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1. Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia: an EBMT registry analysis of 1540 patients

Author

Schmälter, Ann-Kristin, Ngoya, Maud, Galimard, Jacques-Emmanuel, Bazarbachi, Ali, Finke, Jürgen, Kröger, Nicolaus, Bornhäuser, Martin, Stelljes, Matthias, Stölzel, Friedrich, Tischer, Johanna, Schroeder, Thomas, Dreger, Peter, Blau, Igor-Wolfgang, Savani, Bipin, Giebel, Sebastian, Esteve, Jordi, Nagler, Arnon, Schmid, Christoph, Ciceri, Fabio, and Mohty, Mohamad

Published
2024
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3. Age-adjusted high-dose chemotherapy followed by autologous stem cell transplantation or conventional chemotherapy with R-MP as first-line treatment in elderly primary CNS lymphoma patients – the randomized phase III PRIMA-CNS trial

Author

Isbell, Lisa K, Uibeleisen, Roswitha, Friedl, Alexander, Burger, Elvira, Dopatka, Tatja, Scherer, Florian, Orban, Andras, Lauer, Eliza, Malenica, Natalie, Semenova, Inna, Vreden, Annika, Valk, Elke, Wendler, Julia, Neumaier, Simone, Fricker, Heidi, El Rabih, Abed Al Hadi, Gloggengießer, Cora, Hilbig, Daniela, Bleul, Sabine, Weis, Joachim, Gmehlin, Dennis, Backenstrass, Matthias, Wirtz, Sebastian, Ihorst, Gabriele, Finke, Jürgen, Illerhaus, Gerald, and Schorb, Elisabeth

Published
2023
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4. Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial

Author

Schubert, Maria-Luisa, Schmitt, Anita, Hückelhoven-Krauss, Angela, Neuber, Brigitte, Kunz, Alexander, Waldhoff, Philip, Vonficht, Dominik, Yousefian, Schayan, Jopp-Saile, Lea, Wang, Lei, Korell, Felix, Keib, Anna, Michels, Birgit, Haas, Dominik, Sauer, Tim, Derigs, Patrick, Kulozik, Andreas, Kunz, Joachim, Pavel, Petra, Laier, Sascha, Wuchter, Patrick, Schmier, Johann, Bug, Gesine, Lang, Fabian, Gökbuget, Nicola, Casper, Jochen, Görner, Martin, Finke, Jürgen, Neubauer, Andreas, Ringhoffer, Mark, Wolleschak, Denise, Brüggemann, Monika, Haas, Simon, Ho, Anthony D., Müller-Tidow, Carsten, Dreger, Peter, and Schmitt, Michael

Published
2023
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5. Comorbidities in transplant recipients with acute myeloid leukemia receiving low-intensity conditioning regimens: an ALWP EBMT study

Author

Fein, Joshua A., Shouval, Roni, Galimard, Jacques-Emmanuel, Labopin, Myriam, Socié, Gérard, Finke, Jürgen, Cornelissen, Jan J., Malladi, Ram, Itälä-Remes, Maija, Chevallier, Patrice, Orchard, Kim H., Bunjes, Donald, Aljurf, Mahmoud, Rubio, Marie Thérèse, Versluis, Jurjen, Mohty, Mohamad, and Nagler, Arnon

Published
2023
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6. Long-Term Results of Allogeneic Stem Cell Transplantation in Adult Ph- Negative High-Risk Acute Lymphoblastic Leukemia

Author

Beelen, Dietrich W., Arnold, Renate, Stelljes, Matthias, Alakel, Nael, Brecht, Arne, Bug, Gesine, Bunjes, Donald, Faul, Christoph, Finke, Jürgen, Franke, Georg-Nikolaus, Holler, Ernst, Kobbe, Guido, Kröger, Nicolaus, Rösler, Wolf, Scheid, Christof, Schönland, Stefan, Stadler, Michael, Tischer, Johanna, Wagner-Drouet, Eva, Wendelin, Knut, Brüggemann, Monika, Reiser, Lena, Hoelzer, Dieter, and Gökbuget, Nicola

Published
2022
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7. Role of allogeneic transplantation in chronic myelomonocytic leukemia: an international collaborative analysis

Author

Robin, Marie, de Wreede, Liesbeth C., Padron, Eric, Bakunina, Katerina, Fenaux, Pierre, Koster, Linda, Nazha, Aziz, Beelen, Dietrich W., Rampal, Raajit K., Sockel, Katja, Komrokji, Rami S., Gagelmann, Nico, Eikema, Dirk-Jan, Radujkovic, Aleksandar, Finke, Jürgen, Potter, Victoria, Killick, Sally B., Legrand, Faezeh, Solary, Eric, Broom, Angus, Garcia-Manero, Guillermo, Rizzoli, Vittorio, Hayden, Patrick, Patnaik, Mrinal M., Onida, Francesco, Yakoub-Agha, Ibrahim, and Itzykson, Raphael

Published
2022
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9. Impact of comorbidities and body mass index on the outcomes of allogeneic hematopoietic cell transplantation in myelofibrosis: A study on behalf of the Chronic Malignancies Working Party of EBMT

