32 results on '"Fernández-Rodríguez, Juana"'
Search Results
2. Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis
- Author
-
Magallón-Lorenz, Miriam, Terribas, Ernest, Ortega-Bertran, Sara, Creus-Bachiller, Edgar, Fernández, Marco, Requena, Gerard, Rosas, Inma, Mazuelas, Helena, Uriarte-Arrazola, Itziar, Negro, Alex, Lausová, Tereza, Castellanos, Elisabeth, Blanco, Ignacio, DeVries, George, Kawashima, Hiroyuki, Legius, Eric, Brems, Hilde, Mautner, Viktor, Kluwe, Lan, Ratner, Nancy, Wallace, Margaret, Fernández-Rodriguez, Juana, Lázaro, Conxi, Fletcher, Jonathan A., Reuss, David, Carrió, Meritxell, Gel, Bernat, and Serra, Eduard
- Published
- 2023
- Full Text
- View/download PDF
3. Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation
- Author
-
Magallón-Lorenz, Miriam, Fernández-Rodríguez, Juana, Terribas, Ernest, Creus-Batchiller, Edgar, Romagosa, Cleofe, Estival, Anna, Perez Sidelnikova , Diana, Salvador, Héctor, Villanueva, Alberto, Blanco, Ignacio, Carrió, Meritxell, Lázaro, Conxi, Serra, Eduard, and Gel, Bernat
- Published
- 2021
- Full Text
- View/download PDF
4. Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: New patient‐derived orthotopic xenografts, cell lines and tumor entities.
- Author
-
Creus‐Bachiller, Edgar, Fernández‐Rodríguez, Juana, Magallón‐Lorenz, Miriam, Ortega‐Bertran, Sara, Navas‐Rutete, Susana, Romagosa, Cleofe, Silva, Tulio M., Pané, Maria, Estival, Anna, Perez Sidelnikova, Diana, Morell, Mireia, Mazuelas, Helena, Carrió, Meritxell, Lausová, Tereza, Reuss, David, Gel, Bernat, Villanueva, Alberto, Serra, Eduard, and Lázaro, Conxi
- Abstract
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft‐tissue sarcomas with a poor survival rate, presenting either sporadically or in the context of neurofibromatosis type 1 (NF1). The histological diagnosis of MPNSTs can be challenging, with different tumors exhibiting great histological and marker expression overlap. This heterogeneity could be partly responsible for the observed disparity in treatment response due to the inherent diversity of the preclinical models used. For several years, our group has been generating a large patient‐derived orthotopic xenograft (PDOX) MPNST platform for identifying new precision medicine treatments. Herein, we describe the expansion of this platform using six primary tumors clinically diagnosed as MPNSTs, from which we obtained six additional PDOX mouse models and three cell lines, thus generating three pairs of in vitro–in vivo models. We extensively characterized these tumors and derived preclinical models, including genomic, epigenomic, and histological analyses. Tumors were reclassified after these analyses: three remained as MPNSTs (two being classic MPNSTs), one was a melanoma, another was a neurotrophic tyrosine receptor kinase (NTRK)‐rearranged spindle cell neoplasm, and, finally, the last was an unclassifiable tumor bearing neurofibromin‐2 (NF2) inactivation, a neuroblastoma RAS viral oncogene homolog (NRAS) oncogenic mutation, and a SWI/SNF‐related matrix‐associated actin‐dependent regulator of chromatin (SMARCA4) heterozygous truncated variant. New cell lines and PDOXs faithfully recapitulated histology, marker expression, and genomic characteristics of the primary tumors. The diversity in tumor identity and their specific associated genomic alterations impacted treatment responses obtained when we used the new cell lines for testing compounds against known altered pathways in MPNSTs. In summary, we present here an extension of our MPNST precision medicine platform, with new PDOXs and cell lines, including tumor entities confounded as MPNSTs in a real clinical scenario. This platform may constitute a useful tool for obtaining correct preclinical information to guide MPNST clinical trials. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: New patient‐derived orthotopic xenografts, cell lines and tumor entities
- Author
-
Creus‐Bachiller, Edgar, primary, Fernández‐Rodríguez, Juana, additional, Magallón‐Lorenz, Miriam, additional, Ortega‐Bertran, Sara, additional, Navas‐Rutete, Susana, additional, Romagosa, Cleofe, additional, Silva, Tulio M., additional, Pané, Maria, additional, Estival, Anna, additional, Perez Sidelnikova, Diana, additional, Morell, Mireia, additional, Mazuelas, Helena, additional, Carrió, Meritxell, additional, Lausová, Tereza, additional, Reuss, David, additional, Gel, Bernat, additional, Villanueva, Alberto, additional, Serra, Eduard, additional, and Lázaro, Conxi, additional
- Published
- 2023
- Full Text
- View/download PDF
6. Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis
- Author
-
González-Muñoz, Teresa, primary, Di Giannatale, Angela, additional, García-Silva, Susana, additional, Santos, Vanesa, additional, Sánchez-Redondo, Sara, additional, Savini, Claudia, additional, Graña-Castro, Osvaldo, additional, Blanco-Aparicio, Carmen, additional, Fischer, Suzanne, additional, De Wever, Olivier, additional, Creus-Bachiller, Edgar, additional, Ortega-Bertran, Sara, additional, Pisapia, David J., additional, Rodríguez-Peralto, Jose L., additional, Fernández-Rodríguez, Juana, additional, Pérez-Portabella, Cleofé Romagosa, additional, Alaggio, Rita, additional, Benassi, Maria Serena, additional, Pazzaglia, Laura, additional, Scotlandi, Katia, additional, Ratner, Nancy, additional, Yohay, Kaleb, additional, Theuer, Charles P., additional, and Peinado, Héctor, additional
- Published
- 2023
- Full Text
- View/download PDF
7. Biomethanization of solid wastes from the alcoholic beverage industry: Malt and sloe. Kinetic and microbiological analysis
- Author
-
de Diego-Díaz, Beatriz, Fernández-Rodríguez, Juana, Vitas, Ana I., and Peñas, Francisco J.
