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7. The Dual Functions of Andrographolide in the Epstein–Barr Virus-Positive Head-and-Neck Cancer Cells: The Inhibition of Lytic Reactivation of the Epstein–Barr Virus and the Induction of Cell Death

Author

Heawchaiyaphum, Chukkris, primary, Malat, Praphatson, additional, Pientong, Chamsai, additional, Roytrakul, Sittiruk, additional, Yingchutrakul, Yodying, additional, Aromseree, Sirinart, additional, Suebsasana, Supawadee, additional, Mahalapbutr, Panupong, additional, and Ekalaksananan, Tipaya, additional

Published
2023
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11. The Inhibitory Effect of Kerra TM , KS TM , and Minoza TM on Human Papillomavirus Infection and Cervical Cancer.

Author

Choowongkomon, Kiattawee, Choengpanya, Khuanjarat, Pientong, Chamsai, Ekalaksananan, Tipaya, Talawat, Sulak, Srathong, Pussadee, and Chuerduangphui, Jureeporn

Subjects
HUMAN papillomavirus, PAPILLOMAVIRUS diseases, CERVICAL cancer, HELA cells, CELL populations
Abstract

Background and Objectives: Cervical cancer is one of the most common types of frequently found cancers in Thailand. One of the causative agents is the infection of the high-risk human papillomavirus (HPV) type 16 and 18. Traditional medicines are rich sources of bioactive compounds which are a valuable source for the development of novel cancer therapies. In this study, the therapeutic effects of 3 traditional medicines, KerraTM, KSTM, and MinozaTM, were studied on HeLa and CaSki cells. Materials and Methods: The effects of KerraTM, KSTM, and MinozaTM on cancer cells were evaluated through cytotoxicity and cell death assays. The infection assay using HPV-16 pseudovirus was also carried out. Results: All traditional medicines efficiently suppressed cell growths of HeLa and CaSki, with KerraTM being the most potent anticancer agent followed by KSTM and MinozaTM. KerraTM at 158 µg/mL and 261 µg/mL significantly increases the percentage inhibition of the HPV-16 pseudovirus infection in a pre-attachment step in a dose-dependent manner, while KSTM at 261 µg/mL efficiently inhibited viral infection in both pre-attachment and adsorption steps. However, KerraTM, KSTM, and MinozaTM at subtoxic concentrations could not reduce the viral E6 mRNA expressions of HPV-16 and HPV-18. Cell death assay by acridine orange/ethidium bromide showed that KerraTM increased population of dead cells in dose-dependent manner in both CaSki and HeLa. The percentage of secondary necrosis in KerraTM-treated CaSki was higher than that of HeLa cells, while the percentage of late apoptotic cells in HeLa was higher than that of CaSki, indicating that HeLa was more susceptible to KerraTM than CaSki. For KSTM and MinozaTM, these extracts at 250 µg/mL promoted autophagy over cell death. At 500 µg/mL, the percentage of dead cells in KerraTM was higher than that of KSTM and MinozaTM. Conclusions: KerraTM is a potent traditional medicine for promoting cancer cell death. KerraTM is possibly useful in the prevention and treatment of cervical cancer. Further investigation will be carried out to gain a better understanding of the biochemical mechanism and the pharmacological activity underlying this effect. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Epidemiological evidence and association of human papillomavirus with esophageal cancer in northeastern Thailand: a case–control study

Author

Burassakarn, Ati, primary, Pientong, Chamsai, additional, Tongchai, Panwad, additional, Wongjampa, Weerayut, additional, Poosari, Arisara, additional, Udomsin, Apiradee, additional, Sa-ngiamwibool, Prakasit, additional, Ungareewittaya, Piti, additional, Nutravong, Thitima, additional, and Ekalaksananan, Tipaya, additional

Published
2023
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13. Intrahost Genetic Diversity of Dengue Virus in Human Hosts and Mosquito Vectors under Natural Conditions Which Impact Replicative Fitness In Vitro

Author

Nonyong, Patcharaporn, primary, Ekalaksananan, Tipaya, additional, Phanthanawiboon, Supranee, additional, Overgaard, Hans J., additional, Alexander, Neal, additional, Thaewnongiew, Kesorn, additional, Sawaswong, Vorthon, additional, Nimsamer, Pattaraporn, additional, Payungporn, Sunchai, additional, Phadungsombat, Juthamas, additional, Nakayama, Emi E., additional, Shioda, Tatsuo, additional, and Pientong, Chamsai, additional

