'espècies d'origen sahelià en poblacions relictes i aparentment aïllades pel desert del Sàhara. No obstant això espècies molt tolerants a l‟aridesa podrien mantenir poblacions contínues, com podria ser el cas de Echis leucogaster segons indiquen els resultats de l'anàlisi genètica i els models bioclimàtics., This work was carried out under a permit from the Moroccan Government (Department of Water and Forestry resources) to David Donaire.
- Published
- 2009
14. Distribution review, habitat suitability and conservation of the endangered and endemic Moroccan spadefoot toad (Pelobates varaldii)
- Author
-
de Pous, Philip, primary, Beukema, Wouter, additional, Dingemans, Diederik, additional, Donaire, David, additional, Geniez, Philippe, additional, and El Mouden, El Hassan, additional
- Published
- 2012
- Full Text
- View/download PDF
15. Vegetation and vehicle emissions around primary schools across urban Australia: associations with academic performance.
- Author
-
Carver, Alison, Molina, Miguel Alvarado, Claesen, Joep L.A., Klabbers, Gonnie, Donaire, David, Gonzalez, Tham, Rachel, Cerin, Ester, Nieuwenhuijsen, Mark, and Wheeler, Amanda J.
- Subjects
- *
SCHOOL children , *NORMALIZED difference vegetation index , *URBAN schools , *ACADEMIC achievement , *PRIMARY schools - Abstract
Evolving evidence suggests that vegetation surrounding schools is beneficial to children's academic performance, however vehicle emissions are adversely related. Little is known about concurrent impacts of vegetation and vehicle emissions on academic performance. This study examined associations of vegetation and vehicle emissions near urban Australian primary schools with children's academic performance. Vegetation within schoolyards and Euclidean buffers (100, 300 and 1000 m) was assessed using the Normalized Difference Vegetation Index (NDVI). Weighted road density (WRD) was computed for each buffer as a vehicle emissions proxy. Cross-sectional associations and mediating pathways between vegetation and vehicle emissions and standardized average academic scores in Literacy (Reading, Writing, Language Conventions) and Mathematics for Grades 3 and 5 attending 3745 primary schools in urban areas (population ≥10,000) of Australia in 2018 were assessed using generalised linear models adjusted for school socio-educational status. Significant positive associations were found between vegetation and Reading in Grades 3 and 5, Mathematics in Grade 3 (all buffers), Writing in Grade 3 (100 and 300 m), and Language Conventions in Grades 3 and 5 (most buffers). Increased vehicle emissions were negatively associated with Reading and Mathematics in Grades 3 and 5 (most buffers), and Language Conventions in Grade 3 (300 and 1000 m) and Grade 5 (100–1000 m). Within 300 m, vehicle emissions partially mediated associations between vegetation with Mathematics in Grade 3 (proportion mediated, 21%), Reading and Language Conventions in Grade 5 (15%, 37% respectively). Our findings contribute to growing evidence that vegetation around primary schools is associated with higher achievement in Literacy and Mathematics, with partial mediation by vehicle emissions. Future studies should conduct on-site measurement of vehicle emissions and audit vegetation around schools to confirm findings and inform urban/school planners and school leaders on designing and modifying school environments to support learning. • Exposures were examined across diverse geographic and climatic regions of Australia. • Vegetation around schools was associated with literacy and mathematics scores. • Vehicle emissions were inversely associated with literacy and mathematics scores. • Vehicle emissions mediated some associations of vegetation with literacy and maths. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.