- Published
- 2018
- Full Text
- View/download PDF
8. Generation of human iPSC-derived neurofibromaspheres for in vitro and in vivo uses
- Author
-
Mazuelas, Helena, primary, Uriarte-Arrazola, Itziar, additional, Fernández-Rodríguez, Juana, additional, Magallón-Lorenz, Miriam, additional, Villanueva, Alberto, additional, Lázaro, Conxi, additional, Gel, Bernat, additional, Serra, Eduard, additional, and Carrió, Meritxell, additional
- Published
- 2023
- Full Text
- View/download PDF
9. Promoting the Circular Economy on an Island: Anaerobic Co-Digestion of Local Organic Substrates as a Possible Renewable Energy Source
- Author
-
Fernández-Rodríguez, Juana, primary, Di Berardino, Mónica, additional, and Di Berardino, Santino, additional
- Published
- 2023
- Full Text
- View/download PDF
10. Biological Solubilisation of Leather Industry Waste in Anaerobic Conditions: Effect of Chromium (III) Presence, Pre-Treatments and Temperature Strategies
- Author
-
Fernández-Rodríguez, Juana, primary, Lorea, Beñat, additional, and González-Gaitano, Gustavo, additional
- Published
- 2022
- Full Text
- View/download PDF
11. A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
- Author
-
Fernández-Rodríguez, Juana, primary, Creus-Bachiller, Edgar, additional, Zhang, Xiaohu, additional, Martínez-Iniesta, Maria, additional, Ortega-Bertran, Sara, additional, Guha, Rajarshi, additional, Thomas, Craig J., additional, Wallace, Margaret R., additional, Romagosa, Cleofe, additional, Salazar-Huayna, Lourdes, additional, Reilly, Karlyne M., additional, Blakely, Jaishri O., additional, Serra-Musach, Jordi, additional, Pujana, Miguel Angel, additional, Serra, Eduard, additional, Villanueva, Alberto, additional, Ferrer, Marc, additional, and Lázaro, Conxi, additional
- Published
- 2022
- Full Text
- View/download PDF
12. Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas
- Author
-
Mazuelas, Helena, primary, Magallón-Lorenz, Míriam, additional, Fernández-Rodríguez, Juana, additional, Uriarte-Arrazola, Itziar, additional, Richaud-Patin, Yvonne, additional, Terribas, Ernest, additional, Villanueva, Alberto, additional, Castellanos, Elisabeth, additional, Blanco, Ignacio, additional, Raya, Ángel, additional, Chojnacki, Jakub, additional, Heyn, Holger, additional, Romagosa, Cleofé, additional, Lázaro, Conxi, additional, Gel, Bernat, additional, Carrió, Meritxell, additional, and Serra, Eduard, additional
- Published
- 2022
- Full Text
- View/download PDF
13. Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine
- Author
-
Castellsagué, Joan, Gel, Bernat, Fernández-Rodríguez, Juana, Llatjós, Roger, Blanco, Ignacio, Benavente, Yolanda, Pérez-Sidelnikova, Diana, García-del Muro, Javier, Viñals, Joan Maria, Vidal, August, Valdés-Mas, Rafael, Terribas, Ernest, López-Doriga, Adriana, Pujana, Miguel Angel, Capellá, Gabriel, Puente, Xose S, Serra, Eduard, Villanueva, Alberto, and Lázaro, Conxi
- Published
- 2015
- Full Text
- View/download PDF
14. Sustainable management of lignocellulosic wastes: Temperature strategies for anaerobic digestion of artichoke
- Author
-
de Diego-Díaz, Beatriz, primary, Peñas, Francisco J., additional, and Fernández- Rodríguez, Juana, additional
- Published
- 2021
- Full Text
- View/download PDF
15. Additional file 8 of Exploring the link between MORF4L1 and risk of breast cancer
- Author
-
Martrat, Griselda, Maxwell, Christopher A, Tominaga, Emiko, Porta-De-La-Riva, Montserrat, Bonifaci, Núria, Gómez-Baldó, Laia, Bogliolo, Massimo, Conxi Lázaro, Blanco, Ignacio, Brunet, Joan, Aguilar, Helena, Fernández-Rodríguez, Juana, Seal, Sheila, Renwick, Anthony, Nazneen Rahman, Kühl, Julia, Neveling, Kornelia, Schindler, Detlev, Ramírez, María J, Castellà, María, Hernández, Gonzalo, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Platte, Radka, D Gareth Evans, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Kai-Ren Ong, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Brewer, Carole, Morrison, Patrick J, Porteous, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Pasini, Barbara, Ottini, Laura, Putignano, Anna Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Healey, Sue, Spurdle, Amanda, Xiaoqing Chen, Beesley, Jonathan, Rookus, Matti A, Senno Verhoef, Tilanus-Linthorst, Madeleine A, Vreeswijk, Maaike P, Asperen, Christi J, Bodmer, Danielle, Ausems, Margreet GEM, Os, Theo A Van, Blok, Marinus J, Meijers-Heijboer, Hanne EJ, Hogervorst, Frans BL, Goldgar, David E, Buys, Saundra, John, Esther M, Miron, Alexander, Southey, Melissa, Daly, Mary