5,175 results on '"Dong, Yu"'
Search Results
2. Floquet topological phases with time-reversal and space inversion symmetries and dynamical detection of topological charges
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Wu, Hong, Dong, Yu-Chen, and Liu, Hui
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
For spinful systems with spin 1/2, it is generally believed that P and T invariant strong and second-order topologies exist in four band and eight band system, respectively. Here, by using periodic driving, we find it is possible to have strong topological insulator, second-order topological insulator and hybrid-order topological insulator in a single four band system. Furthermore, we established a direct connection between topology and dynamics. More convenient experimental detection for these topological phases has also been proposed. This study provides the theoretical basis for novel topological insulator that possess hybrid-order boundary states beyond the conventional regimes., Comment: 7 pages
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- 2024
3. Superconducting diode effect under time reversal symmetry
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Liu, Fengshuo, Itahashi, Yuki M., Aoki, Shunta, Dong, Yu, Wang, Ziqian, Ogawa, Naoki, Ideue, Toshiya, and Iwasa, Yoshihiro
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Condensed Matter - Superconductivity - Abstract
In noncentrosymmetric superconductors, superconducting and normal conductions can interchange based on the current flow direction. This effect is termed a superconducting diode effect (SDE), which is a focal point of recent research. The broken inversion and time reversal symmetry is believed to be the requirements of SDE but their intrinsic role has remained elusive. Here, we report strain-controlled SDEs in a layered trigonal superconductor, PbTaSe2. The SDE was found exclusively in a strained device with its absence in an unstrained device, despite that it is allowed in unstrained trigonal structure. Moreover, the zero-field or magnetic field-even (magnetic field-odd) SDE is observed when the strain and current are along armchair (zigzag) direction The results unambiguously demonstrate the intrinsic SDE under time-reversal symmetry and the critical role of strain-induced electric polarization., Comment: 35 pages, 11 figures
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- 2024
4. Polarization modes of gravitational waves in general Einstein-vector theory
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Lai, Xiao-Bin, Dong, Yu-Qi, Liu, Yu-Qiang, and Liu, Yu-Xiao
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General Relativity and Quantum Cosmology - Abstract
We study the polarization modes of gravitational waves in general Einstein-vector theory with an arbitrary constant background vector field under a Minkowski background. We compare these polarization modes with those of other vector-tensor theories and constrain the parameter spaces based on the gravitational-wave event GW170817 with its electromagnetic counterpart GRB170817A and observations of pulsar timing arrays. The presence of the background vector field leads to the anisotropy of space and a rich variety of gravitational waves contents. Our results reveal that the polarization modes of gravitational waves depend on the parameter spaces. There are at least two and at most five independent polarization modes in one parameter space. In different parameter spaces, some mixture modes are allowed, including tensor-vector, tensor-scalar, tensor-vector-scalar, vector-scalar, and scalar-scalar mixture modes, as well as five independent modes (excluding $P_l$): $P_+$, $P_{\times}$, $P_x$, $P_y$, and $P_b$. In all regions of the parameter spaces, there are always two tensor modes, which can be either independent of or mixed with other modes. The independent $P_b$ mode consistently exhibits the same speed as light. If the speed of tensorial gravitational waves strictly equals that of light, only the $P_+$, $P_{\times}$, and $P_b$ modes are permitted. Furthermore, through comparisons of some vector-tensor theories and based on the observations of gravitational waves, the $P_b$ mode is expected to be allowed.
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- 2024
5. The coupled-channel analysis of $B^{(*)}_{(s)}\bar{B}^{(*)}_{(s)}$ systems within complex scaling method
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Song, Qing-Fu, Lü, Qi-Fang, Chen, Dian-Yong, and Dong, Yu-Bing
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,Nuclear Theory - Abstract
In present work, we perform a coupled-channel analysis of $B^{(*)}_{(s)}\bar{B}^{(*)}_{(s)}$ systems with the one-boson-exchange potentials. We first study the $I(J^{PC})=1(1^{+-})$ $B\bar{B}^{*}/B^{*}\bar{B}^{*}$ system to describe the $Z_{b}(10610)$ and $Z_{b}(10650)$ particles as molecular states and determine the reasonable range of cutoff parameter $\Lambda$. Then, other $B^{(*)}_{(s)}\bar{B}^{(*)}_{(s)}$ combinations with different quantum numbers are systematically investigated. Some bound states and resonances appear in the isoscalar systems, while only several shallow bound states exist for isovector systems. Far away from the excited conventional $P-$wave bottomium, these predicted states can be easily identified as exotic particles both theoretically and experimentally. Moreover, the $\eta_b(nS)/\Upsilon(nS)$ plus light mesons are the excellent final states to search for the bound states, while the $B\bar B^*+h.c.$ and $B^* \bar B^*$ channels are suitable for the resonances. We highly recommend that the LHCb and Belle II Collaborations can hunt for these bottomonium-like states in future., Comment: 9 pages, 3 figures, comments and suggestions are welcome
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- 2024
6. Quantum Network Tomography via Learning Isometries on Stiefel Manifold
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Li, Ze-Tong, He, Xin-Lin, Zheng, Cong-Cong, Dong, Yu-Qian, Luan, Tian, Yu, Xu-Tao, and Zhang, Zai-Chen
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Quantum Physics - Abstract
Explicit mathematical reconstructions of quantum networks play a significant role in developing quantum information science. However, tremendous parameter requirements and physical constraint implementations have become computationally non-ignorable encumbrances. In this work, we propose an efficient method for quantum network tomography by learning isometries on the Stiefel manifold. Tasks of reconstructing quantum networks are tackled by solving a series of unconstrained optimization problems with significantly less parameters. The stepwise isometry estimation shows the capability for providing information of the truncated quantum comb while processing the tomography. Remarkably, this method enables the compressive quantum comb tomography by specifying the dimensions of isometries. As a result, our proposed method exhibits high accuracy and efficiency.
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- 2024
7. On Capped Higgs Positivity Cone
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Hong, Dong-Yu, Wang, Zhuo-Hui, and Zhou, Shuang-Yong
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
The Wilson coefficients of the Standard Model Effective Field Theory are subject to a series of positivity bounds. It has been shown that, while the positivity part of the UV partial wave unitarity leads to the Wilson coefficients living in a convex cone, further including the non-positivity part caps the cone from above. For the Higgs scattering, a capped positivity cone have been obtained using a simplified, linear unitarity conditions and without utilizing the full internal symmetries of the Higgs scattering. Here we further implement the stronger nonlinear unitarity conditions from the UV, which generically gives rise to better bounds. We show that, for the Higgs case in particular, while the nonlinear unitarity conditions per se do not enhance the bounds, the fuller use of the internal symmetries do shrink the capped positivity cone significantly., Comment: 20 pages, 4 figures, invited contribution to JUSTC
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- 2024
8. Continuously and widely tunable frequency-stabilized laser based on an optical frequency comb
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Shen, Ze-Min, Zhou, Xiao-Long, Huang, Dong-Yu, Pan, Yu-Hao, Li, Li, Wang, Jian, Li, Chuan-Feng, and Guo, Guang-Can
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Physics - Atomic Physics ,Physics - Optics - Abstract
Continuously and widely tunable lasers actively stabilized on a frequency reference are broadly employed in atomic, molecular and optical (AMO) physics. The frequency-stabilized optical frequency comb (OFC) provides a novel optical frequency reference with a broadband spectrum that meets the requirement of laser frequency stabilization. Therefore, we demonstrate a frequency-stabilized and precisely tunable laser system based on it. In this scheme, the laser frequency locked to the OFC is driven to jump over the ambiguity zones, which blocks the wide tuning of the locked laser, and tuned until the mode hopping happens with the always-activated feedback loop. Meanwhile, we compensate the gap of the frequency jump with a synchronized acoustic optical modulator to ensure the continuity. This scheme is applied to an external cavity diode laser (ECDL) and we achieve tuning at a rate of about 7 GHz/s with some readily available commercial electronics. Furthermore, we tune the frequency-stabilized laser only with the feedback of diode current and its average tuning speed can exceed 100 GHz/s. Due to the resource-efficient configuration and the simplicity of completion, this scheme can be referenced and find wide applications in AMO experiments.
