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2. Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus

Author

Zurlo, Matteo, primary, Zuccato, Cristina, additional, Cosenza, Lucia Carmela, additional, Gasparello, Jessica, additional, Gamberini, Maria Rita, additional, Stievano, Alice, additional, Fortini, Monica, additional, Prosdocimi, Marco, additional, Finotti, Alessia, additional, and Gambari, Roberto, additional

Published
2023
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3. Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose

Author

Carsetti, Rita, primary, Agrati, Chiara, additional, Pinto, Valeria Maria, additional, Gianesin, Barbara, additional, Gamberini, Rita, additional, Fortini, Monica, additional, Barella, Susanna, additional, Denotti, Rita, additional, Perrotta, Silverio, additional, Casale, Maddalena, additional, Maggio, Aurelio, additional, Pitrolo, Lorella, additional, Tartaglia, Eleonora, additional, Mortari, Eva Piano, additional, Colavita, Francesca, additional, Puro, Vincenzo, additional, Francalancia, Massimo, additional, Marini, Valeria, additional, Caminati, Marco, additional, Mazzi, Filippo, additional, De Franceschi, Lucia, additional, Forni, Gian Luca, additional, and Locatelli, Franco, additional

Published
2022
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4. sj-pdf-1-tah-10.1177_20406207221100648 – Supplemental material for Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin)

Author

Zuccato, Cristina, Cosenza, Lucia Carmela, Zurlo, Matteo, Gasparello, Jessica, Papi, Chiara, D’Aversa, Elisabetta, Breveglieri, Giulia, Lampronti, Ilaria, Finotti, Alessia, Borgatti, Monica, Scapoli, Chiara, Stievano, Alice, Fortini, Monica, Ramazzotti, Eric, Marchetti, Nicola, Prosdocimi, Marco, Gamberini, Maria Rita, and Gambari, Roberto

Subjects
FOS: Clinical medicine, Cardiology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-tah-10.1177_20406207221100648 for Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin) by Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Chiara Papi, Elisabetta D’Aversa, Giulia Breveglieri, Ilaria Lampronti, Alessia Finotti, Monica Borgatti, Chiara Scapoli, Alice Stievano, Monica Fortini, Eric Ramazzotti, Nicola Marchetti, Marco Prosdocimi, Maria Rita Gamberini and Roberto Gambari in Therapeutic Advances in Hematology

Published
2022
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5. Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-Thalassemia: additional dose role

Author

Carsetti, Rita, Agrati, Chiara, Pinto, Valeria Maria, Gianesin, Barbara, Gamberini, Maria Rita, Fortini, Monica, Barella, Susanna, Denotti, Anna Rita, Perrotta, Silverio, Casale, Maddalena, Maggio, Aurelio, Pitrolo, Lorella, Tartaglia, Eleonora, Piano Mortari, Eva, Colavita, Francesca, Puro, Vincenzo, Francalancia, Massimo, Marini, Valeria, Caminati, Marco, Mazzi, Filippo, De Franceschi, Lucia, Forni, Gian Luca, and Locatelli, Franco

Subjects
covid aging immune system vaccination
Published
2022

6. Thalassaemia is paradoxically associated with a reduced risk of in‐hospital complications and mortality in COVID‐19: Data from an international registry

Author

El‐Battrawy, Ibrahim, primary, Longo, Filomena, additional, Núñez Gil, Iván J., additional, Abumayyaleh, Mohammad, additional, Gianesin, Barbara, additional, Estrada, Vicente, additional, Aparisi, Álvaro, additional, Arroyo‐Espliguero, Ramón, additional, Balocco, Manuela, additional, Barella, Susanna, additional, Beccaria, Andrea, additional, Bonetti, Federico, additional, Casale, Maddalena, additional, De michele, Elisa, additional, Denotti, Anna Rita, additional, Fidone, Carmelo, additional, Fortini, Monica, additional, Gamberini, Maria Rita, additional, Graziadei, Giovanna, additional, Lisi, Roberto, additional, Massa, Antonella, additional, Marcon, Alessia, additional, Rubinski, Bryan, additional, Miano, Maurizio, additional, Motta, Irene, additional, Pinto, Valeria Maria, additional, Piperno, Alberto, additional, Mariani, Raffaella, additional, Putti, Maria Caterina, additional, Quota, Alessandra, additional, Ribersani, Michela, additional, Marziali, Marco, additional, Roberti, Domenico, additional, Rosso, Rosamaria, additional, Tartaglione, Immacolata, additional, Vitucci, Angelantonio, additional, Voi, Vincenzo, additional, Zecca, Marco, additional, Romero, Rodolfo, additional, Marouneld, Charbel, additional, Fernández‐Rozas, Inmaculada, additional, Espejo, Carolina, additional, Marhaeni, Wulandewi, additional, Garcia Aguado, Marcos, additional, Cappellini, Maria Domenica, additional, Perrotta, Silverio, additional, De Franceschi, Lucia, additional, Piga, Antonio, additional, Forni, Gian Luca, additional, and Akin, Ibrahim, additional