B, Harbst, Katja, Borg, Åke, Rantala, Johanna, Barbany-Bustinza, Gisela, Ehrencrona, Hans, Stenmark-Askmalm, Marie, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Friedman, Eitan, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Johannsson, Oskar Thor, Couch, Fergus J, Xianshu Wang, Fredericksen, Zachary, Cuadras, Daniel, Moreno, Víctor, Pientka, Friederike K, Depping, Reinhard, Caldés, Trinidad, Osorio, Ana, Benítez, Javier, Bueren, Juan, Heikkinen, Tuomas, Nevanlinna, Heli, Hamann, Ute, Torres, Diana, Caligo, Maria Adelaide, Godwin, Andrew K, Imyanitov, Evgeny N, Ramunas Janavicius, Sinilnikova, Olga M, Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Verny-Pierre, Carole, Castera, Laurent, Pauw, Antoine De, Yves-Jean Bignon, Uhrhammer, Nancy, Jean-Philippe Peyrat, Vennin, Philippe, Ferrer, Sandra Fert, Marie-Agnès Collonge-Rame, Mortemousque, Isabelle, McGuffog, Lesley, Chenevix-Trench, Georgia, Pereira-Smith, Olivia M, Antoniou, Antonis C, Cerón, Julián, Tominaga, Kaoru, Surrallés, Jordi, and Pujana, Miguel Angel
- Abstract
Additional file 8: Co-AP assays involving MRG15 and MRGX. Supplementary Figure 4 containing results of co-AP assays involving MRG15 and MRGX. (PDF 1 MB)
- Published
- 2020
- Full Text
- View/download PDF
16. Additional file 7 of Exploring the link between MORF4L1 and risk of breast cancer
- Author
-
Martrat, Griselda, Maxwell, Christopher A, Tominaga, Emiko, Porta-De-La-Riva, Montserrat, Bonifaci, Núria, Gómez-Baldó, Laia, Bogliolo, Massimo, Conxi Lázaro, Blanco, Ignacio, Brunet, Joan, Aguilar, Helena, Fernández-Rodríguez, Juana, Seal, Sheila, Renwick, Anthony, Nazneen Rahman, Kühl, Julia, Neveling, Kornelia, Schindler, Detlev, Ramírez, María J, Castellà, María, Hernández, Gonzalo, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Platte, Radka, D Gareth Evans, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Kai-Ren Ong, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Brewer, Carole, Morrison, Patrick J, Porteous, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Pasini, Barbara, Ottini, Laura, Putignano, Anna Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Healey, Sue, Spurdle, Amanda, Xiaoqing Chen, Beesley, Jonathan, Rookus, Matti A, Senno Verhoef, Tilanus-Linthorst, Madeleine A, Vreeswijk, Maaike P, Asperen, Christi J, Bodmer, Danielle, Ausems, Margreet GEM, Os, Theo A Van, Blok, Marinus J, Meijers-Heijboer, Hanne EJ, Hogervorst, Frans BL, Goldgar, David E, Buys, Saundra, John, Esther M, Miron, Alexander, Southey, Melissa, Daly, Mary B, Harbst, Katja, Borg, Åke, Rantala, Johanna, Barbany-Bustinza, Gisela, Ehrencrona, Hans, Stenmark-Askmalm, Marie, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Friedman, Eitan, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Johannsson, Oskar Thor, Couch, Fergus J, Xianshu Wang, Fredericksen, Zachary, Cuadras, Daniel, Moreno, Víctor, Pientka, Friederike K, Depping, Reinhard, Caldés, Trinidad, Osorio, Ana, Benítez, Javier, Bueren, Juan, Heikkinen, Tuomas, Nevanlinna, Heli, Hamann, Ute, Torres, Diana, Caligo, Maria Adelaide, Godwin, Andrew K, Imyanitov, Evgeny N, Ramunas Janavicius, Sinilnikova, Olga M, Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Verny-Pierre, Carole, Castera, Laurent, Pauw, Antoine De, Yves-Jean Bignon, Uhrhammer, Nancy, Jean-Philippe Peyrat, Vennin, Philippe, Ferrer, Sandra Fert, Marie-Agnès Collonge-Rame, Mortemousque, Isabelle, McGuffog, Lesley, Chenevix-Trench, Georgia, Pereira-Smith, Olivia M, Antoniou, Antonis C, Cerón, Julián, Tominaga, Kaoru, Surrallés, Jordi, and Pujana, Miguel Angel
- Subjects
ComputingMethodologies_PATTERNRECOGNITION ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Hardware_INTEGRATEDCIRCUITS ,Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION - Abstract
Additional file 7: Co-AP and co-IP assays. Supplementary Figure 3 containing results of the co-AP and co-IP assays. (PDF 3 MB)
- Published
- 2020
- Full Text
- View/download PDF
17. Additional file 16 of Exploring the link between MORF4L1 and risk of breast cancer
- Author
-
