15 results on '"Feinmesser, R."'
Search Results
2. Computer-assisted image analysis of small cell lymphoma of the thyroid gland
- Author
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Eldar, S., primary, Sabo, E., additional, Cohen, A., additional, Misselevich, I., additional, Cohen, O., additional, Kelner, J., additional, Mor, C., additional, Shvero, J., additional, Feinmesser, R., additional, Shibi, J., additional, Shabtai, M., additional, Bejar, J., additional, and Boss, J.H., additional
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- 1998
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3. Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation.
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Feinmesser, R L, Wicks, S J, Taverner, C J, and Chantry, A
- Abstract
Down-regulation of receptor tyrosine kinase activity plays an essential role in coordinating and controlling cellular growth/differentiation. Ca2+/calmodulin-dependent kinase II (CaM kinase II)-mediated phosphorylation of threonine 1172 in the cytoplasmic tail of HER2/c-erbB2 can modulate tyrosine kinase activity and consensus phosphorylation sites are also found at serines 1046/1047 in the structurally related epidermal growth factor receptor (EGFR). We show that serines 1046/1047 are sites for CaM kinase II phosphorylation, although there is a preference for serine 1047, which resides within the consensus -R-X-X-S-. In addition, we have identified major phosphorylation sites at serine 1142 and serine 1057, which lie within a novel -S-X-D- consensus. Mutation of serines 1046/1047 in full-length EGFR enhanced both fibroblast transformation and tyrosine autokinase activity that was significantly potentiated by additional mutation of serines 1057 and 1142. A single CaM kinase II site was also identified at serine 744 within sub-kinase domain III, and autokinase activity was significantly affected by mutation of this serine to an aspartic acid making this site appear constitutively phosphorylated. We have addressed the mechanism by which CaM kinase II phosphorylation of the EGFR might regulate receptor autokinase activity and show that this modification can hinder association of the cytoplasmic tail with the kinase domain to prevent an enzyme-substrate interaction. We postulate that the location and greater number of CaM kinase II phosphorylation sites in the EGFR compared with HER-2/c-erbB2, leading to differential regulation of autokinase activity, contributes to differences in the strength of downstream signaling events and may explain the higher relative transforming potential of HER-2/cerbB2.
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- 1999
4. Unreviewed Reports.
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Buckley, Alison, Wood, Thomas M.L., Thomas, S.E., Murphy, D., Watters, J., Feinmesser, R., Gay, I., Rutgers, M.J., Roos, P.J., Knight, D.G., and Kernohan, N.
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MEDICINE ,GIARDIASIS ,NIFEDIPINE ,MORPHINE ,PHYSIOLOGY - Abstract
Presents information related to various medical issues and concerns in Great Britain. Features of severe megaloblastic anemia secondary to giardiasis; Characteristics of photosensitivity reactions associated with nifedipine; Complications of self-administered epidural morphine in cancer patients.
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- 1986
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5. Treatment decisions and adherence to guidelines in the treatment of low risk papillary carcinoma of the thyroid.
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Hilly O, Stern-Shavit S, Iran S, and Feinmesser R
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- Attitude of Health Personnel, Carcinoma, Papillary, Guideline Adherence statistics & numerical data, Health Care Surveys, Humans, Israel, Neoplasm Grading, Practice Guidelines as Topic, Risk Adjustment methods, Surveys and Questionnaires, Thyroid Cancer, Papillary, Thyroid Gland pathology, Thyroid Gland surgery, Carcinoma diagnosis, Carcinoma therapy, Endocrinology methods, General Surgery methods, Iodine Radioisotopes therapeutic use, Radiotherapy, Adjuvant methods, Thyroid Neoplasms diagnosis, Thyroid Neoplasms therapy, Thyroidectomy adverse effects, Thyroidectomy methods
- Abstract
Background: Treatment guidelines for well-differentiated papillary thyroid carcinoma (PTC) are based on retrospective studies and vary among professional thyroid associations., Objectives: To evaluate physician adherence to guidelines, overall and by specialty., Methods: Questionnaires on the approach to low risk PTC were distributed among 51 surgeons and endocrinologists treating patients with PTC in tertiary medical centers., Results: A wide range of answers was recorded among physicians regarding the danger posed by low risk PTC to the patient's life, urgency with which treatment should be administered, type of treatment, and risks associated with this treatment. There was a significant between-group difference in treatment preference: endocrinologists chose total thyroidectomy with radioactive iodine, while surgeons favored hemithyroidectomy alone., Conclusions: There is a wide difference in treatment recommendations between treating physicians and different specialties with regard to low risk PTC. The wide variation within and between soecialties may be explained by biases.
