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1. Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

Author: Saul, Sirle, Karim, Marwah, Ghita, Luca, Huang, Pei-Tzu, Chiu, Winston, Durán, Verónica, Lo, Chieh-Wen, Kumar, Sathish, Bhalla, Nishank, Leyssen, Pieter, Alem, Farhang, Boghdeh, Niloufar A, Tran, HoangNhu, Cohen, Courtney A, Brown, Jacquelyn A, Huie, Kathleen E, Tindle, Courtney, Sibai, Mamdouh, Ye, Chengjin, Khalil, Ahmed Magdy, Chiem, Kevin, Martinez-Sobrido, Luis, Dye, John M, Pinsky, Benjamin A, Ghosh, Pradipta, Das, Soumita, Solow-Cordero, David E, Jin, Jing, Wikswo, John P, Jochmans, Dirk, Neyts, Johan, De Jonghe, Steven, Narayanan, Aarthi, and Einav, Shirit
Subjects: Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Rare Diseases, Biodefense, Infectious Diseases, Lung, Coronaviruses, Emerging Infectious Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Animals, Humans, Mice, Antiviral Agents, COVID-19, Cytokines, Hepatitis C, Chronic, Inflammation, Lapatinib, SARS-CoV-2, Drug screens, Protein kinases, Therapeutics, Virology, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract: Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated that lapatinib and other approved inhibitors of the ErbB family of receptor tyrosine kinases suppress replication of SARS-CoV-2, Venezuelan equine encephalitis virus (VEEV), and other emerging viruses with a high barrier to resistance. Lapatinib suppressed SARS-CoV-2 entry and later stages of the viral life cycle and showed synergistic effect with the direct-acting antiviral nirmatrelvir. We discovered that ErbB1, ErbB2, and ErbB4 bind SARS-CoV-2 S1 protein and regulate viral and ACE2 internalization, and they are required for VEEV infection. In human lung organoids, lapatinib protected from SARS-CoV-2-induced activation of ErbB-regulated pathways implicated in non-infectious lung injury, proinflammatory cytokine production, and epithelial barrier injury. Lapatinib suppressed VEEV replication, cytokine production, and disruption of blood-brain barrier integrity in microfluidics-based human neurovascular units, and reduced mortality in a lethal infection murine model. We validated lapatinib-mediated inhibition of ErbB activity as an important mechanism of antiviral action. These findings reveal regulation of viral replication, inflammation, and tissue injury via ErbBs and establish a proof of principle for a repurposed, ErbB-targeted approach to combat emerging viruses.
Published: 2023

2. Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design

Author: Khurana, Surender, Grubbs, Gabrielle, Ravichandran, Supriya, Cluff, Emily, Kim, JungHyun, Kuehne, Ana I., Zak, Samantha, Dye, John M., Lutwama, Julius J., and Herbert, Andrew S.
Published: 2024
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3. Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

Author: Shin, Olivia S., Monticelli, Stephanie R., Hjorth, Christy K., Hornet, Vladlena, Doyle, Michael, Abelson, Dafna, Kuehne, Ana I., Wang, Albert, Bakken, Russell R., Mishra, Akaash K., Middlecamp, Marissa, Champney, Elizabeth, Stuart, Lauran, Maurer, Daniel P., Li, Jiannan, Berrigan, Jacob, Barajas, Jennifer, Balinandi, Stephen, Lutwama, Julius J., Lobel, Leslie, Zeitlin, Larry, Walker, Laura M., Dye, John M., Chandran, Kartik, Herbert, Andrew S., Pauli, Noel T., and McLellan, Jason S.
Published: 2024
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4. SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode

Author: Goike, Jule, Hsieh, Ching-Lin, Horton, Andrew P., Gardner, Elizabeth C., Zhou, Ling, Bartzoka, Foteini, Wang, Nianshuang, Javanmardi, Kamyab, Herbert, Andrew, Abbassi, Shawn, Xie, Xuping, Xia, Hongjie, Shi, Pei-Yong, Renberg, Rebecca, Segall-Shapiro, Thomas H., Terrace, Cynthia I., Wu, Wesley, Shroff, Raghav, Byrom, Michelle, Ellington, Andrew D., Marcotte, Edward M., Musser, James M., Kuchipudi, Suresh V., Kapur, Vivek, Georgiou, George, Weaver, Scott C., Dye, John M., Boutz, Daniel R., McLellan, Jason S., and Gollihar, Jimmy D.
Published: 2023
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5. Author Correction: Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection

Author: Slough, Megan M., Li, Rong, Herbert, Andrew S., Lasso, Gorka, Kuehne, Ana I., Monticelli, Stephanie R., Bakken, Russell R., Liu, Yanan, Ghosh, Agnidipta, Moreau, Alicia M., Zeng, Xiankun, Rey, Félix A., Guardado-Calvo, Pablo, Almo, Steven C., Dye, John M., Jangra, Rohit K., Wang, Zhongde, and Chandran, Kartik
Published: 2023
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6. Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection

Author: Slough, Megan M., Li, Rong, Herbert, Andrew S., Lasso, Gorka, Kuehne, Ana I., Monticelli, Stephanie R., Bakken, Russell R., Liu, Yanan, Ghosh, Agnidipta, Moreau, Alicia M., Zeng, Xiankun, Rey, Félix A., Guardado-Calvo, Pablo, Almo, Steven C., Dye, John M., Jangra, Rohit K., Wang, Zhongde, and Chandran, Kartik
Published: 2023
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7. 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author: Kuhn, Jens H, Adkins, Scott, Agwanda, Bernard R, Al Kubrusli, Rim, Alkhovsky, Sergey V, Amarasinghe, Gaya K, Avšič-Županc, Tatjana, Ayllón, María A, Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J, Basler, Christopher F, Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J, Bente, Dennis A, Bergeron, Éric, Bird, Brian H, Blair, Carol D, Blasdell, Kim R, Blystad, Dag-Ragnar, Bojko, Jamie, Borth, Wayne B, Bradfute, Steven, Breyta, Rachel, Briese, Thomas, Brown, Paul A, Brown, Judith K, Buchholz, Ursula J, Buchmeier, Michael J, Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H, Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N, Cheng, Qi, Chiaki, Yuya, Chiapello, Marco, Choi, Il-Ryong, Ciuffo, Marina, Clegg, J Christopher S, Crozier, Ian, Dal Bó, Elena, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L, Debat, Humberto, Dheilly, Nolwenn M, Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G, Digiaro, Michele, Dolnik, Olga, Drebot, Michael A, Drexler, J Felix, Dundon, William G, Duprex, W Paul, Dürrwald, Ralf, Dye, John M, Easton, Andrew J, Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W, Fooks, Anthony R, Forgia, Marco, Formenty, Pierre BH, Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R, Gaskin, Thomas, Gonzalez, Jean-Paul J, Griffiths, Anthony, Goldberg, Tony L, Groschup, Martin H, Günther, Stephan, Hall, Roy A, Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S, Hu, Tao, Hughes, Holly R, and Hüttner, Florian
Subjects: Biotechnology, Humans, Mononegavirales, Viruses, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract: In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families (Aliusviridae, Crepuscuviridae, Myriaviridae, and Natareviridae), three subfamilies (Alpharhabdovirinae, Betarhabdovirinae, and Gammarhabdovirinae), 42 genera, and 200 species. Thirty-nine species were renamed and/or moved and seven species were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
Published: 2021

8. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author: Kuhn, Jens H, Adkins, Scott, Alioto, Daniela, Alkhovsky, Sergey V, Amarasinghe, Gaya K, Anthony, Simon J, Avšič-Županc, Tatjana, Ayllón, María A, Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J, Bartonička, Tomáš, Basler, Christopher, Bavari, Sina, Beer, Martin, Bente, Dennis A, Bergeron, Éric, Bird, Brian H, Blair, Carol, Blasdell, Kim R, Bradfute, Steven B, Breyta, Rachel, Briese, Thomas, Brown, Paul A, Buchholz, Ursula J, Buchmeier, Michael J, Bukreyev, Alexander, Burt, Felicity, Buzkan, Nihal, Calisher, Charles H, Cao, Mengji, Casas, Inmaculada, Chamberlain, John, Chandran, Kartik, Charrel, Rémi N, Chen, Biao, Chiumenti, Michela, Choi, Il-Ryong, Clegg, J Christopher S, Crozier, Ian, da Graça, John V, Dal Bó, Elena, Dávila, Alberto MR, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L, Di Bello, Patrick L, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G, Digiaro, Michele, Dolja, Valerian V, Dolnik, Olga, Drebot, Michael A, Drexler, Jan Felix, Dürrwald, Ralf, Dufkova, Lucie, Dundon, William G, Duprex, W Paul, Dye, John M, Easton, Andrew J, Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Fernandes, Jorlan, Fooks, Anthony R, Formenty, Pierre BH, Forth, Leonie F, Fouchier, Ron AM, Freitas-Astúa, Juliana, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R, Gbakima, Aiah, Goldstein, Tracey, Gonzalez, Jean-Paul J, Griffiths, Anthony, Groschup, Martin H, Günther, Stephan, Guterres, Alexandro, Hall, Roy A, Hammond, John, Hassan, Mohamed, Hepojoki, Jussi, Hepojoki, Satu, Hetzel, Udo, Hewson, Roger, Hoffmann, Bernd, Hongo, Seiji, Höper, Dirk, Horie, Masayuki, Hughes, Holly R, Hyndman, Timothy H, Jambai, Amara, Jardim, Rodrigo, Jiāng, Dàohóng, Jin, Qi, and Jonson, Gilda B
Subjects: Biotechnology, Mononegavirales, Terminology as Topic, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract: In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 species were added, four were deleted, ten were moved and renamed, and 30 species were renamed. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
Published: 2020

9. Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

Author: Wirchnianski, Ariel S., primary, Nyakatura, Elisabeth K., additional, Herbert, Andrew S., additional, Kuehne, Ana I., additional, Abbasi, Shawn A., additional, Florez, Catalina, additional, Storm, Nadia, additional, McKay, Lindsay G. A., additional, Dailey, Leandrew, additional, Kuang, Erin, additional, Abelson, Dafna M., additional, Wec, Anna Z., additional, Chakraborti, Srinjoy, additional, Holtsberg, Frederick W., additional, Shulenin, Sergey, additional, Bornholdt, Zachary A., additional, Aman, M. Javad, additional, Honko, Anna N., additional, Griffiths, Anthony, additional, Dye, John M., additional, Chandran, Kartik, additional, and Lai, Jonathan R., additional
Published: 2024
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10. Development of an antibody cocktail for treatment of Sudan virus infection

Author: Herbert, Andrew S., Froude, Jeffery W., Ortiz, Ramon A., Kuehne, Ana I., Dorosky, Danielle E., Bakken, Russell R., Zak, Samantha E., Josleyn, Nicole M., Musiychuk, Konstantin, Jones, R. Mark, Green, Brian, Streatfield, Stephen J., Wec, Anna Z., Bohorova, Natasha, Bohorov, Ognian, Kim, Do H., Pauly, Michael H., Velasco, Jesus, Whaley, Kevin J., Stonier, Spencer W., Bornholdt, Zachary A., Chandran, Kartik, Zeitlin, Larry, Sampey, Darryl, Yusibov, Vidadi, and Dye, John M.
Published: 2020

11. Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials.

Author: Postler, Thomas S, Clawson, Anna N, Amarasinghe, Gaya K, Basler, Christopher F, Bavari, Sbina, Benko, Mária, Blasdell, Kim R, Briese, Thomas, Buchmeier, Michael J, Bukreyev, Alexander, Calisher, Charles H, Chandran, Kartik, Charrel, Rémi, Clegg, Christopher S, Collins, Peter L, Juan Carlos, De La Torre, Derisi, Joseph L, Dietzgen, Ralf G, Dolnik, Olga, Dürrwald, Ralf, Dye, John M, Easton, Andrew J, Emonet, Sébastian, Formenty, Pierre, Fouchier, Ron AM, Ghedin, Elodie, Gonzalez, Jean-Paul, Harrach, Balázs, Hewson, Roger, Horie, Masayuki, Jiang, Dàohóng, Kobinger, Gary, Kondo, Hideki, Kropinski, Andrew M, Krupovic, Mart, Kurath, Gael, Lamb, Robert A, Leroy, Eric M, Lukashevich, Igor S, Maisner, Andrea, Mushegian, Arcady R, Netesov, Sergey V, Nowotny, Norbert, Patterson, Jean L, Payne, Susan L, PaWeska, Janusz T, Peters, Clarence J, Radoshitzky, Sheli R, Rima, Bertus K, Romanowski, Victor, Rubbenstroth, Dennis, Sabanadzovic, Sead, Sanfaçon, Hélène, Salvato, Maria S, Schwemmle, Martin, Smither, Sophie J, Stenglein, Mark D, Stone, David M, Takada, Ayato, Tesh, Robert B, Tomonaga, Keizo, Tordo, Noël, Towner, Jonathan S, Vasilakis, Nikos, Volchkov, Viktor E, Wahl-Jensen, Victoria, Walker, Peter J, Wang, Lin-Fa, Varsani, Arvind, Whitfield, Anna E, Zerbini, F Murilo, and Kuhn, Jens H
Subjects: Classification, Terminology as Topic, Viruses, Arenaviridae, binomials, ICTV, International Committee on Taxonomy of Viruses, Mononegavirales, virus nomenclature, virus taxonomy, Evolutionary Biology, Genetics
Abstract: Botanical, mycological, zoological, and prokaryotic species names follow the Linnaean format, consisting of an italicized Latinized binomen with a capitalized genus name and a lower case species epithet (e.g., Homo sapiens). Virus species names, however, do not follow a uniform format, and, even when binomial, are not Linnaean in style. In this thought exercise, we attempted to convert all currently official names of species included in the virus family Arenaviridae and the virus order Mononegavirales to Linnaean binomials, and to identify and address associated challenges and concerns. Surprisingly, this endeavor was not as complicated or time-consuming as even the authors of this article expected when conceiving the experiment. [Arenaviridae; binomials; ICTV; International Committee on Taxonomy of Viruses; Mononegavirales; virus nomenclature; virus taxonomy.].
Published: 2017

12. Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization

Author: Salazar, Eric, Kuchipudi, Suresh V., Christensen, Paul A., Eagar, Todd, Yi, Xin, Zhao, Picheng, Jin, Zhicheng, Long, S. Wesley, Olsen, Randall J., Chen, Jian, Castillo, Brian, Leveque, Christopher, Towers, Dalton, Lavinder, Jason, Gollihar, Jimmy, Cardona, Jose, Ippolito, Gregory, Nissly, Ruth, Bird, Ian, Greenawalt, Denver, Rossi, Randall M., Gontu, Abhinay, Srinivasan, Sreenidhi, Poojary, Indira, Cattadori, Isabella M., Hudson, Peter J., Josleyn, Nicole M., Prugar, Laura, Huie, Kathleen, Herbert, Andrew, Bernard, David W., Dye, John M., Kapur, Vivek, and Musser, James M.
Subjects: Viral proteins -- Health aspects, Epidemics -- Control -- United States, COVID-19 -- Control, Immunoglobulin G -- Health aspects, Health care industry
Abstract: The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the urgent need for assays that detect protective levels of neutralizing antibodies. We studied the relationship among anti-spike ectodomain (anti-ECD), antireceptor-binding domain (anti-RBD) IgG titers, and SARS-CoV-2 virus neutralization (VN) titers generated by 2 in vitro assays using convalescent plasma samples from 68 patients with COVID-19. We report a strong positive correlation between both plasma anti-RBD and anti-ECD IgG titers and in vitro VN titers. The probability of a VN titer of [greater than or equal to] 160, the FDA-recommended level for convalescent plasma used for COVID-19 treatment, was [greater than or equal to] 80% when anti-RBD or anti-ECD titers were [greater than or equal to] 1:1350. Of all donors, 37% lacked VN titers of [greater than or equal to] 160. Dyspnea, hospitalization, and disease severity were significantly associated with higher VN titer. Frequent donation of convalescent plasma did not significantly decrease VN or IgG titers. Analysis of 2814 asymptomatic adults found 73 individuals with anti-ECD IgG titers of [greater than or equal to] 1:50 and strong positive correlation with anti-RBD and VN titers. Fourteen of these individuals had VN titers of [greater than or equal to] 1:160, and all of them had anti-RBD titers of [greater than or equal to] 1:1350. We conclude that anti-RBD or anti-ECD IgG titers can serve as a surrogate for VN titers to identify suitable plasma donors. Plasma anti-RBD or anti-ECD titers of [greater than or equal to] 1:1350 may provide critical information about protection against COVID-19 disease., Introduction The recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus that causes coronavirus disease 2019 (COVID-19) disease, has spread globally and is now responsible for massive [...]
Published: 2020
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13. SARS-CoV-2 Aerosol and Intranasal Exposure Models in Ferrets

Author: Zumbrun, Elizabeth E., primary, Zak, Samantha E., additional, Lee, Eric D., additional, Bowling, Philip A., additional, Ruiz, Sara I., additional, Zeng, Xiankun, additional, Koehler, Jeffrey W., additional, Delp, Korey L., additional, Bakken, Russel R., additional, Hentschel, Shannon S., additional, Bloomfield, Holly A., additional, Ricks, Keersten M., additional, Clements, Tamara L., additional, Babka, April M., additional, Dye, John M., additional, and Herbert, Andrew S., additional
Published: 2023
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14. Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing

Author: Zumbrun, Elizabeth E., primary, Garvey, Carly B., additional, Wells, Jay B., additional, Lynn, Ginger C., additional, Van Tongeren, Sean, additional, Steffens, Jesse T., additional, Wetzel, Kelly S., additional, Gomba, Laura M., additional, O’Brien, Kristan A., additional, Rossi, Franco D., additional, Zeng, Xiankun, additional, Lee, Eric D., additional, Raymond, Jo Lynne W., additional, Hoffman, Diana A., additional, Jay, Alexandra N., additional, Brown, Elizabeth S., additional, Kallgren, Paul A., additional, Norris, Sarah L., additional, Cantey-Kiser, Jean, additional, Kudiya, Humza, additional, Arthur, Chris, additional, Blair, Christiana, additional, Babusis, Darius, additional, Chu, Victor C., additional, Singh, Bali, additional, Bannister, Roy, additional, Porter, Danielle P., additional, Cihlar, Tomas, additional, and Dye, John M., additional
Published: 2023
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15. Multiple viral proteins and immune response pathways act to generate robust long-term immunity in Sudan virus survivors

Author: Sobarzo, Ariel, Stonier, Spencer W., Radinsky, Olga, Gelkop, Sigal, Kuehne, Ana I., Edri, Avishay, Herbert, Andrew S., Fedida-Metula, Shlomit, Lutwama, Julius Julian, Yavelsky, Victoria, Davis, Claytus, Porgador, Angel, Dye, John M., and Lobel, Leslie
Published: 2019
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16. Enhancement of Ebola virus infection by seminal amyloid fibrils

Author: Bart, Stephen M., Cohen, Courtney, Dye, John M., Shorter, James, and Bates, Paul
Published: 2018

17. Structural basis of broad ebolavirus neutralization by a human survivor antibody

Author: West, Brandyn R., Wec, Anna Z., Moyer, Crystal L., Fusco, Marnie L., Ilinykh, Philipp A., Huang, Kai, Wirchnianski, Ariel S., James, Rebekah M., Herbert, Andrew S., Hui, Sean, Goodwin, Eileen, Howell, Katie A., Kailasan, Shweta, Aman, M. Javad, Walker, Laura M., Dye, John M., Bukreyev, Alexander, Chandran, Kartik, and Saphire, Erica Ollmann
Published: 2019
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18. Protocadherin-1 is essential for cell entry by New World hantaviruses

Author: Jangra, Rohit K., Herbert, Andrew S., Li, Rong, Jae, Lucas T., Kleinfelter, Lara M., Slough, Megan M., Barker, Sarah L., Guardado-Calvo, Pablo, Román-Sosa, Gleyder, Dieterle, M. Eugenia, Kuehne, Ana I., Muena, Nicolás A., Wirchnianski, Ariel S., Nyakatura, Elisabeth K., Fels, J. Maximilian, Ng, Melinda, Mittler, Eva, Pan, James, Bharrhan, Sushma, Wec, Anna Z., Lai, Jonathan R., Sidhu, Sachdev S., Tischler, Nicole D., Rey, Félix A., Moffat, Jason, Brummelkamp, Thijn R., Wang, Zhongde, Dye, John M., and Chandran, Kartik
Published: 2018
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19. Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates

Author: Brannan, Jennifer M., He, Shihua, Howell, Katie A., Prugar, Laura I., Zhu, Wenjun, Vu, Hong, Shulenin, Sergey, Kailasan, Shweta, Raina, Henna, Wong, Gary, Rahim, Md Niaz, Banadyga, Logan, Tierney, Kevin, Zhao, Xuelian, Li, Yuxing, Holtsberg, Frederick W., Dye, John M., Qiu, Xiangguo, and Aman, M. Javad
Published: 2019
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20. Dengue fever and chikungunya virus infections: identification in travelers in Uganda – 2017

Author: Kayiwa, John T., Nankya, Annet M., Ataliba, Irene, Nassuna, Charity A., Omara, Isaac E., Koehler, Jeffrey W., Dye, John M., Mossel, Eric C., and Lutwama, Julius J.
Published: 2019
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21. Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

Author: Mittler, Eva, Serris, Alexandra, Esterman, Emma S., Florez, Catalina, Polanco, Laura C., O'Brien, Cecilia M., Slough, Megan M., Tynell, Janne, Gröning, Remigius, Sun, Yan, Abelson, Dafna M., Wec, Anna Z., Haslwanter, Denise, Keller, Markus, Ye, Chunyan, Bakken, Russel R., Jangra, Rohit K., Dye, John M., Ahlm, Clas, Rappazzo, C. Garrett, Ulrich, Rainer G., Zeitlin, Larry, Geoghegan, James C., Bradfute, Steven B., Sidoli, Simone, Forsell, Mattias N. E., Strandin, Tomas, Rey, Felix A., Herbert, Andrew S., Walker, Laura M., Chandran, Kartik, Guardado-Calvo, Pablo, Mittler, Eva, Serris, Alexandra, Esterman, Emma S., Florez, Catalina, Polanco, Laura C., O'Brien, Cecilia M., Slough, Megan M., Tynell, Janne, Gröning, Remigius, Sun, Yan, Abelson, Dafna M., Wec, Anna Z., Haslwanter, Denise, Keller, Markus, Ye, Chunyan, Bakken, Russel R., Jangra, Rohit K., Dye, John M., Ahlm, Clas, Rappazzo, C. Garrett, Ulrich, Rainer G., Zeitlin, Larry, Geoghegan, James C., Bradfute, Steven B., Sidoli, Simone, Forsell, Mattias N. E., Strandin, Tomas, Rey, Felix A., Herbert, Andrew S., Walker, Laura M., Chandran, Kartik, and Guardado-Calvo, Pablo
Abstract: Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (nAb) from a Puumala virus-experienced human donor. Here, we report its structure bound to its target, the Gn/Gc glycoprotein heterodimer comprising the viral fusion complex. The structure explains the broad activity of the nAb: It recognizes conserved Gc fusion loop sequences and the main chain of variable Gn sequences, thereby straddling the Gn/Gc heterodimer and locking it in its prefusion conformation. We show that the nAb's accelerated dissociation from the divergent Andes virus Gn/Gc at endosomal acidic pH limits its potency against this highly lethal virus and correct this liability by engineering an optimized variant that sets a benchmark as a candidate pan-hantavirus therapeutic.
Published: 2023
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22. Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19

Author: Zumbrun, Elizabeth E., primary, Kaku, Chengzi I., additional, Dillinger, Lukas, additional, Zak, Samantha E., additional, Kuehne, Ana I., additional, Bakken, Russel R., additional, Koehler, Jeffrey W., additional, Delp, Korey L., additional, Stefan, Christopher P., additional, Kumar, Raina, additional, Kugelman, Jeffrey R., additional, Moreau, Alicia M., additional, Zeng, Xiankun, additional, Dye, John M., additional, Herbert, Andrew S., additional, Narayan, Kristin, additional, and Walker, Laura M., additional
Published: 2023
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23. 1143. Prophylactic and Therapeutic Activity of AZD7442 (Tixagevimab/Cilgavimab) in SARS-CoV-2 Hamster Challenge Models

Author: Loo, Yueh-Ming, primary, Herbert, Andrew S, additional, Kuehne, Ana I, additional, McTamney, Patrick M, additional, Roque, Richard, additional, Moreau, Alicia M, additional, Bakken, Russell, additional, Stefan, Christopher P, additional, Koehler, Jeffrey W, additional, Delp, Korey L, additional, Coyne, Susan R, additional, Kane, Christopher D, additional, Dye, John M, additional, Cai, Yingyun, additional, and Esser, Mark T, additional
Published: 2022
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24. Detection of biomarkers for filoviral infection with a silicon photonic resonator platform

Author: Meserve, Krista, primary, Qavi, Abraham J., additional, Aman, M. Javad, additional, Vu, Hong, additional, Zeitlin, Larry, additional, Dye, John M., additional, Froude, Jeffrey W., additional, Leung, Daisy W., additional, Yang, Lan, additional, Holtsberg, Frederick W., additional, Amarasinghe, Gaya K., additional, and Bailey, Ryan C., additional
Published: 2022
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25. Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

Author: Bekerman, Elena, Neveu, Gregory, Shulla, Ana, Brannan, Jennifer, Pu, Szu-Yuan, Wang, Stanley, Xiao, Fei, Barouch-Bentov, Rina, Bakken, Russell R., Mateo, Roberto, Govero, Jennifer, Nagamine, Claude M., Diamond, Michael S., De Jonghe, Steven, Herdewijn, Piet, Dye, John M., Randall, Glenn, and Einav, Shirit
Subjects: Host-virus relationships, Enzyme regulation -- Health aspects, Virus diseases -- Drug therapy, Antineoplastic agents -- Patient outcomes, Health care industry
Abstract: Global health is threatened by emerging viral infections, which largely lack effective vaccines or therapies. Targeting host pathways that are exploited by multiple viruses could offer broad-spectrum solutions. We previously reported that AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection, but the underlying mechanism and relevance to other viruses or in vivo infections remained unknown. Here, we have discovered that AP1 and AP2 cotraffic with HCV particles in live cells. Moreover, we found that multiple viruses, including dengue and Ebola, exploit AAK1 and GAK during entry and infectious virus production. In cultured cells, treatment with sunitinib and erlotinib, approved anticancer drugs that inhibit AAK1 or GAK activity, or with more selective compounds inhibited intracellular trafficking of HCV and multiple unrelated RNA viruses with a high barrier to resistance. In murine models of dengue and Ebola infection, sunitinib/erlotinib combination protected against morbidity and mortality. We validated sunitinib- and erlotinib-mediated inhibition of AAK1 and GAK activity as an important mechanism of antiviral action. Additionally, we revealed potential roles for additional kinase targets. These findings advance our understanding of virus-host interactions and establish a proof of principle for a repurposed, host-targeted approach to combat emerging viruses., Introduction A major threat to human health is posed by emerging viruses, such as dengue (DENV) and Ebola (EBOV). Dengue is estimated to infect 390 million people annually in over [...]
Published: 2017
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26. An introduction to the Marburg virus vaccine consortium, MARVAC

