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23 results on '"Föh, Bandik"'

1. Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis

Author

Fererberger, Tanja, primary, Buechler, Christa, additional, Kandulski, Arne, additional, Elger, Tanja, additional, Loibl, Johanna, additional, Schmid, Stephan, additional, Sommersberger, Stefanie, additional, Gunawan, Stefan, additional, Zundler, Sebastian, additional, Huss, Muriel, additional, Bettenworth, Dominik, additional, Kempa, Sally, additional, Weidlich, Simon, additional, Föh, Bandik, additional, Huang, Xinyu, additional, Grzegorzek, Marcin, additional, Derer-Petersen, Stefanie, additional, Günther, Ulrich L., additional, Marquardt, Jens U., additional, Kunst, Claudia, additional, Gülow, Karsten, additional, Müller, Martina, additional, Sina, Christian, additional, Schmelter, Franziska, additional, and Tews, Hauke C., additional

Published
2024
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3. Protocol of the Luebeck longitudinal investigation of SARS-CoV-2 infection (ELISA) study – a prospective population-based cohort study

Author

Balck, Alexander, Föh, Bandik, Borsche, Max, Rahmöller, Johann, Vollstedt, Eva-Juliane, Waldeck, Frederike, Käding, Nadja, Twesten, Christoph, Mischnik, Alexander, Gillessen-Kaesbach, Gabriele, Ehlers, Marc, Sina, Christian, Taube, Stefan, Busch, Hauke, Rupp, Jan, Katalinic, Alexander, and Klein, Christine

Published
2022
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5. Serum Metabolomic Profiling of Patients with Lipedema

Author

Kempa, Sally, primary, Buechler, Christa, additional, Föh, Bandik, additional, Felthaus, Oliver, additional, Prantl, Lukas, additional, Günther, Ulrich L., additional, Müller, Martina, additional, Derer-Petersen, Stefanie, additional, Sina, Christian, additional, Schmelter, Franziska, additional, and Tews, Hauke C., additional

Published
2023
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8. Experimental diets dictate the metabolic benefits of probiotics in obesity

Author

Larsen, Ida Søgaard, primary, Choi, Béatrice S.-Y., additional, Föh, Bandik, additional, Kristensen, Nanna Ny, additional, Ouellette, Adia, additional, Haller, Rune Falkenberg, additional, Olsen, Peter Bjarke, additional, Saulnier, Delphine, additional, Sina, Christian, additional, Jensen, Benjamin A. H., additional, and Marette, André, additional

Published
2023
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9. mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine

Author

Buhre, Jana Sophia, primary, Pongracz, Tamas, additional, Künsting, Inga, additional, Lixenfeld, Anne S., additional, Wang, Wenjun, additional, Nouta, Jan, additional, Lehrian, Selina, additional, Schmelter, Franziska, additional, Lunding, Hanna B., additional, Dühring, Lara, additional, Kern, Carsten, additional, Petry, Janina, additional, Martin, Emily L., additional, Föh, Bandik, additional, Steinhaus, Moritz, additional, von Kopylow, Vera, additional, Sina, Christian, additional, Graf, Tobias, additional, Rahmöller, Johann, additional, Wuhrer, Manfred, additional, and Ehlers, Marc, additional

Published
2023
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11. One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: A model for population-based monitoring of infection risk

Author

Klein, Christine, primary, Borsche, Max, additional, Balck, Alexander, additional, Föh, Bandik, additional, Rahmöller, Johann, additional, Peters, Elke, additional, Knickmann, Jan, additional, Lane, Miranda, additional, Vollstedt, Eva-Juliane, additional, Elsner, Susanne A., additional, Käding, Nadja, additional, Hauswaldt, Susanne, additional, Lange, Tanja, additional, Hundt, Jennifer E., additional, Lehrian, Selina, additional, Giese, Julia, additional, Mischnik, Alexander, additional, Niemann, Stefan, additional, Maurer, Florian, additional, Homolka, Susanne, additional, Paulowski, Laura, additional, Kramer, Jan, additional, Twesten, Christoph, additional, Sina, Christian, additional, Gillessen-Kaesbach, Gabriele, additional, Busch, Hauke, additional, Ehlers, Marc, additional, Taube, Stefan, additional, Rupp, Jan, additional, and Katalinic, Alexander, additional

Published
2022
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12. Additional file 1 of Protocol of the Luebeck longitudinal investigation of SARS-CoV-2 infection (ELISA) study – a prospective population-based cohort study

Author

Balck, Alexander, Föh, Bandik, Borsche, Max, Rahmöller, Johann, Vollstedt, Eva-Juliane, Waldeck, Frederike, Käding, Nadja, Twesten, Christoph, Mischnik, Alexander, Gillessen-Kaesbach, Gabriele, Ehlers, Marc, Sina, Christian, Taube, Stefan, Busch, Hauke, Rupp, Jan, Katalinic, Alexander, and Klein, Christine

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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13. mRNA vaccines against SARSCoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine.