Published
2022
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7. Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin)

Author

Zuccato, Cristina, primary, Cosenza, Lucia Carmela, additional, Zurlo, Matteo, additional, Gasparello, Jessica, additional, Papi, Chiara, additional, D’Aversa, Elisabetta, additional, Breveglieri, Giulia, additional, Lampronti, Ilaria, additional, Finotti, Alessia, additional, Borgatti, Monica, additional, Scapoli, Chiara, additional, Stievano, Alice, additional, Fortini, Monica, additional, Ramazzotti, Eric, additional, Marchetti, Nicola, additional, Prosdocimi, Marco, additional, Gamberini, Maria Rita, additional, and Gambari, Roberto, additional

Published
2022
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8. Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection

Author

Longo, Filomena, primary, Gianesin, Barbara, additional, Voi, Vincenzo, additional, Motta, Irene, additional, Pinto, Valeria Maria, additional, Piolatto, Andrea, additional, Spasiano, Anna, additional, Ruffo, Giovan Battista, additional, Gamberini, Maria Rita, additional, Barella, Susanna, additional, Mariani, Raffaella, additional, Fidone, Carmelo, additional, Rosso, Rosamaria, additional, Casale, Maddalena, additional, Roberti, Domenico, additional, Dal Zotto, Chiara, additional, Vitucci, Angelantonio, additional, Bonetti, Federico, additional, Pitrolo, Lorella, additional, Quaresima, Micol, additional, Ribersani, Michela, additional, Quota, Alessandra, additional, Arcioni, Francesco, additional, Campisi, Saveria, additional, Massa, Antonella, additional, De Michele, Elisa, additional, Lisi, Roberto, additional, Miano, Maurizio, additional, Bagnato, Sabrina, additional, Gentile, Massimo, additional, Carrai, Valentina, additional, Putti, Maria Caterina, additional, Serra, Marilena, additional, Gaglioti, Carmen, additional, Migone De Amicis, Margerita, additional, Graziadei, Giovanna, additional, De Giovanni, Anna, additional, Ricchi, Paolo, additional, Balocco, Manuela, additional, Quintino, Sabrina, additional, Borsellino, Zelia, additional, Fortini, Monica, additional, Denotti, Anna Rita, additional, Tartaglione, Immacolata, additional, Beccaria, Andrea, additional, Marziali, Marco, additional, Maggio, Aurelio, additional, Perrotta, Silverio, additional, Piperno, Alberto, additional, Filosa, Aldo, additional, Cappellini, Maria Domenica, additional, De Franceschi, Lucia, additional, Piga, Antonio, additional, and Forni, Gian Luca, additional

Published
2021
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9. A MRI Prospective Survey on Heart and Liver Iron and Cardiac Function in Thalassemia Major Patients Treated with Deferasirox Versus Deferiprone and Desferrioxamine in Monotherapy

Author

Pepe, Alessia, primary, Pistoia, Laura, additional, Cuccia, Liana, additional, Fortini, Monica, additional, Caruso, Vincenzo, additional, Rosso, Rosamaria, additional, Campisi, Saveria, additional, Peluso, Angelo, additional, Sorrentino, Francesco, additional, Maggio, Aurelio, additional, Positano, Vincenzo, additional, Peritore, Giuseppe, additional, and Meloni, Antonella, additional

Published
2016
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10. Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose

Author

Rita Carsetti, Chiara Agrati, Valeria Maria Pinto, Barbara Gianesin, Rita Gamberini, Monica Fortini, Susanna Barella, Rita Denotti, Silverio Perrotta, Maddalena Casale, Aurelio Maggio, Lorella Pitrolo, Eleonora Tartaglia, Eva Piano Mortari, Francesca Colavita, Vincenzo Puro, Massimo Francalancia, Valeria Marini, Marco Caminati, Filippo Mazzi, Lucia De Franceschi, Gian Luca Forni, Franco Locatelli, Carsetti, Rita, Agrati, Chiara, Pinto, Valeria Maria, Gianesin, Barbara, Gamberini, Rita, Fortini, Monica, Barella, Susanna, Denotti, Rita, Perrotta, Silverio, Casale, Maddalena, Maggio, Aurelio, Pitrolo, Lorella, Tartaglia, Eleonora, Mortari, Eva Piano, Colavita, Francesca, Puro, Vincenzo, Francalancia, Massimo, Marini, Valeria, Caminati, Marco, Mazzi, Filippo, De Franceschi, Lucia, Forni, Gian Luca, and Locatelli, Franco

Subjects
thalassemia, Vaccines, Synthetic, COVID-19 Vaccines, SARS-CoV-2, beta-Thalassemia, Immunology, COVID-19, Aging, Premature, Cell Biology, Hematology, Antibodies, Viral, Biochemistry, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Immune System, Humans, mRNA Vaccines
Abstract

Patients with beta-thalassemia show 5-fold increase in agestandardized lethality due to SARS-CoV-2 infection, representing a high-risk population compared with age- and sex-matched healthy subjects.(1) Vaccination against SARS-CoV-2 is crucial to reduce mortality and morbidity of frail patients.(2) Up to now, limited data have been available on the responses of patients with beta-thalassemia immunized with anti-SARS-CoV-2 mRNA vaccines.(3)

Published
2022

11. Italian patients with hemoglobinopathies exhibit a 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection

Author

Sabrina Quintino, Filomena Longo, Maurizio Miano, Vincenzo Voi, Maria Caterina Putti, Margerita Migone De Amicis, Monica Fortini, Susanna Barella, Barbara Gianesin, Federico Bonetti, Andrea Beccaria, Manuela Balocco, Andrea Piolatto, Saveria Campisi, Rosamaria Rosso, Angelantonio Vitucci, Valentina Carrai, Alessandra Quota, Zelia Borsellino, Antonio Piga, Maddalena Casale, Anna Rita Denotti, Michela Ribersani, Maria Rita Gamberini, Domenico Roberti, Alberto Piperno, Roberto Lisi, Carmelo Fidone, Maria Domenica Cappellini, Sabrina Bagnato, Anna De Giovanni, Micol Quaresima, Valeria Maria, Lorella Pitrolo, Marco Marziali, Giovanna Graziadei, Carmen Gaglioti, Aldo Filosa, Chiara Dal Zotto, Lucia De Franceschi, Irene Motta, Immacolata Tartaglione, Francesco Arcioni, Aurelio Maggio, Marilena Serra, Giovan Battista Ruffo, Massimo Gentile, Elisa De Michele, Anna Spasiano, Paolo Ricchi, Antonella Massa, Silverio Perrotta, R. Mariani, Gian Luca Forni, Longo, Filomena, Gianesin, Barbara, Voi, Vincenzo, Motta, Irene, Pinto, Valeria Maria, Piolatto, Andrea, Spasiano, Anna, Ruffo, Giovan Battista, Gamberini, Maria Rita, Barella, Susanna, Mariani, Raffaella, Fidone, Carmelo, Rosso, Rosamaria, Casale, Maddalena, Roberti, Domenico, Dal Zotto, Chiara, Vitucci, Angelantonio, Bonetti, Federico, Pitrolo, Lorella, Quaresima, Micol, Ribersani, Michela, Quota, Alessandra, Arcioni, Francesco, Campisi, Saveria, Massa, Antonella, De Michele, Elisa, Lisi, Roberto, Miano, Maurizio, Bagnato, Sabrina, Gentile, Massimo, Carrai, Valentina, Putti, Maria Caterina, Serra, Marilena, Gaglioti, Carmen, Migone De Amicis, Margerita, Graziadei, Giovanna, De Giovanni, Anna, Ricchi, Paolo, Balocco, Manuela, Quintino, Sabrina, Borsellino, Zelia, Fortini, Monica, Denotti, Anna Rita, Tartaglione, Immacolata, Beccaria, Andrea, Marziali, Marco, Maggio, Aurelio, Perrotta, Silverio, Piperno, Alberto, Filosa, Aldo, Cappellini, Maria Domenica, De Franceschi, Lucia, Piga, Antonio, and Forni, Gian Luca