Author: Cross, Robert W., primary, Longini, Ira M., additional, Becker, Stephan, additional, Bok, Karin, additional, Boucher, David, additional, Carroll, Miles W., additional, Díaz, Janet V., additional, Dowling, William E., additional, Draghia-Akli, Ruxandra, additional, Duworko, James T., additional, Dye, John M., additional, Egan, Michael A., additional, Fast, Patricia, additional, Finan, Amy, additional, Finch, Courtney, additional, Fleming, Thomas R., additional, Fusco, Joan, additional, Geisbert, Thomas W., additional, Griffiths, Anthony, additional, Günther, Stephan, additional, Hensley, Lisa E., additional, Honko, Anna, additional, Hunegnaw, Ruth, additional, Jakubik, Jocelyn, additional, Ledgerwood, Julie, additional, Luhn, Kerstin, additional, Matassov, Demetrius, additional, Meshulam, Jeffrey, additional, Nelson, Emily V., additional, Parks, Christopher L., additional, Rustomjee, Roxana, additional, Safronetz, David, additional, Schwartz, Lauren M., additional, Smith, Dean, additional, Smock, Paul, additional, Sow, Ydrissa, additional, Spiropoulou, Christina F., additional, Sullivan, Nancy J., additional, Warfield, Kelly L., additional, Wolfe, Daniel, additional, Woolsey, Courtney, additional, Zahn, Roland, additional, Henao-Restrepo, Ana María, additional, Muñoz-Fontela, César, additional, and Marzi, Andrea, additional
Published: 2022
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27. Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding

Author: Husby, Monica L, primary, Amiar, Souad, additional, Prugar, Laura I, additional, David, Emily A, additional, Plescia, Caroline B, additional, Huie, Kathleen E, additional, Brannan, Jennifer M, additional, Dye, John M, additional, Pienaar, Elsje, additional, and Stahelin, Robert V, additional
Published: 2022
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28. Rapid detection of an Ebola biomarker with optical microring resonators

Author: Qavi, Abraham J., primary, Meserve, Krista, additional, Aman, M. Javad, additional, Vu, Hong, additional, Zeitlin, Larry, additional, Dye, John M., additional, Froude, Jeffrey W., additional, Leung, Daisy W., additional, Yang, Lan, additional, Holtsberg, Frederick W., additional, Bailey, Ryan C., additional, and Amarasinghe, Gaya K., additional
Published: 2022
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29. Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19

Author: Frumkin, Lyn R., primary, Lucas, Michaela, additional, Scribner, Curtis L., additional, Ortega-Heinly, Nastassja, additional, Rogers, Jayden, additional, Yin, Gang, additional, Hallam, Trevor J., additional, Yam, Alice, additional, Bedard, Kristin, additional, Begley, Rebecca, additional, Cohen, Courtney A., additional, Badger, Catherine V., additional, Abbasi, Shawn A., additional, Dye, John M., additional, McMillan, Brian, additional, Wallach, Michael, additional, Bricker, Traci L., additional, Joshi, Astha, additional, Boon, Adrianus C. M., additional, Pokhrel, Suman, additional, Kraemer, Benjamin R., additional, Lee, Lucia, additional, Kargotich, Stephen, additional, Agochiya, Mahima, additional, John, Tom St., additional, and Mochly-Rosen, Daria, additional
Published: 2022
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30. LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