Author

Buhre, Jana Sophia, Pongracz, Tamas, Künsting, Inga, Lixenfeld, Anne S., Wenjun Wang, Nouta, Jan, Lehrian, Selina, Schmelter, Franziska, Lunding, Hanna B., Dühring, Lara, Kern, Carsten, Petry, Janina, Martin, Emily L., Föh, Bandik, Steinhaus, Moritz, von Kopylow, Vera, Sina, Christian, Graf, Tobias, Rahmöller, Johann, and Wuhrer, Manfred

Subjects
IMMUNOGLOBULIN G, COMBINED vaccines, VACCINES, PLASMA cells, MESSENGER RNA
Abstract

Background: The new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS-CoV-2 and code for its spike (S) protein. Several studies have investigated short-term antibody (Ab) responses after vaccination. Objective: However, the impact of these new vaccine formats with unclear effects on the long-term Ab response - including isotype, subclass, and their type of Fc glycosylation - is less explored. Methods: Here, we analyzed anti-S Ab responses in blood serum and the saliva of SARS-CoV-2 naïve and non-hospitalized pre-infected subjects upon two vaccinations with different mRNA- and adenovirus-based vaccine combinations up to day 270. Results: We show that the initially high mRNA vaccine-induced blood and salivary anti-S IgG levels, particularly IgG1, markedly decrease over time and approach the lower levels induced with the adenovirus-based vaccine. All three vaccines induced, contrary to the short-term anti-S IgG1 response with high sialylation and galactosylation levels, a long-term anti-S IgG1 response that was characterized by low sialylation and galactosylation with the latter being even below the corresponding total IgG1 galactosylation level. Instead, the mRNA, but not the adenovirus-based vaccines induced long-term IgG4 responses - the IgG subclass with inhibitory effector functions. Furthermore, salivary anti-S IgA levels were lower and decreased faster in naïve as compared to preinfected vaccinees. Predictively, age correlated with lower long-term anti-S IgG titers for the mRNA vaccines. Furthermore, higher total IgG1 galactosylation, sialylation, and bisection levels correlated with higher longterm anti-S IgG1 sialylation, galactosylation, and bisection levels, respectively, for all vaccine combinations. Conclusion: In summary, the study suggests a comparable "adjuvant" potential of the newly developed vaccines on the anti-S IgG Fc glycosylation, as reflected in relatively low long-term anti-S IgG1 galactosylation levels generated by the long-lived plasma cell pool, whose induction might be driven by a recently described TH1-driven B cell response for all three vaccines. Instead, repeated immunization of naïve individuals with the mRNA vaccines increased the proportion of the IgG4 subclass over time which might influence the longterm Ab effector functions. Taken together, these data shed light on these novel vaccine formats and might have potential implications for their longterm efficacy. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Metabolic and Lipidomic Markers Differentiate COVID-19 From Non-Hospitalized and Other Intensive Care Patients

Author

Schmelter, Franziska, primary, Föh, Bandik, additional, Mallagaray, Alvaro, additional, Rahmöller, Johann, additional, Ehlers, Marc, additional, Lehrian, Selina, additional, von Kopylow, Vera, additional, Künsting, Inga, additional, Lixenfeld, Anne Sophie, additional, Martin, Emily, additional, Ragab, Mohab, additional, Meyer-Saraei, Roza, additional, Kreutzmann, Fabian, additional, Eitel, Ingo, additional, Taube, Stefan, additional, Käding, Nadja, additional, Jantzen, Eckard, additional, Graf, Tobias, additional, Sina, Christian, additional, and Günther, Ulrich L., additional

Published
2021
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16. Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy

Author

Skibbe, Kerstin, primary, Brethack, Ann-Kathrin, additional, Sünderhauf, Annika, additional, Ragab, Mohab, additional, Raschdorf, Annika, additional, Hicken, Maren, additional, Schlichting, Heidi, additional, Preira, Joyce, additional, Brandt, Jennifer, additional, Castven, Darko, additional, Föh, Bandik, additional, Pagel, René, additional, Marquardt, Jens U., additional, Sina, Christian, additional, and Derer, Stefanie, additional

Published
2021
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19. Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells.