Subjects
Sars-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sars-CoV-2, hemoglobinopathies, Medicine, hemoglobinopathies,SARS-CoV-2 infection, Lethality, Hematology, hemoglobinopathies, business, Virology
Published
2022

12. Thalassemia Is Paradoxically Associated with a Reduced Risk of In-Hospital Complications and Mortality in COVID-19: Data from an International Registry

Author

Ibrahim El-Battrawy, Elisa De Michele, Manuela Balocco, Immacolata Tartaglione, Carmelo Fidone, Roberto Lisi, Maria Caterina Putti, Marcos Garca-Aguado, Michela Ribersani, Ramón Arroyo-Espliguero, Vicente Estrada, Lucia De Franceschi, Maurizio Miano, Antonella Massa, Alessandra Quota, Vincenzo Voi, Monica Fortini, Maria Domenica Cappellini, Inmaculada Fernández-Rozas, Marco Marziali, Giovanna Graziadei, Angelantonio Vitucci, Alberto Piperno, Iván Núñez Gil Md, Irene Motta, Wulandewi Marhaeni, Marco Zecca, Maddalena Casale, Antonio Piga, Silverio Perrotta, Bryan Rupinski, Charbel Maroun, Filomena Longo, Rodolfo Romero, R. Mariani, Domenico Roberti, Susanna Barella, Andrea Beccaria, Valeria Pinto, Barbara Gianesin, Mohammad Abumayyaleh, Rosamaria Rosso, Carolina Espejo Paeres, Álvaro Aparisi, Gian Luca Forni, Rita Gamberini, Ibrahim Akin, Anna Rita Denotti, Federico Bonetti, Alessia Marcon, El-Battrawy, Ibrahim, Longo, Filomena, Núñez Gil, Iván J, Abumayyaleh, Mohammad, Gianesin, Barbara, Estrada, Vicente, Aparisi, Álvaro, Arroyo-Espliguero, Ramón, Balocco, Manuela, Barella, Susanna, Beccaria, Andrea, Bonetti, Federico, Casale, Maddalena, De Michele, Elisa, Denotti, Anna Rita, Fidone, Carmelo, Fortini, Monica, Gamberini, Maria Rita, Graziadei, Giovanna, Lisi, Roberto, Massa, Antonella, Marcon, Alessia, Rubinski, Bryan, Miano, Maurizio, Motta, Irene, Pinto, Valeria Maria, Piperno, Alberto, Mariani, Raffaella, Putti, Maria Caterina, Quota, Alessandra, Ribersani, Michela, Marziali, Marco, Roberti, Domenico, Rosso, Rosamaria, Tartaglione, Immacolata, Vitucci, Angelantonio, Voi, Vincenzo, Zecca, Marco, Romero, Rodolfo, Marouneld, Charbel, Fernández-Rozas, Inmaculada, Espejo, Carolina, Marhaeni, Wulandewi, Garcia Aguado, Marco, Cappellini, Maria Domenica, Perrotta, Silverio, De Franceschi, Lucia, Piga, Antonio, Forni, Gian Luca, and Akin, Ibrahim

Subjects
Male, Pediatrics, medicine.medical_specialty, Iron Overload, Thalassemia, medicine.medical_treatment, Splenectomy, thalassaemia, Disease, law.invention, law, medicine, Humans, Registries, Continuous positive airway pressure, COVID-19, SARS-CoV-2, mortality, business.industry, Acute kidney injury, Cell Biology, medicine.disease, Intensive care unit, Hospitals, Oxygen, Cohort, Molecular Medicine, Female, business, Kidney disease
Abstract