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- 2014
6. Robot-assisted transaxillary thyroid surgery-feasibility and safety of a novel technique.
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Rabinovics N, Feinmesser R, Aidan P, Hamzany Y, and Bachar G
- Abstract
Developments in technology have led to a rapid progress in robotic endocrine surgery applications. With the advent of minimally invasive techniques in thyroid surgery, robot-assisted transaxillary thyroid surgery (RATS) has emerged as one of the most promising approaches. Its main advantages are improved cosmetic outcome, avoiding cervical incisions, thereby increasing patient satisfaction, and improved visualization, arms articulations, and precision, resulting in fewer surgical complications. The main disadvantages are potential new injuries to the brachial plexus, esophagus, and trachea, longer operative time, and increased cost compared to conventional thyroidectomy. In skilled hands, RATS is a safe alternative to conservative thyroidectomy and should be presented to patients with aesthetic concerns. As with any new emerging technique, careful patient selection is crucial, and further evidence must be sought to confirm its indications over time.
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- 2014
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7. Chondrosarcoma of the larynx.
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Buda I, Hod R, Feinmesser R, and Shvero J
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- Adult, Aged, Biopsy, Chondrosarcoma mortality, Chondrosarcoma therapy, Combined Modality Therapy, Follow-Up Studies, Humans, Incidence, Israel epidemiology, Laryngeal Neoplasms mortality, Laryngeal Neoplasms therapy, Male, Middle Aged, Neoplasm Recurrence, Local epidemiology, Retrospective Studies, Survival Rate trends, Time Factors, Tomography, X-Ray Computed, Young Adult, Chondrosarcoma diagnosis, Laryngeal Neoplasms diagnosis
- Abstract
Background: Chondrosarcoma of the larynx is a rare tumor. The most common symptom is hoarseness. Treatment is controversial., Objectives: To describe six patients with laryngeal chondrosarcoma from a single center., Methods: The medical records of a major tertiary hospital were reviewed for all patients with laryngeal chondrosarcoma diagnosed and treated from 1959 to 2010. Data on background, clinical treatment and outcome were collected., Results: Six patients, all males with a mean age of 53.3 years, were identified. Partial laryngectomy was performed in three patients, and total laryngectomy, local excision, and partial cricoidectomy in one patient each. Four patients had a permanent tracheostomy after surgery. One patient required postoperative chemotherapy and one radiotherapy. Follow-up time was 12-216 months (mean 102 months). Recurrence developed in two patients 2 and 8 years after initial treatment and was treated by salvage surgery in both patients. One patient died during the follow-up from an unrelated cause. The others are currently alive., Conclusions: This study supports earlier reports recommending initial treatment with partial or total laryngectomy for laryngeal chondrosarcoma. Long-term follow-up for recurrence is advised. We recommend preserving the larynx, if possible, even if a permanent tracheostomy is necessary.
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- 2012
8. Familial Mediterranean fever, an amyloid thyroid goiter and an enlarged parathyroid gland.
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Ori Y, Halpern M, Sadov R, Feinmesser R, Ramadan R, and Korzets A
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- Adult, Amyloidosis etiology, Amyloidosis pathology, Amyloidosis surgery, Goiter pathology, Goiter surgery, Humans, Incidental Findings, Kidney Failure, Chronic etiology, Kidney Failure, Chronic surgery, Kidney Transplantation, Male, Parathyroid Diseases pathology, Parathyroid Diseases surgery, Parathyroid Glands surgery, Thyroidectomy, Amyloidosis complications, Familial Mediterranean Fever complications, Goiter etiology, Parathyroid Diseases etiology
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- 2012
9. Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers.