Author

Föh, Bandik, Buhre, Jana Sophia, Lunding, Hanna B., Moreno-Fernandez, Maria E., König, Peter, Sina, Christian, Divanovic, Senad, and Ehlers, Marc

Subjects
*PLASMA cells, *REGULATORY B cells, *B cell differentiation, *BUTYRATES, *SHORT-chain fatty acids, *B cells, *IMMUNOGLOBULIN M
Abstract

The microbially-derived short-chain fatty acid butyrate is a central inhibitor of inflammatory innate and adaptive immune responses. Emerging evidence suggests that butyrate induces differentiation of IL-10-producing (IL-10+) regulatory B cells. However, the underlying mechanisms of butyrate-driven modulation of B cell differentiation are not fully defined. Given the dominant role of regulatory plasma cells (PCs) as the main source of anti-inflammatory cytokines including IL-10 and the observation that butyrate also induces the differentiation of PCs, we here investigated the effect of the microbial metabolite butyrate on the induction of regulatory IL-10+ PCs and underlying mechanisms. Here we show that butyrate induces the differentiation of IL-10+IgM+ PCs. Ex vivo, butyrate, but hardly propionate, another microbially-derived short-chain fatty acid, induced the differentiation of IL-10+IgM+ CD138high PCs from isolated splenic murine B cells. In vivo, administration of butyrate via drinking water or by daily intraperitoneal injection increased the number of IL-10+IgM+ CD138high PCs in the spleens of Ovalbumin (Ova)/complete Freund's adjuvant-immunized mice. The induction of these regulatory PCs was associated with an increase of anti-Ova IgM, but a reduction of anti-Ova class-switched pathogenic IgG2b serum antibodies. Based on the knowledge that butyrate inhibits histone deacetylases (HDACs) thereby increasing histone acetylation, we identified here that HDAC3 inhibition was sufficient to induce PC differentiation and IL-10+ expression. Furthermore, reduced mitochondrial superoxide levels following butyrate treatment and HDAC3 inhibition were necessary for PC differentiation, but not IL-10 expression. In summary, the microbial metabolite butyrate promotes the differentiation of IgM+ PCs and their expression of IL-10. HDAC3 inhibition may be involved as an underlying pathway for both PC differentiation and IL-10 expression, while reduced mitochondrial superoxide levels are crucial only for PC differentiation. The induction of regulatory IL-10+IgM+ PCs and the inhibition of class switching to antigen-specific pathogenic IgG subclasses might represent important pathways of butyrate to limit inflammation. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Carboxypeptidase E Modulates Intestinal Immune Homeostasis and Protects against Experimental Colitis in Mice

Author

Bär, Florian, primary, Föh, Bandik, additional, Pagel, René, additional, Schröder, Torsten, additional, Schlichting, Heidi, additional, Hirose, Misa, additional, Lemcke, Susanne, additional, Klinger, Antje, additional, König, Peter, additional, Karsten, Christian M., additional, Büning, Jürgen, additional, Lehnert, Hendrik, additional, Fellermann, Klaus, additional, Ibrahim, Saleh M., additional, and Sina, Christian, additional

Published
2014
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22. Transition to endemic: 2-year SARS-CoV-2 surveillance follow-up of the ELISA cohort.

Author

Föh B, Schnoor M, Balck A, Waldeck F, Käding N, Borsche M, Rupp J, Katalinic A, and Klein C

Abstract

The 2-year SARS-CoV-2 surveillance follow-up of the ELISA cohort shows the successful transition from COVID-19 pandemic to endemic, confirms occupational risk factors in healthcare and identifies household risk factors in a high-incidence period https://bit.ly/43x8q6i., Competing Interests: Conflict of interest: None declared., (Copyright ©The authors 2023.)

Published
2023
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23. Complications of nasal and pharyngeal swabs: a relevant challenge of the COVID-19 pandemic?

Author

Föh B, Borsche M, Balck A, Taube S, Rupp J, Klein C, and Katalinic A

Subjects
Humans, COVID-19, Nasopharynx virology, Pandemics, Specimen Handling adverse effects
Abstract

Competing Interests: Conflict of interest: B. Föh has nothing to disclose. Conflict of interest: M. Borsche has nothing to disclose. Conflict of interest: A. Balck has nothing to disclose. Conflict of interest: S. Taube has nothing to disclose. Conflict of interest: J. Rupp has nothing to disclose. Conflict of interest: C. Klein reports personal fees from Centogene GmbH, outside the submitted work. Conflict of interest: A. Katalinic reports grants from State of Schleswig-Holstein, Germany and the Federal Ministry of Education and Research, Germany, during the conduct of the study.

Published
2021
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