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- 2024
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9. Polarization modes of gravitational waves in general modified gravity: General metric theory and general scalar-tensor theory
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Dong, Yu-Qi, Liu, Yu-Qiang, and Liu, Yu-Xiao
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
In this paper, we establish a unified parameterized framework for analyzing the polarization modes of gravitational waves in the general metric theory (gravity is only described by the metric) and the general scalar-tensor theory (gravity is described by the metric and an additional scalar field). Specifically, we study the polarization modes of gravitational waves in the most general metric theory and general scalar-tensor theory that satisfy the following conditions: (1) Spacetime is four-dimensional; (2) The theory satisfies the principle of least action; (3) The theory is generally covariant; (4) The action describing a free particle is $\int ds$. We find that the polarization modes of gravitational waves in the theory satisfying the above conditions depends on the selection of parameters in the framework, and the theory allows for up to all six polarization modes. Once we have established our framework, the analysis of the polarization modes of gravitational waves in specific theories will depend on determining the corresponding parameters within our framework. In our analysis, we also find that the polarization modes of gravitational waves in the general metric theory and the general scalar-tensor theory that satisfy the conditions also have some interesting universal properties., Comment: v3: 38 pages, 1 figure, 2 tables, typos corrected
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- 2023
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10. A Simple Yet High-Performing On-disk Learned Index: Can We Have Our Cake and Eat it Too?
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Lan, Hai, Bao, Zhifeng, Culpepper, J. Shane, Borovica-Gajic, Renata, and Dong, Yu
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Computer Science - Databases - Abstract
While in-memory learned indexes have shown promising performance as compared to B+-tree, most widely used databases in real applications still rely on disk-based operations. Based on our experiments, we observe that directly applying the existing learned indexes on disk suffers from several drawbacks and cannot outperform a standard B+-tree in most cases. Therefore, in this work we make the first attempt to show how the idea of learned index can benefit the on-disk index by proposing AULID, a fully on-disk updatable learned index that can achieve state-of-the-art performance across multiple workload types. The AULID approach combines the benefits from both traditional indexing techniques and the learned indexes to reduce the I/O cost, the main overhead under disk setting. Specifically, three aspects are taken into consideration in reducing I/O costs: (1) reduce the overhead in updating the index structure; (2) induce shorter paths from root to leaf node; (3) achieve better locality to minimize the number of block reads required to complete a scan. Five principles are proposed to guide the design of AULID which shows remarkable performance gains and meanwhile is easy to implement. Our evaluation shows that AULID has comparable storage costs to a B+-tree and is much smaller than other learned indexes, and AULID is up to 2.11x, 8.63x, 1.72x, 5.51x, and 8.02x more efficient than FITing-tree, PGM, B+-tree, ALEX, and LIPP., Comment: 14 pages
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- 2023
11. IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
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Zhang, Jiayu, Dong, Yu, Yu, Shan, Hu, Keshu, Zhang, Lingyun, Xiong, Min, Liu, Mengling, Sun, Xun, Li, Suyao, Yuan, Yitao, Zhang, Chi, Zhu, Mengxuan, Wei, Yichou, Zhu, Yanjing, Yu, Yiyi, Zhang, Pengfei, and Liu, Tianshu
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- 2024
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12. EZH2–STAT3 signaling pathway regulates GSDMD-mediated pyroptosis in glioblastoma
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Dong Yu, Shuai Wang, Jiajun Wang, Kang Zhang, Zihui Niu, and Ning Lin
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Glioblastoma multiforme (GBM) is the most therapeutically challenging primary brain tumor owing to the unique physiological structure of the blood–brain barrier. Lately, research on targeted therapy for gliomas has shifted focus toward the tumor microenvironment and local immune responses. Pyroptosis is a newly identified cellular demise characterized by the release of numerous inflammatory factors. While pyroptosis shows promise in impeding the occurrence and progression of GBM, the regulatory mechanisms governing this process in gliomas still require further investigation. The function of the Enhancer of zeste homolog 2 (EZH2) in pyroptosis remains unexplored. In this study, we discovered that 3-Deazaneplanocin A (DZNep), an inhibitor of EZH2, can induce pyroptosis in GBM in vitro experiments. Moreover, our investigation unveiled that the signal transducer and activator of transcription (STAT3) could serve as a downstream regulator influenced by EZH2, impacting pyroptosis in GBM. Following treatment with DZNep and the STAT3 inhibitor (SH-4–54), there was an elevation in the levels of pyroptosis-related factors, namely NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) and Gasdermin D (GSDMD). Moreover, simultaneous inhibition of both EZH2 and STAT3 led to the expression of inflammatory factors such as IL-1β and IL-18. In summary, we have identified that EZH2 regulates pyroptosis in GBM through STAT3, and pyroptosis could potentially be targeted for immunotherapy in GBM.
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- 2024
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13. A Mendelian randomization study between metabolic syndrome and its components with prostate cancer
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Long Xia, Xiao-dong Yu, Li Wang, Lin Yang, Er-hao Bao, Ben Wang, and Ping-yu Zhu
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Prostate cancer ,Metabolic syndrome ,Mendelian randomization ,Genome‐wide association studies ,Meta-analysis ,Medicine ,Science - Abstract
Abstract Previous research has produced inconsistent findings concerning the connection between metabolic syndrome and prostate cancer. It is challenging for observational studies to establish a conclusive causal relationship between the two. However, Mendelian randomization can provide stronger evidence of causality in this context. To examine the causal link between a metabolic composite and its components with prostate cancer, we performed a two-sample Mendelian randomization (MR) study utilizing aggregated data from genome-wide association studies, followed by meta-analyses. In our study, we employed inverse variance weighting as the primary method for MR analysis. Additionally, we assessed potential sources of heterogeneity and horizontal pleiotropy through the Cochran’s Q test and MR-Egger regression. Moreover, we used multivariate MR to determine whether smoking versus alcohol consumption had an effect on the outcomes. We found no causal relationship between metabolic syndrome and its components and prostate cancer(MetS, odds ratio [OR] = 0.95, 95% confidence interval [CI] = 0.738–1.223, p = 0.691; TG, [OR] = 1.02, 95%[CI] = 0.96–1.08, p = 0.59); HDL, [OR] = 1.02, 95% [CI] = 0.97–1.07, p = 0.47; DBP, [OR] = 1.00, 95%[CI] = 0.99–1.01, p = 0.87; SBP, [OR] = 1.00, 95%[CI] = 0.99–1.00, p = 0.26; FBG [OR] = 0.92, 95%[CI] = 0.81–1.05, p = 0.23; WC, [OR] = 0.93, 95%[CI] = 0.84–1.03, p = 0.16). Finally, the MVMR confirms that the metabolic syndrome and its components are independent of smoking and alcohol consumption in prostate cancer. We didn’t find significant evidence to determine a causal relationship between the metabolic syndrome and its components and prostate cancer through MR analysis. Further research is necessary to explore the potential pathogenesis between the two diseases.