Author

Polverelli, Nicola, primary, Bonneville, Edouard F., additional, de Wreede, Liesbeth C., additional, Koster, Linda, additional, Kröger, Nicolaus Martin, additional, Schroeder, Thomas, additional, Peffault de Latour, Régis, additional, Passweg, Jakob, additional, Sockel, Katja, additional, Broers, Annoek E. C., additional, Clark, Andrew, additional, Dreger, Peter, additional, Blaise, Didier, additional, Yakoub‐Agha, Ibrahim, additional, Petersen, Soeren Lykke, additional, Finke, Jürgen, additional, Chevallier, Patrice, additional, Helbig, Grzegorz, additional, Rabitsch, Werner, additional, Sammassimo, Simona, additional, Arcaini, Luca, additional, Russo, Domenico, additional, Drozd‐Sokolowska, Joanna, additional, Raj, Kavita, additional, Robin, Marie, additional, Battipaglia, Giorgia, additional, Czerw, Tomasz, additional, Hernández‐Boluda, Juan Carlos, additional, and McLornan, Donal P., additional

Published
2024
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10. A prognostic score including mutation profile and clinical features for patients with CMML undergoing stem cell transplantation

Author

Gagelmann, Nico, Badbaran, Anita, Beelen, Dietrich W., Salit, Rachel B., Stölzel, Friedrich, Rautenberg, Christina, Becker, Heiko, Radujkovic, Aleksandar, Panagiota, Victoria, Bogdanov, Rashit, Christopeit, Maximilian, Park, Yong, Nibourel, Olivier, Luft, Thomas, Koldehoff, Michael, Corsten, Maarten, Heuser, Michael, Finke, Jürgen, Kobbe, Guido, Platzbecker, Uwe, Robin, Marie, Scott, Bart L., and Kröger, Nicolaus

Published
2021
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11. FLAMSA-Based Reduced-Intensity Conditioning versus Myeloablative Conditioning in Younger Patients with Relapsed/Refractory Acute Myeloid Leukemia with Active Disease at the Time of Allogeneic Stem Cell Transplantation: An Analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Rodríguez-Arbolí, Eduardo, Labopin, Myriam, Tischer, Johanna, Brecht, Arne, Ganser, Arnold, Finke, Jürgen, Blau, Igor Wolfgang, Kröger, Nicolaus, Kalhs, Peter, Forcade, Edouard, Bunjes, Donald, Spyridonidis, Alexandros, Savani, Bipin, Nagler, Arnon, and Mohty, Mohamad

Published
2020
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14. Role of Age and Hematopoietic Cell Transplantation-Specific Comorbidity Index in Myelodysplastic Patients Undergoing an Allotransplant: A Retrospective Study from the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation

Author

Carré, Martin, Porcher, Raphaël, Finke, Jürgen, Ehninger, Gerhard, Koster, Linda, Beelen, Dietrich, Ganser, Arnold, Volin, Liisa, Lozano, Sara, Friis, Lone, Michallet, Mauricette, Tischer, Johanna, Olavarria, Eduardo, Cascon, Maria Jesús Pascual, Iacobelli, Simona, Koc, Yener, Jindra, Pavel, Arat, Mutlu, de Witte, Theo, Yakoub Agha, Ibrahim, Kröger, Nicolaus, and Robin, Marie

Published
2020
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15. Myeloablative and Reduced-Intensity Conditioned Allogeneic Hematopoietic Stem Cell Transplantation in Myelofibrosis: A Retrospective Study by the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation

Author

McLornan, Donal, Szydlo, Richard, Koster, Linda, Chalandon, Yves, Robin, Marie, Wolschke, Christine, Beelen, Dietrich, Socié, Gerard, Bornhäuser, Martin, Angelucci, Emanuele, Niederwieser, Dietger, Gerbitz, Arnim, Finke, Jürgen, Vitek, Antonin, Itälä-Remes, Maija, Radujkovic, Aleksandar, Kanz, Lothar, Potter, Victoria, Chevallier, Patrice, Stelljes, Matthias, Petersen, Eefke, Robinson, Stephen, Poiré, Xavier, Klyuchnikov, Evgeny, Hernández-Boluda, Juan Carlos, Czerw, Tomasz, Hayden, Patrick, Kröger, Nicolaus, and Yakoub-Agha, Ibrahim

Published
2019
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16. Comparable Long-Term Outcome after Allogeneic Stem Cell Transplantation from Sibling and Matched Unrelated Donors in Patients with Acute Myeloid Leukemia Older Than 50 Years: A Report on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Shimoni, Avichai, Labopin, Myriam, Savani, Bipin, Byrne, Michael, Volin, Liisa, Finke, Jürgen, Niederwieser, Dietger, Ehninger, Gerhard, Blaise, Didier, Beelen, Dietrich, Tabrizi, Reza, Sengeloev, Henrik, Ganser, Arnold, Cornelissen, Jan J., Mohty, Mohamad, and Nagler, Arnon

Published
2019
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17. Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party

