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3. The remarkable impact of Opuntia Ficus Indica fruit administration on metabolic syndrome: Correlations between cognitive functions, oxidative stress and lipid dysmetabolism in the high-fat, diet-fed rat model

Author

Di Majo, Danila, Ricciardi, Nicolò, Di Liberto, Valentina, Allegra, Mario, Frinchi, Monica, Urone, Giulia, Scordino, Miriana, Massaro, Alessandro, Mudò, Giuseppa, Ferraro, Giuseppe, Sardo, Pierangelo, Giglia, Giuseppe, and Gambino, Giuditta

Published
2024
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6. Bispyrene functionalization drives self-assembly of graphite nanoplates into highly efficient heat spreader foils

Author

Ferraro, Giuseppe, Bernal, Mar, Carniato, Fabio, Novara, Chiara, Tortello, Mauro, Ronchetti, Silvia, Giorgis, Fabrizio, and Fina, Alberto

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science
Abstract

Thermally conductive nanopapers fabricated from graphene and related materials are currently showing a great potential in thermal management applications. However, thermal contacts between conductive plates represent the bottleneck for thermal conductivity of nanopapers prepared in the absence of a high temperature step for graphitization. In this work, the problem of ineffective thermal contacts is addressed by the use of bifunctional polyaromatic molecules designed to drive self-assembly of graphite nanoplates (GnP) and establish thermal bridges between them. To preserve the high conductivity associated to defect-free sp2 structure, non-covalent functionalization with bispyrene compounds, synthesised on purpose with variable tethering chain length, was exploited. Pyrene terminal groups granted for a strong {\pi}-{\pi} interaction with graphene surface, as demonstrated by UV-Vis, fluorescence and Raman spectroscopies. Bispyrene molecular junctions between GnP were found to control GnP organization and orientation within the nanopaper, delivering significant enhancement in both in-plane and cross-plane thermal diffusivity. Finally, nanopapers were validated as heat spreader devices for electronic components, evidencing comparable or better thermal dissipation performance than conventional Cu foil, while delivering over 90% weight reduction.

Published
2021

9. Mitochondrial transfer from Adipose stem cells to breast cancer cells drives multi-drug resistance

Author

Del Vecchio, Vitale, Rehman, Ayesha, Panda, Sameer Kumar, Torsiello, Martina, Marigliano, Martina, Nicoletti, Maria Maddalena, Ferraro, Giuseppe Andrea, De Falco, Vincenzo, Lappano, Rosamaria, Lieto, Eva, Pagliuca, Francesca, Caputo, Carlo, La Noce, Marcella, Papaccio, Gianpaolo, Tirino, Virginia, Robinson, Nirmal, Desiderio, Vincenzo, and Papaccio, Federica

Published
2024
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15. FTIR and GCMS analysis of epoxy resin decomposition products feeding the flame during UL 94 standard flammability test. Application to the understanding of the blowing-out effect in epoxy/polyhedral silsesquioxane formulations

Author

Zhang, Wenchao, Fina, Alberto, Ferraro, Giuseppe, and Yang, Rongjie

Subjects
Physics - Chemical Physics
Abstract

A novel method was developed for the sampling of volatiles produces by polymer decomposition during UL94 standard flammability tests, allowing to collect, separate and analyze the precise composition of the fuel mixture feeding the flame in the real flammability tests. The system was validated on epoxy resin/polyhedral oligomeric silsesquioxanes and found extremely informative for the understanding of the flame retardancy mechanisms of POSS, previously referred to as the blowing-out effect. Collected products were analyzed by infrared spectroscopy and gas chromatography/mass spectroscopy, to identify the gaseous and liquid decomposition products, allowing to depict a comprehensive decomposition pathway for the epoxy resin. Lightweight volatiles, gaseous at room temperature, showed limited differences as a function of DOPO-POSS, whereas mixtures of liquid products evidenced for dramatic changes in the relative concentration as a function of DOPO-POSS. In pristine epoxy resin, the most abundant products were recognized as benzene, phenol, naphthalene and toluene, along with several tens of other aromatic products observed in lower amounts. The presence of DOPO-POSS at low concentration radically changes the composition of the aromatic volatiles mixture, as no significant amount of benzene is produced, while phenol becomes the main product, accounting for about half of the total, isopropyl phenol and bisphenol A, along with several tens of other products in lower concentrations. Such modification of the fuel mixture feeding the flame provided an explanation for the lower flammability of this formulation, as well as for the phenomenology of the blowing out effect.

