1. (1S,2R)-1-Amino-2-methoxycyclohexane-1-carboxamide hydrochloride 0.25-hydrate
- Author
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Kamalesh Pai Fondekar, August W. Frahm, Franz-Josef Volk, and E. Weckert
- Subjects
Hydrogen bond ,medicine.drug_class ,Stereochemistry ,Strecker amino acid synthesis ,Absolute configuration ,Carboxamide ,Ether ,General Medicine ,Crystal structure ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,chemistry ,medicine ,Molecule ,Hydrate - Abstract
The title compound, (1-carboxamido-2-methoxycyclohexyl)ammonium chloride 0.25-hydrate, C 8 H 17 N 2 O + 2 .Cl - .0.25H 2 O, (I), was obtained in the course of our research efforts towards 2,4-propano analogues of the naturally occurring α-amino acid L s -threonine. In order to elucidate the absolute stereochemistry of (I), the absolute configuration was determined by exploiting anomalous dispersion effects. The crystal structure contains four independent molecules within the asymmetric unit, which are linked by a network of hydrogen bonds and include the Cl - ions. The absolute configuration of all four molecules is the same; however, differences in the conformation of some groups are present.
- Published
- 1999
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