Published
2023
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14. Mathematical Modelling of Cervical Precancerous Lesion Grade Risk Scores: Linear Regression Analysis of Cellular Protein Biomarkers and Human Papillomavirus E6/E7 RNA Staining Patterns

Author

Bumrungthai, Sureewan, primary, Ekalaksananan, Tipaya, additional, Kleebkaow, Pilaiwan, additional, Pongsawatkul, Khajohnsilp, additional, Phatnithikul, Pisit, additional, Jaikan, Jirad, additional, Raumsuk, Puntanee, additional, Duangjit, Sureewan, additional, Chuenchai, Datchani, additional, and Pientong, Chamsai, additional

Published
2023
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17. Human Oncogenic Epstein–Barr Virus in Water and Human Blood Infection of Communities in Phayao Province, Thailand

Author

Pongpakdeesakul, Sutida, primary, Ekalaksananan, Tipaya, additional, Pientong, Chamsai, additional, Iamchuen, Niti, additional, Buddhisa, Surachat, additional, Mahingsa, Khwanruedee, additional, Pingyod, Arunee, additional, Sangsrijun, Wanwipa, additional, Passorn, Supaporn, additional, Chopjitt, Peechanika, additional, Duangjit, Sureewan, additional, and Bumrungthai, Sureewan, additional

Published
2023
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20. Characterization and Involvement of Exosomes Originating from Chikungunya Virus-Infected Epithelial Cells in the Transmission of Infectious Viral Elements

Author

Le, Bao Chi Thi, primary, Burassakarn, Ati, additional, Tongchai, Panwad, additional, Ekalaksananan, Tipaya, additional, Aromseree, Sirinart, additional, Phanthanawiboon, Supranee, additional, Polsan, Yada, additional, Alexander, Neal, additional, Overgaard, Hans J., additional, and Pientong, Chamsai, additional

Published
2022
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25. Mathematical Modelling of Cervical Precancerous Lesion Grade Risk Scores: Linear Regression Analysis of Cellular Protein Biomarkers and Human Papillomavirus E6 / E7 RNA Staining Patterns.

Author

Bumrungthai, Sureewan, Ekalaksananan, Tipaya, Kleebkaow, Pilaiwan, Pongsawatkul, Khajohnsilp, Phatnithikul, Pisit, Jaikan, Jirad, Raumsuk, Puntanee, Duangjit, Sureewan, Chuenchai, Datchani, and Pientong, Chamsai

Subjects
*DISEASE risk factors, *HUMAN papillomavirus, *PRECANCEROUS conditions, *REGRESSION analysis, *CELL analysis, *P16 gene
Abstract

The current practice of determining histologic grade with a single molecular biomarker can facilitate differential diagnosis but cannot predict the risk of lesion progression. Cancer is caused by complex mechanisms, and no single biomarker can both make accurate diagnoses and predict progression risk. Modelling using multiple biomarkers can be used to derive scores for risk prediction. Mathematical models (MMs) may be capable of making predictions from biomarker data. Therefore, this study aimed to develop MM–based scores for predicting the risk of precancerous cervical lesion progression and identifying precancerous lesions in patients in northern Thailand by evaluating the expression of multiple biomarkers. The MMs (Models 1–5) were developed in the test sample set based on patient age range (five categories) and biomarker levels (cortactin, p16INK4A, and Ki–67 by immunohistochemistry [IHC], and HPV E6/E7 ribonucleic acid (RNA) by in situ hybridization [ISH]). The risk scores for the prediction of cervical lesion progression ("risk biomolecules") ranged from 2.56–2.60 in the normal and low–grade squamous intraepithelial lesion (LSIL) cases and from 3.54–3.62 in cases where precancerous lesions were predicted to progress. In Model 4, 23/86 (26.7%) normal and LSIL cases had biomolecule levels that suggested a risk of progression, while 5/86 (5.8%) cases were identified as precancerous lesions. Additionally, histologic grading with a single molecular biomarker did not identify 23 cases with risk, preventing close patient monitoring. These results suggest that biomarker level–based risk scores are useful for predicting the risk of cervical lesion progression and identifying precancerous lesion development. This multiple biomarker–based strategy may ultimately have utility for predicting cancer progression in other contexts. [ABSTRACT FROM AUTHOR]

Published
2023
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28. sj-docx-2-avc-10.1177_20402066221089724 - Supplemental material for Activity of 3,19-isopropylidinyl andrographolide against herpes simplex virus type 1 in an animal model

