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1. Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis

Author

Giuseppe, Palasciano, Felicia, D’Alitto, Ostilio, Palmieri Vincenzo, Daniela, Santovito, Dario, Di Michele, Giuseppe, Croce, David, Sacerdoti, Silvia, Brocco, Silvano, Fasolato, Lara, Cecchetto, Giancarlo, Bombonato, Michele, Bertoni, Tea, Restuccia, Paola, Andreozzi, Livia, Liguori Maria, Francesco, Perticone, Benedetto, Caroleo, Maria, Perticone, Orietta, Staltari, Roberto, Manfredini, Alfredo, De Giorgi, Maurizio, Averna, Antonina, Giammanco, Alessandro, Granito, Irene, Pettinari, Sara, Marinelli, Luigi, Bolondi, Lorenzo, Falsetti, Aldo, Salvi, Emanuele, Durante-Mangoni, Flavio, Cesaro, Vincenza, Farinaro, Enrico, Ragone, Ignazio, Morana, Angelo, Andriulli, Antonio, Ippolito, Angelo, Iacobellis, Grazia, Niro, Antonio, Merla, Giovanni, Raimondo, Sergio, Maimone, Irene, Cacciola, Doriana, Varvara, Davide, Drenaggi, Silvia, Staffolani, Antonio, Picardi, Umberto, Vespasiani-Gentilucci, Giovanni, Galati, Paolo, Gallo, Giovanni, Davì, Cosima, Schiavone, Francesca, Santilli, Claudio, Tana, Anna, Licata, Maurizio, Soresi, Battista, Bianchi Giovanni, Isabella, Carderi, Antonio, Pinto, Antonino, Tuttolomondo, Giovanni, Ferrari, Paolo, Gresele, Tiziana, Fierro, Olivia, Morelli, Giacomo, Laffi, Giulio, Romanelli Roberto, Umberto, Arena, Cristina, Stasi, Antonio, Gasbarrini, Matteo, Gargovich, Assunta, Zocco Maria, Laura, Riccardi, Elena, Ainora Maria, William, Capeci, Pio, Martino Giuseppe, Lorenzo, Nobili, Maurizio, Cavallo, Pierluigi, Frugiuele, Antonio, Greco, Antonello, Pietrangelo, Paolo, Ventura, Chiara, Cuoghi, Matteo, Marcacci, Gaetano, Serviddio, Gianluigi, Vendemiale, Rosanna, Villani, Ruggiero, Gargano, Gianpaolo, Vidili, Valentina, Di Cesare, Maristella, Masala, Giuseppe, Delitala, Pietro, Invernizzi, Giovanni, Di Minno, Antonella, Tufano, Francesco, Purrello, Graziella, Privitera, Alessandra, Forgione, Valentina, Curigliano, Marco, Senzolo, Kryssia Isabel, Rodríguez-Castro, Gianluigi, Giannelli, Carla, Serra, Sergio, Neri, Pietro, Pignataro, Mario, Rizzetto, Wilma, Debernardi Venon, Gianluca, Svegliati Baroni, Gaetano, Bergamaschi, Michela, Masotti, Filippo, Costanzo, Roberto, Corazza Gino, Hugh, Caldwell Stephen, Francesco, Angelico, Ben Maria, Del, Laura, Napoleone, Licia, Polimeni, Marco, Proietti, Valeria, Raparelli, Francesco, Romiti Giulio, Eleonora, Ruscio, Andrea, Severoni, Giovanni, Talerico, Filippo, Toriello, Annarita, Vestri, Cangemi, Roberto, Raparelli, Valeria, Talerico, Giovanni, Basili, Stefania, and Violi, Francesco

Published
2024
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2. Anthropometric parameters and liver histology influence lipid metabolic changes in HCV chronic hepatitis on direct-acting antiviral treatment

Author

Emanuele Durante-Mangoni, Martina Vitrone, Enrico Ragone, Erasmo Falco, Domenico Iossa, Massimo Gagliardi, Rosa Zampino, Iossa, Domenico, Vitrone, Martina, Gagliardi, Massimo, Falco, Erasmo, Ragone, Enrico, Zampino, Rosa, and Durante-Mangoni, Emanuele

Subjects
medicine.medical_specialty, Apolipoprotein B, Hepatitis C virus, medicine.disease_cause, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, lipid, Internal medicine, Medicine, Body mass index (BMI), direct-acting antiviral treatment (DAA treatment), biology, Triglyceride, business.industry, Cholesterol, Fatty liver, Lipid metabolism, General Medicine, medicine.disease, waist circumference, chemistry, 030220 oncology & carcinogenesis, biology.protein, 030211 gastroenterology & hepatology, lipids (amino acids, peptides, and proteins), Original Article, Steatosis, business, hepatitis C virus (HCV)
Abstract