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- 2024
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14. Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS‐CoV‐2 Omicron strain infection in China: A national multicenter survey of 35,566 individuals
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Meng‐Fan Liu, Rui‐Xia Ma, Xian‐Bao Cao, Hua Zhang, Shui‐Hong Zhou, Wei‐Hong Jiang, Yan Jiang, Jing‐Wu Sun, Qin‐Tai Yang, Xue‐Zhong Li, Ya‐Nan Sun, Li Shi, Min Wang, Xi‐Cheng Song, Fu‐Quan Chen, Xiao‐Shu Zhang, Hong‐Quan Wei, Shao‐Qing Yu, Dong‐Dong Zhu, Luo Ba, Zhi‐Wei Cao, Xu‐Ping Xiao, Xin Wei, Zhi‐Hong Lin, Feng‐Hong Chen, Chun‐Guang Shan, Guang‐Ke Wang, Jing Ye, Shen‐Hong Qu, Chang‐Qing Zhao, Zhen‐Lin Wang, Hua‐Bin Li, Feng Liu, Xiao‐Bo Cui, Sheng‐Nan Ye, Zheng Liu, Yu Xu, Xiao Cai, Wei Huang, Ru‐Xin Zhang, Yu‐Lin Zhao, Guo‐Dong Yu, Guang‐Gang Shi, Mei‐Ping Lu, Yang Shen, Yu‐Tong Zhao, Jia‐Hong Pei, Shao‐Bing Xie, Long‐Gang Yu, Ye‐Hai Liu, Shao‐Wei Gu, Yu‐Cheng Yang, Lei Cheng, and Jian‐Feng liu
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epidemiologic studies ,incidence ,olfactory disorders ,prognosis ,SARS‐CoV‐2 ,taste disorders ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Abstract Objective This cross‐sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID‐19 in China. Methods This study was conducted by 45 tertiary Grade‐A hospitals in China. Online and offline questionnaire data were obtained from patients infected with COVID‐19 between December 28, 2022, and February 21, 2023. The collected information included basic demographics, medical history, smoking and drinking history, vaccination history, changes in olfactory and gustatory functions before and after infection, and other postinfection symptoms, as well as the duration and improvement status of olfactory and gustatory disorders. Results Complete questionnaires were obtained from 35,566 subjects. The overall incidence of olfactory and taste dysfunction was 67.75%. Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction. Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction. Before infection, the average olfactory and taste VAS scores were 8.41 and 8.51, respectively; after infection, they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey. The median duration of dysosmia and dysgeusia was 15 and 12 days, respectively, with 0.5% of patients having symptoms lasting for more than 28 days. The overall self‐reported improvement rate was 59.16%. Recovery was higher in males, never smokers, those who received two or three vaccine doses, and those that had never experienced dental health issues, or chronic accompanying symptoms. Conclusions The incidence of dysosmia and dysgeusia following infection with the SARS‐CoV‐2 virus is high in China. Incidence and prognosis are influenced by several factors, including sex, SARS‐CoV‐2 vaccination, history of head‐facial trauma, nasal and oral health status, smoking and drinking history, and the persistence of accompanying symptoms.
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- 2024
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15. WaveDM: Wavelet-Based Diffusion Models for Image Restoration
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Huang, Yi, Huang, Jiancheng, Liu, Jianzhuang, Yan, Mingfu, Dong, Yu, Lv, Jiaxi, Chen, Chaoqi, and Chen, Shifeng
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Latest diffusion-based methods for many image restoration tasks outperform traditional models, but they encounter the long-time inference problem. To tackle it, this paper proposes a Wavelet-Based Diffusion Model (WaveDM). WaveDM learns the distribution of clean images in the wavelet domain conditioned on the wavelet spectrum of degraded images after wavelet transform, which is more time-saving in each step of sampling than modeling in the spatial domain. To ensure restoration performance, a unique training strategy is proposed where the low-frequency and high-frequency spectrums are learned using distinct modules. In addition, an Efficient Conditional Sampling (ECS) strategy is developed from experiments, which reduces the number of total sampling steps to around 5. Evaluations on twelve benchmark datasets including image raindrop removal, rain steaks removal, dehazing, defocus deblurring, demoir\'eing, and denoising demonstrate that WaveDM achieves state-of-the-art performance with the efficiency that is comparable to traditional one-pass methods and over 100$\times$ faster than existing image restoration methods using vanilla diffusion models., Comment: Accepted by TMM
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- 2023
16. Polarization modes of gravitational waves in generalized Proca theory
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Dong, Yu-Qi, Liu, Yu-Qiang, and Liu, Yu-Xiao
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
In this paper, we study polarization modes of gravitational waves in generalized Proca theory in the homogeneous and isotropic Minkowski background. The results show that the polarizations of gravitational waves depend on the parameter space of this gravity theory and can be divided into quite rich cases by parameters. In some parameter space, it only allows two tensor modes, i.e., the $+$ and $\times$ modes. In some parameter space, besides tensor modes, it also allows one scalar mode, or two vector (vector-$x$ and vector-$y$) modes, or both one scalar mode and two vector modes. The scalar mode is a mixture mode of a breathing mode and a longitudinal mode, or just a pure breathing mode. Interestingly, it is found that the amplitude of the vector modes is related to the speed of the tensor modes. This allows us to give the upper bound of the amplitude of the vector modes by detecting the speed of the tensor modes. Specifically, if the speed of tensor modes is strictly equal to the speed of light, then the amplitude of vector modes is zero., Comment: v2: 28 pages, 1 figure, 2 tables, improved version
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- 2023
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17. A unified front-end framework for English text-to-speech synthesis
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Ying, Zelin, Li, Chen, Dong, Yu, Kong, Qiuqiang, Tian, Qiao, Huo, Yuanyuan, and Wang, Yuxuan
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
The front-end is a critical component of English text-to-speech (TTS) systems, responsible for extracting linguistic features that are essential for a text-to-speech model to synthesize speech, such as prosodies and phonemes. The English TTS front-end typically consists of a text normalization (TN) module, a prosody word prosody phrase (PWPP) module, and a grapheme-to-phoneme (G2P) module. However, current research on the English TTS front-end focuses solely on individual modules, neglecting the interdependence between them and resulting in sub-optimal performance for each module. Therefore, this paper proposes a unified front-end framework that captures the dependencies among the English TTS front-end modules. Extensive experiments have demonstrated that the proposed method achieves state-of-the-art (SOTA) performance in all modules., Comment: Accepted in ICASSP 2024
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- 2023
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18. Causality bounds on scalar-tensor EFTs
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Hong, Dong-Yu, Wang, Zhuo-Hui, and Zhou, Shuang-Yong
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High Energy Physics - Theory ,Astrophysics - Cosmology and Nongalactic Astrophysics ,General Relativity and Quantum Cosmology - Abstract
We compute the causality/positivity bounds on the Wilson coefficients of scalar-tensor effective field theories. Two-sided bounds are obtained by extracting IR information from UV physics via dispersion relations of scattering amplitudes, making use of the full crossing symmetry. The graviton $t$-channel pole is carefully treated in the numerical optimization, taking into account the constraints with fixed impact parameters. It is shown that the typical sizes of the Wilson coefficients can be estimated by simply inspecting the dispersion relations. We carve out sharp bounds on the leading coefficients, particularly, the scalar-Gauss-Bonnet couplings, and discuss how some bounds vary with the leading $(\partial\phi)^4$ coefficient and as well as phenomenological implications of the causality bounds., Comment: 76 pages, 15 figures; to appear in JHEP
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- 2023
19. ClinicLens: Visual Analytics for Exploring and Optimizing the Testing Capacity of Clinics given Uncertainty
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Dong, Yu, Liang, Jie, Cao, Longbing, and Catchpoole, Daniel
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Computer Science - Human-Computer Interaction ,Computer Science - Graphics - Abstract
Clinic testing plays a critical role in containing infectious diseases such as COVID-19. However, one of the key research questions in fighting such pandemics is how to optimize testing capacities across clinics. In particular, domain experts expect to know exactly how to adjust the features that may affect testing capacities, given that dynamics and uncertainty make this a highly challenging problem. Hence, as a tool to support both policymakers and clinicians, we collaborated with domain experts to build ClinicLens, an interactive visual analytics system for exploring and optimizing the testing capacities of clinics. ClinicLens houses a range of features based on an aggregated set of COVID-19 data. It comprises Back-end Engine and Front-end Visualization that take users through an iterative exploration chain of extracting, training, and predicting testing-sensitive features and visual representations. It also combines AI4VIS and visual analytics to demonstrate how a clinic might optimize its testing capacity given the impacts of a range of features. Three qualitative case studies along with feedback from subject-matter experts validate that ClinicLens is both a useful and effective tool for exploring the trends in COVID-19 and optimizing clinic testing capacities across regions. The entire approach has been open-sourced online: https://github.com/YuDong5018/clinic-lens.