Author

Chuerduangphui, Jureeporn, Nukpook, Thawaree, Pientong, Chamsai, Aromdee, Chantana, Suebsasana, Supawadee, Khunkitti, Watcharee, So-in, Charinya, Proyrungroj, Kanisara, and Ekalaksananan, Tipaya

Subjects
FOS: Clinical medicine, FOS: Biological sciences, Cell Biology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-2-avc-10.1177_20402066221089724 for Activity of 3,19-isopropylidinyl andrographolide against herpes simplex virus type 1 in an animal model by Jureeporn Chuerduangphui, Thawaree Nukpook, Chamsai Pientong, Chantana Aromdee, Supawadee Suebsasana, Watcharee Khunkitti, Charinya So-in, Kanisara Proyrungroj and Tipaya Ekalaksananan in Antiviral Chemistry and Chemotherapy

Published
2022
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35. Dengue virus in humans and mosquitoes and their molecular characteristics in northeastern Thailand 2016-2018

Author

Nonyong, Patcharaporn, primary, Ekalaksananan, Tipaya, additional, Phanthanawiboon, Supranee, additional, Aromseree, Sirinart, additional, Phadungsombat, Juthamas, additional, Nakayama, Emi E., additional, Shioda, Tatsuo, additional, Sawaswong, Vorthon, additional, Payungporn, Sunchai, additional, Thaewnongiew, Kesorn, additional, Overgaard, Hans J., additional, Bangs, Michael J., additional, Alexander, Neal, additional, and Pientong, Chamsai, additional

Published
2021
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39. Mapping the spatial distribution of the dengue vector Aedes aegypti and predicting its abundance in northeastern Thailand using machine-learning approach

Author

Rahman, M.S., Pientong, Chamsai, Zafar, Sumaira, Ekalaksananan, Tipaya, Paul, Richard E., Haque, Ubydul, Rocklöv, Joacim, Overgaard, Hans J., Rahman, M.S., Pientong, Chamsai, Zafar, Sumaira, Ekalaksananan, Tipaya, Paul, Richard E., Haque, Ubydul, Rocklöv, Joacim, and Overgaard, Hans J.

Abstract

Background: Mapping the spatial distribution of the dengue vector Aedes (Ae.) aegypti and accurately predicting its abundance are crucial for designing effective vector control strategies and early warning tools for dengue epidemic prevention. Socio-ecological and landscape factors influence Ae. aegypti abundance. Therefore, we aimed to map the spatial distribution of female adult Ae. aegypti and predict its abundance in northeastern Thailand based on socioeconomic, climate change, and dengue knowledge, attitude and practices (KAP) and/or landscape factors using machine learning (ML)-based system. Method: A total of 1066 females adult Ae. aegypti were collected from four villages in northeastern Thailand during January–December 2019. Information on household socioeconomics, KAP regarding climate change and dengue, and satellite-based landscape data were also acquired. Geographic information systems (GIS) were used to map the household-based spatial distribution of female adult Ae. aegypti abundance (high/low). Five popular supervised learning models, logistic regression (LR), support vector machine (SVM), k-nearest neighbor (kNN), artificial neural network (ANN), and random forest (RF), were used to predict females adult Ae. aegypti abundance (high/low). The predictive accuracy of each modeling technique was calculated and evaluated. Important variables for predicting female adult Ae. aegypti abundance were also identified using the best-fitted model. Results: Urban areas had higher abundance of female adult Ae. aegypti compared to rural areas. Overall, study respondents in both urban and rural areas had inadequate KAP regarding climate change and dengue. The average landscape factors per household in urban areas were rice crop (47.4%), natural tree cover (17.8%), built-up area (13.2%), permanent wetlands (21.2%), and rubber plantation (0%), and the corresponding figures for rural areas were 12.1, 2.0, 38.7, 40.1 and 0.1% respectively. Among all assessed models, RF

Published
2021
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40. Ecological, social and other environmental determinants of dengue vector abundance in urban and rural areas of Northeastern Thailand

Author

Rahman, Md. Siddikur, Ekalaksananan, Tipaya, Zafar, Sumaira, Poolphol, Petchaboon, Shipin, Oleg, Haque, Ubydul, Paul, Richard, Rocklöv, Joacim, Pientong, Chamsai, Overgaard, Hans J., Rahman, Md. Siddikur, Ekalaksananan, Tipaya, Zafar, Sumaira, Poolphol, Petchaboon, Shipin, Oleg, Haque, Ubydul, Paul, Richard, Rocklöv, Joacim, Pientong, Chamsai, and Overgaard, Hans J.