Martrat, Griselda, Maxwell, Christopher A, Tominaga, Emiko, Porta-De-La-Riva, Montserrat, Bonifaci, Núria, Gómez-Baldó, Laia, Bogliolo, Massimo, Conxi Lázaro, Blanco, Ignacio, Brunet, Joan, Aguilar, Helena, Fernández-Rodríguez, Juana, Seal, Sheila, Renwick, Anthony, Nazneen Rahman, Kühl, Julia, Neveling, Kornelia, Schindler, Detlev, Ramírez, María J, Castellà, María, Hernández, Gonzalo, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Platte, Radka, D Gareth Evans, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Kai-Ren Ong, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Brewer, Carole, Morrison, Patrick J, Porteous, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Pasini, Barbara, Ottini, Laura, Putignano, Anna Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Healey, Sue, Spurdle, Amanda, Xiaoqing Chen, Beesley, Jonathan, Rookus, Matti A, Senno Verhoef, Tilanus-Linthorst, Madeleine A, Vreeswijk, Maaike P, Asperen, Christi J, Bodmer, Danielle, Ausems, Margreet GEM, Os, Theo A Van, Blok, Marinus J, Meijers-Heijboer, Hanne EJ, Hogervorst, Frans BL, Goldgar, David E, Buys, Saundra, John, Esther M, Miron, Alexander, Southey, Melissa, Daly, Mary B, Harbst, Katja, Borg, Åke, Rantala, Johanna, Barbany-Bustinza, Gisela, Ehrencrona, Hans, Stenmark-Askmalm, Marie, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Friedman, Eitan, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Johannsson, Oskar Thor, Couch, Fergus J, Xianshu Wang, Fredericksen, Zachary, Cuadras, Daniel, Moreno, Víctor, Pientka, Friederike K, Depping, Reinhard, Caldés, Trinidad, Osorio, Ana, Benítez, Javier, Bueren, Juan, Heikkinen, Tuomas, Nevanlinna, Heli, Hamann, Ute, Torres, Diana, Caligo, Maria Adelaide, Godwin, Andrew K, Imyanitov, Evgeny N, Ramunas Janavicius, Sinilnikova, Olga M, Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Verny-Pierre, Carole, Castera, Laurent, Pauw, Antoine De, Yves-Jean Bignon, Uhrhammer, Nancy, Jean-Philippe Peyrat, Vennin, Philippe, Ferrer, Sandra Fert, Marie-Agnès Collonge-Rame, Mortemousque, Isabelle, McGuffog, Lesley, Chenevix-Trench, Georgia, Pereira-Smith, Olivia M, Antoniou, Antonis C, Cerón, Julián, Tominaga, Kaoru, Surrallés, Jordi, and Pujana, Miguel Angel
- Subjects
Data_FILES - Abstract
Authors’ original file for figure 2
- Published
- 2020
- Full Text
- View/download PDF
18. Additional file 5 of Exploring the link between MORF4L1 and risk of breast cancer
- Author
-
Martrat, Griselda, Maxwell, Christopher A, Tominaga, Emiko, Porta-De-La-Riva, Montserrat, Bonifaci, Núria, Gómez-Baldó, Laia, Bogliolo, Massimo, Conxi Lázaro, Blanco, Ignacio, Brunet, Joan, Aguilar, Helena, Fernández-Rodríguez, Juana, Seal, Sheila, Renwick, Anthony, Nazneen Rahman, Kühl, Julia, Neveling, Kornelia, Schindler, Detlev, Ramírez, María J, Castellà, María, Hernández, Gonzalo, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Platte, Radka, D Gareth Evans, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Kai-Ren Ong, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Brewer, Carole, Morrison, Patrick J, Porteous, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Pasini, Barbara, Ottini, Laura, Putignano, Anna Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Healey, Sue, Spurdle, Amanda, Xiaoqing Chen, Beesley, Jonathan, Rookus, Matti A, Senno Verhoef, Tilanus-Linthorst, Madeleine A, Vreeswijk, Maaike P, Asperen, Christi J, Bodmer, Danielle, Ausems, Margreet GEM, Os, Theo A Van, Blok, Marinus J, Meijers-Heijboer, Hanne EJ, Hogervorst, Frans BL, Goldgar, David E, Buys, Saundra, John, Esther M, Miron, Alexander, Southey, Melissa, Daly, Mary B, Harbst, Katja, Borg, Åke, Rantala, Johanna, Barbany-Bustinza, Gisela, Ehrencrona, Hans, Stenmark-Askmalm, Marie, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Friedman, Eitan, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Johannsson, Oskar Thor, Couch, Fergus J, Xianshu Wang, Fredericksen, Zachary, Cuadras, Daniel, Moreno, Víctor, Pientka, Friederike K, Depping, Reinhard, Caldés, Trinidad, Osorio, Ana, Benítez, Javier, Bueren, Juan, Heikkinen, Tuomas, Nevanlinna, Heli, Hamann, Ute, Torres, Diana, Caligo, Maria Adelaide, Godwin, Andrew K, Imyanitov, Evgeny N, Ramunas Janavicius, Sinilnikova, Olga M, Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Verny-Pierre, Carole, Castera, Laurent, Pauw, Antoine De, Yves-Jean Bignon, Uhrhammer, Nancy, Jean-Philippe Peyrat, Vennin, Philippe, Ferrer, Sandra Fert, Marie-Agnès Collonge-Rame, Mortemousque, Isabelle, McGuffog, Lesley, Chenevix-Trench, Georgia, Pereira-Smith, Olivia M, Antoniou, Antonis C, Cerón, Julián, Tominaga, Kaoru, Surrallés, Jordi, and Pujana, Miguel Angel
- Subjects
fungi - Abstract
Additional file 5: Gene co-expression. Supplementary Figure 1 containing results of the gene co-expression analysis. (PDF 638 KB)
- Published
- 2020
- Full Text
- View/download PDF
19. Additional file 9 of Exploring the link between MORF4L1 and risk of breast cancer
- Author
-