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- 2023
20. A Visual Modeling Method for Spatiotemporal and Multidimensional Features in Epidemiological Analysis: Applied COVID-19 Aggregated Datasets
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Dong, Yu, Liang, Christy Jie, Chen, Yi, and Hua, Jie
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Statistics - Applications ,Computer Science - Graphics - Abstract
The visual modeling method enables flexible interactions with rich graphical depictions of data and supports the exploration of the complexities of epidemiological analysis. However, most epidemiology visualizations do not support the combined analysis of objective factors that might influence the transmission situation, resulting in a lack of quantitative and qualitative evidence. To address this issue, we have developed a portrait-based visual modeling method called +msRNAer. This method considers the spatiotemporal features of virus transmission patterns and the multidimensional features of objective risk factors in communities, enabling portrait-based exploration and comparison in epidemiological analysis. We applied +msRNAer to aggregate COVID-19-related datasets in New South Wales, Australia, which combined COVID-19 case number trends, geo-information, intervention events, and expert-supervised risk factors extracted from LGA-based censuses. We perfected the +msRNAer workflow with collaborative views and evaluated its feasibility, effectiveness, and usefulness through one user study and three subject-driven case studies. Positive feedback from experts indicates that +msRNAer provides a general understanding of analyzing comprehension that not only compares relationships between cases in time-varying and risk factors through portraits but also supports navigation in fundamental geographical, timeline, and other factor comparisons. By adopting interactions, experts discovered functional and practical implications for potential patterns of long-standing community factors against the vulnerability faced by the pandemic. Experts confirmed that +msRNAer is expected to deliver visual modeling benefits with spatiotemporal and multidimensional features in other epidemiological analysis scenarios.
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- 2023
21. Hydraulic characteristics and flow trajectories under two-sided asymmetric inflow conditions for a deep storage tunnel system
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Wei He, Chao Yu, Xiao-dong Yu, Jian Zhang, Jose G. Vasconcelos, Hui Xu, and Shou-ling Chen
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Deep storage tunnel ,Flow trajectory ,Hydraulic characteristic ,Hydrodynamic and particle simulation ,Physical model test ,River, lake, and water-supply engineering (General) ,TC401-506 - Abstract
Deep storage tunnels (DSTs) are used in densely urbanized areas to relieve stormwater collection systems, thereby reducing urban floods and runoff pollution, due to their substantial storage capacity. The computation of the hydraulic characteristics and flow trajectories of DSTs under rapid filling scenarios can help to predict sediment deposition and pollutant accumulation associated with the stored runoff, as well as the likelihood of operational problems, such as excessive surging. However, such assessments are complicated by various inflow scenarios encountered in tunnel systems during their operation. In this study, the Suzhou River DST in China is selected as a study case. Particles were tracked, and hydraulic analysis was conducted with scaled model experiments and numerical models. The flow field, particle movement, air‒water phase, and pressure patterns in the DST were simulated under various one- and two-sided inflow scenarios. The results showed that with regards to the design conditions involving two-sided inflows, flow reversals occurred with stepwise increases in the water surface and pressure. In contrast, this phenomenon was not observed under the one-sided inflow scenario. Under the asymmetric two-sided inflow scenarios, water inflows led to particle accumulation near the shaft, reducing the received inflows. However, under the symmetric inflow conditions, particles were concentrated near the middle of the tunnel. Compared to those under the symmetric inflow scenario, asymmetric inflow caused surface wave and entrapped air reductions. This study could provide support for regulation of the inflow of the Suzhou River DST and for prediction of sediment and pollutant accumulation.
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- 2024
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22. A visual modeling method for spatiotemporal and multidimensional features in epidemiological analysis: Applied COVID-19 aggregated datasets
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Dong, Yu, Liang, Christy Jie, Chen, Yi, and Hua, Jie
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- 2024
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23. New Insights into Biomarkers for Evaluating Therapy Efficacy in Pulmonary Tuberculosis: A Narrative Review
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Zhang, Fuzhen, Zhang, Fan, Dong, Yu, Li, Liang, and Pang, Yu
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- 2023
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24. The Origin of Two-dimensional Electron Gas in Zn$_{1-x}$Mg$_x$O/ZnO Heterostructures
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Chen, Xiang-Hong, Hou, Dong-Yu, Hu, Zhi-Xin, Gao, Kuang-Hong, and Li, Zhi-Qing
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Although the two-dimensional electron gas (2DEG) in (001) Zn$_{1-x}$Mg$_x$O/ZnO heterostructures has been discovered for about twenty years, the origin of the 2DEG is still inconclusive. In the present letter, the formation mechanisms of 2DEG near the interfaces of (001) Zn$_{1-x}$Mg$_x$O/ZnO heterostructures were investigated via the first-principles calculations method. It is found that the polarity discontinuity near the interface can neither lead to the formation of 2DEG in devices with thick Zn$_{1-x}$Mg$_{x}$O layers nor in devices with thin Zn$_{1-x}$Mg$_{x}$O layers. For the heterostructure with thick Zn$_{1-x}$Mg$_{x}$O layers, the oxygen vacancies near the interface introduce a defect band in the band gap, and the top of the defect band overlaps with the bottom of the conduction band, leading to the formation of the 2DEG near the interface of the device. For the heterostructure with thin Zn$_{1-x}$Mg$_{x}$O layers, the absorption of hydrogen atoms, oxygen atoms, or OH groups on the surface of Zn$_{1-x}$Mg$_{x}$O film plays a key role for the formation of 2DEG in the device. Our results manifest the sources of 2DEGs in Zn$_{1-x}$Mg$_x$O/ZnO heterostructures on the electronic structure level., Comment: 6 pages, 6 figures
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- 2022
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25. Prostate cancer-associated transcript 6 (PCAT6) promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer
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Sun Xun, Yuan Yitao, Li Suyao, Gan Lu, Xu Midie, Li Qingguo, Liu Mengling, Hu Keshu, Nan Ke, Zhang Jiayu, Dong Yu, Lin Yufu, Zhang Xiuping, Hou Pengcong, and Liu Tianshu
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colorectal cancer ,lncRNA ,PCAT6 ,metastasis ,Biochemistry ,QD415-436 ,Genetics ,QH426-470 - Abstract
Approximately 20% of colorectal cancer (CRC) patients are first diagnosed with metastatic colorectal cancer (mCRC) because they develop symptoms at an advanced stage. Despite advancements in treatment, patients with metastatic disease still experience inferior survival rates. Our objective is to investigate the association between long noncoding RNAs (lncRNAs) and prognosis and to explore their role in mCRC. In this study, we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas (TCGA) data, and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center. Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis. Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC, as evidenced by functional assays, demonstrating the suppression of epithelial-mesenchymal transition (EMT) and stemness. Our findings show the significance of PCAT6 in mCRC and its potential use as a prognostic biomarker.