Author

Radujkovic, Aleksandar, Dietrich, Sascha, Blok, Henric-Jan, Nagler, Arnon, Ayuk, Francis, Finke, Jürgen, Tischer, Johanna, Mayer, Jiri, Koc, Yener, Sorà, Federica, Passweg, Jakob, Byrne, Jenny L., Jindra, Pavel, Veelken, Joan Hendrik, Socié, Gerard, Maertens, Johan, Schaap, Nicolaas, Stadler, Michael, Itälä-Remes, Maija, Tholouli, Eleni, Arat, Mutlu, Rocha, Vanderson, Ljungman, Per, Yakoub-Agha, Ibrahim, Kröger, Nicolaus, and Chalandon, Yves

Published
2019
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19. Allogeneic hematopoietic stem cell transplantation in patients aged 60-79 years in Germany (1998-2018): a registry study

Author

Weller, Jan Frederic, primary, Lengerke, Claudia, additional, Finke, Jürgen, additional, Schetelig, Johannes, additional, Platzbecker, Uwe, additional, Einsele, Hermann, additional, Schroeder, Thomas, additional, Faul, Christoph, additional, Stelljes, Matthias, additional, Dreger, Peter, additional, Blau, Igor W., additional, Wulf, Gerald, additional, Tischer, Johanna, additional, Scheid, Christoph, additional, Elmaagacli, Ahmet, additional, Neidlinger, Helga, additional, Flossdorf, Sarah, additional, Bornhäuser, Martin, additional, Bethge, Wolfgang, additional, Fleischhauer, Katharina, additional, Kröger, Nicolaus, additional, De Wreede, Liesbeth C., additional, and Christopeit, Maximilian, additional

Published
2023
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20. Transplant Outcomes for Secondary Acute Myeloid Leukemia: Acute Leukemia Working Party of the European Society for Blood and Bone Marrow Transplantation Study

Author

Sengsayadeth, Salyka, Labopin, Myriam, Boumendil, Ariane, Finke, Jürgen, Ganser, Arnold, Stelljes, Matthias, Ehninger, Gerhard, Beelen, Dietrich, Niederwieser, Dietger, Blaise, Didier, Dreger, Peter, Mufti, Ghulam, Chevallier, Patrice, Mailhol, Audrey, Gatwood, Katie S., Gorin, Norbert, Esteve, Jordi, Ciceri, Fabio, Baron, Frederic, Schmid, Christoph, Giebel, Sebastian, Mohty, Mohamad, Savani, Bipin N., and Nagler, Arnon

Published
2018
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21. Allogeneic Stem Cell Transplantation for Myelodysplastic Syndrome Patients with a 5q Deletion

Author

Garderet, Laurent, Ziagkos, Dimitris, van Biezen, Anja, Iacobelli, Simona, Finke, Jürgen, Maertens, Johan, Volin, Liisa, Ljungman, Per, Chevallier, Patrice, Passweg, Jakob, Schaap, Nicolaas, Beelen, Dietrich, Nagler, Arnon, Blaise, Didier, Poiré, Xavier, Yakoub-Agha, Ibrahim, Lenhoff, Stig, Craddock, Charles, Schots, Rik, Rambaldi, Alessandro, Sanz, Jaime, Jindra, Pavel, Mufti, Ghulam J., Robin, Marie, and Kröger, Nicolaus

Published
2018
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22. Late treatment-related mortality versus competing causes of death after allogeneic transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia

Author

Schetelig, Johannes, de Wreede, Liesbeth C., van Gelder, Michel, Koster, Linda, Finke, Jürgen, Niederwieser, Dietger, Beelen, Dietrich, Mufti, G. J., Platzbecker, Uwe, Ganser, Arnold, Heidenreich, Silke, Maertens, Johan, Socié, Gerard, Brecht, Arne, Stelljes, Matthias, Kobbe, Guido, Volin, Liisa, Nagler, Arnon, Vitek, Antonin, Luft, Thomas, Ljungman, Per, Yakoub-Agha, Ibrahim, Robin, Marie, and Kröger, Nicolaus

Published
2019
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23. Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel

Author

de Witte, Theo, Bowen, David, Robin, Marie, Malcovati, Luca, Niederwieser, Dietger, Yakoub-Agha, Ibrahim, Mufti, Ghulam J., Fenaux, Pierre, Sanz, Guillermo, Martino, Rodrigo, Alessandrino, Emilio Paolo, Onida, Francesco, Symeonidis, Argiris, Passweg, Jakob, Kobbe, Guido, Ganser, Arnold, Platzbecker, Uwe, Finke, Jürgen, van Gelder, Michel, van de Loosdrecht, Arjan A., Ljungman, Per, Stauder, Reinhard, Volin, Liisa, Deeg, H.Joachim, Cutler, Corey, Saber, Wael, Champlin, Richard, Giralt, Sergio, Anasetti, Claudio, and Kröger, Nicolaus

Published
2017
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24. Allogeneic Stem Cell Transplantation for Patients Age ≥ 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic Malignancies Working Party of the EBMT

