11 results on '"Espinosa, María Dolores"'
Search Results
2. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals
- Author
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Martinello, Marianne, Matthews, Gail, Fernando, Fay Fabián, Esteban, Juan I., Müllhaupt, Beat, Wiesch, Julian Schulze zur, Buggisch, Peter, Neumann-Haefelin, Christoph, Berg, Thomas, Berg, Christoph P., Schattenberg, Jörn M., Moreno, Christophe, Stauber, Rudolf, Lloyd, Andrew, Dore, Gregory, Applegate, Tanya, Ignacio, Juan, Garcia-Cehic, Damir, Gregori, Josep, Rodriguez-Frias, Francisco, Rando, Ariadna, Gozlan, Yael, Angelico, Mario, Andreoni, Massimo, Babudieri, Sergio, Bertoli, Ada, Cento, Valeria, Coppola, Nicola, Craxì, Antonio, Paolucci, Stefania, Parruti, Giustino, Pasquazzi, Caterina, Perno, Carlo Federico, Teti, Elisabetta, Vironet, C., Lannergård, Anders, Duberg, Ann-Sofi, Aleman, Soo, Gutteberg, Tore, Soulier, Alexandre, Gourgeon, Aurélie, Chevaliez, Stephane, Pol, Stanislas, Carrat, Fabrice, Salmon, Dominique, Kaiser, Rolf, Knopes, Elena, Gomes, Perpetua, de Kneght, Rob, Rijnders, Bart, Poljak, Mario, Lunar, Maja, Usubillaga, Rafael, Seguin_Devaux, Carole, Tay, Enoch, Wilson, Caroline, Wang, Dao Sen, George, Jacob, Kok, Jen, Pérez, Ana Belén, Chueca, Natalia, García-Deltoro, Miguel, Martínez-Sapiña, Ana María, Lara-Pérez, María Magdalena, García-Bujalance, Silvia, Aldámiz-Echevarría, Teresa, Vera-Méndez, Francisco Jesús, Pineda, Juan Antonio, Casado, Marta, Pascasio, Juan Manuel, Salmerón, Javier, Alados-Arboledas, Juan Carlos, Poyato, Antonio, Téllez, Francisco, Rivero-Juárez, Antonio, Merino, Dolores, Vivancos-Gallego, María Jesús, Rosales-Zábal, José Miguel, Ocete, María Dolores, Simón, Miguel Ángel, Rincón, Pilar, Reus, Sergi, De la Iglesia, Alberto, García-Arata, Isabel, Jiménez, Miguel, Jiménez, Fernando, Hernández-Quero, José, Galera, Carlos, Balghata, Mohamed Omar, Primo, Joaquín, Masiá, Mar, Espinosa, Nuria, Delgado, Marcial, von-Wichmann, Miguel Ángel, Collado, Antonio, Santos, Jesús, Mínguez, Carlos, Díaz-Flores, Felícitas, Fernández, Elisa, Bernal, Enrique, De Juan, José, Antón, José Joaquín, Vélez, Mónica, Aguilera, Antonio, Navarro, Daniel, Arenas, Juan Ignacio, Fernández, Clotilde, Espinosa, María Dolores, Ríos, María José, Alonso, Roberto, Hidalgo, Carmen, Hernández, Rosario, Téllez, María Jesús, Rodríguez, Francisco Javier, Antequera, Pedro, Delgado, Cristina, Martín, Patricia, Crespo, Javier, Becerril, Berta, Pérez, Oscar, García-Herola, Antonio, Montero, José, Freyre, Carolina, Grau, Concepción, Cabezas, Joaquin, Jimenez, Miguel, Rodriguez, Manuel Alberto Macias, Quilez, Cristina, Pardo, Maria Rodriguez, Muñoz-Medina, Leopoldo, Figueruela, Blanca, Howe, Anita Y.M., Rodrigo, Chaturaka, Cunningham, Evan B., Douglas, Mark W., Dietz, Julia, Grebely, Jason, Popping, Stephanie, Sfalcin, Javier Alejandro, Parczewski, Milosz, Sarrazin, Christoph, de Salazar, Adolfo, Fuentes, Ana, Sayan, Murat, Quer, Josep, Kjellin, Midori, Kileng, Hege, Mor, Orna, Lennerstrand, Johan, Fourati, Slim, Di Maio, Velia Chiara, Chulanov, Vladimir, Pawlotsky, Jean-Michel, Harrigan, P. Richard, Ceccherini-Silberstein, Francesca, and Garcia, Federico
- Published
- 2022
- Full Text
- View/download PDF
3. Measures of Motor and Functional Skills for Children With Cerebral Palsy: A Systematic Review
- Author
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Ferre-Fernández, Marina, Murcia-González, María Antonia, Barnuevo Espinosa, María Dolores, and Ríos-Díaz, José
- Published
- 2020
- Full Text
- View/download PDF
4. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals
- Author