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- 2024
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26. Dimensions of the hull of generalized Reed-Solomon codes
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Jing Huang, Jingge Liu, and Dong Yu
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hull of a code ,generalized reed-solomon code ,algebraic geometry code ,Mathematics ,QA1-939 - Abstract
Let GRS$ _k(\boldsymbol{\alpha}, \boldsymbol{\upsilon}) $ be a $ k $-dimensional generalized Reed-Solomon (GRS) code over $ \mathbb{F}_q $ associated with $ \boldsymbol{\alpha} = (\alpha_1, \ldots, \alpha_n) $ and $ \boldsymbol{\upsilon} = (\upsilon_1, \ldots, \upsilon_n) $. In this paper, we determined the dimension of the Euclidean hull GRS$ _k(\boldsymbol{\alpha}, \boldsymbol{\upsilon})\; \cap $ GRS$ _k(\boldsymbol{\alpha}, \boldsymbol{\upsilon})^\bot $, which addresses an open problem posed in [Chen et al., IEEE-TIT, 2023]. We also presentd a new approach to generating all self-dual RS codes.
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- 2024
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27. Correction: Prognostic value of pre-treatment [18F] FDG PET/CT in recurrent nasopharyngeal carcinoma without distant metastasis
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Zhe Dong, Gao-Yuan Wang, Dong-Yu Dai, Guan-Jie Qin, Ling-Long Tang, Cheng Xu, and Jun Ma
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2024
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28. Intelligent Analysis System for Turnout Friction Current Based on Density Clustering Algorithm and Breadth-first Search Algorithm
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Xiaoli QIU, Siyuan HAN, Qing XIONG, and Dong YU
- Subjects
urban rail transit ,signal ,intelligent operation and maintenance ,turnout switch machine ,friction current ,density clustering algorithm ,breadth-first search algorithm ,Transportation engineering ,TA1001-1280 - Abstract
Objective The turnout friction current on-site testing and adjustment involve three major unfavorable aspects of complex processes and high risks, high professional requirements for maintenance personnel, and significant subjective component in determining numerical values, calling for enhancement of the intelligent operation and maintenance level of turnout based on various intelligent algorithms and technologies. Method The characteristics of the four stages of turnout friction current testing curve are analyzed, and an intelligent analysis system for turnout friction current is proposed. The functionality and working principle of the system are elucidated, and standard values and threshold ranges for friction current are established. Based on density clustering algorithm and breadth-first search algorithm, the system can automatically retrieve the turnout friction current value. Screenshots of the system debugging interface are presented to illustrate how the system provides operational suggestions for on-site maintenance personnel in obtaining turnout frictional current values. Result & Conclusion This intelligent system demonstrates excellent usability and achieves the predefined goals of saving maintenance time, reducing maintenance costs, and increasing maintenance efficiency.
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- 2024
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29. Prognostic value of pre-treatment [18F] FDG PET/CT in recurrent nasopharyngeal carcinoma without distant metastasis
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Zhe Dong, Gao-Yuan Wang, Dong-Yu Dai, Guan-Jie Qin, Ling-Long Tang, Cheng Xu, and Jun Ma
- Subjects
Nasopharyngeal carcinoma ,[18F] FDG PET/CT ,TNM ,Locoregional recurrent ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background [18 F]-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has the ability to detect local and/or regional recurrence as well as distant metastasis. We aimed to evaluate the prognosis value of PET/CT in locoregional recurrent nasopharyngeal (lrNPC). Methods A total of 451 eligible patients diagnosed with recurrent I-IVA (rI-IVA) NPC between April 2009 and December 2015 were retrospectively included in this study. The differences in overall survival (OS) of lrNPC patients with and without PET/CT were compared in the I-II, III-IVA, r0-II, and rIII-IVA cohorts, which were grouped by initial staging and recurrent staging (according to MRI). Results In the III-IVA and rIII-IVA NPC patients, with PET/CT exhibited significantly higher OS rates in the univariate analysis (P = 0.045; P = 0.009; respectively). Multivariate analysis revealed that with PET/CT was an independent predictor of OS in the rIII-IVA cohort (hazard ratio [HR] = 0.476; 95% confidence interval [CI]: 0.267 to 0.847; P = 0.012). In the rIII-IVA NPC, patients receiving PET/CT sacns before salvage surgery had a better prognosis compared with MRI alone (P = 0.036). The recurrent stage (based on PET/CT) was an independent predictor of OS. (r0-II versus [vs]. rIII-IVA; HR = 0.376; 95% CI: 0.150 to 0.938; P = 0.036). Conclusion The present study showed that with PET/CT could improve overall survival for rIII-IVA NPC patients. PET/CT appears to be an effective method for assessing rTNM staging.
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- 2024
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30. Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns
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Yu Jiang, Yi-han Dong, Shi-wei Zhao, Dong-yu Liu, Ji-yang Zhang, Xiao-ya Xu, Hao Chen, and Jia-bin Jin
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Pancreatic neuroendocrine tumors ,Multiregion sampling whole-exome sequencing ,MEN1/DAXX ,Medicine ,Cytology ,QH573-671 - Abstract
Abstract Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in metastatic PanNETs were not well understood. To investigate this, we performed multiregion sampling whole-exome sequencing (MRS-WES) on samples from 10 patients who had not received prior treatment for metastatic PanNETs. This included 29 primary tumor samples, 31 lymph node metastases, and 15 liver metastases. We used the MSK-MET dataset for survival analysis and validation of our findings. Our research indicates that mutations in the MEN1/DAXX genes might trigger the early stages of PanNET development. We categorized the patients based on the presence (MEN1/DAXX mut, n = 7) or absence (MEN1/DAXX wild, n = 3) of these mutations. Notable differences were observed between the two groups in terms of genetic alterations and clinically relevant mutations, confirmed using the MSK-MET dataset. Notably, patients with mutations in MEN1/DAXX/ATRX genes had a significantly longer median overall survival compared to those without these mutations (median not reached vs. 43.63 months, p = 0.047). Multiplex immunohistochemistry (mIHC) analysis showed a more prominent immunosuppressive environment in metastatic tumors, especially in patients with MEN1/DAXX mutations. These findings imply that MEN1/DAXX mutations lead PanNETs through a unique evolutionary path. The disease’s progression pattern indicates that PanNETs can spread early, even before clinical detection, highlighting the importance of identifying biomarkers related to metastasis to guide personalized treatment strategies.