Published
2018

16. CGRP Antagonism and Ketogenic Diet in the Treatment of Migraine

Author

Finelli, Francesca, primary, Catalano, Alessia, additional, De Lisa, Michele, additional, Ferraro, Giuseppe Andrea, additional, Genovese, Sabino, additional, Giuzio, Federica, additional, Salvia, Rosanna, additional, Scieuzo, Carmen, additional, Sinicropi, Maria Stefania, additional, Svolacchia, Fabiano, additional, Vassallo, Antonio, additional, Santarsiere, Alessandro, additional, and Saturnino, Carmela, additional

Published
2024
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18. Exosomes and Signaling Nanovesicles from the Nanofiltration of Preconditioned Adipose Tissue with Skin-B ® in Tissue Regeneration and Antiaging: A Clinical Study and Case Report.

Author

Svolacchia, Fabiano, Svolacchia, Lorenzo, Falabella, Patrizia, Scieuzo, Carmen, Salvia, Rosanna, Giglio, Fabiana, Catalano, Alessia, Saturnino, Carmela, Di Lascio, Pierpaolo, Guarro, Giuseppe, Imbriani, Giusy Carmen, Ferraro, Giuseppe, and Giuzio, Federica

Subjects
ADIPOSE tissues, SKIN regeneration, REGENERATION (Biology), NANOFILTRATION, EXOSOMES, ADIPOSE tissue diseases
Abstract

Background and Objectives: This three-year clinical trial aimed to demonstrate that only the signaling vesicles produced by ADSCa, containing mRNA, microRNA, growth factors (GFs), and bioactive peptides, provide an advantage over classical therapy with adipose disaggregate to make the tissue regeneration technique safer due to the absence of interfering materials and cells, while being extremely minimally invasive. The infiltration of disaggregated adipose nanofat, defined by the Tonnard method, for the regeneration of the dermis and epidermis during physiological or pathological aging continues to be successfully used for the presence of numerous adult stem cells in suspension (ADSCa). An improvement in this method is the exclusion of fibrous shots and cellular debris from the nanofat to avoid inflammatory phenomena by microfiltration. Materials and Methods: A small amount of adipose tissue was extracted after surface anesthesia and disaggregated according to the Tonnard method. An initial microfiltration at 20/40 microns was performed to remove fibrous shots and cellular debris. The microfiltration was stabilized with a sterile solution containing hyaluronic acid and immediately ultrafiltered to a final size of 0.20 microns to exclude the cellular component and hyaluronic acid chains of different molecular weights. The suspension was then injected into the dermis using a mesotherapy technique with microinjections. Results: This study found that it is possible to extract signaling microvesicles using a simple ultrafiltration system. The Berardesca Scale, Numeric Rating Scale (NRS), and Modified Vancouver Scale (MVS) showed that it is possible to obtain excellent results with this technique. The ultrafiltrate can validly be used in a therapy involving injection into target tissues affected by chronic and photoaging with excellent results. Conclusions: This retrospective clinical evaluation study allowed us to consider the results obtained with this method for the treatment of dermal wrinkles and facial tissue furrows as excellent. The method is safe and an innovative regenerative therapy as a powerful and viable alternative to skin regeneration therapies, antiaging therapies, and chronic inflammatory diseases because it lacks the inflammatory component produced by cellular debris and fibrous sprouts and because it can exclude the mesenchymal cellular component by reducing multiple inflammatory cytokine levels. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Red and golden tomato administration improves fat diet-induced hepatic steatosis in rats by modulating HNF4α, Lepr, and GK expression

Author

Pipitone, Rosaria Maria, primary, Zito, Rossella, additional, Gambino, Giuditta, additional, Di Maria, Gabriele, additional, Javed, Ayesha, additional, Lupo, Giulia, additional, Giglia, Giuseppe, additional, Sardo, Pierangelo, additional, Ferraro, Giuseppe, additional, Rappa, Francesca, additional, Carlisi, Daniela, additional, Di Majo, Danila, additional, and Grimaudo, Stefania, additional

Published
2023
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24. “Golden” Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on the Redox Balance in the High-Fat-Diet-Fed Rat