Background: Although numerous patient specific co-factors have been shown to be associated with worse outcomes in COVID-19, the prognostic value of thalasemic syndromes in COVID-19 patients remains poorly understood. Aims: We studied the outcomes of 137 COVID-19 patients with a history of Transfusion Dependent Thalassemia (TDT) and non-Transfusion Dependent Thalassemia (NTDT) extracted from a large international cohort and compared them with the outcomes from a matched cohort of COVID-19 patients with no history of thalasemia. Results: The mean age of thalassemia patients included in our study was 41±16 years (48.9% male). Almost 81% of these patients suffered from TDT requiring blood transfusions on a regular basis. 38.7% of patients were blood group O. Cardiac iron overload was documented in 6.8% of study patients, whereas liver iron overload was documented in 35% of study patients. 25% of thalassemia patients had a history of splenectomy. 27.7% of study patients required hospitalization due to COVID-19 infection. Amongst the hospitalized patients, one patient died (0.7%) and one patient required intubation. Continuous positive airway pressure (CPAP) was required in almost 5% of study patients. After adjustment for age-, sex- and other known risk factors (cardiac disease, kidney disease and pulmonary disease), the rate of in-hospital complications (supplemental oxygen use, admission to the an intensive care unit for CPAP therapy or intubation) and all-cause mortality was significantly lower in the thalassemia group compared to the matched cohort with no history of thalassemia. Amongst thalassemia patients in general, the NTDT group exhibited a higher rate of hospitalization compared to the TDT group (p=0.001). In addition, the rate of complications such as acute kidney injury and need for supplemental oxygen was significantly higher in the NTDT group compared to the TDT group. In the multivariable logistic regression analysis, age and history of heart or kidney disease were all found to be independent risk factors for increased in-hospital, all-cause mortality, whereas the presence of thalassemia (either TDT or NTDT) was found to be independently associated with reduced all-cause mortality. Conclusions: The presence of thalassemia in COVID-19 patients was independently associated with lower in-hospital, all-cause mortality and few in-hospital complications in in our study. The pathophysiology of this is unclear and needs to be studied in vitro and in animal models. Trial Registration for sources of data extraction: NCT: 04334291, 04746066 Funding Statement: This study was funded by a non-conditioned grant from FUNDACION INTERHOSPITALARIA PARA LA INVESTIGACION CARDIOVASCULAR, FIC. (Madrid, Spain). This nonprofit institution had no role in the study design, the collection, analysis and interpretation of data, the writing of the report, or the decision to submit the paper for publication. Declaration of Interests: The authors declare no conflicts of interest. Ethics Approval Statement: The study was approved by the Ethics Committees in all of the centers involved (Banjarmasin, Bari, Cagliari, Catania, Ferrara, Gela, Genoa, Getafe, Guadalajara, Legan, Madrid, Mannheim, Milan, Monza, Naples, Olbia, Padua, Pavia, Ragusa, Rome, Salerno, Turin, Valladolid and Verona).

Published
2021

13. Italian patients with hemoglobinopathies exhibit a 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection.

Author

Longo F, Gianesin B, Voi V, Motta I, Pinto VM, Piolatto A, Spasiano A, Ruffo GB, Gamberini MR, Barella S, Mariani R, Fidone C, Rosso R, Casale M, Roberti D, Dal Zotto C, Vitucci A, Bonetti F, Pitrolo L, Quaresima M, Ribersani M, Quota A, Arcioni F, Campisi S, Massa A, De Michele E, Lisi R, Miano M, Bagnato S, Gentile M, Carrai V, Putti MC, Serra M, Gaglioti C, Migone De Amicis M, Graziadei G, De Giovanni A, Ricchi P, Balocco M, Quintino S, Borsellino Z, Fortini M, Denotti AR, Tartaglione I, Beccaria A, Marziali M, Maggio A, Perrotta S, Piperno A, Filosa A, Cappellini MD, De Franceschi L, Piga A, and Forni GL

Subjects
Adult, Age Factors, Aged, Aged, 80 and over, COVID-19 epidemiology, COVID-19 mortality, Female, Hemoglobinopathies epidemiology, Hemoglobinopathies mortality, Humans, Italy epidemiology, Male, Middle Aged, Prevalence, Risk Factors, SARS-CoV-2 isolation & purification, Thalassemia complications, Thalassemia epidemiology, Thalassemia mortality, Young Adult, COVID-19 complications, Hemoglobinopathies complications
Published
2022
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