Martrat, Griselda, Maxwell, Christopher A, Tominaga, Emiko, Porta-De-La-Riva, Montserrat, Bonifaci, Núria, Gómez-Baldó, Laia, Bogliolo, Massimo, Conxi Lázaro, Blanco, Ignacio, Brunet, Joan, Aguilar, Helena, Fernández-Rodríguez, Juana, Seal, Sheila, Renwick, Anthony, Nazneen Rahman, Kühl, Julia, Neveling, Kornelia, Schindler, Detlev, Ramírez, María J, Castellà, María, Hernández, Gonzalo, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Platte, Radka, D Gareth Evans, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Kai-Ren Ong, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Brewer, Carole, Morrison, Patrick J, Porteous, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Pasini, Barbara, Ottini, Laura, Putignano, Anna Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Healey, Sue, Spurdle, Amanda, Xiaoqing Chen, Beesley, Jonathan, Rookus, Matti A, Senno Verhoef, Tilanus-Linthorst, Madeleine A, Vreeswijk, Maaike P, Asperen, Christi J, Bodmer, Danielle, Ausems, Margreet GEM, Os, Theo A Van, Blok, Marinus J, Meijers-Heijboer, Hanne EJ, Hogervorst, Frans BL, Goldgar, David E, Buys, Saundra, John, Esther M, Miron, Alexander, Southey, Melissa, Daly, Mary B, Harbst, Katja, Borg, Åke, Rantala, Johanna, Barbany-Bustinza, Gisela, Ehrencrona, Hans, Stenmark-Askmalm, Marie, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Friedman, Eitan, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Johannsson, Oskar Thor, Couch, Fergus J, Xianshu Wang, Fredericksen, Zachary, Cuadras, Daniel, Moreno, Víctor, Pientka, Friederike K, Depping, Reinhard, Caldés, Trinidad, Osorio, Ana, Benítez, Javier, Bueren, Juan, Heikkinen, Tuomas, Nevanlinna, Heli, Hamann, Ute, Torres, Diana, Caligo, Maria Adelaide, Godwin, Andrew K, Imyanitov, Evgeny N, Ramunas Janavicius, Sinilnikova, Olga M, Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Verny-Pierre, Carole, Castera, Laurent, Pauw, Antoine De, Yves-Jean Bignon, Uhrhammer, Nancy, Jean-Philippe Peyrat, Vennin, Philippe, Ferrer, Sandra Fert, Marie-Agnès Collonge-Rame, Mortemousque, Isabelle, McGuffog, Lesley, Chenevix-Trench, Georgia, Pereira-Smith, Olivia M, Antoniou, Antonis C, Cerón, Julián, Tominaga, Kaoru, Surrallés, Jordi, and Pujana, Miguel Angel
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,hemic and lymphatic diseases ,nutritional and metabolic diseases - Abstract
Additional file 9: siRNA-mediated depletion of MRG15 and FANCD2 monoubiquitinylation. Supplementary Figure 5 containing results of siRNA-mediated depletion of MRG15 and FANCD2 monoubiquitinylation. (PDF 1 MB)
- Published
- 2020
- Full Text
- View/download PDF
20. Additional file of Exploring the link between MORF4L1 and risk of breast cancer
- Author
-
Martrat, Griselda, Maxwell, Christopher A, Tominaga, Emiko, Porta-De-La-Riva, Montserrat, Bonifaci, Núria, Gómez-Baldó, Laia, Bogliolo, Massimo, Conxi Lázaro, Blanco, Ignacio, Brunet, Joan, Aguilar, Helena, Fernández-Rodríguez, Juana, Seal, Sheila, Renwick, Anthony, Nazneen Rahman, Kühl, Julia, Neveling, Kornelia, Schindler, Detlev, Ramírez, María J, Castellà, María, Hernández, Gonzalo, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Platte, Radka, D Gareth Evans, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Kai-Ren Ong, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Brewer, Carole, Morrison, Patrick J, Porteous, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Pasini, Barbara, Ottini, Laura, Putignano, Anna Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Healey, Sue, Spurdle, Amanda, Xiaoqing Chen, Beesley, Jonathan, Rookus, Matti A, Senno Verhoef, Tilanus-Linthorst, Madeleine A, Vreeswijk, Maaike P, Asperen, Christi J, Bodmer, Danielle, Ausems, Margreet GEM, Os, Theo A Van, Blok, Marinus J, Meijers-Heijboer, Hanne EJ, Hogervorst, Frans BL, Goldgar, David E, Buys, Saundra, John, Esther M, Miron, Alexander, Southey, Melissa, Daly, Mary B, Harbst, Katja, Borg, Åke, Rantala, Johanna, Barbany-Bustinza, Gisela, Ehrencrona, Hans, Stenmark-Askmalm, Marie, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Friedman, Eitan, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Johannsson, Oskar Thor, Couch, Fergus J, Xianshu Wang, Fredericksen, Zachary, Cuadras, Daniel, Moreno, Víctor, Pientka, Friederike K, Depping, Reinhard, Caldés, Trinidad, Osorio, Ana, Benítez, Javier, Bueren, Juan, Heikkinen, Tuomas, Nevanlinna, Heli, Hamann, Ute, Torres, Diana, Caligo, Maria Adelaide, Godwin, Andrew K, Imyanitov, Evgeny N, Ramunas Janavicius, Sinilnikova, Olga M, Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Verny-Pierre, Carole, Castera, Laurent, Pauw, Antoine De, Yves-Jean Bignon, Uhrhammer, Nancy, Jean-Philippe Peyrat, Vennin, Philippe, Ferrer, Sandra Fert, Marie-Agnès Collonge-Rame, Mortemousque, Isabelle, McGuffog, Lesley, Chenevix-Trench, Georgia, Pereira-Smith, Olivia M, Antoniou, Antonis C, Cerón, Julián, Tominaga, Kaoru, Surrallés, Jordi, and Pujana, Miguel Angel