Author: Westendorf, Kathryn, primary, Žentelis, Stefanie, additional, Wang, Lingshu, additional, Foster, Denisa, additional, Vaillancourt, Peter, additional, Wiggin, Matthew, additional, Lovett, Erica, additional, van der Lee, Robin, additional, Hendle, Jörg, additional, Pustilnik, Anna, additional, Sauder, J. Michael, additional, Kraft, Lucas, additional, Hwang, Yuri, additional, Siegel, Robert W., additional, Chen, Jinbiao, additional, Heinz, Beverly A., additional, Higgs, Richard E., additional, Kallewaard, Nicole L., additional, Jepson, Kevin, additional, Goya, Rodrigo, additional, Smith, Maia A., additional, Collins, David W., additional, Pellacani, Davide, additional, Xiang, Ping, additional, de Puyraimond, Valentine, additional, Ricicova, Marketa, additional, Devorkin, Lindsay, additional, Pritchard, Caitlin, additional, O’Neill, Aoise, additional, Dalal, Kush, additional, Panwar, Pankaj, additional, Dhupar, Harveer, additional, Garces, Fabian A., additional, Cohen, Courtney A., additional, Dye, John M., additional, Huie, Kathleen E., additional, Badger, Catherine V., additional, Kobasa, Darwyn, additional, Audet, Jonathan, additional, Freitas, Joshua J., additional, Hassanali, Saleema, additional, Hughes, Ina, additional, Munoz, Luis, additional, Palma, Holly C., additional, Ramamurthy, Bharathi, additional, Cross, Robert W., additional, Geisbert, Thomas W., additional, Menachery, Vineet, additional, Lokugamage, Kumari, additional, Borisevich, Viktoriya, additional, Lanz, Iliana, additional, Anderson, Lisa, additional, Sipahimalani, Payal, additional, Corbett, Kizzmekia S., additional, Yang, Eun Sung, additional, Zhang, Yi, additional, Shi, Wei, additional, Zhou, Tongqing, additional, Choe, Misook, additional, Misasi, John, additional, Kwong, Peter D., additional, Sullivan, Nancy J., additional, Graham, Barney S., additional, Fernandez, Tara L., additional, Hansen, Carl L., additional, Falconer, Ester, additional, Mascola, John R., additional, Jones, Bryan E., additional, and Barnhart, Bryan C., additional
Published: 2022
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31. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author: National Institute of Allergy and Infectious Diseases (US), National Cancer Institute (US), National Institutes of Health (US), Frederick National Laboratory for Cancer Research (US), US Department of Homeland Security, National Institute of Food and Agriculture (US), Kuhn, Jens H. [0000-0002-7800-6045], Adkins, Scott [0000-0003-0095-8414], Alioto, Daniela [0000-0002-4954-8363], Alkhovsky, Sergey V. [0000-0001-6913-5841], Amarasinghe, Gaya K. [0000-0002-0418-9707], Avsic-Zupanc, Tatjana [0000-0001-6243-0688], Ayllón, María A. [0000-0001-7893-6106], Bahl, Justin [0000-0001-7572-4300], Balkema-Buschmann, A. [0000-0001-7613-9592], Ballinger, Matthew J. [0000-0001-7453-8725], Bartonička, Tomáš [0000-0001-7335-2435], Basler, Christopher F. [0000-0003-4195-425X], Bavari, Sina [0000-0001-8424-5635], Beer, Martin [0000-0002-0598-5254], Bente, Dennis A. [0000-0002-5150-7368], Bergeron, Éric [0000-0003-3398-8628], Bird, Brian H. [0000-0001-8170-8710], Blair, Carol D. [0000-0002-2803-0354], Blasdell, Kim R. [0000-0003-2121-0376], Bradfute, Steven B. [0000-0002-1985-751X], Breyta, Rachel [0000-0002-9106-1014], Briese, Thomas [0000-0002-4819-8963], Brown, Paul A. [0000-0002-6697-7688], Buchholz, Ursula J. [0000-0002-2329-3198], Buchmeier, Michael J. [0000-0002-2387-9287], Bukreyev, Alexander [0000-0002-0342-4824], Burt, Felicity [0000-0002-7238-7799], Buzkan, Nihal [0000-0002-0428-0447], Calisher, Charles H. [0000-0003-0213-294X], Cao, Mengji [0000-0003-0396-262X], Casas, Inmaculada [0000-0003-1840-1198], Chamberlain, John [0000-0002-7387-6420], Chandran, Kartik [0000-0003-0232-7077], Charrel, Rémi N. [0000-0002-7675-8251], Chen, Biao [0000-0002-2450-9296], Chiumenti, Michela [0000-0002-8412-3037], Choi, Il-Ryong [0000-0002-8035-7573], Clegg, J Christopher S. [0000-0003-3765-1862], Crozier, Ian [0000-0003-2485-4011], da Graça, John V. [0000-0003-0743-1519], Dávila, Alberto M.R. [0000-0002-6918-7673], de la Torre, J. C. [0000-0002-8171-8115], de Lamballerie, Xavier [0000-0001-7895-2720], De Swart, Rik L. [0000-0003-3599-8969], Di Bello, Patrick L. [0000-0002-4773-8040], Di Paola, Nicholas [0000-0002-9694-3913], Di Serio, Francesco [0000-0003-2822-704X], Dietzgen, Ralf G. [0000-0002-7772-2250], Digiaro, Michele [0009-0006-3089-3606], Dolja, Valerian V. [0000-0002-8148-4670], Dolnik, Olga [0000-0001-7739-4798], Drexler, J. Felix [0000-0002-3509-0232], Dürrwald, Ralf [0000-0002-3432-0438], Dufkova, Lucie [0000-0001-7302-2057], Dundon, William G. [0000-0002-2776-169X], Duprex, W. Paul [0000-0003-1716-6376], Dye, John M. [0000-0002-0883-5016], Easton, Andrew J. [0000-0002-2288-3882], Ebihara, Hideki [0000-0002-2576-9735], Elbeaino, Toufic [0000-0003-2211-7907], Ergünay, Koray [0000-0001-5422-1982], Fernandes, Jorlan [0000-0002-5039-0604], Fooks, Anthony R. [0000-0002-3243-6154], Formenty, Pierre B.H. [0000-0002-9482-5411], Forth, Leonie F [0000-0002-2708-2515], Fouchier, Ron A.M. [0000-0001-8095-2869], Freitas-Astúa, Juliana [0000-0002-0506-6880], Gago-Zachert, Selma [0000-0002-1084-2119], Gāo, George Fú [0000-0002-3869-615X], García, María Laura [0000-0001-6468-6943], García-Sastre, Adolfo [0000-0002-6551-1827], Garrison, Aura R. [0000-0003-3034-6400], Gbakima, Aiah [0000-0002-7642-0752], Goldstein, Tracey [0000-0002-1672-7410], Gonzalez, Jean-Paul J. [0000-0003-3063-1770], Griffiths, Anthony [0000-0001-5435-8364], Groschup, M. H. [0000-0003-0215-185X], Günther, Stephan [0000-0002-6562-0230], Guterres, Alexandro [0000-0001-8323-1477], Hall, Roy A. [0000-0001-5778-1387], Hammond, John [0000-0001-7593-747X], Hassan, Mohamed [0000-0002-1289-0878], Hepojoki, Jussi [0000-0001-5699-214X], Hepojoki, Satu [0000-0002-0696-1879], Hetzel, Udo [0000-0001-9142-560X], Hewson, Roger [0000-0003-2273-3152], Höper, Dirk [0000-0001-8408-2274], Horie, Masayuki [0000-0003-4682-7698], Hyndman, Timothy [0000-0002-7047-5023], Hughes, Holly R. [0000-0003-1380-8263], Hyndman, Timothy [0000-0003-4083-562X], Jambai, Amara [0000-0003-3754-2500], Jardim, Rodrigo [0000-0002-0943-5356], Jiāng, Dàohóng [0000-0002-3862-7461], Jonson, Gilda B. [0000-0003-0097-8634], Junglen, Sandra [0000-0002-3799-6011], Klempa, B. [0000-0002-6931-1224], Klingström, Jonas [0000-0001-9076-1441], Kobinger, Gary [0000-0003-0612-2298], Kondō, Hideki [0000-0001-9220-5350], Koonin, Eugene V. [0000-0003-3943-8299], Krupovic, Mart [0000-0001-5486-0098], Kurath, Gael [0000-0003-3294-560X], Laenen, Lies [0000-0001-9118-8608], Langevin, Stanley L. [0000-0002-6833-271X], Lee, Benhur [0000-0003-0760-1709], Lemos, Elba R.S. [0000-0003-3761-0200], Lukashevich, Igor S. [0000-0001-6523-5116], Maes, Piet [0000-0002-4571-5232], Marklewitz, Marco [0000-0003-1828-8770], Marzano, Shin-Yi L. [0000-0003-0548-3761], Mielke-Ehret, Nicole [0000-0003-0096-0696], Minafra, Angelantonio [0000-0002-0547-7129], Minutolo, Maria [0000-0001-7816-2657], Mühlberger, Elke [0000-0003-3547-9376], Naidu, Rayapati [0000-0002-7273-5116], Natsuaki, Tomohide [0000-0003-1823-7308], Navarro, José A. [0000-0002-0536-6074], Netesov, Sergey V. [0000-0002-7786-2464], Neumann, Gabriele [0000-0001-7054-1775], Nowotny, N. [0000-0002-3548-571X], Nunes, Márcio R.T. [0000-0003-0529-0230], Nylund, Are [0000-0002-1932-6604], Okland, Arnfinn Lodden [0000-0003-3062-4386], Oliveira, Renata C. [0000-0002-1904-7533], Pallás, Vicente [0000-0003-4954-989X], Pályi, Bernadett [0000-0003-1975-4198], Parrish, Colin R. [0000-0002-1836-6655], Pauvolid-Corrêa, Alex [0000-0002-6924-157X], Pawęska, Janusz T. [0000-0001-8776-7519], Radoshitzky, Sheli R. [0000-0001-8976-8056], Rahman, Aziz-Ul [0000-0002-3342-4462], Ramos-González, Pedro L. [0000-0002-9640-6587], Resende, Renato O. [0000-0003-3852-1576], Romanowski, Víctor [0000-0001-6378-7929], Robles Luna, Gabriel [0000-0003-3409-5557], Rota, Paul [0000-0002-8595-4094], Rubbenstroth, Dennis [0000-0002-8209-6274], Runstadler, Jonathan A. [0000-0002-6747-7765], Ruzek, Daniel [0000-0003-4655-2380], Sabanadzovic, Sead [0000-0002-2995-2633], Salát, Jiří [0000-0002-9915-8953], Sarpkaya, Kamil [0000-0001-5794-668X], Sasaya, Takahide [0000-0002-5020-9377], Shabbir, Muhammad Z. [0000-0003-4908-3313], Shí, Zhènglì [0000-0002-7309-6838], Sironi, Manuela [0000-0002-2267-5266], Smither, Sophie [0000-0002-7835-3581], Smura, Teemu [0000-0002-9187-3151], Spann, Kirsten [0000-0003-0567-8382], Spengler, Jessica R. [0000-0002-5383-0513], Stenglein, Mark D. [0000-0002-0993-813X], Takada, Ayato [0000-0003-2464-6642], Tesh, Robert B. [0000-0002-9226-397X], Thornburg, Natalie J. [0000-0003-3523-3616], Tomonaga, Keizō [0000-0003-0405-7103], Tordo, Noël [0000-0001-5873-059X], Towner, Jonathan S. [0000-0002-6473-3049], Turina, Massimo [0000-0002-9659-9470], Tzanetakis, Ioannis E. [0000-0002-5970-1763], Ulrich, R. G. [0000-0002-5620-1528], Vaira, Anna Maria [0000-0003-2526-4419], Van den Hoogen, Bernadette [0000-0003-1996-8559], Varsani, Arvind [0000-0003-4111-2415], Verbeek, Martin [0000-0002-8973-3803], Wahl, Victoria [0000-0002-6588-4308], Whitfield, Anna E. [0000-0002-3538-015X], Wolf, Yuri I. [0000-0002-0247-8708], Yutin, Natalya [0000-0002-3633-5123], Zerbini, F. Murilo [0000-0001-8617-0200], Kuhn, Jens H., Adkins, Scott, Alioto, Daniela, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Anthony, Simon J., Avsic-Zupanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, A., Ballinger, Matthew J., Bartonička, Tomáš, Basler, Christopher F., Bavari, Sina, Beer, Martin, Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D., Blasdell, Kim R., Bradfute, Steven B., Breyta, Rachel, Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Buzkan, Nihal, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chamberlain, John, Chandran, Kartik, Charrel, Rémi N., Chen, Biao, Chiumenti, Michela, Choi, Il-Ryong, Clegg, J Christopher S., Crozier, Ian, da Graça, John V., Dal Bó, Elena, Dávila, Alberto M.R., de la Torre, J. C., de Lamballerie, Xavier, De Swart, Rik L., Di Bello, Patrick L., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolja, Valerian V., Dolnik, Olga, Drebot, Michael A., Drexler, J. Felix, Dürrwald, Ralf, Dufkova, Lucie, Dundon, William G., Duprex, W. Paul, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Fernandes, Jorlan, Fooks, Anthony R., Formenty, Pierre B.H., Forth, Leonie F., Fouchier, Ron A.M., Freitas-Astúa, Juliana, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gbakima, Aiah, Goldstein, Tracey, Gonzalez, Jean-Paul J., Griffiths, Anthony, Groschup, M. H., Günther, Stephan, Guterres, Alexandro, Hall, Roy A., Hammond, John, Hassan, Mohamed, Hepojoki, Jussi, Hepojoki, Satu, Hetzel, Udo, Hewson, Roger, Hoffmann, Bernd, Hongo, Seiji, Höper, Dirk, Horie, Masayuki, Hughes, Holly R., Hyndman, Timothy, Jambai, Amara, Jardim, Rodrigo, Jiāng, Dàohóng, Jin, Qi, Jonson, Gilda B., Junglen, Sandra, Karadağ, Serpil, Keller, Karen E., Klempa, B., Klingström, Jonas, Kobinger, Gary, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kurath, Gael, Kuzmin, Ivan V., Laenen, Lies, Lamb, Robert A., Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lemos, Elba R.S., Leroy, Eric M., Li, Dexin, Li, Jianrong, Liang, Mifang, Liú, Wénwén, Liu, Yang, Lukashevich, Igor S., Maes, Piet, Marciel de Souza, William, Marklewitz, Marco, Marshall, Sergio H., Martelli, Giovanni P, Martin, Robert R., Marzano, Shin-Yi L., Massart, Sebastien, McCauley, John W., Mielke-Ehret, Nicole, Minafra, Angelantonio, Minutolo, Maria, Mirazimi, Ali, Mühlbach, Hans-Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, N., Nunes, Márcio R.T., Nylund, Are, Okland, Arnfinn Lodden, Oliveira, Renata C., Palacios, Gustavo, Pallás, Vicente, Pályi, Bernadett, Papa, Anna, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Pérez, Daniel R., Pfaff, Florian, Radoshitzky, Sheli R., Rahman, Aziz-Ul, Ramos-González, Pedro L., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Romanowski, Víctor, Robles Luna, Gabriel, Rota, Paul, Rubbenstroth, Dennis, Runstadler, Jonathan A., Ruzek, Daniel, Sabanadzovic, Sead, Salát, Jiří, Sall, Amadou Alpha, Salvato, Maria S., Sarpkaya, Kamil, Sasaya, Takahide, Schwemmle, Martin, Shabbir, Muhammad Z., Shí, Xiǎohóng, Shí, Zhènglì, Shirako, Yukio, Simmonds, Peter, Širmarová, Jana, Sironi, Manuela, Smither, Sophie, Smura, Teemu, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Straková, Petra, Takada, Ayato, Tesh, Robert B., Thornburg, Natalie J., Tomonaga, Keizō, Tordo, Noël, Towner, Jonathan S., Turina, Massimo, Tzanetakis, Ioannis E., Ulrich, R. G., Vaira, Anna Maria, Van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, Wahl, Victoria, Walker, Peter J., Wang, Hui, Wang, Jianwei, Wang, Xifeng, Wang, Lin-Fa, Wèi, Tàiyún, Wells, Heather, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wú, Zhìqiáng, Yang, Xin, Yáng, Xīnglóu, Yu, Xuejie, Yutin, Natalya, Zerbini, F. Murilo, Zhang, Tong, Zhang, Yong-Zhen, Zhou, Guohui, Zhou, Xueping, National Institute of Allergy and Infectious Diseases (US), National Cancer Institute (US), National Institutes of Health (US), Frederick National Laboratory for Cancer Research (US), US Department of Homeland Security, National Institute of Food and Agriculture (US), Kuhn, Jens H. [0000-0002-7800-6045], Adkins, Scott [0000-0003-0095-8414], Alioto, Daniela [0000-0002-4954-8363], Alkhovsky, Sergey V. [0000-0001-6913-5841], Amarasinghe, Gaya K. [0000-0002-0418-9707], Avsic-Zupanc, Tatjana [0000-0001-6243-0688], Ayllón, María A. [0000-0001-7893-6106], Bahl, Justin [0000-0001-7572-4300], Balkema-Buschmann, A. [0000-0001-7613-9592], Ballinger, Matthew J. [0000-0001-7453-8725], Bartonička, Tomáš [0000-0001-7335-2435], Basler, Christopher F. [0000-0003-4195-425X], Bavari, Sina [0000-0001-8424-5635], Beer, Martin [0000-0002-0598-5254], Bente, Dennis A. [0000-0002-5150-7368], Bergeron, Éric [0000-0003-3398-8628], Bird, Brian H. [0000-0001-8170-8710], Blair, Carol D. [0000-0002-2803-0354], Blasdell, Kim R. [0000-0003-2121-0376], Bradfute, Steven B. [0000-0002-1985-751X], Breyta, Rachel [0000-0002-9106-1014], Briese, Thomas [0000-0002-4819-8963], Brown, Paul A. [0000-0002-6697-7688], Buchholz, Ursula J. [0000-0002-2329-3198], Buchmeier, Michael J. [0000-0002-2387-9287], Bukreyev, Alexander [0000-0002-0342-4824], Burt, Felicity [0000-0002-7238-7799], Buzkan, Nihal [0000-0002-0428-0447], Calisher, Charles H. [0000-0003-0213-294X], Cao, Mengji [0000-0003-0396-262X], Casas, Inmaculada [0000-0003-1840-1198], Chamberlain, John [0000-0002-7387-6420], Chandran, Kartik [0000-0003-0232-7077], Charrel, Rémi N. [0000-0002-7675-8251], Chen, Biao [0000-0002-2450-9296], Chiumenti, Michela [0000-0002-8412-3037], Choi, Il-Ryong [0000-0002-8035-7573], Clegg, J Christopher S. [0000-0003-3765-1862], Crozier, Ian [0000-0003-2485-4011], da Graça, John V. [0000-0003-0743-1519], Dávila, Alberto M.R. [0000-0002-6918-7673], de la Torre, J. C. [0000-0002-8171-8115], de Lamballerie, Xavier [0000-0001-7895-2720], De Swart, Rik L. [0000-0003-3599-8969], Di Bello, Patrick L. [0000-0002-4773-8040], Di Paola, Nicholas [0000-0002-9694-3913], Di Serio, Francesco [0000-0003-2822-704X], Dietzgen, Ralf G. [0000-0002-7772-2250], Digiaro, Michele [0009-0006-3089-3606], Dolja, Valerian V. [0000-0002-8148-4670], Dolnik, Olga [0000-0001-7739-4798], Drexler, J. Felix [0000-0002-3509-0232], Dürrwald, Ralf [0000-0002-3432-0438], Dufkova, Lucie [0000-0001-7302-2057], Dundon, William G. [0000-0002-2776-169X], Duprex, W. Paul [0000-0003-1716-6376], Dye, John M. [0000-0002-0883-5016], Easton, Andrew J. [0000-0002-2288-3882], Ebihara, Hideki [0000-0002-2576-9735], Elbeaino, Toufic [0000-0003-2211-7907], Ergünay, Koray [0000-0001-5422-1982], Fernandes, Jorlan [0000-0002-5039-0604], Fooks, Anthony R. [0000-0002-3243-6154], Formenty, Pierre B.H. [0000-0002-9482-5411], Forth, Leonie F [0000-0002-2708-2515], Fouchier, Ron A.M. [0000-0001-8095-2869], Freitas-Astúa, Juliana [0000-0002-0506-6880], Gago-Zachert, Selma [0000-0002-1084-2119], Gāo, George Fú [0000-0002-3869-615X], García, María Laura [0000-0001-6468-6943], García-Sastre, Adolfo [0000-0002-6551-1827], Garrison, Aura R. [0000-0003-3034-6400], Gbakima, Aiah [0000-0002-7642-0752], Goldstein, Tracey [0000-0002-1672-7410], Gonzalez, Jean-Paul J. [0000-0003-3063-1770], Griffiths, Anthony [0000-0001-5435-8364], Groschup, M. H. [0000-0003-0215-185X], Günther, Stephan [0000-0002-6562-0230], Guterres, Alexandro [0000-0001-8323-1477], Hall, Roy A. [0000-0001-5778-1387], Hammond, John [0000-0001-7593-747X], Hassan, Mohamed [0000-0002-1289-0878], Hepojoki, Jussi [0000-0001-5699-214X], Hepojoki, Satu [0000-0002-0696-1879], Hetzel, Udo [0000-0001-9142-560X], Hewson, Roger [0000-0003-2273-3152], Höper, Dirk [0000-0001-8408-2274], Horie, Masayuki [0000-0003-4682-7698], Hyndman, Timothy [0000-0002-7047-5023], Hughes, Holly R. [0000-0003-1380-8263], Hyndman, Timothy [0000-0003-4083-562X], Jambai, Amara [0000-0003-3754-2500], Jardim, Rodrigo [0000-0002-0943-5356], Jiāng, Dàohóng [0000-0002-3862-7461], Jonson, Gilda B. [0000-0003-0097-8634], Junglen, Sandra [0000-0002-3799-6011], Klempa, B. [0000-0002-6931-1224], Klingström, Jonas [0000-0001-9076-1441], Kobinger, Gary [0000-0003-0612-2298], Kondō, Hideki [0000-0001-9220-5350], Koonin, Eugene V. [0000-0003-3943-8299], Krupovic, Mart [0000-0001-5486-0098], Kurath, Gael [0000-0003-3294-560X], Laenen, Lies [0000-0001-9118-8608], Langevin, Stanley L. [0000-0002-6833-271X], Lee, Benhur [0000-0003-0760-1709], Lemos, Elba R.S. [0000-0003-3761-0200], Lukashevich, Igor S. [0000-0001-6523-5116], Maes, Piet [0000-0002-4571-5232], Marklewitz, Marco [0000-0003-1828-8770], Marzano, Shin-Yi L. [0000-0003-0548-3761], Mielke-Ehret, Nicole [0000-0003-0096-0696], Minafra, Angelantonio [0000-0002-0547-7129], Minutolo, Maria [0000-0001-7816-2657], Mühlberger, Elke [0000-0003-3547-9376], Naidu, Rayapati [0000-0002-7273-5116], Natsuaki, Tomohide [0000-0003-1823-7308], Navarro, José A. [0000-0002-0536-6074], Netesov, Sergey V. [0000-0002-7786-2464], Neumann, Gabriele [0000-0001-7054-1775], Nowotny, N. [0000-0002-3548-571X], Nunes, Márcio R.T. [0000-0003-0529-0230], Nylund, Are [0000-0002-1932-6604], Okland, Arnfinn Lodden [0000-0003-3062-4386], Oliveira, Renata C. [0000-0002-1904-7533], Pallás, Vicente [0000-0003-4954-989X], Pályi, Bernadett [0000-0003-1975-4198], Parrish, Colin R. [0000-0002-1836-6655], Pauvolid-Corrêa, Alex [0000-0002-6924-157X], Pawęska, Janusz T. [0000-0001-8776-7519], Radoshitzky, Sheli R. [0000-0001-8976-8056], Rahman, Aziz-Ul [0000-0002-3342-4462], Ramos-González, Pedro L. [0000-0002-9640-6587], Resende, Renato O. [0000-0003-3852-1576], Romanowski, Víctor [0000-0001-6378-7929], Robles Luna, Gabriel [0000-0003-3409-5557], Rota, Paul [0000-0002-8595-4094], Rubbenstroth, Dennis [0000-0002-8209-6274], Runstadler, Jonathan A. [0000-0002-6747-7765], Ruzek, Daniel [0000-0003-4655-2380], Sabanadzovic, Sead [0000-0002-2995-2633], Salát, Jiří [0000-0002-9915-8953], Sarpkaya, Kamil [0000-0001-5794-668X], Sasaya, Takahide [0000-0002-5020-9377], Shabbir, Muhammad Z. [0000-0003-4908-3313], Shí, Zhènglì [0000-0002-7309-6838], Sironi, Manuela [0000-0002-2267-5266], Smither, Sophie [0000-0002-7835-3581], Smura, Teemu [0000-0002-9187-3151], Spann, Kirsten [0000-0003-0567-8382], Spengler, Jessica R. [0000-0002-5383-0513], Stenglein, Mark D. [0000-0002-0993-813X], Takada, Ayato [0000-0003-2464-6642], Tesh, Robert B. [0000-0002-9226-397X], Thornburg, Natalie J. [0000-0003-3523-3616], Tomonaga, Keizō [0000-0003-0405-7103], Tordo, Noël [0000-0001-5873-059X], Towner, Jonathan S. [0000-0002-6473-3049], Turina, Massimo [0000-0002-9659-9470], Tzanetakis, Ioannis E. [0000-0002-5970-1763], Ulrich, R. G. [0000-0002-5620-1528], Vaira, Anna Maria [0000-0003-2526-4419], Van den Hoogen, Bernadette [0000-0003-1996-8559], Varsani, Arvind [0000-0003-4111-2415], Verbeek, Martin [0000-0002-8973-3803], Wahl, Victoria [0000-0002-6588-4308], Whitfield, Anna E. [0000-0002-3538-015X], Wolf, Yuri I. [0000-0002-0247-8708], Yutin, Natalya [0000-0002-3633-5123], Zerbini, F. Murilo [0000-0001-8617-0200], Kuhn, Jens H., Adkins, Scott, Alioto, Daniela, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Anthony, Simon J., Avsic-Zupanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, A., Ballinger, Matthew J., Bartonička, Tomáš, Basler, Christopher F., Bavari, Sina, Beer, Martin, Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D., Blasdell, Kim R., Bradfute, Steven B., Breyta, Rachel, Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Buzkan, Nihal, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chamberlain, John, Chandran, Kartik, Charrel, Rémi N., Chen, Biao, Chiumenti, Michela, Choi, Il-Ryong, Clegg, J Christopher S., Crozier, Ian, da Graça, John V., Dal Bó, Elena, Dávila, Alberto M.R., de la Torre, J. C., de Lamballerie, Xavier, De Swart, Rik L., Di Bello, Patrick L., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolja, Valerian V., Dolnik, Olga, Drebot, Michael A., Drexler, J. Felix, Dürrwald, Ralf, Dufkova, Lucie, Dundon, William G., Duprex, W. Paul, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Fernandes, Jorlan, Fooks, Anthony R., Formenty, Pierre B.H., Forth, Leonie F., Fouchier, Ron A.M., Freitas-Astúa, Juliana, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gbakima, Aiah, Goldstein, Tracey, Gonzalez, Jean-Paul J., Griffiths, Anthony, Groschup, M. H., Günther, Stephan, Guterres, Alexandro, Hall, Roy A., Hammond, John, Hassan, Mohamed, Hepojoki, Jussi, Hepojoki, Satu, Hetzel, Udo, Hewson, Roger, Hoffmann, Bernd, Hongo, Seiji, Höper, Dirk, Horie, Masayuki, Hughes, Holly R., Hyndman, Timothy, Jambai, Amara, Jardim, Rodrigo, Jiāng, Dàohóng, Jin, Qi, Jonson, Gilda B., Junglen, Sandra, Karadağ, Serpil, Keller, Karen E., Klempa, B., Klingström, Jonas, Kobinger, Gary, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kurath, Gael, Kuzmin, Ivan V., Laenen, Lies, Lamb, Robert A., Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lemos, Elba R.S., Leroy, Eric M., Li, Dexin, Li, Jianrong, Liang, Mifang, Liú, Wénwén, Liu, Yang, Lukashevich, Igor S., Maes, Piet, Marciel de Souza, William, Marklewitz, Marco, Marshall, Sergio H., Martelli, Giovanni P, Martin, Robert R., Marzano, Shin-Yi L., Massart, Sebastien, McCauley, John W., Mielke-Ehret, Nicole, Minafra, Angelantonio, Minutolo, Maria, Mirazimi, Ali, Mühlbach, Hans-Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, N., Nunes, Márcio R.T., Nylund, Are, Okland, Arnfinn Lodden, Oliveira, Renata C., Palacios, Gustavo, Pallás, Vicente, Pályi, Bernadett, Papa, Anna, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Pérez, Daniel R., Pfaff, Florian, Radoshitzky, Sheli R., Rahman, Aziz-Ul, Ramos-González, Pedro L., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Romanowski, Víctor, Robles Luna, Gabriel, Rota, Paul, Rubbenstroth, Dennis, Runstadler, Jonathan A., Ruzek, Daniel, Sabanadzovic, Sead, Salát, Jiří, Sall, Amadou Alpha, Salvato, Maria S., Sarpkaya, Kamil, Sasaya, Takahide, Schwemmle, Martin, Shabbir, Muhammad Z., Shí, Xiǎohóng, Shí, Zhènglì, Shirako, Yukio, Simmonds, Peter, Širmarová, Jana, Sironi, Manuela, Smither, Sophie, Smura, Teemu, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Straková, Petra, Takada, Ayato, Tesh, Robert B., Thornburg, Natalie J., Tomonaga, Keizō, Tordo, Noël, Towner, Jonathan S., Turina, Massimo, Tzanetakis, Ioannis E., Ulrich, R. G., Vaira, Anna Maria, Van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, Wahl, Victoria, Walker, Peter J., Wang, Hui, Wang, Jianwei, Wang, Xifeng, Wang, Lin-Fa, Wèi, Tàiyún, Wells, Heather, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wú, Zhìqiáng, Yang, Xin, Yáng, Xīnglóu, Yu, Xuejie, Yutin, Natalya, Zerbini, F. Murilo, Zhang, Tong, Zhang, Yong-Zhen, Zhou, Guohui, and Zhou, Xueping
Abstract: In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 species were added, four were deleted, ten were moved and renamed, and 30 species were renamed. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
Published: 2020