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Bachar G, Cohen K, Hod R, Feinmesser R, Mizrachi A, Shpitzer T, Katz O, and Peer D
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- Adult, Aged, Animals, Antibiotics, Antineoplastic chemistry, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic therapeutic use, Drug Carriers metabolism, Female, Head and Neck Neoplasms metabolism, Humans, Hyaluronan Receptors metabolism, Hyaluronic Acid metabolism, Male, Materials Testing, Mice, Middle Aged, Paclitaxel chemistry, Paclitaxel therapeutic use, Particle Size, Antibiotics, Antineoplastic therapeutic use, Drug Carriers chemistry, Head and Neck Neoplasms drug therapy, Hyaluronic Acid chemistry, Mitomycin chemistry, Mitomycin therapeutic use, Nanostructures chemistry
- Abstract
CD44, a well-documented cell surface receptor, is involved in cell proliferation, migration, signaling, adhesion, differentiation and angiogenesis, which are important properties for normal and cancerous cell function. We recently developed particle clusters coated with hyaluronan (termed gagomers; GAG), and showed that they can deliver the insoluble drug paclitaxel directly into CD44-over-expressing tumors in a mouse tumor model. Here, we tested primary head and neck cancers (HNC) and normal cells taken from the same patient, and found that although CD44 expression in both types of cells was high, GAGs bind only to the cancerous cells in a selective manner. We next formulated the anti cancer agent mitomycin C (MMC) in the GAGs. MMC-based chemoradiation is a potential treatment for HNC, however, due to patient's toxicity, MMC is not part of the standard treatment of HNC. MMC encapsulation efficiency was about 70% with a half-life drug efflux of 1.2 ± 0.3 days. The Ex vivo study of the targeted MMC-GAG showed significant increase in the therapeutic effect on HNC cells (compared to free MMC), while it had no effect on normal cells taken from the same patient. These results demonstrate the specificity of the nanovectors towards head and neck cancers, which might be applicable as future therapy to many CD44-expressing tumors., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
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- 2011
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10. Concomitant analysis of salivary tumor markers--a new diagnostic tool for oral cancer.
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Nagler R, Bahar G, Shpitzer T, and Feinmesser R
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- Adult, Aged, Aged, 80 and over, Enzyme-Linked Immunosorbent Assay methods, Female, Humans, Male, Middle Aged, Neoplasm Staging, Predictive Value of Tests, Sensitivity and Specificity, Survival Rate, Biomarkers, Tumor analysis, Carcinoma, Squamous Cell diagnosis, Mouth Neoplasms diagnosis, Saliva chemistry, Salivary Gland Neoplasms diagnosis
- Abstract
Purpose: Oral squamous cell carcinoma (OSCC) is a common human malignancy. Circulatory epithelial tumor markers were previously investigated in the serum of OSCC patients but almost never in their saliva, in spite of the fact that there is a direct contact between the saliva and the oral cancer lesion. The purpose of the current study was to examine tumor markers in the saliva of OSCC patients., Experimental Design: We measured the concentrations of the six most studied epithelial serum circulatory tumor markers in the saliva of OSCC (tongue) patients., Results: Significant increases (of 400%) in salivary concentrations of Cyfra 21-1, tissue polypeptide antigen, and CA125 were shown. Salivary concentrations of CA19-9, SCC, and carcinoembryonic antigen were increased without statistical significance. A concurrent analysis of the three significantly increased markers revealed sensitivity, specificity, and negative and positive predictive values of 71%, 75%, 71%, and 75%, respectively., Conclusions: The increase reported in salivary tumor markers may be used as a diagnostic tool, especially when a concurrent analysis for significantly increased markers is done. Salivary testing is noninvasive, making it an attractive, effective alternative to serum testing, and the possibility of developing home testing kits would further facilitate it as a diagnostic aid, enabling patients to monitor their own health at home and is important for those who live far from their treatment centers and especially for those at risk of developing OSCC.
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- 2006
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11. Endoscopic laser-assisted posterior ventriculocordectomy without tracheostomy for bilateral vocal cord immobility.
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Joshua B, Feinmesser R, Zohar L, and Shvero J
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- Adolescent, Adult, Aged, Aged, 80 and over, Carbon Dioxide therapeutic use, Female, Humans, Laryngeal Diseases etiology, Male, Middle Aged, Tracheostomy, Treatment Outcome, Vocal Cord Paralysis complications, Endoscopy methods, Laryngeal Diseases surgery, Laser Therapy methods, Vocal Cord Paralysis surgery
- Abstract
Background: Laryngeal obstruction due to bilateral vocal cord immobility in adduction may cause dyspnea, hoarseness and dysphagia and can lead to dependence on a tracheostomy. Treatment poses a challenge because of the opposing functions of the larynx and the risk of neck and laryngeal tissue damage., Objectives: To describe our experience with endoscopic CO2-laser-assisted posterior ventriculocordectomy without tracheostomy for the treatment of bilateral vocal cord immobility in adduction., Method: The study group consisted of five male and five female patients aged 17-81 years. The procedure was performed with an endoscope and operating microscope connected to a CO2 laser. A C-shaped incision was made, and the posterior third of one vocal cord, the vocal process of the arytenoid, and the posterior third of the false vocal cord were excised. Tracheostomy was not performed., Results: The technique allowed for a convenient approach to the difficult-to-view areas of the larynx. The procedure was short and bloodless, with minimal damage to laryngeal tissue and no local edema. Hospitalization time was short. Postoperatively, patients had sufficient breathing and mostly fair to good voice quality. None of the patients had severe aspirations and only three patients had mild aspirations., Conclusions: We recommend this procedure for patients with bilateral vocal cord immobility prior to tracheostomy. Delaying surgery beyond the time of possible re-innervation may place the patient at risk of decompensation, which requires tracheostomy.