- Subjects
skin and connective tissue diseases - Abstract
Additional file of Exploring the link between MORF4L1 and risk of breast cancer
- Published
- 2020
- Full Text
- View/download PDF
21. KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors
- Author
-
Terribas, Ernest, primary, Fernández, Marco, primary, Mazuelas, Helena, primary, Fernández-Rodríguez, Juana, primary, Biayna, Josep, primary, Blanco, Ignacio, primary, Bernal, Gabriela, primary, Ramos-Oliver, Irma, primary, Thomas, Craig, primary, Guha, Rajiv, primary, Zhang, Xiaohu, primary, Gel, Bernat, primary, Romagosa, Cleofé, primary, Ferrer, Marc, primary, Lázaro, Conxi, primary, and Serra, Eduard, primary
- Published
- 2020
- Full Text
- View/download PDF
22. Use of patient derived orthotopic xenograft models for real-time therapy guidance in a pediatric sporadic malignant peripheral nerve sheath tumor
- Author
-
Fernández-Rodríguez, Juana, primary, Morales La Madrid, Andrés, additional, Gel, Bernat, additional, Castañeda Heredia, Alicia, additional, Salvador, Héctor, additional, Martínez-Iniesta, María, additional, Moutinho, Catia, additional, Morata, Jordi, additional, Heyn, Holger, additional, Blanco, Ignacio, additional, Creus-Bachiller, Edgar, additional, Capella, Gabriel, additional, Farré, Lourdes, additional, Vidal, August, additional, Soldado, Francisco, additional, Krauel, Lucas, additional, Suñol, Mariona, additional, Serra, Eduard, additional, Villanueva, Alberto, additional, and Lázaro, Conxi, additional
- Published
- 2020
- Full Text
- View/download PDF
23. Exploring the link between MORF4L1 and risk of breast cancer
- Author
-
Martrat, Griselda, Maxwell, Christopher A, Tominaga, Emiko, Porta-de-la-Riva, Montserrat, Bonifaci, Núria, Gómez-Baldó, Laia, Bogliolo, Massimo, Lázaro, Conxi, Blanco, Ignacio, Brunet, Joan, Aguilar, Helena, Fernández-Rodríguez, Juana, Seal, Sheila, Renwick, Anthony, Rahman, Nazneen, Kühl, Julia, Neveling, Kornelia, Schindler, Detlev, Ramírez, María J, Castellà, María, Hernández, Gonzalo, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Platte, Radka, Evans, D Gareth, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Ong, Kai-Ren, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Brewer, Carole, Morrison, Patrick J, Porteous, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Pasini, Barbara, Ottini, Laura, Putignano, Anna Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Healey, Sue, Spurdle, Amanda, Chen, Xiaoqing, Beesley, Jonathan, Rookus, Matti A, Verhoef, Senno, Tilanus-Linthorst, Madeleine A, Vreeswijk, Maaike P, Asperen, Christi J, Bodmer, Danielle, Ausems, Margreet GEM, van Os, Theo A, Blok, Marinus J, Meijers-Heijboer, Hanne EJ, Hogervorst, Frans BL, Goldgar, David E, Buys, Saundra, John, Esther M, Miron, Alexander, Southey, Melissa, Daly, Mary B, Harbst, Katja, Borg, Åke, Rantala, Johanna, Barbany-Bustinza, Gisela, Ehrencrona, Hans, Stenmark-Askmalm, Marie, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Friedman, Eitan, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Johannsson, Oskar Thor, Couch, Fergus J, Wang, Xianshu, Fredericksen, Zachary, Cuadras, Daniel, Moreno, Víctor, Pientka, Friederike K, Depping, Reinhard, Caldés, Trinidad, Osorio, Ana, Benítez, Javier, Bueren, Juan, Heikkinen, Tuomas, Nevanlinna, Heli, Hamann, Ute, Torres, Diana, Caligo, Maria Adelaide, Godwin, Andrew K, Imyanitov, Evgeny N, Janavicius, Ramunas, Sinilnikova, Olga M, Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Verny-Pierre, Carole, Castera, Laurent, de Pauw, Antoine, Bignon, Yves-Jean, Uhrhammer, Nancy, Peyrat, Jean-Philippe, Vennin, Philippe, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Mortemousque, Isabelle, McGuffog, Lesley, Chenevix-Trench, Georgia, Pereira-Smith, Olivia M, Antoniou, Antonis C, Cerón, Julián, Tominaga, Kaoru, Surrallés, Jordi, and Pujana, Miguel Angel
- Published
- 2011
- Full Text
- View/download PDF
24. Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families
- Author
-
Fernández-Rodríguez Juana, Quiles Francisco, Blanco Ignacio, Teulé Alex, Feliubadaló Lídia, Valle Jesús, Salinas Mónica, Izquierdo Àngel, Darder Esther, Schindler Detlev, Capellá Gabriel, Brunet Joan, Lázaro Conxi, and Pujana Miguel