Abstract

Aedes aegypti is the main vector of dengue globally. The variables that influence the abundance of dengue vectors are numerous and complex. This has generated a need to focus on areas at risk of disease transmission, the spatial-temporal distribution of vectors, and the factors that modulate vector abundance. To help guide and improve vector-control efforts, this study identified the ecological, social, and other environmental risk factors that affect the abundance of adult female and immature Ae. aegypti in households in urban and rural areas of northeastern Thailand. A one-year entomological study was conducted in four villages of northeastern Thailand between January and December, 2019. Socio-demographic; self-reported prior dengue infections; housing conditions; durable asset ownership; water management; characteristics of water containers; knowledge, atti-tudes, and practices (KAP) regarding climate change and dengue; and climate data were collected. Household crowding index (HCI), premise condition index (PCI), socio-economic status (SES), and entomological indices (HI, CI, BI, and PI) were calculated. Negative binomial generalized linear models (GLMs) were fitted to identify the risk factors associated with the abundance of adult females and immature Ae. aegypti. Urban sites had higher entomological indices and numbers of adult Ae. aegypti mosquitoes than rural sites. Overall, participants’ KAP about climate change and dengue were low in both settings. The fitted GLM showed that a higher abundance of adult female Ae. aegypti was significantly (p < 0.05) associated with many factors, such as a low education level of household respondents, crowded households, poor premise conditions, surrounding house den-sity, bathrooms located indoors, unscreened windows, high numbers of wet containers, a lack of adult control, prior dengue infections, poor climate change adaptation, dengue, and vector-related practices. Many of the above were also significantly associated

Published
2021
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41. Serological biomarker for assessing human exposure to Aedes mosquito bites during a randomized vector control intervention trial in northeastern Thailand

Author

Fustec, Benedicte, primary, Phanitchat, Thipruethai, additional, Aromseree, Sirinart, additional, Pientong, Chamsai, additional, Thaewnongiew, Kesorn, additional, Ekalaksananan, Tipaya, additional, Cerqueira, Dominique, additional, Poinsignon, Anne, additional, Elguero, Eric, additional, Bangs, Michael J., additional, Alexander, Neal, additional, Overgaard, Hans J., additional, and Corbel, Vincent, additional

Published
2021
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42. Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos

Author

Doum, Dyna, Overgaard, Hans J., Mayxay, Mayfong, Suttiprapa, Sutas, Saichua, Prasert, Ekalaksananan, Tipaya, Tongchai, Panwad, Rahman, Md. Siddikur, Haque, Ubydul, Phommachanh, Sysavanh, Pongvongsa, Tiengkham, Rocklöv, Joacim, Paul, Richard, Pientong, Chamsai, Doum, Dyna, Overgaard, Hans J., Mayxay, Mayfong, Suttiprapa, Sutas, Saichua, Prasert, Ekalaksananan, Tipaya, Tongchai, Panwad, Rahman, Md. Siddikur, Haque, Ubydul, Phommachanh, Sysavanh, Pongvongsa, Tiengkham, Rocklöv, Joacim, Paul, Richard, and Pientong, Chamsai

Abstract

Dengue is the most rapidly spreading mosquito-borne viral disease in the world. The detection of clinical cases enables us to measure the incidence of dengue infection, whereas serological surveys give insights into the prevalence of infection. This study aimed to determine dengue seroprevalence and seroconversion rates in northeastern Thailand and southern Laos and to assess any association of mosquito control methods and socioeconomic factors with dengue virus (DENV) infection. Cross-sectional seroprevalence surveys were performed in May and November 2019 on the same individuals. Blood samples were collected from one adult and one child, when possible, in each of 720 randomly selected households from two urban and two rural sites in both northeastern Thailand and southern Laos. IgG antibodies against DENV were detected in serum using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Overall, 1071 individuals participated in the study. The seroprevalence rate was high (91.5%) across all 8 study sites. Only age and province were associated with seroprevalence rates. There were 33 seroconversions during the period from May to November, of which seven reported fever. More than half of the seroconversions occurred in the rural areas and in Laos. Dengue seroconversion was significantly associated with young age (<15 years old), female gender, province, and duration of living in the current residence. No socioeconomic factors or mosquito control methods were found to be associated with seroprevalence or seroconversion. Notably, however, the province with most seroconversions had lower diurnal temperature ranges than elsewhere. In conclusion, our study has highlighted the homogeneity of dengue exposure across a wide range of settings and most notably those from rural and urban areas. Dengue can no longer be considered to be solely an urban disease nor necessarily one linked to poverty., Errata: Doum D, Overgaard HJ, Mayxay M, Suttiprapa S, Saichua P, Ekalaksananan T, Tongchai P, Rahman MS, Haque U, Phommachanh S, Pongvongsa T, Rocklöv J, Paul R, Pientong C. Correction: Doum, D., et al. Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos. Int. J. Environ. Res. Public Health 2020, 17, 9134. International Journal of Environmental Research and Public Health. 2021; 18(4):1439. DOI: 10.3390/ijerph18041439

