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1. A novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle

Author

Wang, Yulong, primary, Fan, Linjin, additional, Ye, Pengfei, additional, Wang, Zequn, additional, Liang, Chudan, additional, Liu, Quan, additional, Yang, Xiaofeng, additional, Long, Zhenyu, additional, Shi, Wendi, additional, Zhou, Yuandong, additional, Lin, Jingyan, additional, Yan, Huijun, additional, Huang, Hongxin, additional, Liu, Linna, additional, and Qian, Jun, additional

Published
2024
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2. RNA binding motif 4 inhibits the replication of ebolavirus by directly targeting 3′-leader region of genomic RNA

Author

Fan, Linjin, primary, Wang, Yulong, additional, Huang, Hongxin, additional, Wang, Zequn, additional, Liang, Chudan, additional, Yang, Xiaofeng, additional, Ye, Pengfei, additional, Lin, Jingyan, additional, Shi, Wendi, additional, Zhou, Yuandong, additional, Yan, Huijun, additional, Long, Zhenyu, additional, Wang, Zhongyi, additional, Liu, Linna, additional, and Qian, Jun, additional

Published
2024
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3. Case Report: First case of HIV, hepatitis B, hepatitis C, and Vibrio vulnificus coinfection

Author

Zeng, Huimin, primary, Guan, Jialong, additional, Liang, Chudan, additional, Wang, Yulong, additional, Feng, Lizhi, additional, Zhao, Han, additional, Fan, Linjin, additional, Yang, Xiaofeng, additional, Pan, Nenglang, additional, Wang, Zequn, additional, He, Haolan, additional, Chen, Zhimin, additional, Qian, Jun, additional, Li, Yueping, additional, and Liu, Linna, additional

Published
2023
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6. Residues 318 and 323 in capsid protein are involved in immune circumvention of the atypical epizootic infection of infectious bursal disease virus

Author

Fan, Linjin, primary, Wang, Yulong, additional, Jiang, Nan, additional, Gao, Yulong, additional, Niu, Xinxin, additional, Zhang, Wenying, additional, Huang, Mengmeng, additional, Bao, Keyan, additional, Liu, Aijing, additional, Wang, Suyan, additional, Gao, Li, additional, Li, Kai, additional, Cui, Hongyu, additional, Pan, Qing, additional, Liu, Changjun, additional, Zhang, Yanping, additional, Wang, Xiaomei, additional, and Qi, Xiaole, additional

Published
2022
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7. Pure Red Cell Aplasia Caused by Parvovirus B19 in Patients with Human Immunodeficiency Virus Infection: A Series of Four Cases

Author

Xu, Feilong, Wang, Yulong, Wang, Haijuan, Fan, Linjin, He, Yaozu, Chen, Xiejie, Ye, Pengfei, Liu, Linna, Qian, Jun, and Li, Linghua

Abstract

Parvovirus B19 (B19V) infection can cause pure red cell aplasia (PRCA) in patients with human immunodeficiency virus (HIV) infection. Intravenous immunoglobulin (IVIG) is a preferred treatment option. From July 2019 to March 2022, four patients with HIV infection were admitted to Guangzhou Eighth People’s Hospital with dizziness and fatigue and were diagnosed with PRCA. Blood investigations revealed severe anemia and the B19V genome. Therefore, the four patients were diagnosed with B19V-induced PRCA. All four patients received red blood cell transfusion in the setting of antiretroviral therapy, and two of the four patients received intravenous immunoglobulin (IVIG). After 3–7 months of treatment, all four patients recovered, although two did not receive IVIG. This suggests that IVIG is not always necessary for the treatment of PRCA in patients with HIV infection and that effective antiretroviral therapy and immunological reconstitution play an important role in the eradication of parvovirus.