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Howe, Anita Y.M., primary, Rodrigo, Chaturaka, additional, Cunningham, Evan B., additional, Douglas, Mark W., additional, Dietz, Julia, additional, Grebely, Jason, additional, Popping, Stephanie, additional, Sfalcin, Javier Alejandro, additional, Parczewski, Milosz, additional, Sarrazin, Christoph, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Sayan, Murat, additional, Quer, Josep, additional, Kjellin, Midori, additional, Kileng, Hege, additional, Mor, Orna, additional, Lennerstrand, Johan, additional, Fourati, Slim, additional, Di Maio, Velia Chiara, additional, Chulanov, Vladimir, additional, Pawlotsky, Jean-Michel, additional, Harrigan, P. Richard, additional, Ceccherini-Silberstein, Francesca, additional, Garcia, Federico, additional, Martinello, Marianne, additional, Matthews, Gail, additional, Fernando, Fay Fabián, additional, Esteban, Juan I., additional, Müllhaupt, Beat, additional, Wiesch, Julian Schulze zur, additional, Buggisch, Peter, additional, Neumann-Haefelin, Christoph, additional, Berg, Thomas, additional, Berg, Christoph P., additional, Schattenberg, Jörn M., additional, Moreno, Christophe, additional, Stauber, Rudolf, additional, Lloyd, Andrew, additional, Dore, Gregory, additional, Applegate, Tanya, additional, Ignacio, Juan, additional, Garcia-Cehic, Damir, additional, Gregori, Josep, additional, Rodriguez-Frias, Francisco, additional, Rando, Ariadna, additional, Gozlan, Yael, additional, Angelico, Mario, additional, Andreoni, Massimo, additional, Babudieri, Sergio, additional, Bertoli, Ada, additional, Cento, Valeria, additional, Coppola, Nicola, additional, Craxì, Antonio, additional, Paolucci, Stefania, additional, Parruti, Giustino, additional, Pasquazzi, Caterina, additional, Perno, Carlo Federico, additional, Teti, Elisabetta, additional, Vironet, C., additional, Lannergård, Anders, additional, Duberg, Ann-Sofi, additional, Aleman, Soo, additional, Gutteberg, Tore, additional, Soulier, Alexandre, additional, Gourgeon, Aurélie, additional, Chevaliez, Stephane, additional, Pol, Stanislas, additional, Carrat, Fabrice, additional, Salmon, Dominique, additional, Kaiser, Rolf, additional, Knopes, Elena, additional, Gomes, Perpetua, additional, de Kneght, Rob, additional, Rijnders, Bart, additional, Poljak, Mario, additional, Lunar, Maja, additional, Usubillaga, Rafael, additional, Seguin_Devaux, Carole, additional, Tay, Enoch, additional, Wilson, Caroline, additional, Wang, Dao Sen, additional, George, Jacob, additional, Kok, Jen, additional, Pérez, Ana Belén, additional, Chueca, Natalia, additional, García-Deltoro, Miguel, additional, Martínez-Sapiña, Ana María, additional, Lara-Pérez, María Magdalena, additional, García-Bujalance, Silvia, additional, Aldámiz-Echevarría, Teresa, additional, Vera-Méndez, Francisco Jesús, additional, Pineda, Juan Antonio, additional, Casado, Marta, additional, Pascasio, Juan Manuel, additional, Salmerón, Javier, additional, Alados-Arboledas, Juan Carlos, additional, Poyato, Antonio, additional, Téllez, Francisco, additional, Rivero-Juárez, Antonio, additional, Merino, Dolores, additional, Vivancos-Gallego, María Jesús, additional, Rosales-Zábal, José Miguel, additional, Ocete, María Dolores, additional, Simón, Miguel Ángel, additional, Rincón, Pilar, additional, Reus, Sergi, additional, De la Iglesia, Alberto, additional, García-Arata, Isabel, additional, Jiménez, Miguel, additional, Jiménez, Fernando, additional, Hernández-Quero, José, additional, Galera, Carlos, additional, Balghata, Mohamed Omar, additional, Primo, Joaquín, additional, Masiá, Mar, additional, Espinosa, Nuria, additional, Delgado, Marcial, additional, von-Wichmann, Miguel Ángel, additional, Collado, Antonio, additional, Santos, Jesús, additional, Mínguez, Carlos, additional, Díaz-Flores, Felícitas, additional, Fernández, Elisa, additional, Bernal, Enrique, additional, De Juan, José, additional, Antón, José Joaquín, additional, Vélez, Mónica, additional, Aguilera, Antonio, additional, Navarro, Daniel, additional, Arenas, Juan Ignacio, additional, Fernández, Clotilde, additional, Espinosa, María