Author

Gambino, Giuditta, primary, Giglia, Giuseppe, additional, Allegra, Mario, additional, Di Liberto, Valentina, additional, Zummo, Francesco Paolo, additional, Rappa, Francesca, additional, Restivo, Ignazio, additional, Vetrano, Filippo, additional, Saiano, Filippo, additional, Palazzolo, Eristanna, additional, Avellone, Giuseppe, additional, Ferraro, Giuseppe, additional, Sardo, Pierangelo, additional, and Di Majo, Danila, additional

Published
2023
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27. An Unconventional Oral Candidiasis in an Immunocompetent Patient

Author

Fusco, Alessandra, primary, Contaldo, Maria, additional, Savio, Vittoria, additional, Baroni, Adone, additional, Ferraro, Giuseppe A., additional, Di Stasio, Dario, additional, Lucchese, Alberta, additional, Chiaromonte, Adriana, additional, Donnarumma, Giovanna, additional, and Serpico, Rosario, additional

Published
2023
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28. Correlation of Metabolic Syndrome with Redox Homeostasis Biomarkers: Evidence from High-Fat Diet Model in Wistar Rats

Author

Di Majo, Danila, primary, Sardo, Pierangelo, additional, Giglia, Giuseppe, additional, Di Liberto, Valentina, additional, Zummo, Francesco Paolo, additional, Zizzo, Maria Grazia, additional, Caldara, Gaetano Felice, additional, Rappa, Francesca, additional, Intili, Giorgia, additional, van Dijk, Roelof Maarten, additional, Gallo, Daniele, additional, Ferraro, Giuseppe, additional, and Gambino, Giuditta, additional

Published
2022
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31. Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through Non-Invasive Brain Stimulation

Author

Gambino, Giuditta, primary, Brighina, Filippo, additional, Allegra, Mario, additional, Marrale, Maurizio, additional, Collura, Giorgio, additional, Gagliardo, Cesare, additional, Attanzio, Alessandro, additional, Tesoriere, Luisa, additional, Di Majo, Danila, additional, Ferraro, Giuseppe, additional, Sardo, Pierangelo, additional, and Giglia, Giuseppe, additional

Published
2022
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32. Validation of the INCREMENT‐SOT‐CPE score in a large cohort of liver transplant recipients with carbapenem‐resistant Enterobacterales infection

Author

Rinaldi, Matteo, Bonazzetti, Cecilia, Gallo, Mena, Ferraro, Giuseppe, Freire, Maristela, Terrabuio, Débora Raquel Benedita, Tandoi, Francesco, Romagnoli, Renato, De Rosa, Francesco Giuseppe, Mularoni, Alessandra, Ferrarese, Alberto, Burra, Patrizia, Halpern, Marcia, Balbi, Elizabeth, Simkins, Jacques, Abbo, Lilian, Morrás, Ignacio, Cantero, Mireia, Alagna, Laura, Bandera, Alessandra, Clemente, Wanessa Trinidade, Valerio, Maricela, Fernández, Ainhoa, Muñoz, Patricia, Statlender, Liran, Yahav, Dafna, Camargo, Luis Fernando Aranha, Girão, Evelyne Santana, Grossi, Paolo, Viale, Pierluigi, Curti, Stefania, Giannella, Maddalena, Rinaldi M., Bonazzetti C., Gallo M., Ferraro G., Freire M., Terrabuio D.R.B., Tandoi F., Romagnoli R., De Rosa F.G., Mularoni A., Ferrarese A., Burra P., Halpern M., Balbi E., Simkins J., Abbo L., Morrás I., Cantero M., Alagna L., Bandera A., Clemente W.T., Valerio M., Fernández A., Muñoz P., Statlender L., Yahav D., Camargo L.F.A., Girão E.S., Grossi P., Viale P., Curti S., and Giannella M.