Author

Heidenreich, Silke, Ziagkos, Dimitris, de Wreede, Liesbeth C., van Biezen, Anja, Finke, Jürgen, Platzbecker, Uwe, Niederwieser, Dietger, Einsele, Hermann, Bethge, Wolfgang, Schleuning, Michael, Beelen, Dietrich W., Tischer, Johanna, Nagler, Arnon, Glass, Bertram, Maertens, Johan, Yáñez, Lucrecia, Beguin, Yves, Sill, Heinz, Scheid, Christof, Stelljes, Matthias, Ganser, Arnold, Zachée, Pierre, Selleslag, Dominik, de Witte, Theo, Robin, Marie, and Kröger, Nicolaus

Published
2017
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26. Feasibility and Outcomes of a Third Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Rank, Andreas, Peczynski, Christophe, Labopin, Myriam, Stelljes, Matthias, Simand, Celestine, Helbig, Grzegorz, Finke, Jürgen, Santarone, Stella, Tischer, Johanna, Lange, Andrzej, Mistrik, Martin, Houhou, Mohamed, Schmid, Christoph, Nagler, Arnon, and Mohty, Mohamad

Published
2021
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27. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Author

Mathew, Nimitha R, Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A, Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L, Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael, Bettinger, Dominik, Thimme, Robert, Ullrich, Evelyn, Tanriver, Yakup, Vuong, Giang Lam, Arnold, Renate, Hemmati, Philipp, Wolf, Dominik, Ditschkowski, Markus, Jilg, Cordula, Wilhelm, Konrad, Leiber, Christian, Gerull, Sabine, Halter, Jörg, Lengerke, Claudia, Pabst, Thomas, Schroeder, Thomas, Kobbe, Guido, Rösler, Wolf, Doostkam, Soroush, Meckel, Stephan, Stabla, Kathleen, Metzelder, Stephan K, Halbach, Sebastian, Brummer, Tilman, Hu, Zehan, Dengjel, Joern, Hackanson, Björn, Schmid, Christoph, Holtick, Udo, Scheid, Christof, Spyridonidis, Alexandros, Stölzel, Friedrich, Ordemann, Rainer, Müller, Lutz P, Sicre-de-Fontbrune, Flore, Ihorst, Gabriele, Kuball, Jürgen, Ehlert, Jan E, Feger, Daniel, Wagner, Eva-Maria, Cahn, Jean-Yves, Schnell, Jacqueline, Kuchenbauer, Florian, Bunjes, Donald, Chakraverty, Ronjon, Richardson, Simon, Gill, Saar, Kröger, Nicolaus, Ayuk, Francis, Vago, Luca, Ciceri, Fabio, Müller, Antonia M, Kondo, Takeshi, Teshima, Takanori, Klaeger, Susan, Kuster, Bernhard, Weisdorf, Daniel, van der Velden, Walter, Dörfel, Daniela, Bethge, Wolfgang, Hilgendorf, Inken, Hochhaus, Andreas, Andrieux, Geoffroy, Börries, Melanie, Busch, Hauke, Magenau, John, Reddy, Pavan, Labopin, Myriam, Antin, Joseph H, Henden, Andrea S, Hill, Geoffrey R, Kennedy, Glen A, Bar, Merav, Sarma, Anita, McLornan, Donal, Mufti, Ghulam, Oran, Betul, Rezvani, Katayoun, Shah, Omid, Negrin, Robert S, Nagler, Arnon, Prinz, Marco, Burchert, Andreas, Neubauer, Andreas, Beelen, Dietrich, Mackensen, Andreas, von Bubnoff, Nikolas, Herr, Wolfgang, Becher, Burkhard, Socié, Gerard, Caligiuri, Michael A, Ruggiero, Eliana, Bonini, Chiara, Häcker, Georg, Duyster, Justus, Finke, Jürgen, Pearce, Erika, Blazar, Bruce R, and Zeiser, Robert

Subjects
Interleukin-15 -- Health aspects, Gene mutation -- Health aspects, Sorafenib -- Patient outcomes, Gene expression -- Health aspects, Acute myelocytic leukemia -- Genetic aspects -- Development and progression -- Drug therapy, Biological sciences, Health
Abstract

Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) have a 1-year survival rate below 20%. We observed that sorafenib, a multitargeted tyrosine kinase inhibitor, increased IL-15 production by FLT3-ITD[sup.+] leukemia cells. This synergized with the allogeneic CD8[sup.+] T cell response, leading to long-term survival in six mouse models of FLT3-ITD[sup.+] AML. Sorafenib-related IL-15 production caused an increase in CD8[sup.+]CD107a[sup.+]IFN-[gamma][sup.+] T cells with features of longevity (high levels of Bcl-2 and reduced PD-1 levels), which eradicated leukemia in secondary recipients. Mechanistically, sorafenib reduced expression of the transcription factor ATF4, thereby blocking negative regulation of interferon regulatory factor 7 (IRF7) activation, which enhanced IL-15 transcription. Both IRF7 knockdown and ATF4 overexpression in leukemia cells antagonized sorafenib-induced IL-15 production in vitro. Human FLT3-ITD[sup.+] AML cells obtained from sorafenib responders following sorafenib therapy showed increased levels of IL-15, phosphorylated IRF7, and a transcriptionally active IRF7 chromatin state. The mitochondrial spare respiratory capacity and glycolytic capacity of CD8[sup.+] T cells increased upon sorafenib treatment in sorafenib responders but not in nonresponders. Our findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7-IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans. Therefore, sorafenib treatment has the potential to contribute to an immune-mediated cure of FLT3-ITD-mutant AML relapse, an otherwise fatal complication after allo-HCT., Author(s): Nimitha R Mathew [1, 2]; Francis Baumgartner [1]; Lukas Braun [1]; David O'Sullivan [3]; Simone Thomas [4]; Miguel Waterhouse [1]; Tony A Müller [1]; Kathrin Hanke [1, 2]; Sanaz [...]

