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Your search keyword '"Eieland, Alexander Kirkeby"' showing total 2 results
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2 results on '"Eieland, Alexander Kirkeby"'

1. HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization

Author

Meisal, Roger, primary, Rounge, Trine Ballestad, additional, Christiansen, Irene Kraus, additional, Eieland, Alexander Kirkeby, additional, Worren, Merete Molton, additional, Molden, Tor Faksvaag, additional, Kommedal, Øyvind, additional, Hovig, Eivind, additional, Leegaard, Truls Michael, additional, and Ambur, Ole Herman, additional

Published
2017
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2. Gene expression profiling of fast- and slow-growing non-functioning gonadotroph pituitary adenomas.

Author

Falch, Camilla Maria, Sundaram, Arvind Y. M., Øystese, Kristin Astrid, Normann, Kjersti Ringvoll, Lekva, Tove, Silamikelis, Ivars, Eieland, Alexander Kirkeby, Andersen, Marianne, Bollerslev, Jens, and Olarescu, Nicoleta Cristina

Subjects
GENE expression, GONADOTROPIN, ADENOMA
Abstract

Objective: Reliable biomarkers associated with aggressiveness of non-functioning gonadotroph adenomas (GAs) are lacking. As the growth of tumor remnants is highly variable, molecular markers for growth potential prediction are necessary. We hypothesized that fast- and slow-growing GAs present different gene expression profiles and reliable biomarkers for tumor growth potential could be identified, focusing on the specific role of epithelial-mesenchymal transition (EMT). Design and methods: Eight GAs selected for RNA sequencing were equally divided into fast- and slow-growing group by the tumor volume doubling time (TVDT) median (27.75 months). Data were analyzed by tophat2, cufflinks and cummeRbund pipeline. 40 genes were selected for RT-qPCR validation in 20 GAs based on significance, fold-change and pathway analyses. The effect of silencing MTDH (metadherin) and EMCN (endomucin) on in vitro migration of human adenoma cells was evaluated. Results: 350 genes were significantly differentially expressed (282 genes upregulated and 68 downregulated in the fast group, P-adjusted <0.05). Among 40 selected genes, 11 showed associations with TVDT (--0.669

Published
2018
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