Dolores, additional, Ríos, María José, additional, Alonso, Roberto, additional, Hidalgo, Carmen, additional, Hernández, Rosario, additional, Téllez, María Jesús, additional, Rodríguez, Francisco Javier, additional, Antequera, Pedro, additional, Delgado, Cristina, additional, Martín, Patricia, additional, Crespo, Javier, additional, Becerril, Berta, additional, Pérez, Oscar, additional, García-Herola, Antonio, additional, Montero, José, additional, Freyre, Carolina, additional, Grau, Concepción, additional, Cabezas, Joaquin, additional, Jimenez, Miguel, additional, Rodriguez, Manuel Alberto Macias, additional, Quilez, Cristina, additional, Pardo, Maria Rodriguez, additional, Muñoz-Medina, Leopoldo, additional, and Figueruela, Blanca, additional
- Published
- 2022
- Full Text
- View/download PDF
5. Prevalence of resistance associated substitutions and efficacy of baseline resistance-guided chronic hepatitis C treatment in Spain from the GEHEP-004 cohort
- Author
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Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Fundación Progreso y Salud, Pérez, Ana Belén, Chueca, Natalia, Macías Sánchez, Juan, Pineda, Juan A., Salmerón, Javier, Rivero-Juárez, Antonio, Hidalgo-Tenorio, Carmen, Espinosa, María Dolores, Téllez, Francisco, von Wichman, Miguel A., Omar, Mohamed, Santos, Jesús, Hernández Quero, José, Antón, José Joaquín, Collado, Antonio, Lozano Serrano, A. B., García-Deltoro, Miguel, Casado, Marta, Pascasio, Juan Manuel, Selfa, Aída, Rosales-Zábal, José Miguel, Iglesia, Alberto de la, Arenas, Juan Ignacio, García-Bujalance, Silvia, Ríos-Villegas, María José, Bernal-Morell, Enrique, Martínez-Madrid, Onofre, García-Herola, Antonio, Vélez, Mónica, Rincón, Pilar, García, Federico, Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Fundación Progreso y Salud, Pérez, Ana Belén, Chueca, Natalia, Macías Sánchez, Juan, Pineda, Juan A., Salmerón, Javier, Rivero-Juárez, Antonio, Hidalgo-Tenorio, Carmen, Espinosa, María Dolores, Téllez, Francisco, von Wichman, Miguel A., Omar, Mohamed, Santos, Jesús, Hernández Quero, José, Antón, José Joaquín, Collado, Antonio, Lozano Serrano, A. B., García-Deltoro, Miguel, Casado, Marta, Pascasio, Juan Manuel, Selfa, Aída, Rosales-Zábal, José Miguel, Iglesia, Alberto de la, Arenas, Juan Ignacio, García-Bujalance, Silvia, Ríos-Villegas, María José, Bernal-Morell, Enrique, Martínez-Madrid, Onofre, García-Herola, Antonio, Vélez, Mónica, Rincón, Pilar, and García, Federico
- Abstract
Treatment guidelines differ in their recommendation to determine baseline resistance associated substitutions (RAS) before starting a first-line treatment with direct-acting antivirals (DAAs). Here we analyze the efficacy of DAA treatment with baseline RAS information. We conducted a prospective study involving 23 centers collaborating in the GEHEP-004 DAA resistance cohort. Baseline NS5A and NS3 RASs were studied by Sanger sequencing. After issuing a comprehensive resistance report, the treating physician decided the therapy, duration and ribavirin use. Sustained virological response (SVR12) data are available in 275 patients. Baseline NS5A RAS prevalence was between 4.3% and 26.8% according to genotype, and NS3 RASs prevalence (GT1a) was 6.3%. Overall, SVR12 was 97.8%. Amongst HCV-GT1a patients, 75.0% had >800,000 IU/ml and most of those that started grazoprevir/elbasvir were treated for 12 weeks. In genotype 3, NS5A Y93H was detected in 9 patients. 42.8% of the HCV-GT3 patients that started sofosbuvir/velpatasvir included ribavirin, although only 14.7% carried Y93H. The efficacy of baseline resistance-guided treatment in our cohort has been high across the most prevalent HCV genotypes in Spain. The duration of the grazoprevir/elbasvir treatment adhered mostly to AASLD/IDSA recommendations. In cirrhotic patients infected with GT-3 there has been a high use of ribavirin.