Background: Hepatitis C virus (HCV) infection affects lipid metabolism. We investigated the impact of direct-acting antiviral (DAA) treatment on lipid metabolism in chronic hepatitis C (CHC), with a focus on the effects of anthropometric parameters and liver histology. We also analyzed the dynamics of metabolic indexes used to estimate cardiovascular risk.Methods: In 49 patients with CHC treated with DAAs, lipid metabolic changes, anthropometric parameters, liver histology and cardiovascular risk indexes, including triglyceride to HDL ratio (Tr/HDL), fatty liver index (FLI) and visceral adiposity index (VAI) were evaluated at baseline (BL), end of treatment (EOT) and 12 [sustained virological response (SVR) 12] and 24 (SVR24) weeks after EOT.Results: SVR occurred in 96% of cases. Total and LDL cholesterol and ApoB levels increased significantly between BL and EOT (P

Published
2021

3. Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis

Author

Lawrence P. Park, Vivian H. Chu, Gail Peterson, Athanasios Skoutelis, Tatjana Lejko‐Zupa, Emilio Bouza, Pierre Tattevin, Gilbert Habib, Ren Tan, Javier Gonzalez, Javier Altclas, Jameela Edathodu, Claudio Querido Fortes, Rinaldo Focaccia Siciliano, Orathai Pachirat, Souha Kanj, Andrew Wang, Liliana Clara, Marisa Sanchez, José Casabé, Claudia Cortes, Francisco Nacinovich, Pablo Fernandez Oses, Ricardo Ronderos, Adriana Sucari, Jorge Thierer, Silvia Kogan, Denis Spelman, Eugene Athan, Owen Harris, Karina Kennedy, David Gordon, Lito Papanicolas, Tony Korman, Despina Kotsanas, Robyn Dever, Phillip Jones, Pam Konecny, Richard Lawrence, David Rees, Suzanne Ryan, Michael P. Feneley, John Harkness, Jeffrey Post, Porl Reinbott, Rainer Gattringer, Franz Wiesbauer, Adriana Ribas Andrade, Ana Cláudia Passos de Brito, Armenio Costa Guimarães, Max Grinberg, Alfredo José Mansur, Tania Mara Varejao Strabelli, Marcelo Luiz Campos Vieira, Regina Aparecida de Medeiros Tranchesi, Marcelo Goulart Paiva, Auristela de Oliveira Ramos, Clara Weksler, Giovanna Ferraiuoli, Wilma Golebiovski, Cristiane Lamas, James A. Karlowsky, Yoav Keynan, Andrew M. Morris, Ethan Rubinstein, Sandra Braun Jones, Patricia Garcia, Alberto Fica, Rodrigo Montagna Mella, Ricardo Fernandez, Liliana Franco, Astrid Natalia Jaramillo, Bruno Barsic, Suzana Bukovski, Vladimir Krajinovic, Ana Pangercic, Igor Rudez, Josip Vincelj, Tomas Freiberger, Jiri Pol, Barbora Zaloudikova, Zainab Ashour, Amani El Kholy, Marwa Mishaal, Dina Osama, Hussien Rizk, Neijla Aissa, Corentine Alauzet, Francois Alla, Catherine Campagnac, Thanh Doco‐Lecompte, Christine Selton‐Suty, Jean‐Paul Casalta, Pierre‐Edouard Fournier, Didier Raoult, Franck Thuny, Francois Delahaye, Armelle Delahaye, Francois Vandenesch, Erwan Donal, Pierre Yves Donnio, Erwan Flecher, Christian Michelet, Matthieu Revest, Florent Chevalier, Antoine Jeu, Jean Paul Rémadi, Dan Rusinaru, Christophe Tribouilloy, Yvette Bernard, Catherine Chirouze, Bruno Hoen, Joel Leroy, Patrick Plesiat, Christoph Naber, Carl Neuerburg, Bahram Mazaheri, Sophia Athanasia, Ioannis Deliolanis, Helen Giamarellou, Tsaganos Thomas, Efthymia Giannitsioti, Elena Mylona, Olga Paniara, Konstantinos Papanicolaou, John Pyros, Konstantinos Papanikolaou, Gautam Sharma, Johnson Francis, Lathi Nair, Vinod Thomas, Krishnan Venugopal, Margaret M. Hannan, John P. Hurley, Amos Cahan, Dan Gilon, Sarah Israel, Maya Korem, Jacob Strahilevitz, Emanuele Durante‐Mangoni, Irene Mattucci, Daniela Pinto, Federica Agrusta, Alessandra Senese, Enrico Ragone, Riccardo Utili, Enrico Cecchi, Francesco De Rosa, Davide Forno, Massimo Imazio, Rita Trinchero, Paolo Grossi, Mariangela Lattanzio, Antonio Toniolo, Antonio Goglio, Annibale Raglio, Veronica Ravasio, Marco Rizzi, Fredy Suter, Giampiero Carosi, Silvia Magri, Liana Signorini, Zeina Kanafani, Souha S. Kanj, Ahmad Sharif‐Yakan, Imran Abidin, Syahidah Syed Tamin, Eduardo Rivera Martínez, Gabriel Israel Soto Nieto, Jan T.M. van der Meer, Stephen Chambers, David Holland, Arthur Morris, Nigel Raymond, Kerry Read, David R. Murdoch, Stefan Dragulescu, Adina Ionac, Cristian Mornos, O.M. Butkevich, Natalia Chipigina, Ozerecky Kirill, Kulichenko Vadim, Tatiana Vinogradova, Magid Halim, Yee‐Yun Liew, Ru‐San Tan, Mateja Logar, Manica Mueller‐Premru, Patrick Commerford, Anita Commerford, Eduan Deetlefs, Cass Hansa, Mpiko Ntsekhe, Manuel Almela, Yolanda Armero, Manuel Azqueta, Ximena Castañeda, Carlos Cervera, Carlos Falces, Cristina Garcia‐de‐la‐Maria, Guillermina Fita, Jose M. Gatell, Magda Heras, Jaime Llopis, Francesc Marco, Carlos A. Mestres, José M. Miró, Asuncion Moreno, Salvador Ninot, Carlos Paré, Juan M. Pericas, Jose Ramirez, Irene Rovira, Marta Sitges, Ignasi Anguera, Bernat Font, Joan Raimon Guma, Javier Bermejo, Miguel Angel Garcia Fernández, Victor Gonzalez‐Ramallo, Mercedes Marín, Patricia Muñoz, Miguel Pedromingo, Jorge Roda, Marta Rodríguez‐Créixems, Jorge Solis, Benito Almirante, Nuria Fernandez‐Hidalgo, Pilar Tornos, Arístides de Alarcón, Ricardo Parra, Eric Alestig, Magnus Johansson, Lars Olaison, Ulrika Snygg‐Martin, Pimchitra Pachirat, Burabha Pussadhamma, Vichai Senthong, Anna Casey, Tom Elliott, Peter Lambert, Richard Watkin, Christina Eyton, John L. Klein, Suzanne Bradley, Carol Kauffman, Roger Bedimo, G. Ralph Corey, Anna Lisa Crowley, Pamela Douglas, Laura Drew, Vance G. Fowler, Thomas Holland, Tahaniyat Lalani, Daniel Mudrick, Zaniab Samad, Daniel Sexton, Martin Stryjewski, Christopher W. Woods, Stamatios Lerakis, Robert Cantey, Lisa Steed, Dannah Wray, Stuart A. Dickerman, Hector Bonilla, Joseph DiPersio, Sara‐Jane Salstrom, John Baddley, Mukesh Patel, Amy Stancoven, Donald Levine, Jonathan Riddle, Michael Rybak, Christopher H. Cabell, Khaula Baloch, Christy C. Dixon, Tina Harding, Marian Jones‐Richmond, Bob Sanderford, Judy Stafford, Kevin Anstrom, Arnold S. Bayer, A. W. Karchmer, Daniel J. Sexton, Vivian Chu, David T. Durack, Susannah Eykyn, Phillipe Moreillon, Duke University Medical Center, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Fonction, structure et inactivation d'ARN bactériens, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Jonchère, Laurent, Universitat de Barcelona, Mazaheri, Bahram (Beitragende*r), Naber, Christoph (Beitragende*r), and Neuerburg, Carl (Beitragende*r)