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- 2024
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31. Constraining Palatini-Horndeski theory with gravitational waves after GW170817
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Dong, Yu-Qi, Liu, Yu-Qiang, and Liu, Yu-Xiao
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
In this paper, we investigate the possible parameter space of Palatini-Horndeski theory with gravitational waves in a spatially flat Universe. We find that if the theory satisfies the following condition: in any spatially flat cosmological background, the tensor gravitational wave speed is the speed of light $c$, then only $S = \int d^4x \sqrt{-g} \big[K(\phi,X)-G_{3}(\phi,X){\tilde{\Box}}\phi+G_{4}(\phi)\tilde{R}\big]$ is left as the possible action in Palatini-Horndeski theory., Comment: 23 pages, no figure
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- 2022
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32. Light meson emissions of the selected charmonium-like states within compact tetraquark configurations
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Li, Ning, He, Hui-Zhen, Liang, Wei, Lü, Qi-Fang, Chen, Dian-Yong, and Dong, Yu-Bing
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
We adopt the quark pair creation model to investigate the light meson emissions of several charmonium-like states. The quark pair creation model is applied to the four-body systems, and we calculate the pion/kaon emissions of the $X(4700)$, $Z_c(4430)$, $Y(4230)$, $Y(4360)$, $Y(4390)$ and $Y(4660)$ within the compact tetraquark assumptions. It is found that the pion/kaon decay widths for the $X(4700)$ and $Z_c(4430)$ are relatively small, while the partial decay widths for the resonances $Y(4230)$, $Y(4360)$, $Y(4390)$ and $Y(4660)$ are significant. We expect that our exploration of these decay behaviors can provide useful information for future experimental searches and theoretical interpretations., Comment: 10 pages, 4 figures, to be published in Chinese Physics C
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- 2022
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33. Production of dibaryon $d_{N\Omega}$ in kaon induced reactions
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Liu, Jing, Lü, Qi-Fang, Liu, Chun-Hua, Chen, Dian-Yong, and Dong, Yu-Bing
- Subjects
High Energy Physics - Phenomenology - Abstract
In this work, we propose to investigate the $d_{N\Omega}$ dibaryon production in the process $K^- p \rightarrow d_{N\Omega} \bar{\Xi}^0$ by utilizing the kaon beam with the typical momentum to be around 10 GeV, which may be available at COMPASS, OKA@U-70 and SPS@CERN. The cross sections for $K^- p \rightarrow d_{N\Omega} \bar{\Xi}^0$ are estimated and in particular, the magnitude of the cross sections are evaluated to be several hundreds nanobarn at $P_K=20$ GeV. Considering that $d_{N\Omega}$ dibaryon dominantly decay into $\Xi \Lambda$ and $\Xi \Sigma$, we also estimate the cross sections for $K^- p \to \Xi^0 \Lambda \bar{\Xi}^0$ and $K^- p \to \Xi^- \Sigma^+ \bar{\Xi}^0$, where the $d_{N\Omega}$ dibaryon can be observed in the invariant mass distributions of $\Xi^0 \Lambda$ and $\Xi^- \Sigma^+ $, respectively., Comment: 7 pages, 4 figures
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- 2022
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34. Artificial intelligence‐assisted point‐of‐care testing system for ultrafast and quantitative detection of drug‐resistant bacteria
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Yang Ding, Jingjie Chen, Qiong Wu, Bin Fang, Wenhui Ji, Xin Li, Changmin Yu, Xuchun Wang, Xiamin Cheng, Hai‐Dong Yu, Zhangjun Hu, Kajsa Uvdal, Peng Li, Lin Li, and Wei Huang
- Subjects
antimicrobial resistance ,artificial intelligence ,fluorogenic probe ,microfluidic sensors ,mobile health ,point‐of‐care testing ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract As one of the major causes of antimicrobial resistance, β‐lactamase develops rapidly among bacteria. Detection of β‐lactamase in an efficient and low‐cost point‐of‐care testing (POCT) way is urgently needed. However, due to the volatile environmental factors, the quantitative measurement of current POCT is often inaccurate. Herein, we demonstrate an artificial intelligence (AI)‐assisted mobile health system that consists of a paper‐based β‐lactamase fluorogenic probe analytical device and a smartphone‐based AI cloud. An ultrafast broad‐spectrum fluorogenic probe (B1) that could respond to β‐lactamase within 20 s was first synthesized, and the detection limit was determined to be 0.13 nmol/L. Meanwhile, a three‐dimensional microfluidic paper‐based analytical device was fabricated for integration of B1. Also, a smartphone‐based AI cloud was developed to correct errors automatically and output results intelligently. This smart system could calibrate the temperature and pH in the β‐lactamase level detection in complex samples and mice infected with various bacteria, which shows the problem‐solving ability in interdisciplinary research, and demonstrates potential clinical benefits.
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- 2024
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35. Discussions with patients about referral pathways and costs in the diagnosis and treatment of colorectal cancer in Victoria, Australia
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Bergin, Rebecca J, Yao-Dong Yu, Angus, White, Victoria, and Emery, Jon D
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- 2024
36. hidden charm decays of $X(4014)$ in a $D^{*}\bar{D}^{*}$ molecule scenario
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Yue, Zi-Li, Duan, Man-Yu, Liu, Chun-Hua, Chen, Dian-Yong, and Dong, Yu-Bing
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High Energy Physics - Phenomenology - Abstract
Inspired by the recent observation of a new structure, $X(4014)$, in the process $\gamma\gamma\to \gamma\psi(2S)$, we evaluate the possibility of assigning $X(4014)$ as a $D^\ast \bar{D}^\ast$ molecular state with $I(J^{PC})=0(0^{++})$ by investigating the hidden charm decays of $X(4014)$. The partial widths of $J/\psi\omega$, $ \eta_{c}\eta$ and $\eta_{c}\eta^{\prime}$ channels are evaluated to be about $(0.41\sim 5.00)$, $(2.05\sim7.49)$ and $(0.11\sim0.51)\ \mathrm{MeV}$, respectively. Considering the experimental observation and the present estimations, we proposed to search $X(4014)$ in the $\gamma \gamma \to J/\psi \omega$ process in Belle II., Comment: 7 pages, 5 figures, accepted for publication in Phys. Rev. D
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- 2022
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37. Not all entangled states are useful for ancilla-assisted quantum process tomography
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Lu, Guo-Dong, Zhang, Zhou, Dai, Yue, Dong, Yu-Li, and Zhang, Cheng-Jie
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Quantum Physics - Abstract
It is well known that one can extract all the information of an unknown quantum channel by means of quantum process tomography, such as standard quantum-process tomography and ancilla-assisted quantum process tomography (AAQPT). Furthermore, it has been shown that entanglement is not necessary for AAQPT, there exist separable states which are also useful for it. Surprisingly, in this work we find that not all entangled states are useful for AAQPT, there also exist some entangled states which are useless. The realignment operation used in entanglement detection can be related to the question whether a bipartite state is useful for AAQPT. We derive the relationship between them and show the process of extracting the complete information of an unknown channel by the realignment operation. Based on this relationship, we present examples of a two-qutrit entangled state and a two-qutrit bound entangled state. Both of these two examples are entangled but they cannot be used for AAQPT. Last but not least, experimental verification has also been performed on the IBM platform.