- Published
- 2019
6. Prevalence of resistance associated substitutions and efficacy of baseline resistance-guided chronic hepatitis C treatment in Spain from the GEHEP-004 cohort
- Author
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Pérez, Ana Belén, primary, Chueca, Natalia, additional, Macías, Juan, additional, Pineda, Juan Antonio, additional, Salmerón, Javier, additional, Rivero-Juárez, Antonio, additional, Hidalgo-Tenorio, Carmen, additional, Espinosa, María Dolores, additional, Téllez, Francisco, additional, Von-Wichmann, Miguel Ángel, additional, Omar, Mohamed, additional, Santos, Jesús, additional, Hernández-Quero, José, additional, Antón, José Joaquin, additional, Collado, Antonio, additional, Lozano, Ana Belén, additional, García-Deltoro, Miguel, additional, Casado, Marta, additional, Pascasio, Juan Manuel, additional, Selfa, Aida, additional, Rosales, José Miguel, additional, De la Iglesia, Alberto, additional, Arenas, Juan Ignacio, additional, García-Bujalance, Silvia, additional, Ríos, María José, additional, Bernal, Enrique, additional, Martínez, Onofre, additional, García-Herola, Antonio, additional, Vélez, Mónica, additional, Rincón, Pilar, additional, and García, Federico, additional
- Published
- 2019
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7. Efecto del consumo de quinua (Chenopodium quinoa) como coadyuvante en la intervención nutricional en sujetos prediabéticos
- Author
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Abellán Ruiz, María Salud, Barnuevo Espinosa, María Dolores, García Santamaría, Carlos, Contreras Fernández, Carlos J., Aldeguer García, Miriam, Soto Méndez, Fulgencio, Guillén Guillén, Isabel, Luque Rubia, Antonio J., Quinde Ràzuri, Francisco Javier, Martínez Garrido, Antonio, and López Román, Francisco Javier
- Subjects
Plenitud ,Diabetes mellitus tipo 2 ,Hemoglobina glicada ,Glycated hemoglobin ,Complete ,Type 2 diabetes mellitus ,Saciedad ,Chenopodium quinoa ,Índice de masa corporal ,Satiation ,Prediabetes ,Body mass index - Abstract
Introducción: la quinua es un pseudocereal que contiene hidratos de carbono de bajo índice glucémico, fibra alimentaria, proteínas de alto valor biológico, fitoesteroles y ácidos grasos n-3 y n-6, y que ha suscitado interés en la intervención nutricional de la prediabetes. Este estudio aleatorizado (2:1), controlado con placebo y doble ciego, evaluó los efectos de la quinua sobre el índice de masa corporal (IMC), hemoglobina glicada (HbA1c), glucemia basal (GB) y el grado de saciedad y plenitud en pacientes prediabéticos. Material y método: se aleatorizaron (2:1) 30 pacientes en dos ramas a estudio: el producto Kuska Active (quinua procesada) y placebo (maltodextrina). El periodo de ingesta fue de 28 días. Antes de iniciar el tratamiento y a los 28 días se determinó el IMC, HbA1c y la GB. La sensación de saciedad y plenitud se evaluó mediante escala visual analógica (EVA). Para demostrar la eficacia de la quinua procesada Kuska Active sobre las variables a estudio se realizó ANOVA para medidas repetidas con dos factores a estudio (factor intrasujeto: tiempo y factor intersujeto: producto consumido). Resultados: finalizaron el estudio un total de 29 pacientes (placebo, n = 10; quinua, n = 19). Se detectó en el grupo quinua procesada una disminución significativa en los valores de IMC (p < 0,05) y HbA1c (p < 0,001) y un aumento en la sensación de saciedad y plenitud (p < 0,001). No se encontraron diferencias significativas en los niveles de GB desde el momento basal hasta el periodo postingesta. Conclusiones: los resultados muestran que la quinua procesada disminuye el IMC y los niveles de HbA1c, mantiene los niveles de GB y aumenta la sensación de saciedad y plenitud en pacientes prediabéticos. Introduction: Quinoa is a pseudocereal containing low glycemic index carbohydrates, dietary fiber, high biological value protein, phytosterols, and n-3 and n-6 fatty acids, which has generated interest in prediabetes nutritional interventions. This randomized (2:1), placebo-controlled, double-blind study evaluated the effects of processed quinoa on body mass index (BMI), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and the satiation and fullness (complete) degree in prediabetic patients. Material and method: Thirty patients were randomized (2:1) in two study arms: Kuska Active product (processed quinoa) and placebo (maltodextrin), with an intake period of 28 days. BMI, HbA1c and FPG were determined before starting treatment and at 28-day intake. Satiety and fullness sensation were just assessed by visual analog scale (VAS) at the day 28. ANOVA was performed for repeated measures