Subjects
Male, Infeccions quirúrgiques, Surgical wound infection, Medizin, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, 0302 clinical medicine, Risk Factors, Clinical Studies, Registries, 030212 general & internal medicine, Original Research, Framingham Risk Score, Endocarditis, Hazard ratio, Middle Aged, Prognosis, infection, mortality, prognosis, surgery, valves, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Infective endocarditis, Cohort, Female, Mortality/Survival, Cardiology and Cardiovascular Medicine, Risk assessment, Infection, Cohort study, Adult, medicine.medical_specialty, Lower risk, Risk Assessment, Sensitivity and Specificity, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Mortalitat, medicine, Humans, Infectious Endocarditis, Mortality, Propensity Score, Aged, Models, Statistical, Cirurgia, business.industry, Proportional hazards model, Reproducibility of Results, medicine.disease, Surgery, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Valvular Heart Disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

Background Host factors and complications have been associated with higher mortality in infective endocarditis ( IE ). We sought to develop and validate a model of clinical characteristics to predict 6‐month mortality in IE . Methods and Results Using a large multinational prospective registry of definite IE (International Collaboration on Endocarditis [ ICE ]–Prospective Cohort Study [ PCS ], 2000–2006, n=4049), a model to predict 6‐month survival was developed by Cox proportional hazards modeling with inverse probability weighting for surgery treatment and was internally validated by the bootstrapping method. This model was externally validated in an independent prospective registry ( ICE ‐ PLUS , 2008–2012, n=1197). The 6‐month mortality was 971 of 4049 (24.0%) in the ICE ‐ PCS cohort and 342 of 1197 (28.6%) in the ICE ‐ PLUS cohort. Surgery during the index hospitalization was performed in 48.1% and 54.0% of the cohorts, respectively. In the derivation model, variables related to host factors (age, dialysis), IE characteristics (prosthetic or nosocomial IE , causative organism, left‐sided valve vegetation), and IE complications (severe heart failure, stroke, paravalvular complication, and persistent bacteremia) were independently associated with 6‐month mortality, and surgery was associated with a lower risk of mortality (Harrell's C statistic 0.715). In the validation model, these variables had similar hazard ratios (Harrell's C statistic 0.682), with a similar, independent benefit of surgery (hazard ratio 0.74, 95% CI 0.62–0.89). A simplified risk model was developed by weight adjustment of these variables. Conclusions Six‐month mortality after IE is ≈25% and is predicted by host factors, IE characteristics, and IE complications. Surgery during the index hospitalization is associated with lower mortality but is performed less frequently in the highest risk patients. A simplified risk model may be used to identify specific risk subgroups in IE .