Published
2018
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28. Continuously Improving Outcome over Time after Second Allogeneic Stem Cell Transplantation in Relapsed Acute Myeloid Leukemia - a Retrospective Analysis of 1540 Patients on Behalf of the Acute Leukemia Working Party of EBMT

Author

Schmälter, Ann-Kristin, Ngoya, Maud, Finke, Jürgen, Kröger, Nicolaus, Stölzel, Friedrich, Stelljes, Matthias, Valerius, Thomas, Tischer, Johanna, Schröder, Thomas, Dreger, Peter, Blau, Igor Wolfgang, Savani, Bipin, Giebel, Sebastian, Esteve, Jordi, Bazarbachi, Ali, Nagler, Arnon, Schmid, Christoph, Ciceri, Fabio, and Mohty, Mohamad

Subjects
Immunology, ddc:610, Cell Biology, Hematology, Biochemistry
Published
2022

29. Treosulfan compared with <scp>reduced‐intensity</scp> busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial

Author

Beelen, Dietrich, Stelljes, Matthias, Reményi, Péter, Wagner‐Drouet, Eva‐Maria, Dreger, Peter, Bethge, Wolfgang, Ciceri, Fabio, Stölzel, Friedrich, Junghanß, Christian, Labussiere‐Wallet, Hélène, Schaefer‐Eckart, Kerstin, Grigoleit, Goetz U., Scheid, Christof, Patriarca, Francesca, Rambaldi, Alessandro, Niederwieser, Dietger, Hilgendorf, Inken, Russo, Domenico, Socié, Gérard, Holler, Ernst, Glass, Bertram, Casper, Jochen, Wulf, Gerald, Basara, Nadezda, Bieniaszewska, Maria, Stuhler, Gernot, Verbeek, Mareike, La Rocca, Ursula, Finke, Jürgen, Benedetti, Fabio, Pichlmeier, Uwe, Klein, Anja, Baumgart, Joachim, Markiewicz, Miroslaw, and Rocca, Ursula La

Subjects
Leukemia, Myeloid, Acute, Transplantation Conditioning, Myelodysplastic Syndromes, Medizin, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Humans, Prospective Studies, Hematology, Middle Aged, Busulfan, Vidarabine, Aged
Abstract

The phase III study was designed to compare event-free survival (EFS) after treosulfan-based conditioning with a widely applied reduced-intensity conditioning (RIC) busulfan regimen in older or comorbid patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). A previously reported confirmatory interim analysis of the randomized clinical study including 476 patients demonstrated statistically significant noninferiority for treosulfan with clinically meaningful improvement in EFS. Here, the final study results and pre-specified subgroup analyses of all 570 randomized patients with completed longer-term follow-up are presented. Patients presenting HCT-specific comorbidity index >2 or aged >= 50 years were randomly assigned (1:1) to intravenous (IV) fludarabine with either treosulfan (30 g/m(2) IV) or busulfan (6.4 mg/kg IV) after stratification by disease risk group, donor type, and participating institution. The primary endpoint was EFS with disease recurrence, graft failure, or death from any cause as events. EFS of patients (median age 60 years) was superior after treosulfan compared to RIC busulfan: 36-months-EFS rate 59.5% (95% CI, 52.2-66.1) vs. 49.7% (95% CI, 43.3-55.7) with a hazard ratio (HR) of 0.64 (95% CI, 0.49-0.84), p = 0.0006. Likewise, overall survival (OS) with treosulfan was superior compared to busulfan: 36-month-OS rate 66.8% vs. 56.3%; HR 0.64 (95% CI, 0.48-0.87), p = 0.0037. Post hoc analyses revealed that these differences were consistent with the confirmatory interim analysis, and thereby the treosulfan regimen appears particularly suitable for older AML and MDS patients.

Published
2022

30. Primary Cancer Matters in Therapy-related Myeloid Neoplasm Patients Receiving Allogeneic Hematopoietic Cell Transplantation: A Study From the Chronic Malignancies Working Party of the EBMT

Author

Robin, Marie, primary, de Wreede, Liesbeth C., additional, Schroeder, Thomas, additional, Stölzel, Friedrich, additional, Kröger, Nicolaus, additional, Koster, Linda, additional, Platzbecker, Uwe, additional, Finke, Jürgen, additional, Ganser, Arnold, additional, Blaise, Didier, additional, Ciceri, Fabio, additional, Maertens, Johan, additional, Labussière Wallet, Hélène, additional, Wang, Junfeng, additional, Chevallier, Patrice, additional, Passweg, Jakob, additional, Cornelissen, Jan J, additional, Nguyen, Stéphanie, additional, Forcade, Edouard, additional, Charbonnier, Amandine, additional, Bonifazi, Francesca, additional, Hayden, Patrick, additional, McLornan, Donal P., additional, and Yakoub-Agha, Ibrahim, additional