with two factors to study (within-subject factor: time; intersubject factor: product consumed) to demonstrate the effectiveness of processed quinoa on the study variables. Results: Twenty-nine patients (placebo, n = 10; quinoa, n = 19) completed the study, and the quinoa group shows a significant decrease in BMI (p < 0.05) and HbA1c values (p < 0.001), and an increase in the satiation and fullness (complete) degree (p < 0.001). No significant differences were found in FPG levels from baseline to post-intake period. Conclusions: The results show that processed quinoa intake during 28 days decreases BMI and HbA1c levels, maintains FPG levels, and increases the satiation and fullness (complete) degree in prediabetic patients.
- Published
- 2017
8. Efecto del consumo de quinua (Chenopodium quinoa) como coadyuvante en la intervención nutricional en sujetos prediabéticos.
- Author
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López Román, Francisco Javier, primary, Abellán Ruiz, María Salud, additional, Barnuevo Espinosa, María Dolores, additional, García Santamaría, Carlos, additional, Contreras Fernández, Carlos Javier, additional, Aldeguer García, Miriam, additional, Soto Méndez, Fulgencio, additional, Guillén Guillén, Isabel, additional, Luque Rubia, Antonio Jesús, additional, Quinde Ràzuri, Francisco Javier, additional, and Martínez Garrido, Antonio, additional
- Published
- 2017
- Full Text
- View/download PDF
9. Manual de comunicación corporativa que permita difundir y sistematizar las actividades de balance social en el público interno de Diners Club del Ecuador
- Author
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Gandarillas Espinosa, María Dolores and Soto Sandoval, Miguel Ángel
- Subjects
DINERS CLUB DEL ECUADOR ,COMUNICACIÓN SOCIAL ,IMAGEN CORPORATIVA ,COMUNICACIÓN ORGANIZACIONAL - Abstract
The present manual offers a response to the empresarial necessities that reffers about an internal comunication that is because it presents practical guidelines to carry out an organizational diagnosis; and also the effective and efficient use of the comunication tools for the internal public. Many theories of global and corporative comunication have been exposed by experts with the objective of interpret the different arguments to construct a practice tool that could offer effective comunicative solutions for “Diners Club Ecuador” In this case, the social responsable corporative activities that “Diners Club Ecuador” realises have been analyzed; and also the various means of communication currently used, for in this way seek the appropriate mechanisms to disseminate and systematize such initiatives to involve their partners with the community, in an honest way. What will be achieved with the development and implementation of this manual of internal communication is to give back to the community and the environment in a certain way what the company offers; and also improve the humanitarian development and ecological sense among all members of Diners Club, forging better workers and better citizens that are committed with the integral development of the society and thus obtaining a recognition and improvement of the institutional image. El presente manual ofrece una respuesta a las necesidades empresariales en cuanto se refiere a su comunicación interna, ya que presenta lineamientos prácticos para llevar a cabo un diagnóstico organizacional, así como también el uso eficaz y eficiente de las herramientas de comunicación para el público interno. Se han expuesto varias teorías sobre comunicación global y comunicación corporativa de varios expertos con la finalidad de interpretar sus diferentes argumentos para construir una herramienta práctica que ofrezcan soluciones comunicacionales efectivas para Diners Club del Ecuador. En el siguiente caso se han analizado las actividades de responsabilidad social corporativa realizadas por la empresa Diners Club del Ecuador, como también los diversos medios de comunicación utilizados actualmente para de esta manera buscar los mecanismos idóneos para difundir y sistematizar dichas iniciativas para hacer partícipes a sus colaboradores creando así vínculos francos con la comunidad. Lo que se pretende conseguir con el desarrollo e implementación de este manual de comunicación interna es devolver a la comunidad y el entorno de cierta forma lo que ofrece a la empresa y fomentar el sentido humanitario y ecológico entre todos los miembros de Diners Club, forjando así mejores trabajadores y mejores ciudadanos comprometidos con el desarrollo integral de las sociedad obteniendo así un reconocimiento y mejoramiento de la imagen institucional.