Published
2020
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43. Epstein-Barr Virus Infection of Oral Squamous Cells

Author

Heawchaiyaphum Chukkris, IIZASA, Hisashi, Ekalaksananan Tipaya, Burassakarn Ati, Kiyono Tohru, KANEHIRO, Yuichi, YOSHIYAMA, Hironori, Pientong Chamsai, Heawchaiyaphum Chukkris, IIZASA, Hisashi, Ekalaksananan Tipaya, Burassakarn Ati, Kiyono Tohru, KANEHIRO, Yuichi, YOSHIYAMA, Hironori, and Pientong Chamsai

Published
2020

44. Correction: Doum, D., et al. Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos. Int. J. Environ. Res. Public Health 2020, 17, 9134

Author

Doum, Dyna, primary, Overgaard, Hans J., additional, Mayxay, Mayfong, additional, Suttiprapa, Sutas, additional, Saichua, Prasert, additional, Ekalaksananan, Tipaya, additional, Tongchai, Panwad, additional, Rahman, Md. Siddikur, additional, Haque, Ubydul, additional, Phommachanh, Sysavanh, additional, Pongvongsa, Tiengkham, additional, Rocklöv, Joacim, additional, Paul, Richard, additional, and Pientong, Chamsai, additional

Published
2021
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45. Knowledge, attitudes, and practices on climate change and dengue in Lao People's Democratic Republic and Thailand

Author

Rahman, Md. Siddikur, primary, Overgaard, Hans J., additional, Pientong, Chamsai, additional, Mayxay, Mayfong, additional, Ekalaksananan, Tipaya, additional, Aromseree, Sirinart, additional, Phanthanawiboon, Supranee, additional, Zafar, Sumaira, additional, Shipin, Oleg, additional, Paul, Richard E., additional, Phommachanh, Sysavanh, additional, Pongvongsa, Tiengkham, additional, Vannavong, Nanthasane, additional, and Haque, Ubydul, additional

Published
2021
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47. Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos

Author

Doum, Dyna, primary, Overgaard, Hans J., additional, Mayxay, Mayfong, additional, Suttiprapa, Sutas, additional, Saichua, Prasert, additional, Ekalaksananan, Tipaya, additional, Tongchai, Panwad, additional, Rahman, Md. Siddikur, additional, Haque, Ubydul, additional, Phommachanh, Sysavanh, additional, Pongvongsa, Tiengkham, additional, Rocklöv, Joacim, additional, Paul, Richard, additional, and Pientong, Chamsai, additional

Published
2020
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48. Interepidemic Detection of Chikungunya Virus Infection and Transmission in Northeastern Thailand

Author

Le, Bao Chi Thi, primary, Ekalaksananan, Tipaya, additional, Thaewnongiew, Kesorn, additional, Phanthanawiboon, Supranee, additional, Aromseree, Sirinart, additional, Phanitchat, Thipruethai, additional, Chuerduangphui, Jureeporn, additional, Suwannatrai, Apiporn T., additional, Alexander, Neal, additional, Overgaard, Hans J., additional, Bangs, Michael J., additional, and Pientong, Chamsai, additional

Published
2020
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49. Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand

Author

Fustec, Benedicte, primary, Phanitchat, Thipruethai, additional, Hoq, Mohammad Injamul, additional, Aromseree, Sirinart, additional, Pientong, Chamsai, additional, Thaewnongiew, Kesorn, additional, Ekalaksananan, Tipaya, additional, Bangs, Michael J., additional, Corbel, Vincent, additional, Alexander, Neal, additional, and Overgaard, Hans J., additional

Published
2020
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