Subjects
INCREMENT-SOT-CPE score, Transplantation, Infectious Diseases, CRE infection, liver transplantation, SOT
Abstract

Background: Management of infections due to carbapenemase-resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT-SOT-CPE score has been specifically developed from SOT recipients to stratify mortality risk, but an external validation is lacking.Methods: Multicenter retrospective cohort study of liver transplant (LT) recipients colonized with CRE infection who developed infection after transplant over 7-year period. Primary endpoint was all-cause 30-day mortality from infection onset. A comparison between INCREMENT-SOT-CPE and other selected scores was performed. A two-level mixed effects logistic regression model with random effects for the center was fitted. Performance characteristics at optimal cut-point were calculated. Multivariable Cox regression analysis of risk factors for all-cause 30-day mortality was carried out.Results: Overall, 250 CRE carriers developed infection after LT and were analyzed. The median age was 55 years (interquartile range [IQR]: 46-62) and 157 were males (62.8%). All-cause 30-day mortality was 35.6%. A sequential organ failure assessment (SOFA) score >= 11 showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of 69.7%, 76.4%, 62.0%, 82.0%, and 74.0%, respectively. An INCREMENT-SOT-CPE >= 11 reported a sensitivity, specificity, PPV, NPV, and accuracy of 73.0%, 62.1%, 51.6%, 80.6% and 66.0%, respectively. At multivariable analysis acute renal failure, prolonged mechanical ventilation, INCREMENT-SOT-CPE score >= 11 and SOFA score >= 11 were independently associated with all-cause 30-day mortality, while a tigecycline-based targeted regimen was found to be protective.Conclusions: Both INCREMENT-SOT-CPE >= 11 and SOFA >= 11 were identified as strong predictors of all-cause 30-day mortality in a large cohort of CRE carriers developing infection after LT.

Published
2023

37. Systemic Beta-Hydroxybutyrate Affects BDNF and Autophagy into the Retina of Diabetic Mice

Author

Trotta, Maria Consiglia, primary, Gesualdo, Carlo, additional, Herman, Hildegard, additional, Gharbia, Sami, additional, Balta, Cornel, additional, Lepre, Caterina Claudia, additional, Russo, Marina, additional, Itro, Annalisa, additional, D’Amico, Giovanbattista, additional, Peluso, Luisa, additional, Panarese, Iacopo, additional, Pieretti, Gorizio, additional, Ferraro, Giuseppe, additional, Simonelli, Francesca, additional, D’Amico, Michele, additional, Rossi, Settimio, additional, and Hermenean, Anca, additional

Published
2022
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38. Polydatin Incorporated in Polycaprolactone Nanofibers Improves Osteogenic Differentiation

Author

Lama, Stefania, primary, Luce, Amalia, additional, Bitti, Giuseppe, additional, Chacon-Millan, Pilar, additional, Itro, Annalisa, additional, Ferranti, Pasquale, additional, D’Auria, Giovanni, additional, Cammarota, Marcella, additional, Nicoletti, Giovanni Francesco, additional, Ferraro, Giuseppe Andrea, additional, Schiraldi, Chiara, additional, Caraglia, Michele, additional, Amler, Evzen, additional, and Stiuso, Paola, additional

Published
2022
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41. Dual Passive Reactive Brain-Computer Interface: A Novel Approach to Human-Machine Symbiosis

Author

Dehais, Frédéric, Ladouce, Simon, Darmet, Ludovic, Nong, Tran-Vu, Ferraro, Giuseppe, Torre Tresols, Juan, Velut, Sébastien, Labedan, Patrice, Institut Supérieur de l'Aéronautique et de l'Espace - ISAE-SUPAERO (FRANCE), and Artificial and Natural Intelligence Toulouse Institute - ANITI (FRANCE)

Subjects
Neurosciences, Brain Computer Interface, Geriatrics and Gerontology, Aviation
Abstract

The present study proposes a novel concept of neuroadaptive technology, namely a dual passive-reactive Brain-Computer Interface (BCI), that enables bi-directional interaction between humans and machines. We have implemented such a system in a realistic flight simulator using the NextMind classification algorithms and framework to decode pilots' intention (reactive BCI) and to infer their level of attention (passive BCI). Twelve pilots used the reactive BCI to perform checklists along with an anti-collision radar monitoring task that was supervised by the passive BCI. The latter simulated an automatic avoidance maneuver when it detected that pilots missed an incoming collision. The reactive BCI reached 100% classification accuracy with a mean reaction time of 1.6 s when exclusively performing the checklist task. Accuracy was up to 98.5% with a mean reaction time of 2.5 s when pilots also had to fly the aircraft and monitor the anti-collision radar. The passive BCI achieved aF1−score of 0.94. This first demonstration shows the potential of a dual BCI to improve human-machine teaming which could be applied to a variety of applications.

Published
2022

44. Correlation of Metabolic Syndrome with Redox Homeostasis Biomarkers: Evidence from High-Fat Diet Model in Wistar Rats.