- Published
- 2015
10. Comparación en términos de no inferioridad de la eficacia de latanoprost sin conservantes vs xalatan ® en el tratamiento del glaucoma ángulo abierto
- Author
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Barnuevo Espinosa, María Dolores, López Román, Francisco Javier, Zafrilla Rentero, Pilar, and Lajara Blesa, Jerónimo
- Subjects
Absorción de los Fármacos ,Evaluación de Fármacos ,Oftalmología - Abstract
El glaucoma, ha sido definido por la Academia Americana de Oftalmología, como una neuropatía óptica multifactorial, en la que existe una pérdida adquirida y progresiva de las células ganglionares de la retina. La desaparición de las fibras nerviosas de la retina provoca un daño, característico, en la cabeza del nervio óptico, lo que origina pérdida del campo visual. El glaucoma es considerado como la segunda causa de ceguera evitable en todo el mundo. El único factor de riesgo cuya modificación ha resultado eficaz es la disminución de la presión intraocular. Objetivo: Demostrar la no inferioridad de Latanoprost sin conservantes frente a Xalatan® en el mantenimiento de la presión intraocular dentro de cifras fisiiologocas. Material y método: Ensayo clínico de no inferioridad, aleatorizado, simple ciego, con dos brazo paralelos, y con un tamaño muestral de 67 sujetos por brazo a estudio, los cuales se someterán la tratamiento asignado durante 28 días consecutivos.Resultados y conclusiones: tras análisis de las presiones intraoculares observadas durante el periodo ha estudio se puede afirmar que, Latanoprost sin conservantes no es inferior, en términos de efectividad, al medicamento Xalatan®. Farmacia
- Published
- 2014
11. Efecto del consumo de quinua (Chenopodium quinoa)como coadyuvante en la intervención nutricional en sujetos prediabéticos.
- Author
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Abellán Ruiz, María Salud, Barnuevo Espinosa, María Dolores, García Santamaría, Carlos, Contreras Fernández, Carlos J., Aldeguer García, Miriam, Soto Méndez, Fulgencio, Guillén Guillén, Isabel, Luque Rubia, Antonio J., Quinde Ràzuri, Francisco Javier, Martínez Garrido, Antonio, López Román, Francisco Javier, Contreras Fernández, Carlos Javier, and Luque Rubia, Antonio Jesús
- Abstract
Introduction: Quinoa is a pseudocereal containing low glycemic index carbohydrates, dietary fiber, high biological value protein, phytosterols, and n-3 and n-6 fatty acids, which has generated interest in prediabetes nutritional interventions. This randomized (2:1), placebo-controlled, double-blind study evaluated the effects of processed quinoa on body mass index (BMI), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and the satiation and fullness (complete) degree in prediabetic patients.Material and Method: Thirty patients were randomized (2:1) in two study arms: Kuska Active product (processed quinoa) and placebo (maltodextrin), with an intake period of 28 days. BMI, HbA1c and FPG were determined before starting treatment and at 28-day intake. Satiety and fullness sensation were just assessed by visual analog scale (VAS) at the day 28. ANOVA was performed for repeated measures with two factors to study (within-subject factor: time; intersubject factor: product consumed) to demonstrate the effectiveness of processed quinoa on the study variables.Results: Twenty-nine patients (placebo, n = 10; quinoa, n = 19) completed the study, and the quinoa group shows a significant decrease in BMI (p < 0.05) and HbA1c values (p < 0.001), and an increase in the satiation and fullness (complete) degree (p < 0.001). No significant differences were found in FPG levels from baseline to post-intake period.Conclusions: The results show that processed quinoa intake during 28 days decreases BMI and HbA1c levels, maintains FPG levels, and incr eases the satiation and fullness (complete) degree in prediabetic patients. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
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