Published
2016
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4. Molecular epidemiology of a clonal outbreak of multidrug-resistant Acinetobacter baumannii in a university hospital in Italy

Author

Susanna Cuccurullo, Enrico Ragone, Raffaele Zarrilli, Marie Francoise Tripodi, A. Di Popolo, Nicola Galdieri, Annunziata Mattei, R. Utili, Maria Bagattini, Maria Triassi, R. Casillo, Valeria Crivaro, Zarrilli, Raffaele, Casillo, R, DI POPOLO, A, Tripodi, M. F., Bagattini, M, Cuccurullo, S, Crivaro, V, Ragone, E, Mattei, A, Galdieri, N, Triassi, Maria, Utili, R., Zarrilli, R., Casillo, R., Bagattini, M., Cuccurullo, S., Crivaro, V., Ragone, E., Mattei, A., Galdieri, N., Triassi, M., Utili, Riccardo, Zarrilli, R, and Tripodi, Mf

Subjects
Acinetobacter baumannii, Male, Microbiology (medical), Imipenem, carbapenem resistance, Microbial Sensitivity Tests, Integron, molecular epidemiology, beta-Lactamases, Microbiology, Disease Outbreaks, Hospitals, University, Drug Resistance, Multiple, Bacterial, Pulsed-field gel electrophoresis, medicine, polycyclic compounds, Humans, Antibacterial agent, Aged, Cross Infection, Molecular epidemiology, biology, outbreak, Outbreak, General Medicine, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, Electrophoresis, Gel, Pulsed-Field, Community-Acquired Infections, Intensive Care Units, Infectious Diseases, Carbapenems, Italy, nosocomial infection, biology.protein, Colistin, bacteria, epidemiology, Female, A. baumannii, OXA-58, medicine.drug, Acinetobacter Infections
Abstract

This study investigated the molecular epidemiology of a clonal outbreak of multidrug-resistant Acinetobacter baumannii that occurred between June 2003 and June 2004 in a tertiary-care hospital in Naples, Italy. A. baumannii was isolated from 74 patients, of whom 38 were infected and 36 were colonised. Thirty-three patients had ventilator-associated pneumonia, three had hospital-acquired pneumonia, and two had sepsis. Genotypic analysis of 45 available A. baumannii isolates revealed two distinct pulsed-field gel electrophoresis (PFGE) patterns. Of these, PFGE pattern 1 was represented by isolates from 44 patients and was identical to that of an epidemic A. baumannii clone isolated in another hospital of Naples during 2002. All A. baumannii isolates of PFGE type 1 showed identical multiresistant antibiotypes, characterised by resistance to all antimicrobial agents tested, including carbapenems, with the exception of colistin. In these isolates, inhibition of OXA enzymes by 200 mM NaCl reduced the imipenem MIC by up to four-fold. Molecular analysis of antimicrobial resistance genes showed that all A. baumannii isolates of PFGE type 1 harboured a class 1 integron containing the aacA4, orfX and blaOXA-20 gene cassettes, an ampC gene and a blaOXA-51-like allele. Moreover, a blaOXA-58-like gene surrounded by the regulatory elements ISAba2 and ISAba3 was identified in a 30-kb plasmid from A. baumannii isolates of PFGE type 1, but not PFGE type 2. Thus, selection of a single A. baumannii clone producing an OXA-58-type carbapenem-hydrolysing oxacillinase was responsible for the increase in the number of A. baumannii infections that occurred in this hospital.

Published
2007
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5. Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study