32. Toll-like receptor 4 mediates blood-brain barrier permeability and disease in C3H mice during Venezuelan equine encephalitis virus infection

Author: Hollidge, Bradley S., Cohen, Courtney A., Akuoku Frimpong, Justice, Badger, Catherine V., Dye, John M., and Schmaljohn, Connie S.
Subjects: veev, Mice, Inbred C3H, Venezuelan equine encephalitis virus, toll-like receptor 4, Brain, Encephalomyelitis, Venezuelan Equine, blood-brain barrier, tlr4, Virus Replication, Permeability, Encephalitis Virus, Venezuelan Equine, Disease Models, Animal, Mice, Animals, Female, Research Article, Research Paper
Abstract: Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus that can cause debilitating, acute febrile illness and potentially result in encephalitis. Currently, there are no FDA-licensed vaccines or specific therapeutics for VEEV. Previous studies have demonstrated that VEEV infection results in increased blood-brain barrier (BBB) permeability that is mediated by matrix metalloproteinases (MMPs). Furthermore, after subarachnoid hemorrhage in mice, MMP-9 is upregulated in the brain and mediates BBB permeability in a toll-like receptor 4 (TLR4)-dependent manner. Here, we demonstrate that disease in C3H mice during VEEV TC-83 infection is dependent on TLR4 because intranasal infection of C3H/HeN (TLR4WT) mice with VEEV TC-83 resulted in mortality as opposed to survival of TLR4-defective C3H/HeJ (TLR4mut) mice. In addition, BBB permeability was induced to a lesser extent in TLR4mut mice compared with TLR4WT mice during VEEV TC-83 infection as determined by sodium fluorescein and fluorescently-conjugated dextran extravasation. Moreover, MMP-9, MMP-2, ICAM-1, CCL2 and IFN-γ were all induced to significantly lower levels in the brains of infected TLR4mut mice compared with infected TLR4WT mice despite the absence of significantly different viral titers or immune cell populations in the brains of infected TLR4WT and TLR4mut mice. These data demonstrate the critical role of TLR4 in mediating BBB permeability and disease in C3H mice during VEEV TC-83 infection, which suggests that TLR4 is a potential target for the development of therapeutics for VEEV.
Published: 2021

33. Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Author: Mittler, Eva, Wec, Anna Z., Tynell, Janne, Guardado-Calvo, Pablo, Wigren, Julia, Polanco, Laura C., O'Brien, Cecilia M., Slough, Megan M., Abelson, Dafna M., Serris, Alexandra, Sakharkar, Mrunal, Pehau-Arnaudet, Gerard, Bakken, Russell R., Geoghegan, James C., Jangra, Rohit K., Keller, Markus, Zeitlin, Larry, Vapalahti, Olli, Ulrich, Rainer G., Bornholdt, Zachary A., Ahlm, Clas, Rey, Felix A., Dye, John M., Bradfute, Steven B., Strandin, Tomas, Herbert, Andrew S., Forsell, Mattias N. E., Walker, Laura M., Chandran, Kartik, Mittler, Eva, Wec, Anna Z., Tynell, Janne, Guardado-Calvo, Pablo, Wigren, Julia, Polanco, Laura C., O'Brien, Cecilia M., Slough, Megan M., Abelson, Dafna M., Serris, Alexandra, Sakharkar, Mrunal, Pehau-Arnaudet, Gerard, Bakken, Russell R., Geoghegan, James C., Jangra, Rohit K., Keller, Markus, Zeitlin, Larry, Vapalahti, Olli, Ulrich, Rainer G., Bornholdt, Zachary A., Ahlm, Clas, Rey, Felix A., Dye, John M., Bradfute, Steven B., Strandin, Tomas, Herbert, Andrew S., Forsell, Mattias N. E., Walker, Laura M., and Chandran, Kartik
Abstract: The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (ANDV) and Sin Nombre virus, cause a distinct zoonotic disease, hantavirus cardiopulmonary syndrome (HCPS). Although these infections are severe and have substantial case fatality rates, no FDA-approved hantavirus countermeasures are available. Recent work suggests that monoclonal antibodies may have therapeutic utility. We describe here the isolation of human neutralizing antibodies (nAbs) against tetrameric Gn/Gc glycoprotein spikes from PUUV-experienced donors. We define a dominant class of nAbs recognizing the "capping loop" of Gn that masks the hydrophobic fusion loops in Gc. A subset of nAbs in this class, including ADI-42898, bound Gn/Gc complexes but not Gn alone, strongly suggesting that they recognize a quaternary epitope encompassing both Gn and Gc. ADI-42898 blocked the cell entry of seven HCPS- and HFRS-associated hantaviruses, and single doses of this nAb could protect Syrian hamsters and bank voles challenged with the highly virulent HCPS-causing ANDV and HFRS-causing PUUV, respectively. ADI-42898 is a promising candidate for clinical development as a countermeasure for both HCPS and HFRS, and its mode of Gn/Gc recognition informs the development of broadly protective hantavirus vaccines.
Published: 2022
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34. How to turn competitors into collaborators

Author: Saphire, Erica Ollmann, Dye, John M., Kobinger, Gary P., Zeitlin, Larry, Chandran, Kartik, and Garry, Robert F.
Published: 2017
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35. Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease

Author: Dye, John M., Herbert, Andrew S., Kuehne, Ana I., Barth, James F., Muhammad, Majidat A., Zak, Samantha E., Ortiz, Ramon A., Prugar, Laura I., and Pratt, William D.
Published: 2012

36. Antibody Response to SARS-CoV-2 Infection and Vaccination in COVID-19-Naïve and Experienced Individuals

Author: Uprichard, Susan L., primary, O’Brien, Amornrat, additional, Evdokimova, Monika, additional, Rowe, Cynthia L., additional, Joyce, Cara, additional, Hackbart, Matthew, additional, Cruz-Pulido, Yazmin E., additional, Cohen, Courtney A., additional, Rock, Michelle L., additional, Dye, John M., additional, Kuehnert, Paul, additional, Ricks, Keersten M., additional, Casper, Marybeth, additional, Linhart, Lori, additional, Anderson, Katrina, additional, Kirk, Laura, additional, Maggiore, Jack A., additional, Herbert, Andrew S., additional, Clark, Nina M., additional, Reid, Gail E., additional, and Baker, Susan C., additional
Published: 2022
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37. A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge

Author: Phoolcharoen, Waranyoo, Dye, John M., Kilbourne, Jacquelyn, Piensook, Khanrat, Pratt, William D., Arntzen, Charles J., Chen, Qiang, Mason, Hugh S., and Herbst-Kralovetz, Melissa M.
Published: 2011

38. Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen

Author: Saul, Sirle, Karim, Marwah, Huang, Pei-Tzu, Ghita, Luca, Chiu, Winston, Kumar, Sathish, Bhalla, Nishank, Leyssen, Pieter, Cohen, Courtney A., Huie, Kathleen, Tindle, Courtney, Sibai, Mamdouh, Pinsky, Benjamin A., Das, Soumita, Ghosh, Pradipta, Dye, John M., Solow-Cordero, David E., Jin, Jing, Jochmans, Dirk, Neyts, Johan, Narayanan, Aarthi, De Jonghe, Steven, and Einav, Shirit
Subjects: viruses, skin and connective tissue diseases, Article
Abstract: Effective therapies are needed to combat emerging viruses. Seventeen candidates that rescue cells from SARS-CoV-2-induced lethality and target diverse functions emerged in a screen of 4,413 compounds. Among the hits was lapatinib, an approved inhibitor of the ErbB family of receptor tyrosine kinases. Lapatinib and other pan-ErbB inhibitors suppress replication of SARS-CoV-2 and unrelated viruses with a high barrier to resistance. ErbB4, but not lapatinib's cancer targets ErbB1 and ErbB2, is required for SARS-CoV-2 entry and encephalitis alphavirus infection and is a molecular target mediating lapatinib's antiviral effect. In human lung organoids, lapatinib protects from SARS-CoV-2-induced activation of pathways implicated in non-infectious acute lung injury and fibrosis downstream of ErbBs (p38-MAPK, MEK/ERK, and AKT/mTOR), pro-inflammatory cytokine production, and epithelial barrier injury. These findings reveal regulation of viral infection, inflammation, and lung injury via ErbBs and propose approved candidates to counteract these effects with implications for pandemic coronaviruses and unrelated viruses.
Published: 2021

39. A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

Author: Haslwanter, Denise, primary, Dieterle, M. Eugenia, additional, Wec, Anna Z., additional, O’Brien, Cecilia M., additional, Sakharkar, Mrunal, additional, Florez, Catalina, additional, Tong, Karen, additional, Rappazzo, C. Garrett, additional, Lasso, Gorka, additional, Vergnolle, Olivia, additional, Wirchnianski, Ariel S., additional, Bortz, Robert H., additional, Laudermilch, Ethan, additional, Fels, J. Maximilian, additional, Mengotto, Amanda, additional, Malonis, Ryan J., additional, Georgiev, George I., additional, Quiroz, Jose A., additional, Wrapp, Daniel, additional, Wang, Nianshuang, additional, Dye, Kathryn E., additional, Barnhill, Jason, additional, Dye, John M., additional, McLellan, Jason S., additional, Daily, Johanna P., additional, Lai, Jonathan R., additional, Herbert, Andrew S., additional, Walker, Laura M., additional, Chandran, Kartik, additional, and Jangra, Rohit K., additional
Published: 2021
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40. Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity

Author: Wirchnianski, Ariel S., primary, Wec, Anna Z., additional, Nyakatura, Elisabeth K., additional, Herbert, Andrew S., additional, Slough, Megan M., additional, Kuehne, Ana I., additional, Mittler, Eva, additional, Jangra, Rohit K., additional, Teruya, Jonathan, additional, Dye, John M., additional, Lai, Jonathan R., additional, and Chandran, Kartik, additional
Published: 2021
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41. On-Demand Patient-Specific Phenotype-to-Genotype Ebola Virus Characterization

Author: Beitzel, Brett F., primary, Radoshitzky, Sheli R., additional, Di Paola, Nicholas, additional, Brannan, Jennifer M., additional, Kimmel, David, additional, Caviness, Katie, additional, Soloveva, Veronica, additional, Yu, Shuiqing, additional, Postnikova, Elena N., additional, Finch, Courtney L., additional, Liu, Hu, additional, Prugar, Laura, additional, Bakken, Russell, additional, Dye, John M., additional, Kugelman, Jeffrey R., additional, Cunningham, James M., additional, Sanchez-Lockhart, Mariano, additional, Kuhn, Jens H., additional, and Palacios, Gustavo, additional
Published: 2021
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42. Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets

Author: Clinton, Tracy R., Weinstock, Matthew T., Jacobsen, Michael T., Szabo-Fresnais, Nicolas, Pandya, Maya J., Whitby, Frank G., Herbert, Andrew S., Prugar, Laura I., McKinnon, Rena, Hill, Christopher P., Welch, Brett D., Dye, John M., Eckert, Debra M., and Kay, Michael S.
Published: 2015
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43. Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever

Author: Fels, J. Maximilian, primary, Maurer, Daniel P., additional, Herbert, Andrew S., additional, Wirchnianski, Ariel S., additional, Vergnolle, Olivia, additional, Cross, Robert W., additional, Abelson, Dafna M., additional, Moyer, Crystal L., additional, Mishra, Akaash K., additional, Aguilan, Jennifer T., additional, Kuehne, Ana I., additional, Pauli, Noel T., additional, Bakken, Russell R., additional, Nyakatura, Elisabeth K., additional, Hellert, Jan, additional, Quevedo, Gregory, additional, Lobel, Leslie, additional, Balinandi, Stephen, additional, Lutwama, Julius J., additional, Zeitlin, Larry, additional, Geisbert, Thomas W., additional, Rey, Felix A., additional, Sidoli, Simone, additional, McLellan, Jason S., additional, Lai, Jonathan R., additional, Bornholdt, Zachary A., additional, Dye, John M., additional, Walker, Laura M., additional, and Chandran, Kartik, additional
Published: 2021
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44. Heparin: A simplistic repurposing to prevent SARS-CoV-2 transmission in light of its in-vitro nanomolar efficacy

Author: Gupta, Yash, Maciorowski, Dawid, Zak, Samantha E, Kulkarni, Chandrashekhar Vishwanath, Herbert, Andrew S, Durvasula, Ravi, Fareed, Jawed, Dye, John M, Kempaiah, Prakasha, Gupta, Yash, Maciorowski, Dawid, Zak, Samantha E, Kulkarni, Chandrashekhar Vishwanath, Herbert, Andrew S, Durvasula, Ravi, Fareed, Jawed, Dye, John M, and Kempaiah, Prakasha
Abstract: The world is currently facing a novel coronavirus (SARS-CoV-2) pandemic. The greatest threat that is disrupting the normal functioning of society is the exceptionally high species independent transmission. Drug repurposing is understood to be the best strategy to immediately deploy well-characterized agents against new pathogens. Several repurposable drugs are already in evaluation for determining suitability to treat COVID-19. One such promising compound includes heparin, which is widely used in reducing thrombotic events associated with COVID-19 induced pathology. As part of identifying target-specific antiviral compounds among FDA and world-approved libraries using high-throughput virtual screening (HTVS), we previously evaluated top hits for anti-SARS-CoV-2 activity. Here, we report results of highly efficacious viral entry blocking properties of heparin (IC = 12.3 nM) in the complete virus assay, and further, propose ways to use it as a potential transmission blocker. Exploring further, our in-silico analysis indicated that the heparin interacts with post-translational glycoconjugates present on spike proteins. The patterns of accessible spike-glycoconjugates in open and closed states are completely contrasted by one another. Heparin-binding to the open conformation of spike structurally supports the state and may aid ACE2 binding as reported with cell surface-bound heparan sulfate. We also studied spike protein mutant variants' heparin interactions for possible resistance. Based on available data and optimal absorption properties by the skin, heparin could potentially be used to block SARS-CoV-2 transmission. Studies should be designed to exploit its nanomolar antiviral activity to formulate heparin as topical or inhalation-based formulations, particularly on exposed areas and sites of primary viremia e.g. ACE2 rich epithelia of the eye (conjunctiva/lids), nasal cavity, and mouth. [Abstract copyright: Copyright © 2018 Elsevier B.V. All rights reserved.]
Published: 2021

45. 2021 Taxonomic update of phylum Negarnaviricota (Riboviria : Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author: Kuhn, Jens H., Adkins, Scott, Agwanda, Bernard R., Al Kubrusli, Rim, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J., Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D., Blasdell, Kim R., Blystad, Dag Ragnar, Bojko, Jamie, Borth, Wayne B., Bradfute, Steven, Breyta, Rachel, Briese, Thomas, Brown, Paul A., Brown, Judith K., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Cheng, Qi, Chiaki, Yuya, Chiapello, Marco, Choi, Il Ryong, Ciuffo, Marina, Clegg, J. Christopher S., Crozier, Ian, Dal Bó, Elena, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolnik, Olga, Drebot, Michael A., Drexler, J. Felix, Dundon, William G., Duprex, W. Paul, Dürrwald, Ralf, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W., Fooks, Anthony R., Forgia, Marco, Formenty, Pierre B.H., Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas, Gonzalez, Jean Paul J., Griffiths, Anthony, Goldberg, Tony L., Groschup, Martin H., Günther, Stephan, Hall, Roy A., Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S., Hu, Tao, Hughes, Holly R., Hüttner, Florian, Hyndman, Timothy H., Ilyas, M., Jalkanen, Risto, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Kaukinen, Karia H., Kawate, Michael, Klempa, Boris, Klingström, Jonas, Kobinger, Gary, Koloniuk, Igor, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lefkowitz, Elliot J., Leroy, Eric M., Li, Shaorong, Li, Longhui, Lǐ, Jiànróng, Liu, Huazhen, Lukashevich, Igor S., Maes, Piet, de Souza, William Marciel, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin Yi L., Massart, Sebastien, McCauley, John W., Melzer, Michael, Mielke-Ehret, Nicole, Miller, Kristina M., Ming, Tobi J., Mirazimi, Ali, Mordecai, Gideon J., Mühlbach, Hans Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R.T., Olmedo-Velarde, Alejandro, Palacios, Gustavo, Pallás, Vicente, Pályi, Bernadett, Papa, Anna, Paraskevopoulou, Sofia, Park, Adam C., Parrish, Colin R., Patterson, David A., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Peracchio, Carlotta, Pérez, Daniel R., Postler, Thomas S., Qi, Liying, Radoshitzky, Sheli R., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Luna, Gabriel Robles, Romanowski, Víctor, Rota, Paul, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sall, Amadou Alpha, Salvato, Maria S., Sang, Rosemary, Sasaya, Takahide, Schulze, Angela D., Schwemmle, Martin, Shi, Mang, Shí, Xiǎohóng, Shí, Zhènglì, Shimomoto, Yoshifumi, Shirako, Yukio, Siddell, Stuart G., Simmonds, Peter, Sironi, Manuela, Smagghe, Guy, Smither, Sophie, Song, Jin Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Sugano, Jari, Suttle, Curtis A., Tabata, Amy, Takada, Ayato, Takeuchi, Shigeharu, Tchouassi, David P., Teffer, Amy, Tesh, Robert B., Thornburg, Natalie J., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Torto, Baldwyn, Towner, Jonathan S., Tsuda, Shinya, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Uchida, Janice, Usugi, Tomio, Vaira, Anna Maria, Vallino, Marta, van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Wang, Lin Fa, Wang, Guoping, Wang, Yanxiang, Wang, Yaqin, Waqas, Muhammad, Wèi, Tàiyún, Wen, Shaohua, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wu, Jiangxiang, Xu, Lei, Yanagisawa, Hironobu, Yang, Caixia, Yang, Zuokun, Zerbini, F. Murilo, Zhai, Lifeng, Zhang, Yong Zhen, Zhang, Song, Zhang, Jinguo, Zhang, Zhe, Kuhn, Jens H., Adkins, Scott, Agwanda, Bernard R., Al Kubrusli, Rim, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J., Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D., Blasdell, Kim R., Blystad, Dag Ragnar, Bojko, Jamie, Borth, Wayne B., Bradfute, Steven, Breyta, Rachel, Briese, Thomas, Brown, Paul A., Brown, Judith K., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Cheng, Qi, Chiaki, Yuya, Chiapello, Marco, Choi, Il Ryong, Ciuffo, Marina, Clegg, J. Christopher S., Crozier, Ian, Dal Bó, Elena, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolnik, Olga, Drebot, Michael A., Drexler, J. Felix, Dundon, William G., Duprex, W. Paul, Dürrwald, Ralf, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W., Fooks, Anthony R., Forgia, Marco, Formenty, Pierre B.H., Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas, Gonzalez, Jean Paul J., Griffiths, Anthony, Goldberg, Tony L., Groschup, Martin H., Günther, Stephan, Hall, Roy A., Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S., Hu, Tao, Hughes, Holly R., Hüttner, Florian, Hyndman, Timothy H., Ilyas, M., Jalkanen, Risto, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Kaukinen, Karia H., Kawate, Michael, Klempa, Boris, Klingström, Jonas, Kobinger, Gary, Koloniuk, Igor, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lefkowitz, Elliot J., Leroy, Eric M., Li, Shaorong, Li, Longhui, Lǐ, Jiànróng, Liu, Huazhen, Lukashevich, Igor S., Maes, Piet, de Souza, William Marciel, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin Yi L., Massart, Sebastien, McCauley, John W., Melzer, Michael, Mielke-Ehret, Nicole, Miller, Kristina M., Ming, Tobi J., Mirazimi, Ali, Mordecai, Gideon J., Mühlbach, Hans Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R.T., Olmedo-Velarde, Alejandro, Palacios, Gustavo, Pallás, Vicente, Pályi, Bernadett, Papa, Anna, Paraskevopoulou, Sofia, Park, Adam C., Parrish, Colin R., Patterson, David A., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Peracchio, Carlotta, Pérez, Daniel R., Postler, Thomas S., Qi, Liying, Radoshitzky, Sheli R., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Luna, Gabriel Robles, Romanowski, Víctor, Rota, Paul, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sall, Amadou Alpha, Salvato, Maria S., Sang, Rosemary, Sasaya, Takahide, Schulze, Angela D., Schwemmle, Martin, Shi, Mang, Shí, Xiǎohóng, Shí, Zhènglì, Shimomoto, Yoshifumi, Shirako, Yukio, Siddell, Stuart G., Simmonds, Peter, Sironi, Manuela, Smagghe, Guy, Smither, Sophie, Song, Jin Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Sugano, Jari, Suttle, Curtis A., Tabata, Amy, Takada, Ayato, Takeuchi, Shigeharu, Tchouassi, David P., Teffer, Amy, Tesh, Robert B., Thornburg, Natalie J., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Torto, Baldwyn, Towner, Jonathan S., Tsuda, Shinya, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Uchida, Janice, Usugi, Tomio, Vaira, Anna Maria, Vallino, Marta, van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Wang, Lin Fa, Wang, Guoping, Wang, Yanxiang, Wang, Yaqin, Waqas, Muhammad, Wèi, Tàiyún, Wen, Shaohua, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wu, Jiangxiang, Xu, Lei, Yanagisawa, Hironobu, Yang, Caixia, Yang, Zuokun, Zerbini, F. Murilo, Zhai, Lifeng, Zhang, Yong Zhen, Zhang, Song, Zhang, Jinguo, and Zhang, Zhe
Abstract: In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families (Aliusviridae, Crepuscuviridae, Myriaviridae, and Natareviridae), three subfamilies (Alpharhabdovirinae, Betarhabdovirinae, and Gammarhabdovirinae), 42 genera, and 200 species. Thirty-nine species were renamed and/or moved and seven species were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
Published: 2021

46. Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author: 0000-0002-7800-6045, 0000-0003-0095-8414, 0000-0003-4135-4537, 0000-0001-6913-5841, 0000-0002-0418-9707, 0000-0001-6243-0688, Ayllón, María A. [0000-0001-7893-6106], 0000-0001-7572-4300, Balkema-Buschmann, A. [0000-0001-7613-9592], 0000-0001-7453-8725, 0000-0003-4195-425X, 0000-0001-8424-5635, 0000-0002-0598-5254, 0000-0002-7851-3506, 0000-0003-1032-4781, 0000-0003-3398-8628, 0000-0001-8170-8710, 0000-0002-2803-0354, 0000-0003-2121-0376, 0000-0001-5490-3334, 0000-0001-5972-0844, 0000-0002-1985-751X, 0000-0002-9106-1014, 0000-0002-4819-8963, 0000-0002-6697-7688, 0000-0003-4669-8443, 0000-0002-2329-3198, 0000-0002-2387-9287, 0000-0002-0342-4824, 0000-0002-7238-7799, 0000-0002-2086-2594, 0000-0003-0396-262X, 0000-0003-1840-1198, 0000-0003-0232-7077, 0000-0002-7675-8251, 0000-0002-7565-8881, Chiapello, M. [0000-0001-7768-3047], 0000-0003-0422-408X, 0000-0003-2485-4011, 0000-0002-8171-8115, De Swart, Rik L. [0000-0003-3599-8969], 0000-0003-3056-3739, 0000-0002-3675-5013, 0000-0002-9694-3913, 0000-0003-2822-704X, 0000-0002-7772-2250, 0000-0001-7739-4798, Drexler, J. Felix [0000-0002-3509-0232], 0000-0002-2776-169X, 0000-0003-1716-6376, 0000-0002-3432-0438, 0000-0002-0883-5016, 0000-0002-2288-3882, 0000-0002-2576-9735, 0000-0003-2211-7907, 0000-0001-5422-1982, 0000-0002-3243-6154, 0000-0003-0101-1046, 0000-0002-9482-5411, 0000-0001-8451-1454, 0000-0002-0506-6880, 0000-0002-1084-2119, 0000-0001-6468-6943, 0000-0002-6551-1827, 0000-0003-3034-6400, 0000-0003-3063-1770, 0000-0001-5435-8364, 0000-0003-3962-4913, Groschup, M. H. [0000-0003-0215-185X], 0000-0002-6562-0230, 0000-0001-5778-1387, 0000-0001-7593-747X, 0000-0001-5699-214X, 0000-0003-2273-3152, 0000-0002-1285-4455, 0000-0003-4682-7698, 0000-0003-3003-4140, 0000-0003-1380-8263, Von Bargen, Susanne [0000-0001-8321-1572], Kuhn, Jens H., Adkins, Scott, Agwanda, Bernard R., Al Kubrusli, Rim, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Avsic-Zupanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, A., Ballinger, Matthew J., Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J., Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D., Blasdell, Kim R., Blystad, Dag-Ragnar, Bojko, Jamie, Borth, Wayne B., Bradfute, Steven B., Breyta, Rachel, Briese, Thomas, Brown, Paul A., Brown, Judith K., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Cheng, Qi, Chiaki, Yuya, Chiapello, M., Choi, Il-Ryong, Ciuffo, Marina, Clegg, J Christopher S., Crozier, Ian, Dal Bó, Elena, de la Torre, J. C., de Lamballerie, Xavier, De Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolnik, Olga, Drebot, Michael A., Drexler, J. Felix, Dundon, William G., Duprex, W. Paul, Dürrwald, Ralf, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W., Fooks, Anthony R., Forgia, Marco, Formenty, Pierre B.H., Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gonzalez, Jean-Paul J., Griffiths, Anthony, Goldberg, Tony L., Groschup, M. H., Günther, Stephan, Hall, Roy A., Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S., Hu, Tao, Hughes, Holly R., Hüttner, Florian, Hyndman, Timothy, Ilyas, M., Jalkanen, Risto, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Kaukinen, Karia H., Kawate, Michael, Klempa, B., Klingström, Jonas, Kobinger, Gary, Koloniuk, Igor, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lefkowitz, Elliot J., Leroy, Eric M., Li, Shaorong, Li, Longhui, Li, Jianrong, Liu, Huazhen, Lukashevich, Igor S., Maes, Piet, de Souza, William Marciel, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., Massart, Sebastien, McCauley, John W., Melzer, Michael, Mielke-Ehret, Nicole, Miller, Kristina M., Ming, Tobi J., Mirazimi, Ali, Mordecai, Gideon J., Mühlbach, Hans-Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, N., Nunes, Márcio R.T., Olmedo-Velarde, Alejandro, Palacios, Gustavo, Pallás, Vicente, Pályi, Bernadett, Papa, Anna, Paraskevopoulou, Sofia, Park, Adam C., Parrish, Colin R., Patterson, David A., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Peracchio, Carlotta, Pérez, Daniel R., Postler, Thomas S., Qi, Liying, Radoshitzky, Sheli R., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Luna, Gabriel Robles, Romanowski, Víctor, Rota, Paul, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sall, Amadou Alpha, Salvato, Maria S., Sang, Rosemary, Sasaya, Takahide, Schulze, Angela D., Schwemmle, Martin, Shi, Mang, Shí, Xiǎohóng, Shí, Zhènglì, Shimomoto, Yoshifumi, Shirako, Yukio, Siddell, Stuart G., Simmonds, Peter, Sironi, Manuela, Smagghe, Guy, Smither, Sophie, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Sugano, Jari, Suttle, Curtis A., Tabata, Amy, Takada, Ayato, Takeuchi, Shigeharu, Tchouassi, David P., Teffer, Amy, Tesh, Robert B., Thornburg, Natalie J., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Torto, Baldwyn, Towner, Jonathan S., Tsuda, Shinya, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Uchida, Janice, Usugi, Tomio, Vaira, Anna Maria, Vallino, Marta, Van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, Von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Wang, Lin-Fa, Wang, Guoping, Wang, Yanxiang, Wang, Yaqin, Waqas, Muhammad, Wèi, Tàiyún, Wen, Shaohua, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wu, Jiangxiang, Xu, Lei, Yanagisawa, Hironobu, Yang, Caixia, Yang, Zuokun, Zerbini, F. Murilo, Zhai, Lifeng, Zhang, Yong-Zhen, Zhang, Song, Zhang, Jinguo, Zhang, Zhe, Zhou, Xueping, 0000-0002-7800-6045, 0000-0003-0095-8414, 0000-0003-4135-4537, 0000-0001-6913-5841, 0000-0002-0418-9707, 0000-0001-6243-0688, Ayllón, María A. [0000-0001-7893-6106], 0000-0001-7572-4300, Balkema-Buschmann, A. [0000-0001-7613-9592], 0000-0001-7453-8725, 0000-0003-4195-425X, 0000-0001-8424-5635, 0000-0002-0598-5254, 0000-0002-7851-3506, 0000-0003-1032-4781, 0000-0003-3398-8628, 0000-0001-8170-8710, 0000-0002-2803-0354, 0000-0003-2121-0376, 0000-0001-5490-3334, 0000-0001-5972-0844, 0000-0002-1985-751X, 0000-0002-9106-1014, 0000-0002-4819-8963, 0000-0002-6697-7688, 0000-0003-4669-8443, 0000-0002-2329-3198, 0000-0002-2387-9287, 0000-0002-0342-4824, 0000-0002-7238-7799, 0000-0002-2086-2594, 0000-0003-0396-262X, 0000-0003-1840-1198, 0000-0003-0232-7077, 0000-0002-7675-8251, 0000-0002-7565-8881, Chiapello, M. [0000-0001-7768-3047], 0000-0003-0422-408X, 0000-0003-2485-4011, 0000-0002-8171-8115, De Swart, Rik L. [0000-0003-3599-8969], 0000-0003-3056-3739, 0000-0002-3675-5013, 0000-0002-9694-3913, 0000-0003-2822-704X, 0000-0002-7772-2250, 0000-0001-7739-4798, Drexler, J. Felix [0000-0002-3509-0232], 0000-0002-2776-169X, 0000-0003-1716-6376, 0000-0002-3432-0438, 0000-0002-0883-5016, 0000-0002-2288-3882, 0000-0002-2576-9735, 0000-0003-2211-7907, 0000-0001-5422-1982, 0000-0002-3243-6154, 0000-0003-0101-1046, 0000-0002-9482-5411, 0000-0001-8451-1454, 0000-0002-0506-6880, 0000-0002-1084-2119, 0000-0001-6468-6943, 0000-0002-6551-1827, 0000-0003-3034-6400, 0000-0003-3063-1770, 0000-0001-5435-8364, 0000-0003-3962-4913, Groschup, M. H. [0000-0003-0215-185X], 0000-0002-6562-0230, 0000-0001-5778-1387, 0000-0001-7593-747X, 0000-0001-5699-214X, 0000-0003-2273-3152, 0000-0002-1285-4455, 0000-0003-4682-7698, 0000-0003-3003-4140, 0000-0003-1380-8263, Von Bargen, Susanne [0000-0001-8321-1572], Kuhn, Jens H., Adkins, Scott, Agwanda, Bernard R., Al Kubrusli, Rim, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Avsic-Zupanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, A., Ballinger, Matthew J., Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J., Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D., Blasdell, Kim R., Blystad, Dag-Ragnar, Bojko, Jamie, Borth, Wayne B., Bradfute, Steven B., Breyta, Rachel, Briese, Thomas, Brown, Paul A., Brown, Judith K., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Cheng, Qi, Chiaki, Yuya, Chiapello, M., Choi, Il-Ryong, Ciuffo, Marina, Clegg, J Christopher S., Crozier, Ian, Dal Bó, Elena, de la Torre, J. C., de Lamballerie, Xavier, De Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolnik, Olga, Drebot, Michael A., Drexler, J. Felix, Dundon, William G., Duprex, W. Paul, Dürrwald, Ralf, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W., Fooks, Anthony R., Forgia, Marco, Formenty, Pierre B.H., Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gonzalez, Jean-Paul J., Griffiths, Anthony, Goldberg, Tony L., Groschup, M. H., Günther, Stephan, Hall, Roy A., Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S., Hu, Tao, Hughes, Holly R., Hüttner, Florian, Hyndman, Timothy, Ilyas, M., Jalkanen, Risto, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Kaukinen, Karia H., Kawate, Michael, Klempa, B., Klingström, Jonas, Kobinger, Gary, Koloniuk, Igor, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lefkowitz, Elliot J., Leroy, Eric M., Li, Shaorong, Li, Longhui, Li, Jianrong, Liu, Huazhen, Lukashevich, Igor S., Maes, Piet, de Souza, William Marciel, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., Massart, Sebastien, McCauley, John W., Melzer, Michael, Mielke-Ehret, Nicole, Miller, Kristina M., Ming, Tobi J., Mirazimi, Ali, Mordecai, Gideon J., Mühlbach, Hans-Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, N., Nunes, Márcio R.T., Olmedo-Velarde, Alejandro, Palacios, Gustavo, Pallás, Vicente, Pályi, Bernadett, Papa, Anna, Paraskevopoulou, Sofia, Park, Adam C., Parrish, Colin R., Patterson, David A., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Peracchio, Carlotta, Pérez, Daniel R., Postler, Thomas S., Qi, Liying, Radoshitzky, Sheli R., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Luna, Gabriel Robles, Romanowski, Víctor, Rota, Paul, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sall, Amadou Alpha, Salvato, Maria S., Sang, Rosemary, Sasaya, Takahide, Schulze, Angela D., Schwemmle, Martin, Shi, Mang, Shí, Xiǎohóng, Shí, Zhènglì, Shimomoto, Yoshifumi, Shirako, Yukio, Siddell, Stuart G., Simmonds, Peter, Sironi, Manuela, Smagghe, Guy, Smither, Sophie, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Sugano, Jari, Suttle, Curtis A., Tabata, Amy, Takada, Ayato, Takeuchi, Shigeharu, Tchouassi, David P., Teffer, Amy, Tesh, Robert B., Thornburg, Natalie J., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Torto, Baldwyn, Towner, Jonathan S., Tsuda, Shinya, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Uchida, Janice, Usugi, Tomio, Vaira, Anna Maria, Vallino, Marta, Van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, Von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Wang, Lin-Fa, Wang, Guoping, Wang, Yanxiang, Wang, Yaqin, Waqas, Muhammad, Wèi, Tàiyún, Wen, Shaohua, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wu, Jiangxiang, Xu, Lei, Yanagisawa, Hironobu, Yang, Caixia, Yang, Zuokun, Zerbini, F. Murilo, Zhai, Lifeng, Zhang, Yong-Zhen, Zhang, Song, Zhang, Jinguo, Zhang, Zhe, and Zhou, Xueping
Abstract: Unfortunately, the inclusion of original names (in non-Latin script) of the following authors caused problems with author name indexing in PubMed. Therefore, these original names were removed from XML data to correct the PubMed record. Mengji Cao, Yuya Chiaki, Hideki Ebihara, Jingjing Fu, George Fú Gāo, Tong Han, Jiang Hong, Ni Hong, Seiji Hongo, Masayuki Horie, Dàohóng Jiāng, Fujio Kadono, Hideki Kondō, Kenji Kubota, Shaorong Li, Longhui Li, Jiànróng Lǐ, Huazhen Liu, Tomohide Natsuaki, Sergey V. Netesov, Anna Papa, Sofia Paraskevopoulou, Liying Qi, Takahide Sasaya, Mang Shi, Xiǎohóng Shí, Zhènglì Shí, Yoshifumi Shimomoto, Jin‑Won Song, Ayato Takada, Shigeharu Takeuchi, Yasuhiro Tomitaka, Keizō Tomonaga, Shinya Tsuda, Changchun Tu, Tomio Usugi, Nikos Vasilakis, Jiro Wada, Lin‑Fa Wang, Guoping Wang, Yanxiang Wang, Yaqin Wang, Tàiyún Wèi, Shaohua Wen, Jiangxiang Wu, Lei Xu, Hironobu Yanagisawa, Caixia Yang, Zuokun Yang, Lifeng Zhai, Yong‑Zhen Zhang, Song Zhang, Jinguo Zhang, Zhe Zhang, Xueping Zhou. In addition, the publication call-out in the supplementary material was updated from issue 11 to issue 12. The original article has been corrected.
Published: 2021

47. Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

Author: Carette, Jan E., Raaben, Matthijs, Wong, Anthony C., Herbert, Andrew S., Obernosterer, Gregor, Mulherkar, Nirupama, Kuehne, Ana I., Kranzusch, Philip J., Griffin, April M., Ruthel, Gordon, Cin, Paola Dal, Dye, John M., Whelan, Sean P., Chandran, Kartik, and Brummelkamp, Thijn R.
Published: 2011
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48. Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization

Author: Wang, Yimeng, primary, Howell, Katie A., additional, Brannan, Jennifer, additional, Agans, Krystle N., additional, Turner, Hannah L., additional, Wirchnianski, Ariel S., additional, Kailasan, Shweta, additional, Fusco, Marnie, additional, Galkin, Andrey, additional, Chiang, Chi-I, additional, Zhao, Xuelian, additional, Saphire, Erica Ollmann, additional, Chandran, Kartik, additional, Ward, Andrew B., additional, Dye, John M., additional, Aman, M. Javad, additional, Geisbert, Thomas W., additional, and Li, Yuxing, additional
Published: 2021
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49. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author: Kuhn, Jens H., Adkins, Scott, Alioto, Daniela, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Anthony, Simon J., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Bartonička, Tomáš, Basler, Christopher, Bavari, Sina, Beer, Martin, Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol, Blasdell, Kim R., Bradfute, Steven B., Breyta, Rachel, Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Buzkan, Nihal, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chamberlain, John, Chandran, Kartik, Charrel, Rémi N., Chen, Biao, Chiumenti, Michela, Choi, Il Ryong, Clegg, J. Christopher S., Crozier, Ian, da Graça, John V., Dal Bó, Elena, Dávila, Alberto M.R., de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L., Di Bello, Patrick L., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolja, Valerian V., Dolnik, Olga, Drebot, Michael A., Drexler, Jan Felix, Dürrwald, Ralf, Dufkova, Lucie, Dundon, William G., Duprex, W. Paul, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Fernandes, Jorlan, Fooks, Anthony R., Formenty, Pierre B.H., Forth, Leonie F., Fouchier, Ron A.M., Freitas-Astúa, Juliana, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gbakima, Aiah, Goldstein, Tracey, Gonzalez, Jean Paul J., Griffiths, Anthony, Groschup, Martin H., Günther, Stephan, Guterres, Alexandro, Hall, Roy A., Hammond, John, Hassan, Mohamed, Hepojoki, Jussi, Hepojoki, Satu, Hetzel, Udo, Hewson, Roger, Hoffmann, Bernd, Hongo, Seiji, Höper, Dirk, Horie, Masayuki, Hughes, Holly R., Hyndman, Timothy H., Jambai, Amara, Jardim, Rodrigo, Jiāng, Dàohóng, Jin, Qi, Jonson, Gilda B., Junglen, Sandra, Karadağ, Serpil, Keller, Karen E., Klempa, Boris, Klingström, Jonas, Kobinger, Gary, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kurath, Gael, Kuzmin, Ivan V., Laenen, Lies, Lamb, Robert A., Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lemos, Elba R.S., Leroy, Eric M., Li, Dexin, Lǐ, Jiànróng, Liang, Mifang, Liú, Wénwén, Liú, Yàn, Lukashevich, Igor S., Maes, Piet, Marciel de Souza, William, Marklewitz, Marco, Marshall, Sergio H., Martelli, Giovanni P., Martin, Robert R., Marzano, Shin Yi L., Massart, Sébastien, McCauley, John W., Mielke-Ehret, Nicole, Minafra, Angelantonio, Minutolo, Maria, Mirazimi, Ali, Mühlbach, Hans Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R.T., Nylund, Are, Økland, Arnfinn L., Oliveira, Renata C., Palacios, Gustavo, Pallas, Vicente, Pályi, Bernadett, Papa, Anna, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Pérez, Daniel R., Pfaff, Florian, Radoshitzky, Sheli R., Rahman, Aziz ul, Ramos-González, Pedro L., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Romanowski, Víctor, Robles Luna, Gabriel, Rota, Paul, Rubbenstroth, Dennis, Runstadler, Jonathan A., Ruzek, Daniel, Sabanadzovic, Sead, Salát, Jiří, Sall, Amadou Alpha, Salvato, Maria S., Sarpkaya, Kamil, Sasaya, Takahide, Schwemmle, Martin, Shabbir, Muhammad Z., Shí, Xiǎohóng, Shí, Zhènglì, Shirako, Yukio, Simmonds, Peter, Širmarová, Jana, Sironi, Manuela, Smither, Sophie, Smura, Teemu, Song, Jin Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Straková, Petra, Takada, Ayato, Tesh, Robert B., Thornburg, Natalie J., Tomonaga, Keizō, Tordo, Noël, Towner, Jonathan S., Turina, Massimo, Tzanetakis, Ioannis, Ulrich, Rainer G., Vaira, Anna Maria, van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, Wahl, Victoria, Walker, Peter J., Wang, Hui, Wang, Jianwei, Wang, Xifeng, Wang, Lin Fa, Wèi, Tàiyún, Wells, Heather, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wú, Zhìqiáng, Yang, Xin, Yáng, Xīnglóu, Yu, Xuejie, Yutin, Natalya, Zerbini, F. Murilo, Zhang, Tong, Zhang, Yong Zhen, Zhou, Guohui, Zhou, Xueping, Kuhn, Jens H., Adkins, Scott, Alioto, Daniela, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Anthony, Simon J., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Bartonička, Tomáš, Basler, Christopher, Bavari, Sina, Beer, Martin, Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol, Blasdell, Kim R., Bradfute, Steven B., Breyta, Rachel, Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Buzkan, Nihal, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chamberlain, John, Chandran, Kartik, Charrel, Rémi N., Chen, Biao, Chiumenti, Michela, Choi, Il Ryong, Clegg, J. Christopher S., Crozier, Ian, da Graça, John V., Dal Bó, Elena, Dávila, Alberto M.R., de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L., Di Bello, Patrick L., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolja, Valerian V., Dolnik, Olga, Drebot, Michael A., Drexler, Jan Felix, Dürrwald, Ralf, Dufkova, Lucie, Dundon, William G., Duprex, W. Paul, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Fernandes, Jorlan, Fooks, Anthony R., Formenty, Pierre B.H., Forth, Leonie F., Fouchier, Ron A.M., Freitas-Astúa, Juliana, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gbakima, Aiah, Goldstein, Tracey, Gonzalez, Jean Paul J., Griffiths, Anthony, Groschup, Martin H., Günther, Stephan, Guterres, Alexandro, Hall, Roy A., Hammond, John, Hassan, Mohamed, Hepojoki, Jussi, Hepojoki, Satu, Hetzel, Udo, Hewson, Roger, Hoffmann, Bernd, Hongo, Seiji, Höper, Dirk, Horie, Masayuki, Hughes, Holly R., Hyndman, Timothy H., Jambai, Amara, Jardim, Rodrigo, Jiāng, Dàohóng, Jin, Qi, Jonson, Gilda B., Junglen, Sandra, Karadağ, Serpil, Keller, Karen E., Klempa, Boris, Klingström, Jonas, Kobinger, Gary, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kurath, Gael, Kuzmin, Ivan V., Laenen, Lies, Lamb, Robert A., Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lemos, Elba R.S., Leroy, Eric M., Li, Dexin, Lǐ, Jiànróng, Liang, Mifang, Liú, Wénwén, Liú, Yàn, Lukashevich, Igor S., Maes, Piet, Marciel de Souza, William, Marklewitz, Marco, Marshall, Sergio H., Martelli, Giovanni P., Martin, Robert R., Marzano, Shin Yi L., Massart, Sébastien, McCauley, John W., Mielke-Ehret, Nicole, Minafra, Angelantonio, Minutolo, Maria, Mirazimi, Ali, Mühlbach, Hans Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R.T., Nylund, Are, Økland, Arnfinn L., Oliveira, Renata C., Palacios, Gustavo, Pallas, Vicente, Pályi, Bernadett, Papa, Anna, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Pérez, Daniel R., Pfaff, Florian, Radoshitzky, Sheli R., Rahman, Aziz ul, Ramos-González, Pedro L., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Romanowski, Víctor, Robles Luna, Gabriel, Rota, Paul, Rubbenstroth, Dennis, Runstadler, Jonathan A., Ruzek, Daniel, Sabanadzovic, Sead, Salát, Jiří, Sall, Amadou Alpha, Salvato, Maria S., Sarpkaya, Kamil, Sasaya, Takahide, Schwemmle, Martin, Shabbir, Muhammad Z., Shí, Xiǎohóng, Shí, Zhènglì, Shirako, Yukio, Simmonds, Peter, Širmarová, Jana, Sironi, Manuela, Smither, Sophie, Smura, Teemu, Song, Jin Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Straková, Petra, Takada, Ayato, Tesh, Robert B., Thornburg, Natalie J., Tomonaga, Keizō, Tordo, Noël, Towner, Jonathan S., Turina, Massimo, Tzanetakis, Ioannis, Ulrich, Rainer G., Vaira, Anna Maria, van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, Wahl, Victoria, Walker, Peter J., Wang, Hui, Wang, Jianwei, Wang, Xifeng, Wang, Lin Fa, Wèi, Tàiyún, Wells, Heather, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wú, Zhìqiáng, Yang, Xin, Yáng, Xīnglóu, Yu, Xuejie, Yutin, Natalya, Zerbini, F. Murilo, Zhang, Tong, Zhang, Yong Zhen, Zhou, Guohui, and Zhou, Xueping
Abstract: In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 species were added, four were deleted, ten were moved and renamed, and 30 species were renamed. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
Published: 2020

50. A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition

Author: Dieterle, M. Eugenia, primary, Haslwanter, Denise, additional, Bortz, Robert H., additional, Wirchnianski, Ariel S., additional, Lasso, Gorka, additional, Vergnolle, Olivia, additional, Abbasi, Shawn A., additional, Fels, J. Maximilian, additional, Laudermilch, Ethan, additional, Florez, Catalina, additional, Mengotto, Amanda, additional, Kimmel, Duncan, additional, Malonis, Ryan J., additional, Georgiev, George, additional, Quiroz, Jose, additional, Barnhill, Jason, additional, Pirofski, Liise-anne, additional, Daily, Johanna P., additional, Dye, John M., additional, Lai, Jonathan R., additional, Herbert, Andrew S., additional, Chandran, Kartik, additional, and Jangra, Rohit K., additional
Published: 2020
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