Published
2023
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8. TRIM25 inhibits infectious bursal disease virus replication by targeting VP3 for ubiquitination and degradation

Author

Wang, Suyan, primary, Yu, Mengmeng, additional, Liu, Aijing, additional, Bao, Yuanling, additional, Qi, Xiaole, additional, Gao, Li, additional, Chen, Yuntong, additional, Liu, Peng, additional, Wang, Yulong, additional, Xing, Lixiao, additional, Meng, Lingzhai, additional, Zhang, Yu, additional, Fan, Linjin, additional, Li, Xinyi, additional, Pan, Qing, additional, Zhang, Yanping, additional, Cui, Hongyu, additional, Li, Kai, additional, Liu, Changjun, additional, He, Xijun, additional, Gao, Yulong, additional, and Wang, Xiaomei, additional

Published
2021
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9. Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Author

Wang, Yulong, primary, Jiang, Nan, additional, Fan, Linjin, additional, Niu, Xinxin, additional, Zhang, Wenying, additional, Huang, Mengmeng, additional, Gao, Li, additional, Li, Kai, additional, Gao, Yulong, additional, Liu, Changjun, additional, Cui, Hongyu, additional, Liu, Aijing, additional, Pan, Qing, additional, Zhang, Yanping, additional, Wang, Xiaomei, additional, and Qi, Xiaole, additional

Published
2021
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10. Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus

Author

Wang, Yulong, primary, Jiang, Nan, additional, Fan, Linjin, additional, Gao, Li, additional, Li, Kai, additional, Gao, Yulong, additional, Niu, Xinxin, additional, Zhang, Wenying, additional, Cui, Hongyu, additional, Liu, Aijing, additional, Pan, Qing, additional, Liu, Changjun, additional, Zhang, Yanping, additional, Wang, Xiaomei, additional, and Qi, Xiaole, additional

Published
2021
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12. Applying improved ddPCR to reliable quantification of MPXV in clinical settings.

Author

Liang C, Yang H, Yang X, Long Z, Zhou Y, Wang J, Fan L, Zeng M, Wang Y, Zheng H, Wang Z, Ye P, Lin J, Shi W, Huang H, Yan H, Qian J, Li L, and Liu L

Abstract

Monkeypox virus (MPXV) poses a global health threat. Droplet digital PCR (ddPCR) holds potential as an accurate diagnostic tool for clinical microbiology. However, there is limited literature on the applicability of ddPCR in clinical settings. In this study, the clinical features of patients with MPXV during the initial outbreak in China in June 2023 were reviewed, and an optimized ddPCR method with dilution and/or inhibitor removal was developed to enhance MPXV detection efficiency. Eighty-two MPXV samples were tested from nine different clinical specimen types, including feces, urine, pharyngeal swabs, anal swabs, saliva, herpes fluid, crust, and semen, and the viral load of each specimen was quantified. A comparative analysis was performed with qPCR to assess sensitivity and specificity and to investigate the characteristics of MPXV infection by analyzing viral loads in different clinical specimens. Consequently, common pharyngeal and gastrointestinal symptoms were observed in patients with MPXV. The optimized ddPCR method demonstrated relatively high sensitivity for MPXV quantification in the clinical materials, with a limit of detection of 0.1 copies/μL. This was particularly evident in low-concentration samples like whole blood, semen, and urine. The optimized ddPCR demonstrated greater detection accuracy compared with normal ddPCR and qPCR, with an area under the curve (AUC) of 0.939. Except for crust samples, viral loads in the specimens gradually decreased as the disease progressed. Virus levels in feces and anal swabs kept a high detection rate at each stage of post-symptom onset, and feces and anal swabs samples may be suitable for clinical diagnosis and continuous monitoring of MPXV., Importance: The ddPCR technique proved to be a sensitive and valuable tool for accurately quantifying MPXV viral loads in various clinical specimen types. The findings provided valuable insights into the necessary pre-treatment protocols for MPXV diagnosis in ddPCR detection and the potentially suitable sample types for collection. Therefore, such results can aid in comprehending the potential characteristics of MPXV infection and the usage of ddPCR in clinical settings.

Published
2024
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