Author

Richard Watkin, Pierre-Edouard Fournier, David R. Murdoch, Yoav Keynan, Florent Chevalier, Tania Mara Varejão Strabelli, Imran Zainal Abidin, Denis Spelman, Roger Bedimo, Jeffrey J. Post, Francesc Marco, Alan C Street, Claudio Querido Fortes, Francisco Nacinovich, Antonio Goglio, Stephen T. Chambers, Fredy Suter, Claire Sorel, Alessandro Tebini, Phillip Jones, Robyn Dever, Emilio Bouza, G. Ralph Corey, Karina Kennedy, Alfredo José Mansur, Nigel Raymond, Guillermina Fita, Martin E. Stryjewski, Joan R. Guma, Asunción Moreno, John W. Baddley, Johnson Francis, Magnus Johansson, José H. Casabé, Margaret M. Hannan, Krishnan Venugopal, Thanh Doco-Lecompte, Jacob Strahilevitz, Annibale Raglio, Carl Neuerburg, Vichai Senthong, Cass Hansa, Ana Pangerčić, Adina Ionac, Vladimir Krajinović, Christine Selton-Suty, Marwa Mishaal, Mateja Logar, Erwan Donal, Elena Mylona, Clara Weksler, Joseph Di Persio, Antoine Jeu, Pilar Tornos, Konstantinos Papanicolaou, François Vandenesch, Tom S.J. Elliott, Jan van der Meer, Patricia Muñoz, Regina Aparecida De Medeiros Tranchesi, Lathi Nair, Dannah Wray, Arnold S. Bayer, Pamela Konecny, David L. Gordon, Gilbert Habib, Armênio Costa Guimarães, Alberto Fica, Mercedes Marín, Francesco Giuseppe De Rosa, Marian Jones-Richmond, Marcelo Luiz Campos Vieira, Max Grinberg, Luis Afonso, Khaula Baloch, Pimchitra Pachirat, Anna Lisa Crowley, Marie Line Erpelding, Miguel Pedromingo, Daniel W. Mudrick, John Harkness, Barbora Zaloudikova, Christophe Tribouilloy, Cristina Garcia-de-la-Maria, Kerry Read, Athanasios Skoutelis, Marco Rizzi, Michael J. Rybak, Ioannis Deliolanis, Stuart Dickerman, Carol A. Kauffman, John L Klein, Suzanne Ryan, Christopher W. Woods, Gautam Sharma, Silvia Magri, Susannah J. Eykyn, Veronica Ravasio, Auristela De Oliveira Ramos, J. Leroy, Bruno Baršić, Burabha Pussadhamma, Jameela Edathodu, Franck Thuny, Eduan Deetlefs, Yvette Bernard, Rinaldo Focaccia Siciliano, Lito E. Papanicolas, Salvador Ninot, Nuria Fernández-Hidalgo, Zaniab Samad, Arístides de Alarcón, Neijla Aissa, Claudia Cortés, Thomas L. Holland, Tina Harding, Tania A. Baban, Irene Rovira, Ethan Rubinstein, Jorge Solis, Maya Korem, Giampiero Carosi, Marie Francoise Tripodi, Andrew Wang, Orathai Pachirat, Davide Forno, Ana Cláudia Passos De Brito, Catherine Campagnac, Anna L. Casey, Ana del Río, Gail E. Peterson, Carlos Falces, Christopher H. Cabell, François Delahaye, Emanuele Durante-Mangoni, Mattucci Irene, Despina Kotsanas, Javier Bermejo, Pierre Tattevin, Richard Lawrence, John Pyros, José M. Gatell, Jérémie Violette, Igor Rudez, Peter A. Lambert, Jean Paul Casalta, Jiri Pol, Kulichenko Vadim, Pablo Fernandez Oses, Ximena Castañeda, José Ramírez, Rita Trinchero, Sarah Israel, Mariangela Lattanzio, Eugene Athan, Arthur J. Morris, Bahram Mazaheri, Leeanne Grigg, Mohamad Yasmine, Adriana Andrade, Owen Harris, Syahidah Syed Tamin, Adolf W. Karchmer, Joan Pericas, Manica Mueller-Premru, Ozerecky Kirill, Eduardo Rivera Martínez, Christina Eyton, Josip Vincelj, Marisa Santos, Marisa Sanchez, David T. Durack, Dan Gilon, Marcelo Goulart Paiva, G. Ferraiuoli, Susanna Cuccurullo, Chipigina Ns, Lars Olaison, Patrick Plésiat, Michael P. Feneley, Amy B. Stancoven, Efthymia Giannitsioti, Cristiane da Cruz Lamas, Silvia Kogan, Kevin J. Anstrom, Manuel Almela, Liliana Clara, Stamatios Lerakis, Massimo Imazio, Rainer Gattringer, Javier Altclas, Wilma F. Golebiovski, Cristian Mornos, Damon P. Eisen, Pierre-Yves Donnio, Bernat Font, Eric Alestig, Liana Signorini, Sandra Braun Jones, Pamela S. Douglas, Helen Giamarellou, Gabriel Israel Soto Nieto, Tatjana Lejko-Zupanc, Benito Almirante, Dan Rusinaru, Anita Commerford, Yolanda Armero, Donald P. Levine, Mukesh Patel, M. Azqueta, Mpiko Ntsekhe, Phillipe Moreillon, Matthieu Revest, Adriana Sucari, Ashour Zainab, Olga Paniara, Víctor González-Ramallo, Miguel Ángel García Fernández, Ricardo Parra, Christoph Naber, Hector Bonilla, John P. Hurley, Rodrigo Montagna Mella, James A. Karlowsky, Lisa L. Steed, Armelle Delahaye, Marta Rodríguez-Créixems, José M. Miró, Enrico Cecchi, Enrico Ragone, Catherine Chirouze, J. Roda, David Holland, Marta Sitges, Luh Nah Lum, Patricia García, Thomas Redick, Theresa Kulman, Paul A. Pappas, Carlos Paré, Riccardo Utili, Stefan Dragulescu, Robert Cantey, Paolo Grossi, Vivian H. Chu, Porl Reinbott, Bruno Hoen, Amani El Kholy, Judy Stafford, Tomáš Freiberger, Hussien Rizk, Corentine Alauzet, Ricardo Ronderos, Ru San Tan, Christian Michelet, Suzanne F. Bradley, R. Casillo, Thomas Tsaganos, M. Cereceda, Laura A. Drew, Magid Halim, François Alla, Tahaniyat Lalani, Carlos A. Mestres, David Rees, Sara Jane Salstrom, O. M. Butkevich, Patrick J. Commerford, Ignasi Anguera, Franz Wiesbauer, Ulrika Snygg-Martin, Lawrence P. Park, Didier Raoult, Tony M. Korman, Giovanni Dialetto, Zeina Kanafani, Antonio Toniolo, Suzana Bukovski, Christy C. Dixon, Tatiana Vinogradova, Jorge Thierer, Souha S. Kanj, Vinod Thomas, Daniel J. Sexton, Vance G. Fowler, Andrew M. Morris, S. Athanasia, Ren Tan, Carlos Cervera, Chirouze, C, Alla, F, Fowler VG, Jr, Sexton, Dj, Corey, Gr, Chu, Vh, Wang, A, Erpelding, Ml, DURANTE MANGONI, Emanuele, Fernández Hidalgo, N, Giannitsioti, E, Hannan, Mm, Lejko Zupanc, T, Miró, Jm, Muñoz, P, Murdoch, Dr, Tattevin, P, Tribouilloy, C, Hoen, B., Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Service des maladies infectieuses et tropicales, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques, Duke University Medical Center, Monaldi Hospital, Mater Hospitals, University Medical Center Ljubljana, Institut d'Investigacions Biomèdiques August Pi i Sunyer ( IDIBAPS ), Universitat de Barcelona ( UB ), Clinical Microbiology and Infectious Diseases Department, Universidad Complutense de Madrid [Madrid] ( UCM ), Department of Pathology, University of Otago, Microbiology Unit, Canterbury Health Laboratories, Service des maladies infectieuses et réanimation médicale, Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou, Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne ( UPJV ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), University of Otago [Dunedin, Nouvelle-Zélande], Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Hôpital Saint-Jacques, Service des maladies infectieuses et réanimation médicale [Rennes], Hôpital Pontchaillou-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
Male, diagnosis, International Cooperation, Medizin, blood culture, Cohort Studies, surgery, [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology, Prospective Studies, Prospective cohort study, Endocarditis, Mortality rate, heart valve, Middle Aged, Staphylococcal Infections, Heart Valves, prosthetic valve, 3. Good health, Treatment Outcome, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infective endocarditis, Cohort, endocarditis, Female, Cohort study, Adult, Microbiology (medical), Staphylococcus aureus, medicine.medical_specialty, Endocarditis, Staphylococcus aureus, heart valve, combined treatment, blood culture, clinical microbiology, etiology, diagnosis, Prosthesis-Related Infections, etiology, Staphylococcal infections, Internal medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, 1-year mortality, Prosthetic valve, Surgery, Aged, Humans, Survival Analysis, medicine, combined treatment, clinical microbiology, Proportional hazards model, business.industry, medicine.disease, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background - The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. Methods - Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use. Results - EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15). Conclusions - In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.