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- 2022
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38. Fully-heavy hexaquarks in a constituent quark model
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Lü, Qi-Fang, Chen, Dian-Yong, and Dong, Yu-Bing
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
In this work, we systematically investigate the mass spectra of fully-heavy hexaquarks within a constituent quark model by including the color Coulomb potential, linear confining potential, and spin-spin interactions. Our results show that all of the fully-heavy hexaquarks lie above the corresponding baryon-baryon thresholds, and thus no stable compact one exists. These states may subsist as resonances and decay into two fully-heavy baryons easily through the fall-apart mechanism, which can be searched in future experiments., Comment: 8 pages, 2 figures, comments and suggestions are welcome
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- 2022
39. Classification of Gravitational Waves in Higher-dimensional Space-time and Possibility of Observation
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Liu, Yu-Qiang, Dong, Yu-Qi, and Liu, Yu-Xiao
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General Relativity and Quantum Cosmology - Abstract
The direct detection of gravitational waves opens the possibility to test general relativity and its alternatives in the strong field regime. Here we focus on the test of the existence of extra dimensions. The classification of gravitational waves in metric gravity theories according to their polarizations in higher-dimensional space-time and the possible observation of these polarizations in 3-dimensional subspace are discussed in this work. And we show that the difference in the response of gravitational waves in detectors with and without extra dimensions can serve as evidence for the existence of extra dimensions., Comment: 19 pages, 4 figures
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- 2022
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40. Clinical value of magnetic resonance spectroscopy in assessment of early curing impact of concurrent chemoradiotherapy after high-grade glioma surgery
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Gao Yu, Yan Wen-Ming, Wang Hong-Wei, Li Xin-Hong, Zhang Ru-Tao, Dong Yu-Bo, Zhang Wei-Han, and Guo Qi-Wei
- Subjects
biomarkers ,chemoradiotherapy ,chemotherapy ,adjuvant ,glioma ,magnetic resonance spectroscopy ,prognosis ,surgery ,Medicine (General) ,R5-920 - Abstract
Background/Aim. High-grade glioma (HGG) is an interstitial cell-derived primary tumor of the nervous system. The current guidelines for the diagnosis and treatment of glioma recommend the maximum safe range of tumor resection for treatment methods. Adjuvant concurrent chemoradiotherapy is recommended after surgery, followed by six cycles of single-drug chemotherapy, temozolomide. Evaluation of the early efficacy of concurrent chemoradio-therapy after HGG surgery, especially for patients with a high risk of recurrence, is a crucial step in enhancing the treatment efficiency for patients diagnosed with HGG. In this study, we investigated the clinical utility of magnetic resonance (MR) spectroscopy (MRS) in assessing the early curing impact of concurrent chemoradiotherapy following HGG surgery. Methods. A total of 50 patients with incomplete resection or suspected residual postoperative HGG, treated in the radiotherapy department of our hospital between January 2016 and June 2021, were selected for routine concurrent chemoradiotherapy. Conventional MR imaging and MRS were performed one week prior to treatment and one month after treatment to assess changes in specific brain metabolites. All 50 patients were followed up for 6 to 12 months. Based on the follow-up results, the patients were divided into two groups: the tumor recurrence group and the tumor suppression group. One month after the end of the treatment, the differences in levels of brain metabolites between the two groups were analyzed using MRS. Results. The levels of N-acetylaspartate (NAA) and creatine (Cr) increased after radiotherapy, while choline (Cho) peak value, and Cho/Cr, NAA/Cr, and Cho/NAA ratios decreased compared to pre-treatment levels. There were statistically significant differences in the NAA peak value, and Cho/Cr, and Cho/NAA ratios in the tumor enhancement area before and after treatment (p < 0.05). There were also statistically significant differences in Cho/Cr ratio in the peritumoral edema area before and after treatment (p < 0.05). Conclusion. After concurrent chemoradiotherapy, MRS can be used to detect early metabolic changes in the tumor enhancement and peritumoral edema areas of HGG.
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- 2024
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41. Analysis of gut microbiota of ladybug beetle (Harmonia axyridis) after feeding on different artificial diets
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Bing-Hua Xie, Lei Chao, Si-Jing Wan, Hui-Ru Si, Wei-Dong Yu, Zhen Huang, Shi-Gui Wang, Nicolas Desneux, Bin Tang, and Si-Si Sun
- Subjects
Firmicutes ,Harmonia axyridis ,Proteobacteria ,Synergistic substance ,Microbiology ,QR1-502 - Abstract
Abstract Background Harmonia axyridis is an effective natural enemy insect to a variety of phloem-sucking pests and Lepidopteran larvae, such as aphids, scabies, and phylloxera, while its industrial production is limited due to unmature artificial diet. Insect intestinal microbiota affect host development and reproduction. The aim of this study is to understand intestinal microbiota composition of H. axyridis and screen effective probiotics on artificial diet. Considering the role of the components and composition of the diet on the structure and composition of the intestinal microbiome, four kinds of diets were set up: (1) aphid; (2) basic diet; (3) basic diet + glucose; (4) basic diet + trehalose. The gut microbiota of H. axyridis was detected after feeding on different diets. Results Results showed that the gut microbiota between artificial diet group and aphid groups were far apart, while the basic and glucose groups were clearly clustered. Besides, the glucose group and trehalose group had one unique phylum, Cryptophyta and Candidatus Saccharibacteria, respectively. The highest abundance of Proteobacteria was found in the aphid diet. The highest abundance of Firmicutes was found in the basic diet. However, the addition of glucose or trehalose alleviated the change. In addition, the relative abundance of Enterobacter, Klebsiella, Enterobacteriaceae_unclassified, Enterobacteriales_unclassified and Serratia in the aphid group was higher than other groups. Moreover, the function of gut genes in each group also showed clear differences. Conclusion These results have offered a strong link between artificial diets and gut microbes, and also have provided a theoretical basis for the screening of synergistic probiotics in artificial diet.
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- 2024
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42. Using time-series chest radiographs and laboratory data by machine learning for identifying pulmonary infection and colonization of Acinetobacter baumannii
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Zhaodong Zeng, Jiefang Wu, Genggeng Qin, Dong Yu, Zilong He, Weixiong Zeng, Hao Zhou, Jiongbin Lin, Laiyu Liu, Chunxia Qi, and Weiguo Chen
- Subjects
Acinetobacter baumannii ,Machine learning ,Time-series chest radiographs and laboratory data ,Infection and colonization ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Accurately distinguishing between pulmonary infection and colonization in patients with Acinetobacter baumannii is of utmost importance to optimize treatment and prevent antibiotic abuse or inadequate therapy. An efficient automated sorting tool could prompt individualized interventions and enhance overall patient outcomes. This study aims to develop a robust machine learning classification model using a combination of time-series chest radiographs and laboratory data to accurately classify pulmonary status caused by Acinetobacter baumannii. Methods We proposed nested logistic regression models based on different time-series data to automatically classify the pulmonary status of patients with Acinetobacter baumannii. Advanced features were extracted from the time-series data of hospitalized patients, encompassing dynamic pneumonia indicators observed on chest radiographs and laboratory indicator values recorded at three specific time points. Results Data of 152 patients with Acinetobacter baumannii cultured from sputum or alveolar lavage fluid were retrospectively analyzed. Our model with multiple time-series data demonstrated a higher performance of AUC (0.850, with a 95% confidence interval of [0.638–0.873]), an accuracy of 0.761, a sensitivity of 0.833. The model, which only incorporated a single time point feature, achieved an AUC of 0.741. The influential model variables included difference in the chest radiograph pneumonia score. Conclusion Dynamic assessment of time-series chest radiographs and laboratory data using machine learning allowed for accurate classification of colonization and infection with Acinetobacter baumannii. This demonstrates the potential to help clinicians provide individualized treatment through early detection.