Author

Di Majo, Danila, Sardo, Pierangelo, Giglia, Giuseppe, Di Liberto, Valentina, Zummo, Francesco Paolo, Zizzo, Maria Grazia, Caldara, Gaetano Felice, Rappa, Francesca, Intili, Giorgia, van Dijk, Roelof Maarten, Gallo, Daniele, Ferraro, Giuseppe, and Gambino, Giuditta

Subjects
HIGH-fat diet, LABORATORY rats, METABOLIC syndrome, HOMEOSTASIS, OXIDATION-reduction reaction
Abstract

Metabolic Syndrome (MetS) is an extremely complex disease. A non-balanced diet such as high-fat diet (HFD) induces metabolic dysfunction that could modify redox homeostasis. We here aimed at exploring redox homeostasis in male Wistar rats, following 8 weeks of HFD, correlating the eventual modification of selected biomarkers that could be associated with the clinical manifestations of MetS. Therefore, we selected parameters relative to both the glucose tolerance and lipid altered metabolism, but also oxidative pattern. We assessed some biomarkers of oxidative stress i.e., thiols balance, lipid peroxidation and antioxidant barriers, via the use of specific biochemical assays, individuating eventual cross correlation with parameters relative to MetS through a Principal Component Analysis (PCA). The present study shows that 8 weeks of HFD induce MetS in rats, altering glucose and lipid homeostasis and increasing visceral adipose tissue, but also impairing the physiological antioxidant responses that could not counteract the oxidative stress condition. Crucially, cross-correlation analysis suggested that the assessment of specific oxidative stress parameters reported here can provide information comparable to the more widely acquired biomarkers of Mets such as glucose tolerance. Lastly, hepatic steatosis in association with the oxidative stress condition was also highlighted by histological analysis. This research will elucidate the fundamental impact of these oxidative stress parameters on MetS induced in the HFD rat model, tracing paths for developing prevention approaches. [ABSTRACT FROM AUTHOR]

Published
2023
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48. A New Treatment for Stretch Marks and Skin Ptosis with Electromagnetic Fields and Negative Pressure: A Clinical and Histological Study

Author

Scarano, Antonio, Sbarbati, Andrea, Amore, Roberto, Iorio, Eugenio L, Ferraro, Giuseppe, Lorusso, Felice, and Amuso, Domenico

Subjects
electromagnetic fields, stretch marks, negative pressure, RD1-811, Surgery, skin aging
Abstract

Background: Stretch marks (SM) are nowadays the most common aesthetic pathology of the body; in the XX century, it mainly affected pregnant women, while today it also affects teenagers during puberty, boys and girls without distinction. The aim of this study was to evaluate possible variations in the histological structure of the skin—in terms of quality/quantity of the extracellular matrix and of the collagen and elastic fibers—following the electromagnetic fields and negative pressure (V-EMF) treatment as regards hypotonia and SMs. Materials and Methods: For the current study, 60 women, aged between 25 and 45, were examined. All of them presented deep, white or pearly white colored SMs having had them for between 12 and 25 years. These were documented, asking patients their level of satisfaction, through pictures and biopsies. All patients underwent a cycle of 6 or 8 weekly sessions; everyone was highly satisfied with the results obtained. Results: Biopsies proved that the tissue was reorganized and restored to the original volume, characterized by the production of new, high-quality collagen and elastin molecules, by the reorganization of the basement membrane and by the correct positioning of the melanocytes. No side effects were observed during the treatments. This synergy stands as the most suitable treatment of striae rubra and alba. Conclusion: V-EMF enhances the keratinocyte migration base, melanocytes, and promotes neoangiogenesis with the result of improvement in the SM.

Published
2021

49. Hyaluronan-Based Gel Promotes Human Dental Pulp Stem Cells Bone Differentiation by Activating YAP/TAZ Pathway

Author

La Noce, Marcella, primary, Stellavato, Antonietta, additional, Vassallo, Valentina, additional, Cammarota, Marcella, additional, Laino, Luigi, additional, Desiderio, Vincenzo, additional, Del Vecchio, Vitale, additional, Nicoletti, Giovanni Francesco, additional, Tirino, Virginia, additional, Papaccio, Gianpaolo, additional, Schiraldi, Chiara, additional, and Ferraro, Giuseppe Andrea, additional

Published
2021
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