Published
2015
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6. Streptococcus bovis Endocarditis and Its Association with Chronic Liver Disease: An Underestimated Risk Factor

Author

Le Adinolfi, Marie Francoise Tripodi, Riccardo Utili, Enrico Ragone, Giuseppe Ruggiero, D Iarussi, R Fortunato, E Durante Mangoni, Tripodi, Mf, Adinolfi, Luigi Elio, Ragone, E, DURANTE MANGONI, Emanuele, Fortunato, R, Iarussi, D, Ruggiero, G, and Utili, Riccardo

Subjects
Male, Microbiology (medical), medicine.medical_specialty, Pathology, Discitis, Gastrointestinal Diseases, Embolism, Chronic liver disease, Gastroenterology, Liver disease, S. bovis Endocarditis and Liver Disease, Liver Function Tests, Risk Factors, Streptococcal Infections, Internal medicine, medicine, Humans, Endocarditis, Risk factor, biology, medicine.diagnostic_test, business.industry, Liver Diseases, Mortality rate, Endocarditis, Bacterial, Middle Aged, medicine.disease, Streptococcus bovis, biology.organism_classification, Anti-Bacterial Agents, Infectious Diseases, Chronic Disease, Colonic Neoplasms, Female, business, Liver function tests
Abstract

Clinical and epidemiological characteristics of Streptococcus bovis endocarditis were prospectively studied among 199 patients with definite endocarditis. Thirty patients (15.1%) had S. bovis endocarditis. Compared with patients with non–S. bovis endocarditis, these 30 patients were older (mean age, 58.6*12.4 years vs. 46.0*17.0 years; P < .001) and had higher rates of bivalvular involvement (43.3% vs. 7.7%; P

Published
2004
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7. Prospective validation of the CLIP score: A new prognostic system for patients with cirrhosis and hepatocellular carcinoma