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- 2024
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43. Comprehensive Evaluation of Environmental Risk of Oil Spill
- Author
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Ruitong CHEN, Yan XU, Yahui LIANG, Dong YU, and Shuang XU
- Subjects
ningbo marine area ,oil spill risk ,index system ,comprehensive evaluation ,Oceanography ,GC1-1581 - Abstract
The environmental risk of oil spill was comprehensively evaluated based on the risk source of hazardous chemicals, sea-related sensitive targets and ship traffic density. Firstly, from the perspective of spatial distribution and quantitative characteristics, the impact factors of marine environmental risk in Ningbo City were extracted, and the assessment methods and index system of marine environmental risk were established. Then the GIS spatial information platform was used to evaluate the spatial distribution of environmental risks in Ningbo coastal waters. The results show that Cixi City in northwest and Zhenhai potential environmental risk of oil spill is extremely high, to the sensitivity of oil spill is relatively high, that these areas as the key control object; Beilun and Fenghua area in southeast coastal area and Xiangshan island in the east China sea, its environmental risk is general risk, that these areas for general control object, the potential environmental risk belongs to the medium sensitivity; The east and southeast of Xiangshan County and the south of Ninghai County have very low potential environmental risk, and their sensitivity to oil spill is low. The evaluation results can provide a scientific basis and effective reference for Ningbo's marine environmental risk prevention and control, emergency response measures, and the utilization and allocation of sea space resources.
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- 2024
44. Therapeutic effect and mechanism of Yougui Wan in rats with intervertebral disk degeneration
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She Ma, Kan Liu, Jing-yan Yang, Ren-jun Huang, and Dong Yu
- Subjects
Intervertebral disk degeneration ,Yougui Wan ,Notch signaling pathway ,Inflammatory response ,Nucleus pulposus cells ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Objective To explore the potential mechanism of Yougui Wan on deformed lumbar intervertebral disk structure in rats. Methods Thirty male Sprague–Dawley rats were randomly divided into 3 groups, with 10 rats in each group. The animals in the blank control group were healthy rats without specific treatment, and those in the model group and traditional Chinese medicine (TCM) group were used to establish the intervertebral disk degeneration (IDD) model by puncturing the annulus. Four weeks after modeling, rats in the TCM group were administered Yougui Wan by gavage for 2 consecutive weeks. Serum interleukin-6 (IL-10), macrophage migration inhibitory factor (MIF) and tumor necrosis factor alpha (TNF-α) levels were measured by ELISA, and the protein expression levels of collagen II and Notch1 in intervertebral disk tissues were examined by Western blotting. Apoptosis was detected by the TUNEL method. Results Compared with those in the blank group, IL-10, MIF and TNF-α levels in the model group and TCM group were increased (P
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- 2024
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45. GypSum: Learning Hybrid Representations for Code Summarization
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Wang, Yu, Dong, Yu, Lu, Xuesong, and Zhou, Aoying
- Subjects
Computer Science - Software Engineering ,Computer Science - Machine Learning ,Computer Science - Programming Languages ,Computer Science - Social and Information Networks - Abstract
Code summarization with deep learning has been widely studied in recent years. Current deep learning models for code summarization generally follow the principle in neural machine translation and adopt the encoder-decoder framework, where the encoder learns the semantic representations from source code and the decoder transforms the learnt representations into human-readable text that describes the functionality of code snippets. Despite they achieve the new state-of-the-art performance, we notice that current models often either generate less fluent summaries, or fail to capture the core functionality, since they usually focus on a single type of code representations. As such we propose GypSum, a new deep learning model that learns hybrid representations using graph attention neural networks and a pre-trained programming and natural language model. We introduce particular edges related to the control flow of a code snippet into the abstract syntax tree for graph construction, and design two encoders to learn from the graph and the token sequence of source code, respectively. We modify the encoder-decoder sublayer in the Transformer's decoder to fuse the representations and propose a dual-copy mechanism to facilitate summary generation. Experimental results demonstrate the superior performance of GypSum over existing code summarization models., Comment: 12 pages, 6 figures, 6 tables
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- 2022
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46. Mamba: a systematic software solution for beamline experiments at HEPS
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Liu, Yu, Geng, Yan-Da, Bi, Xiao-Xue, Li, Xiang, Tao, Ye, Cao, Jian-She, Dong, Yu-Hui, and Zhang, Yi
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Physics - Accelerator Physics - Abstract
To cater for the diverse experiment requirements at the High Energy Photon Source (HEPS) with often limited human resources, Bluesky is chosen as the basis for our software framework, Mamba. In our attempt to address Bluesky's lack of integrated GUIs, command injection with feedback is chosen as the main way for the GUIs to cooperate with the CLI; a RPC service is provided, which also covers functionalities unsuitable for command injection, as well as pushing of status updates. In order to fully support high-frequency applications like fly scans, Bluesky's support for asynchronous control is being improved; to support high-throughput experiments, Mamba Data Worker (MDW) is being developed to cover the complexity in asynchronous online data processing for these experiments. To systematically simplify the specification of metadata, scan parameters and data-processing graphs for each type of experiments, an experiment parameter generator (EPG) will be developed; experiment-specific modules to automate preparation steps will also be made. The integration of off-the-shelf code in Mamba for domain-specific needs is under investigation, and Mamba GUI Studio (MGS) is being developed to simplify the implementation and integration of GUIs., Comment: 9 pages, 6 figures, accepted for J. Synchrotron Rad
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- 2022
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47. Three-dimensional positional relationship between impacted mandibular third molars and the mandibular canal
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Yang, Yun, Bao, Dong-Yu, Ni, Can, and Li, Zhen
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- 2023
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48. Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma
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Chai, Jin-wen, Hu, Xi-wen, Zhang, Miao-miao, and Dong, Yu-na
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- 2023
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49. High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA
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Mo, Zhi-Wei, Peng, Yue-Ming, Zhang, Yi-Xin, Li, Yan, Kang, Bi-Ang, Chen, Ya-Ting, Li, Le, Sorci-Thomas, Mary G., Lin, Yi-Jun, Cao, Yang, Chen, Si, Liu, Ze-Long, Gao, Jian-Jun, Huang, Zhan-Peng, Zhou, Jia-Guo, Wang, Mian, Chang, Guang-Qi, Deng, Meng-Jie, Liu, Yu-Jia, Ma, Zhen-Sheng, Hu, Zuo-Jun, Dong, Yu-Gang, Ou, Zhi-Jun, and Ou, Jing-Song
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- 2023
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50. Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer
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Jiang, Zhe, Ju, YoungJun, Ali, Amjad, Chung, Philip E. D., Skowron, Patryk, Wang, Dong-Yu, Shrestha, Mariusz, Li, Huiqin, Liu, Jeff C., Vorobieva, Ioulia, Ghanbari-Azarnier, Ronak, Mwewa, Ethel, Koritzinsky, Marianne, Ben-David, Yaacov, Woodgett, James R., Perou, Charles M., Dupuy, Adam, Bader, Gary D., Egan, Sean E., Taylor, Michael D., and Zacksenhaus, Eldad
- Published
- 2023
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