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Your search keyword '"Feng, Jianpeng"' showing total 9 results
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9 results on '"Feng, Jianpeng"'

5. Preparation of Ni 2 P/Al 2 O 3 by temperature-programmed reduction of a phosphate precursor with a low P/Ni ratio

Author

Yongying Chen, Anjie Wang, Xinping Duan, Xiang Li, Feng Jianpeng, Roel Prins, and Guo Jingyu

Subjects
Phosphorus, Inorganic chemistry, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Phosphate, 01 natural sciences, Catalysis, 0104 chemical sciences, law.invention, chemistry.chemical_compound, Cerium, chemistry, Phosphorus oxide, law, Dibenzothiophene, Calcination, Reactivity (chemistry), Physical and Theoretical Chemistry, Temperature-programmed reduction, 0210 nano-technology
Abstract

Ni 2 P that was highly active in the hydrodesulfurization of dibenzothiophene was obtained by reduction of a phosphate precursor with a P/Ni molar ratio as low as 1.2 over cerium oxide-modified Al 2 O 3 (Ce–Al 2 O 3 ) and macromesoporous Al 2 O 3 (M-Al 2 O 3 ). 27 Al MAS NMR revealed that this is likely due to the low reactivity of pentahedrally coordinated Al 3+ (Al(P)) with phosphorus oxide. Because the major Al species in Ce–Al 2 O 3 and M-Al 2 O 3 is Al(P), less phosphorus is consumed by the Al 2 O 3 support upon calcination and thus more phosphorus is available for the formation of Ni 2 P during the reduction stage.

Published
2016

9. Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin.

Author

Zhang Y, Jiang X, Peng K, Chen C, Fu L, Wang Z, Feng J, Liu Z, Zhang H, Liang G, and Pan Z

Subjects
Animals, Anti-Inflammatory Agents, Non-Steroidal chemical synthesis, Anti-Inflammatory Agents, Non-Steroidal chemistry, Biological Products chemical synthesis, Biological Products chemistry, Cell Line, Curcumin chemical synthesis, Curcumin chemistry, Cytokines antagonists & inhibitors, Cytokines biosynthesis, Dose-Response Relationship, Drug, Humans, Lipopolysaccharides administration & dosage, Lipopolysaccharides antagonists & inhibitors, Lipopolysaccharides pharmacology, Macrophages drug effects, Male, Mice, Mice, Inbred C57BL, Molecular Structure, Shock, Septic drug therapy, Structure-Activity Relationship, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Biological Products pharmacology, Curcumin pharmacology, Drug Discovery
Abstract

Curcumin is a natural active product that has various pharmacological activities such as anti-inflammatory effects. Here, we report the synthesis and evaluation of 34 monocarbonyl curcumin analogs as novel anti-inflammatory agents. Among the analogs, the symmetrical heterocyclic type displayed the strongest inhibition of lipopolysaccharide (LPS)-stimulated expression of pro-inflammatory cytokines in macrophages. Analogs S1-S5 and AS29 reduced tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production in a dose-dependent manner and also displayed excellent stability and low cytotoxicity in vitro. In addition, analog S1 dose-dependently inhibited LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation. Furthermore, analogs S1 and S4 displayed a significant protective effect on LPS-induced septic death in mouse models, with 40% and 50% survival rates, respectively. These data demonstrate that the heterocyclic monocarbonyl curcumin analogs have potential therapeutic effects in acute inflammatory diseases.

Published
2014
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