Author

Francesco, Izzo, 1 Oreste Cuomo, 2 Gaetano Capuano, 3 Giuseppe Ruggiero, 4 Roberto Mazzanti, 5 Fabio Farinati, 7 Participating Investigators: Bruno Daniele, 6 Silvana E. l. b. a., 1 Sandro Pignata, 1 Francesco Cremona, 1 Francesco Izzo, 1 Valerio Parisi, 1 Francesco Fiore, 1 Paolo Vallone, 1 Francesco Perrone1, Oreste, Cuomo, 2 Massimo Di Palma, 2 Emilio Manno, 2 Giuseppe Militerno2, Gabriele, Budillon, 3 Gaetano Capuano, 3 Lucia Cimino, 3 Domenico Pomponi3, Luigi Elio Adinolfi, 4 Enrico Ragone, 4 Giuseppe Ruggiero, 4 Riccardo Utili4, Umberto, Arena, 5 Giuseppe Di Fiore, 5 Paolo Gentilini, 5 Roberto Mazzanti5, Fabio, Farinati, 6 Michela Rinaldi6, Silvana, Elba, 7 Angelo Coviello, 7 Onofrio Giuseppe Manghisi7, Bernardino, Crispino, 8 Raffaele Laviscio, 8 Guido Piai8, Nicola, Caporaso, 9 Ilario De Sio9, Giulio, Belli, 10 Antonio Iannelli, 10 Mario Luigi Santangelo10, Giovanni Battista Gaeta, 11 Tiziana Ascione, 11 Giuseppe Giusti11, Valentina, D’Angelo, 12 Giampiero Francica, 12 Giampiero Marone12, Giuseppe, Pasquale, 13 Felice Piccinino, 13 Maria Stanzione13, Angelo Raffaele Bianco, 14 Sabino De Placido, 14 Giovannella Palmieri14, Luciano, D’Agostino, 15 Daniele Mattera, Puzziello, Alessandro, Antonino, Aiello, 16 Oscar Ferrau`, 16 Maria Antonietta Freni16, Vincenza, Aloisio, 17 Antonio Giorgio, 17 Anna Perrotta17, Maria, Calandra, 18 Luigi Castellano, 18 Camillo Del Vecchio Blanco18, Fabiana, Castiglione, 19 Gabriele Mazzacca, 19 Antonio Rispo19, Raffaele, Colurcio, 20 Bruno Galanti, 20 Michele Russo20, Bruno, Palmentieri, Persico, Marcello, Martina, Felder, 22 Laura Zancanella22, Mario, Belli, 23 Giuseppe Colantuoni, 23 Guido De Sena23, Francesco, Guardascione, 24 Gino Petrelli24, Bruno, Lamorgese, 25 Luigi Manzione25, Tonino, Pedicini26, Modesto, D’Aprile27, Ciro G. a. l. l. o., 28, 29 Participating Institutions 1Istituto Nazionale Tumori, Napoli, Cardarelli, 2Ospedale A., 3gastroenterologia, Ii, Universita` Federico II, 4Terapia Medica II Seconda Universita` di Napoli, 5Medicina Interna Universita` di Firenze, 6Malattie dell’apparato digerente Universita` di Padova, 7IRCCS De Bellis, Castellana, Grotte, 8Ospedale di Marcianise, Magrassi, 9Dipartimento di Internistica Clinica F., Sun, dei Trapianti, 10Chirurgia Generale e., Fed, 11Istituto di Malattie Infettive, I, 12ospedale, Ascalesi, Subtropicali SUN, 13Malattie Tropicali e., 14Oncologia Medica FED, Chirurgia Generale FED, 15Dipartimento Patologia Digestiva e., 16gastroenterologia, Universita` di Messina, 17ospedale, Cotugno, 18gastroenterologia, Sun, 19gastroenterologia, I, 20servizio, Aids, 21VII Medicina Generale ed Epatologia, 22ospedale, Civile, Bolzano, 23ospedale, Civile, Avellino, 24Ospedale di Giugliano, Carlo, 25Ospedale S., Potenza, 26ospedale, Fatebenefratelli, Benevento, Maria Goretti, 27Ospedale S., Latina, 28Metodologia Epidemiologica Clinica, 29Centro Elaborazione Dati Clinici del Mezzogiorno, and CNR PF ACRO

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Hepatocellular carcinoma, Medicine, business, medicine.disease
Published
2000
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8. Dual or Single Hepatitis B and C Virus Infections in Childhood Cancer Survivors: Long-Term Follow-Up and Effect of Interferon Treatment

Author

Enrico Ragone, Paolo Indolfi, Maria Teresa Di Tullio, Maria Capasso, Giuseppe Ruggiero, Riccardo Utili, Adele Martini, Fiorina Casale, Marta Marracino, Pasquale Bellopede, Rosa Zampino, L. E. Adinolfi, Utili, Riccardo, Zampino, Rosa, Bellopede, P, Marracino, M, Ragone, E, Adinolfi, Luigi Elio, Ruggiero, G, Capasso, M, Indolfi, P, Casale, Fiorina, Martini, A, and DI TULLIO, Mt

Subjects
Male, HBsAg, medicine.medical_specialty, Cirrhosis, Adolescent, Hepatitis C virus, Immunology, medicine.disease_cause, Antiviral Agents, Biochemistry, Gastroenterology, Neoplasms, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Prospective Studies, Seroconversion, Child, Hepatitis B virus, Hepatitis, business.industry, Infant, Interferon-alpha, virus diseases, Cell Biology, Hematology, Hepatitis B, medicine.disease, Hepatitis C, digestive system diseases, HBeAg, Child, Preschool, Female, business, Follow-Up Studies
Abstract