Published
2023
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31. Outcomes after allogeneic hematopoietic cell transplant in patients diagnosed with blast phase of myeloproliferative neoplasms: A retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation

Author

Ortí, Guillermo, primary, Gras, Luuk, additional, Zinger, Nienke, additional, Finazzi, Maria Chiara, additional, Sockel, Katja, additional, Robin, Marie, additional, Forcade, Edouard, additional, Avenoso, Daniele, additional, Kröger, Nicolaus, additional, Finke, Jürgen, additional, Radujkovic, Aleksandar, additional, Hunault‐Berger, Mathilde, additional, Schroyens, Wilfried, additional, Zuckerman, Tsila, additional, Bourhis, Jean Henri, additional, Chalandon, Yves, additional, Bloor, Adrian, additional, Schots, Rik, additional, de Wreede, Liesbeth C., additional, Drozd‐Sokolowska, Joana, additional, Raj, Kavita, additional, Polverelli, Nicola, additional, Czerw, Tomasz, additional, Hernández‐Boluda, Juan Carlos, additional, McLornan, Donal, additional, and Yakoub‐Agha, Ibrahim, additional

Published
2023
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32. Comorbidities in recipients of low transplant conditioning intensity regimens for acute myeloid leukemia: an ALWP EBMT study

Author

Fein, Joshua Alexander, primary, Shouval, Roni, additional, Galimard, Jacques-Emmanuel, additional, Labopin, Myriam, additional, Socié, Gerard, additional, Finke, Jürgen, additional, Cornelissen, Jan J, additional, Malladi, Ram, additional, Itälä-Remes, Maija, additional, Chevallier, Patrice, additional, Orchard, Kim, additional, Bunjes, Donald, additional, Aljurf, Mahmoud, additional, Rubio, Marie-Thérèse, additional, Versluis, Jurjen, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2023
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33. Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Author

Noviello, Maddalena, Manfredi, Francesco, Ruggiero, Eliana, Perini, Tommaso, Oliveira, Giacomo, Cortesi, Filippo, De Simone, Pantaleo, Toffalori, Cristina, Gambacorta, Valentina, Greco, Raffaella, Peccatori, Jacopo, Casucci, Monica, Casorati, Giulia, Dellabona, Paolo, Onozawa, Masahiro, Teshima, Takanori, Griffioen, Marieke, Halkes, Constantijn J. M., Falkenburg, J. H. F., Stölzel, Friedrich, Altmann, Heidi, Bornhäuser, Martin, Waterhouse, Miguel, Zeiser, Robert, Finke, Jürgen, Cieri, Nicoletta, Bondanza, Attilio, Vago, Luca, Ciceri, Fabio, and Bonini, Chiara

Published
2019
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36. Comparison of Unrelated Cord Blood and Peripheral Blood Stem Cell Transplantation in Adults with Myelodysplastic Syndrome after Reduced-Intensity Conditioning Regimen: A Collaborative Study from Eurocord (Cord blood Committee of Cellular Therapy & Immunobiology Working Party of EBMT) and Chronic Malignancies Working Party

Author

Robin, Marie, Ruggeri, Annalisa, Labopin, Myriam, Niederwieser, Dietger, Tabrizi, Reza, Sanz, Guillermo, Bourhis, Jean-Henri, van Biezen, Anja, Koenecke, Christian, Blaise, Didier, Tischer, Johanna, Craddock, Charles, Maillard, Natacha, Mohty, Mohamad, Russel, Nigel, Schetelig, Johannes, Finke, Jürgen, Gluckman, Eliane, de Witte, Theo M., Rocha, Vanderson, and Kroger, Nicolaus

Published
2015
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37. Effects on Survival of Non-Myeloablative Chemoimmunotherapy Compared to High-Dose Chemotherapy Followed By Autologous Stem Cell Transplantation (HDC-ASCT) As Consolidation Therapy in Patients with Primary CNS Lymphoma - Results of an International Randomized Phase III Trial (MATRix/IELSG43)

Author

Illerhaus, Gerald, primary, Ferreri, Andrés J.M., additional, Binder, Mascha, additional, Borchmann, Peter, additional, Hasenkamp, Justin, additional, Stilgenbauer, Stephan, additional, Roeth, Alexander, additional, Weber, Thomas, additional, Egerer, Gerlinde, additional, Ernst, Thomas, additional, Hertenstein, Bernd, additional, Lenz, Georg, additional, Kobbe, Guido, additional, Brunnberg, Uta, additional, Schmidt, Christian, additional, Kneba, Michael, additional, Dreyling, Martin, additional, Möhle, Robert, additional, Panse, Jens, additional, Heinicke, Thomas, additional, Schroll, Sebastian, additional, Larsen, Thomas S., additional, Salwender, Hans, additional, Naumann, Ralph, additional, Hess, Georg, additional, Thurner, Lorenz, additional, Pukrop, Tobias, additional, Keller, Ulrich, additional, Blystadt, Anne Kirsti, additional, Kroschinsky, Frank P., additional, Re, Francesca, additional, Pulczynski, Elisa, additional, Orsucci, Lorella, additional, Pospiech, Lisa, additional, Deckert, Martina, additional, Ponzoni, Maurilio, additional, Wendler, Julia, additional, Valk, Elke, additional, Calimeri, Teresa, additional, Kasenda, Benjamin, additional, Trepel, Martin, additional, Fricker, Heidi, additional, von Gottberg, Philipp, additional, Burger, Elvira, additional, Ihorst, Gabriele, additional, Grishina, Olga, additional, Hader, Claudia, additional, Zucca, Emanuele, additional, Finke, Jürgen, additional, and Schorb, Elisabeth, additional