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Genes that, when mutated, cause Fanconi anemia or greatly increase breast cancer risk encode for proteins that converge on a homology-directed DNA damage repair process. Mutations in the SLX4 gene, which encodes for a scaffold protein involved in the repair of interstrand cross-links, have recently been identified in unclassified Fanconi anemia patients. A mutation analysis of SLX4 in German or Byelorussian familial cases of breast cancer without detected mutations in BRCA1 or BRCA2 has been completed, with globally negative results. Methods The genomic region of SLX4, comprising all exons and exon-intron boundaries, was sequenced in 94 Spanish familial breast cancer cases that match a criterion indicating the potential presence of a highly-penetrant germline mutation, following exclusion of BRCA1 or BRCA2 mutations. Results This mutational analysis revealed extensive genetic variation of SLX4, with 21 novel single nucleotide variants; however, none could be linked to a clear alteration of the protein function. Nonetheless, genotyping 10 variants (nine novel, all missense amino acid changes) in a set of controls (138 women and 146 men) did not detect seven of them. Conclusions Overall, while the results of this study do not identify clearly pathogenic mutations of SLX4 contributing to breast cancer risk, further genetic analysis, combined with functional assays of the identified rare variants, may be warranted to conclusively assess the potential link with the disease.
- Published
- 2012
- Full Text
- View/download PDF
25. Mutations in JMJD1C are involved in Rett syndrome and intellectual disability
- Author
-
Sáez, Mauricio A., primary, Fernández-Rodríguez, Juana, additional, Moutinho, Catia, additional, Sanchez-Mut, Jose V., additional, Gomez, Antonio, additional, Vidal, Enrique, additional, Petazzi, Paolo, additional, Szczesna, Karolina, additional, Lopez-Serra, Paula, additional, Lucariello, Mario, additional, Lorden, Patricia, additional, Delgado-Morales, Raul, additional, de la Caridad, Olga J., additional, Huertas, Dori, additional, Gelpí, Josep L., additional, Orozco, Modesto, additional, López-Doriga, Adriana, additional, Milà, Montserrat, additional, Perez-Jurado, Luís A., additional, Pineda, Mercedes, additional, Armstrong, Judith, additional, Lázaro, Conxi, additional, and Esteller, Manel, additional
- Published
- 2016
- Full Text
- View/download PDF
26. Optimización de la digestión anaerobia seca de la Fracción Orgánica de los Residuos Sólidos Urbanos (FORSU) en reactores en fases de temperatura
- Author
-
Fernández Rodríguez, Juana, Pérez García, Montserrat, Romero García, Luis Isidoro, and Ingeniería Química y Tecnología de Alimentos
- Subjects
eliminación de residuos ,ingeniería de la contaminación - Abstract
Las elevadas cantidades de Residuos Sólidos Urbanos (RSU) que se producen actualmente requieren la adopción de medidas de gestión eficaces con el fin de minimizar su impacto sobre el medio ambiente. En este sentido, la legislación vigente propugna la disminución de las cantidades a depositar en vertederos, proponiendo otras alternativas más sostenibles para la gestión de los mismos, entre las que destacan los procesos de índole biológico, compostaje y/o biometanización, como consecuencia de que la Fracción Orgánica contenida en los Residuos Sólidos Urbanos (FORSU) es muy elevada, alcanzando porcentajes en torno al 44%. Los resultados obtenidos en este estudio, han puesto de manifiesto la viabilidad de implementar la tecnología de biometanización con residuos que tienen alto contenido en sólidos y alta heterogeneidad, como es la FORSU, y muestran que el proceso en fases de temperatura puede ser competitivo frente a los tratamientos individuales mesofílico y termofílico, ya que, en similares condiciones de tiempo global de retención, resulta más eficaz en cuanto a la depuración de materia orgánica y a la producción de metano.
- Published
- 2010
27. Generation of human iPSC-derived neurofibromaspheres for in vitroand in vivouses
- Author
-
Mazuelas, Helena, Uriarte-Arrazola, Itziar, Fernández-Rodríguez, Juana, Magallón-Lorenz, Miriam, Villanueva, Alberto, Lázaro, Conxi, Gel, Bernat, Serra, Eduard, and Carrió, Meritxell
- Abstract
Neurofibromas are benign peripheral nervous system tumors associated with neurofibromatosis type 1, which originate from NF1(−/−) Schwann cell precursors. We describe a protocol to generate neurofibromaspheres by differentiating NF1(−/−) Schwann cells from induced pluripotent stem cells and combining them with neurofibroma primary fibroblasts. We also describe the development of neurofibroma-like tumors when neurofibromaspheres are engrafted in the sciatic nerve of nude mice. This model constitutes a versatile platform for drug screening and the study of neurofibroma biology.