We conducted a long-term prospective study of 89 cancer survivor children who had acquired hepatitis B virus (HBV) and/or hepatitis C virus (HCV) during treatment for neoplasia, the aim being to evaluate the natural history of the diseases and the effect of interferon (IFN) treatment. Patients were followed up for a median period of 13 years (range, 8 to 20); 46 were infected by HBV, 11 by HCV, and 32 coinfected by HBV and HCV. A spontaneous clearance of hepatitis B surface antigen (HBsAg) occurred more frequently in coinfected patients (19%) than in the HBV-infected (2%; P = .004), with an annual seroconversion rate of 2.1% and 0.2%, respectively (P= .008). Loss of hepatitis Be antigen (HBeAg) occurred in 44% of coinfected and in 28% of HBV-infected patients. Clearance of serum HCV-RNA was observed in 34% and 9%, respectively, of coinfected and HCV-infected patients. Seventeen HBV-infected, 4 HCV-infected, and 16 coinfected patients received -IFN treatment. In the HBV group, 6 patients (35%) cleared serum HBV DNA and seroconverted to anti-HBe; in the HCV-group, none cleared HCV-RNA. In the coinfected group, 1 patient cleared both HBV DNA and HCV-RNA, 6 patients cleared serum HCV-RNA alone, and 1 only HBV DNA and HBeAg. Overall, the diseases showed a mild histological course with no evidence of liver cirrhosis. A reciprocal interference on viral replication between HBV and HCV may occur in coinfected patients. Treatment seems to be effective for selected cases and is justified in view of the uncertain prognosis of the disease in these patients.

Published
1999
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9. High-dose daptomycin for cardiac implantable electronic device-related infective endocarditis

Author

Emanuele Durante-Mangoni, Roberta Caprioli, Riccardo Utili, C. Caianiello, Irene Mattucci, Daniela Di Pinto, Rosina Albisinni, Mariano Bernardo, Enrico Ragone, R. Casillo, and Federica Agrusta

Subjects
Microbiology (medical), Adult, Male, medicine.medical_specialty, Pacemaker, Artificial, Prosthesis-Related Infections, Staphylococcus, medicine.disease_cause, Drug Administration Schedule, Daptomycin, Staphylococcus epidermidis, Drug Resistance, Bacterial, medicine, Endocarditis, Humans, Adverse effect, Aged, Aged, 80 and over, biology, Dose-Response Relationship, Drug, business.industry, Endocarditis, Bacterial, Middle Aged, Staphylococcal Infections, medicine.disease, biology.organism_classification, Surgery, Discontinuation, Anti-Bacterial Agents, Infectious Diseases, Treatment Outcome, Staphylococcus aureus, Infective endocarditis, Bacteremia, Female, business, medicine.drug
Abstract

Background Cardiac implantable electronic device (CIED)-related endocarditis is a growing challenge because of increasing incidence and significant mortality. Current treatment is based on complete hardware removal coupled with long-term administration of effective and safe antimicrobials. Daptomycin at the dose of 6 mg/kg/day has been found to be effective in staphylococcal endocarditis, but limited data exist on CIED endocarditis. Moreover, whether higher doses could be more effective but equally safe in this setting is currently unknown. Methods We report here our experience with high-dose daptomycin in the treatment of 25 cases of CIED endocarditis due to staphylococci. Results Patients were mostly elderly and male, with large lead vegetations and severe comorbidities. Pathogens were Staphylococcus epidermidis (56%), Staphylococcus aureus (28%), and other coagulase-negative staphylococci (16%). Only 4 patients (16%) had a normal pretreatment renal function. The median daptomycin daily dose was 8.3 mg/kg (range, 6.4-10.7). Daptomycin was administered for a median of 20 days (range, 8-52). Percutaneous lead extraction was performed in 88% of patients. Two patients (8%) failed to clear bacteremia. The overall clinical success of treatment was 80%, whereas a complete microbiological success was observed in 92% of patients. Creatine phosphokinase values were monitored and increased above normal in 5 cases (20%). No serious adverse event related to high-dose daptomycin was observed and no patient required discontinuation because of muscle toxicity. Conclusions Our experience suggests that high-dose daptomycin may be a safe therapeutic option in staphylococcal CIED endocarditis and may be associated with high microbiological responses and clinical success.

Published
2011

10. The effects of the level of ampicillin resistance and the inoculum size on the in-vitro bactericidal activity of the combination of ampicillin and ciprofloxacin against high-level gentamicin-resistant strains of Enterococcus faecium

Author

Marie Francoise Tripodi, A Rambaldi, R. Utili, G. Sarnataro, Enrico Ragone, Tripodi, Mf, Rambaldi, A, Sarnataro, G, Ragone, E, and Utili, Riccardo

Subjects
Microbiology (medical), Enterococcus faecium, Microbial Sensitivity Tests, Penicillins, Microbiology, Amp resistance, Anti-Infective Agents, Ciprofloxacin, Ampicillin, medicine, Humans, Pharmacology (medical), Pharmacology, biology, Drug Resistance, Microbial, biology.organism_classification, In vitro, Drug Resistance, Multiple, Drug Combinations, Infectious Diseases, Gentamicin, Gentamicins, Ampicillin Resistance, medicine.drug
Published
1999

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