Published
2022
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38. Comparison of Fludarabine/Melphalan (FluMel) with Fludarabine/Melphalan/BCNU or Thiotepa (FBM/FTM) in Patients with AML in First Complete Remission Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - a Registry Study on Behalf of the EBMT Acute Leukemia Working Party

Author

Duque Afonso, Jesus, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Orchard, Kim H., additional, Valerius, Thomas, additional, Snowden, John A., additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew P., additional, Wilson, Keith, additional, Gadisseur, Alain, additional, Protheroe, Rachel Elizabeth, additional, Wagner, Eva Maria, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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39. Allogeneic Hematopoietic Cell Transplantation in Patients with Therapy-Related Myeloid Neoplasm Following Treatment for Lymphoma: A Study of the Chronic Malignancies Working Party of the EBMT

Author

Nabergoj, Mitja, primary, Eikema, Dirk-Jan, additional, Zinger, Nienke, additional, Platzbecker, Uwe, additional, Sockel, Katja, additional, Finke, Jürgen, additional, Kröger, Nicolaus, additional, Forcade, Edouard, additional, Nagler, Arnon, additional, Ganser, Arnold, additional, Tischer, Johanna, additional, Broers, Annoek E.C., additional, Kuball, Jurgen, additional, Wilson, Keith, additional, Mathilde, Hunault-Berger, additional, Collin, Matthew P., additional, Russo, Domenico, additional, Pérez López, Estefanía, additional, Helbig, Grzegorz, additional, Mussetti, Alberto, additional, Raj, Kavita, additional, Scheid, Christof, additional, McLornan, Donal P., additional, Robin, Marie, additional, and Yakoub-Agha, Ibrahim, additional

Published
2022
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40. Allogeneic Hematopoietic Cell Transplantation (Allo-HCT) in Patients with Calr-Mutated Myelofibrosis

Author

Hernandez Boluda, Juan Carlos, primary, Eikema, Dirk-Jan, additional, Erazo, Nadia, additional, Kröger, Nicolaus, additional, Robin, Marie, additional, de Witte, Moniek, additional, Finke, Jürgen, additional, Rambaldi, Alessandro, additional, Broers, Annoek E.C., additional, Raida, Ludek, additional, Schaap, Nicolaas, additional, Chiusolo, Patrizia, additional, Verbeek, Mareike, additional, Choi, Goda, additional, Halaburda, Kazimierz, additional, Kulagin, Alexander D., additional, Labussiere-Wallet, Helene, additional, Gedde-Dahl, Tobias, additional, Rabitsch, Werner, additional, Raj, Kavita, additional, Drozd-Sokolowska, Joanna, additional, Polverelli, Nicola, additional, Czerw, Tomasz, additional, Yakoub-Agha, Ibrahim, additional, and McLornan, Donal P., additional

Published
2022
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41. Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation from Different Donor Types in Primary Refractory Acute Myeloid Leukemia: A Report from the ALWP of the EBMT

Author

Barbullushi, Kordelia, primary, Labopin, Myriam, additional, Kröger, Nicolaus, additional, Finke, Jürgen, additional, Stelljes, Matthias, additional, Ganser, Arnold, additional, Bethge, Wolfgang, additional, Einsele, Hermann, additional, Schetelig, Johannes, additional, Fanin, Renato, additional, Jindra, Pavel, additional, Casper, Jochen, additional, Schroeder, Thomas, additional, Edinger, Matthias, additional, Passweg, Jakob, additional, Forcade, Edouard, additional, Tischer, Johanna, additional, Nagler, Arnon, additional, Ciceri, Fabio, additional, and Mohty, Mohamad, additional

Published
2022
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42. Outcomes of Allogeneic Haematopoietic Stem Cell Transplantation for Therapy-Related Myeloid Neoplasms Following Treatment for Myeloma

Author

Lawless, Sarah, primary, Morris, Curly, additional, Eikema, Dirk-Jan, additional, Kostner, Linda, additional, Stoelzel, Friedrich, additional, Kröger, Nicolaus, additional, Platzbecker, Uwe, additional, Bethge, Wolfgang, additional, Brossart, Peter, additional, Fanin, Renato, additional, Finke, Jürgen, additional, Kuball, Jurgen, additional, Leblond, Veronique, additional, Nicholson, Emma, additional, Passweg, Jakob, additional, Avenoso, Daniele, additional, Bay, Jacques-Olivier, additional, Bazarbachi, Ali, additional, Caballero, Dolores, additional, Drozd-Sokolowska, Joanna, additional, Scheid, Christof, additional, McLornan, Donal P., additional, Robin, Marie, additional, and Yakoub-Agha, Ibrahim, additional

