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A series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a-c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential. The antimicrobial activity of some selected products was evaluated and showed good results. 5,5'-(3,4-Dimethylthieno[2,3-b]thiophene-2,5- diyl)bis(3-acetyl-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile) (5d) was found to be more potent than the standard drug amphotericin B against Geotricum candidum and equipotent to amphotericin B against Syncephalastrum racemosum. In addition, it was found to be equipotent to the standard drug Penicillin G against Staphylococcus aureus. Moreover, it was more potent than the standard drug streptomycin against Pseudomonas aeruginosa and Escherichia coli. [ABSTRACT FROM AUTHOR]

A new quinoline-based Pd(II)-complex was synthesized and its structure was established by single crystal X-ray analysis. Applications of the obtained complex as a precatalyst in Suzuki-Miyaura C-C cross-coupling reactions of 4-bromoacetophenone and 5-bromobenzofuran-2-carboxylate esters with several aryl- and heteroarylboronic acids were investigated. The catalytic activity of the Pd(II)-precatalyst under microwave irradiating conditions was evaluated. [ABSTRACT FROM AUTHOR]

2-Acetyl-5-bromothiophene and 4-(5-bromothiophen-2-yl)-2-methyl-1,3-thiazole, as deactivated bromide candidates, were prepared and used for Suzuki cross-coupling reactions with a number of aryl(hetaryl)boronic acids in water or DMF as solvents. The cross-coupling reactions were carried out under thermal heating as well as microwave irradiating conditions using a benzothiazole-based Pd(II)-precatalyst. Optimization of the catalytic reaction condition was also studied. [ABSTRACT FROM AUTHOR]

The reaction between 1 H -benzimidazol-2-ylmethyl-( N -aryl)amine derivatives (L R ) and [ReBr(CO) 5 ] afforded octahedral Re(i) complexes of the general formula of [ReBr(CO) 3 L R ] (R = 4-Cl and 4-COOCH 3 ). The Re(i) complexes were screened for their potential cytotoxicity against three malignant cell lines and one normal cell line of different origins. The solvatochromic characteristics of the complexes were examined by UV/vis. spectroscopy with the aid of time-dependent density functional theory calculations. Strong autofluorescence emission can be seen in the two Re(i) complexes between 460 and 488 nm. They appeared to accumulate inside intercellular connections and surrounding cellular membranes. The substances gathered also, along the cell membrane, waiting for their entry. The mode of cell death staining and the DNA fragmentation analysis revealed that the 4-Cl complex showed increased apoptotic changes in the MCF-7, and the Caco-2 cell line, while the HepG2 cell line showed little apoptotic changes., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)