- Published
- 2023
- Full Text
- View/download PDF
28. Gradients and regeneration: the case of TNEX59 in planarians (Platyhelminthes, Tricladida)
- Author
-
Fernández-Rodríguez, Juana, Reigada, S., Romero Benedí, Rafael, Bueno i Torrens, David, 1965, and Universitat de Barcelona
- Subjects
Planària (Gènere) ,Developmental genetics ,Regeneration (Biology) ,Regeneració (Biologia) ,Genètica del desenvolupament ,Planaria (Genus) - Abstract
During development, multicellular organisms determine and then differentiate regions that constitute the body's architecture. These regions are established and controlled by a number of molecules, including nuclear factors, that drive the organism from the egg to its final shape. We studied the molecules involved in the regionalisation of the freshwater planarian body (Platyhelminthes, Turbelleria, Tricladida).
- Published
- 2001
29. RNA interference: a new powerful tool for functional genomic analysis
- Author
-
Hernández-Hernández, Víctor, Fernández-Rodríguez, Juana, Bueno i Torrens, David, Vila-Farré, Miquel, Cardona, Albert T., Sancho, Vanessa, and Romero i Benedí, Rafael
- Abstract
En moltes espècies, la introducció de RNAs de doble cadena indueix un silenciament gènic molt específic i potent, anomenat interferència induïda per RNA. Aquest fenomen, basat en la degradació dirigida de mRNAs, es produeix en gairebé tots els eucariotes, des de tripanosomes a ratolins, incloent-hi fongs i plantes. Les seves possibles aplicacions en ciència bàsica i aplicada han despertat un interès general. La interferència induïda per RNA, que actualment s'empra per investigar la funció gènica en sistemes molt diversos, està relacionada amb la resistència natural a virus i al silenciament de transposons, com si fos un sistema immunitari primitiu implicat en la vigilància i control del genoma. En aquest article, fem una revisió dels mecanismes d'actuació del silenciament gènic postranscripcional induït per la interferència de RNA, de la seva funció a la natura, de la importància que té la seva aplicació en estudis de genòmica funcional i de les modificacions i millores que el fan més efectiu i heretable, i discutim les perspectives de futur d'aquesta tècnica tan versàtil en ciència bàsica i aplicada., In many species, the introduction of double-stranded RNA induces potent and specific gene silencing, referred to as RNA interference. This phenomenon, which is based on targeted degradation of mRNAs and occurs in almost any eukaryote, from trypanosomes to mice including plants and fungi, has sparked general interest from both applied and fundamental standpoints. RNA interference, which is currently used to investigate gene function in a variety of systems, is linked to natural resistance to viruses and transposon silencing, as if it were a primitive immune system involved in genome surveillance. Here, we review the mechanism of RNA interference in post-transcriptional gene silencing, its function in nature, its value for functional genomic analysis, and the modifications and improvements that may make it more efficient and inheritable. We also discuss the future directions of this versatile technique in both fundamental and applied science.
- Published
- 2001
30. Functional and Structural Analysis of C-Terminal BRCA1 Missense Variants
- Author
-
Quiles, Francisco, primary, Fernández-Rodríguez, Juana, additional, Mosca, Roberto, additional, Feliubadaló, Lídia, additional, Tornero, Eva, additional, Brunet, Joan, additional, Blanco, Ignacio, additional, Capellá, Gabriel, additional, Pujana, Miquel Àngel, additional, Aloy, Patrick, additional, Monteiro, Alvaro, additional, and Lázaro, Conxi, additional
- Published
- 2013
- Full Text
- View/download PDF
31. Modulation of aberrant NF1 pre-mRNA splicing by kinetin treatment
- Author
-
Pros, Eva, primary, Fernández-Rodríguez, Juana, additional, Benito, Llúcia, additional, Ravella, Anna, additional, Capellá, Gabriel, additional, Blanco, Ignacio, additional, Serra, Eduard, additional, and Lázaro, Conxi, additional
- Published
- 2009
- Full Text
- View/download PDF
32. Modulation of aberrant NF1 pre-mRNA splicing by kinetin treatment.
- Author
-
Pros, Eva, Fernández-Rodríguez, Juana, Benito, Llúcia, Ravella, Anna, Capellá, Gabriel, Blanco, Ignacio, Serra, Eduard, and Lázaro, Conxi
- Subjects
- *
MESSENGER RNA , *GENETIC disorders , *MEDICAL genetics , *CELL lines , *CELL culture - Abstract
Neurofibromatosis type 1 is one of the most common neurocutaneous autosomal dominant disorders. It is caused by mutations in the neurofibromatosis type 1 (NF1) gene and approximately 30–40% of them affect the correct splicing of NF1 pre-mRNA. In this report, we evaluate the effect of five different drugs, previously found to modify splicing in several genetic disorders, on the splicing of mutated NF1 alleles. For this purpose, cell lines derived from patients bearing 19 different NF1-splicing defects were used. Our results showed that kinetin partially corrects the splicing defect in four of the studied mutations (c.910C>T, c.3113G>A, c.6724C>T and c.6791dupA). Our study is a valuable contribution to the field because it identifies new exon-skipping events that can be reversed by kinetin treatment and provides new information about kinetin splicing modulation. However, owing to the nature of mutations in our patients, kinetin treatment could not be used as a therapeutic agent in these cases. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.