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- 2004
12. Revision parathyroidectomy guided by intraoperative radionuclide imaging.
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Nageris B, Guttman D, Bahar G, Melloul M, Feinmesser R, and Schneebaum S
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- Adenoma blood, Adult, Aged, Calcium blood, Equipment Design, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Monitoring, Intraoperative instrumentation, Parathyroid Hormone blood, Parathyroid Neoplasms blood, Phosphorus blood, Radiography, Interventional instrumentation, Radionuclide Imaging, Reoperation instrumentation, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Adenoma diagnostic imaging, Adenoma surgery, Gamma Rays, Monitoring, Intraoperative methods, Parathyroid Neoplasms diagnostic imaging, Parathyroid Neoplasms surgery, Parathyroidectomy methods, Radiography, Interventional methods, Radiopharmaceuticals, Reoperation methods, Technetium Tc 99m Sestamibi
- Abstract
Background: Technetium-99m sestamibi scintigraphy has become one of the most popular techniques for localization of the parathyroid gland after failure of primary neck exploration., Objective: To examine the efficacy of sestamibi with the hand-held gamma ray detecting probe for the identification of parathyroid adenomas during revision parathyroidectomy., Methods: We reviewed six cases of probe-assisted neck exploration for parathyroid lesions following unsuccessful primary exploration., Results: In all cases the pathologic glands were successfully detected and removed., Conclusions: With careful planning, a gamma ray detecting probe can be used optimally 2-3 hours after technetium-99m sestamibi injection. The probe is efficient, easy and convenient to use.
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- 2003
13. The evolving management of penetrating neck injuries.
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Feinmesser R and Reifen E
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- Humans, Neck Injuries etiology, Neck Injuries therapy, Wounds, Penetrating therapy
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- 2001
14. Noise-induced vestibular dysfunction.
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Nageris BI, Attias J, and Feinmesser R
- Abstract
An association between noise exposure and vestibular function has long been suspected. Our wide experience in a major otologic outpatient clinic yielded six patients within the last seven years who presented with Meniere's disease and a history of long-term exposure to noise. Two of the cases are described in detail. Our evaluation in light of the data in the literature suggests that the relationship between vestibular dysfunction and exposure to hazardous noise may be more than coincidental.
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- 2000
15. Serum thyroglobulin and iodine-131 whole-body scan in the diagnosis and assessment of treatment for metastatic differentiated thyroid carcinoma.
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Lubin E, Mechlis-Frish S, Zatz S, Shimoni A, Segal K, Avraham A, Levy R, and Feinmesser R
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- Adenocarcinoma, Follicular diagnostic imaging, Adenocarcinoma, Follicular pathology, Adenocarcinoma, Follicular surgery, Adult, Aged, Carcinoma, Papillary diagnostic imaging, Carcinoma, Papillary pathology, Carcinoma, Papillary surgery, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Metastasis, Radionuclide Imaging, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms surgery, Thyroidectomy, Iodine Radioisotopes therapeutic use, Thyroglobulin blood, Thyroid Neoplasms pathology
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Unlabelled: Because of the limitations of periodic 131I whole-body scans, including suspension of substitution therapy, questionable sensitivity and low yield in detecting metastases in patients who have undergone thyroidectomy, serum thyroglobulin and 131I whole-body scans were evaluated for sensitivity in detecting local, regional or distant metastases in 261 patients with differentiated thyroid carcinoma after total thyroidectomy and ablation., Methods: A noncompetitive immunoradiometric assay was used for serum thyroglobulin determination. An 131I whole-body scan was obtained after replacement therapy had been suspended for 6 wk or when TSH reached levels higher than 50 microU/ml. In patients who underwent radiological procedures with iodinated contrast media, the waiting period before the 131I whole-body scan was no less than 10 wk., Results: Of the 58 patients with proven metastases who were followed for 12 yr (mean 7 +/- 3.3 yr), 51 (88.4%) had high serum thyroglobulin assays performed while under full replacement therapy and 32 (55%) showed clear 131I whole-body scan localization. There were no instances of positive whole-body scans and negative serum thyroglobulin., Conclusion: In patients treated with 131I, serum thyroglobulin assay was an excellent method to assess treatment. Patients with metastatic disease and negative whole-body scans with or without serum thyroglobulin exhibited a trend toward higher mortality. This trend may also indicate that the lack of 131I trapping and low thyroglobulin is a sign of metabolic dedifferentiation of otherwise histologically differentiated thyroid tumors.
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- 1994
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