Published
2022
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43. CART Therapy or Allogeneic Stem Cell Transplantation in ≥ Third Line Treatment of Large B Cell Lymphoma (LBCL)

Author

Glass, Bertram, primary, Sureda, Anna, additional, Boumendil, Ariane, additional, Dreger, Peter, additional, Corradini, Paolo, additional, Ram, Ron, additional, Kroeger, Nicolaus, additional, Castagna, Luca, additional, Pabst, Thomas, additional, Kwon, Mi, additional, Wulf, Gerald, additional, Martín García-Sancho, Alejandro, additional, Solano, Carlos, additional, Stelljes, Matthias, additional, Reinhardt, Hans Christian, additional, Rubio, Marie Thérèse, additional, Malladi, Ram, additional, Blaise, Didier, additional, Besley, Caroline, additional, Forcade, Edouard, additional, von Bonin, Malte, additional, Finke, Jürgen, additional, Hilgendorf, Inken, additional, Martínez-López, Joaquín, additional, Perez-Simon, Jose A., additional, Bethge, Wolfgang, additional, and Schmitz, Norbert, additional

Published
2022
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44. Registry Data Indicate a Meaningful Chance for Successful Pregnancies after Allogeneic Stem Cell Transplantation: Results from the German Stem Cell Transplant Registry (DRST)

Author

Sockel, Katja, primary, Frank, Sandra, additional, Neu, Annika, additional, Ditschkowski, Markus, additional, Hilgendorf, Inken, additional, Goeckenjan, Mareen, additional, Stoelzel, Friedrich, additional, Middeke, Jan Moritz, additional, Kröger, Nicolaus, additional, Ayuk, Francis A., additional, Eder, Matthias, additional, Bethge, Wolfgang, additional, Finke, Jürgen, additional, Bertz, Hartmut, additional, Kobbe, Guido, additional, Kaufmann, Martin, additional, Platzbecker, Uwe, additional, Beverungen, David, additional, Schmid, Christoph, additional, von Bonin, Malte, additional, Egger-Heidrich, Katharina, additional, Heberling, Lisa, additional, Trautmann-Grill, Karolin, additional, Teipel, Raphael, additional, Bug, Gesine, additional, Tischer, Johanna, additional, Fraccaroli, Alessia, additional, Holler, Barbara, additional, Wolff, Daniel, additional, Luft, Thomas, additional, Roesler, Wolf, additional, Schäfer-Eckart, Kerstin, additional, Dressler, Sabine, additional, Scheid, Christof, additional, Holtick, Udo, additional, Klein, Stefan, additional, Blau, Igor Wolfgang, additional, Burchert, Andreas, additional, Wulf, Gerald, additional, Hasenkamp, Justin, additional, Schwerdtfeger, Rainer, additional, Kaun, Stephan, additional, Wittke, Christoph, additional, Wortmann, Friederike, additional, Neidlinger, Helga, additional, Bornhaeuser, Martin, additional, Schetelig, Johannes, additional, and of the German Cooperative Transplant Study Group, on Behalf, additional

Published
2022
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45. High-Dose Chemotherapy and Autologous Stem Cell Transplant in Elderly and Fit Primary CNS Lymphoma Patients - a Multicenter Study By the Cooperative PCNSL Study Group (MARTA study)

Author

Schorb, Elisabeth, primary, Isbell, Lisa, additional, Kerkhoff, Andrea, additional, Mathas, Stephan, additional, Braulke, Friederike, additional, Egerer, Gerlinde, additional, Roeth, Alexander, additional, Schliffke, Simon Christian, additional, Borchmann, Peter, additional, Brunnberg, Uta, additional, Kroschinsky, Frank P., additional, Möhle, Robert, additional, Rank, Andreas, additional, Wellnitz, Dominique, additional, Kasenda, Benjamin, additional, Pospiech, Lisa, additional, Wendler, Julia, additional, Ihorst, Gabriele, additional, Scherer, Florian, additional, Deckert, Martina, additional, Henkes, Elina, additional, Duyster, Justus, additional, Finke, Jürgen, additional, and Illerhaus, Gerald, additional

Published
2022
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46. Trends in the Use of Hematopoietic Stem Cell Transplantation in the Management of Relapsed/Refractory Diffuse Large B Cell Lymphoma. a Retrospective Analysis of the Lymphoma Working Party of the EBMT

Author

Sureda, Anna, primary, Boumendil, Ariane, additional, Berning, Philipp, additional, Finel, Hervé, additional, Caillot, Denis, additional, Roesler, Wolf, additional, Finke, Jürgen, additional, Blau, Igor Wolfgang, additional, Leblond, Veronique, additional, Bittenbring, Joerg, additional, Tsoulkani, Anna, additional, Carpenter, Ben, additional, Nagler, Arnon, additional, Blaise, Didier, additional, Dreger, Peter, additional, and Schmitz, Norbert, additional

Published
2022
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