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1. Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports

Author

Berardis, Domenico De, primary, Fornaro, Michele, additional, Ventriglio, Antonio, additional, Valchera, Alessandro, additional, Vellante, Federica, additional, Pettorruso, Mauro, additional, Martinotti, Giovanni, additional, Fraticelli, Silvia, additional, and Giannantonio, Massimo Di, additional

Published
2021
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3. Gut Microbiota and Bipolar Disorder: An Overview on a Novel Biomarker for Diagnosis and Treatment

Author

Lucidi, Lorenza, primary, Pettorruso, Mauro, additional, Vellante, Federica, additional, Di Carlo, Francesco, additional, Ceci, Franca, additional, Santovito, Maria Chiara, additional, Di Muzio, Ilenia, additional, Fornaro, Michele, additional, Ventriglio, Antonio, additional, Tomasetti, Carmine, additional, Valchera, Alessandro, additional, Gentile, Alessandro, additional, Kim, Yong-Ku, additional, Martinotti, Giovanni, additional, Fraticelli, Silvia, additional, Di Giannantonio, Massimo, additional, and De Berardis, Domenico, additional

Published
2021
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4. Religious Coping, Hopelessness, and Suicide Ideation in Subjects with First-Episode Major Depression: An Exploratory Study in the Real World Clinical Practice

Author

De Berardis, Domenico, primary, Olivieri, Luigi, additional, Rapini, Gabriella, additional, Serroni, Nicola, additional, Fornaro, Michele, additional, Valchera, Alessandro, additional, Carano, Alessandro, additional, Vellante, Federica, additional, Bustini, Massimiliano, additional, Serafini, Gianluca, additional, Pompili, Maurizio, additional, Ventriglio, Antonio, additional, Perna, Giampaolo, additional, Fraticelli, Silvia, additional, Martinotti, Giovanni, additional, and Di Giannantonio, Massimo, additional

Published
2020
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6. Understanding the Complex of Suicide in Depression: from Research to Clinics

Author

Orsolini, Laura, primary, Latini, Roberto, additional, Pompili, Maurizio, additional, Serafini, Gianluca, additional, Volpe, Umberto, additional, Vellante, Federica, additional, Fornaro, Michele, additional, Valchera, Alessandro, additional, Tomasetti, Carmine, additional, Fraticelli, Silvia, additional, Alessandrini, Marco, additional, La Rovere, Raffaella, additional, Trotta, Sabatino, additional, Martinotti, Giovanni, additional, Di Giannantonio, Massimo, additional, and De Berardis, Domenico, additional

Published
2020
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7. Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports.

Author

De Berardis, Domenico, Fornaro, Michele, Ventriglio, Antonio, Valchera, Alessandro, Vellante, Federica, Pettorruso, Mauro, Martinotti, Giovanni, Fraticelli, Silvia, and Di Giannantonio, Massimo

Subjects
MEDICAL personnel, POST-traumatic stress disorder, TRAZODONE, COVID-19, COVID-19 treatment, SELF-efficacy, BROMOMETHANE
Abstract

COVID-19 represents a significant stress factor for all people worldwide due to several factors, including quarantine, lockdowns, fear of contagion, deaths, and other traumatic events. However, the healthcare workers (HCWs) have paid the higher price of this pandemic in terms of fatalities, contagions, and psychological well-being. Studies suggest that this particular population is at increased risk of developing a severe post-traumatic stress disorder (PTSD). The early diagnosis and timely treatment of PTSD in HCWs may restore well-being and significantly impact health services functioning, reducing burnout, days spent far from work, disrupted personal and team empowerment, and worse job performances. In the present article, we reported on two cases of HCWs directly involved in the treatment of COVID-19 patients who showed selective serotonin reuptake inhibitor-resistant PTSD, which was successfully treated with extended-release trazodone TRZ ContramidⓇ add-on. [ABSTRACT FROM AUTHOR]

Published
2021
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8. The interplay among psychopathology, personal resources, context‐related factors and real‐life functioning in schizophrenia: stability in relationships after 4 years and differences in network structure between recovered and non‐recovered patients

Author

Galderisi, Silvana, Rucci, Paola, Mucci, Armida, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Bellomo, Antonello, Bozzatello, Paola, Bucci, Paola, Carpiniello, Bernardo, Collantoni, Enrico, Cuomo, Alessandro, Dell'Osso, Liliana, Di Fabio, Fabio, Giannantonio, Massimo, Gibertoni, Dino, Giordano, Giulia Maria, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Catapano, Francesco, Piegari, Giuseppe, Aiello, Carmen, Brando, Francesco, Giuliani, Luigi, Pietrafesa, Daria, Papalino, Marco, Mercadante, Giovanni, Di Palo, Piergiuseppe, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Pinna, Federica, Olivieri, Benedetta, Manca, Daniela, Signorelli, Maria Salvina, Poli, Laura Fusar, De Berardis, Domenico, Fraticelli, Silvia, Corbo, Mariangela, Pallanti, Stefano, Altamura, Mario, Carnevale, Raffaella, Malerba, Stefania, Calcagno, Pietro, Zampogna, Domenico, Corso, Alessandro, Giusti, Laura, Salza, Anna, Ussorio, Donatella, Talevi, Dalila, Socci, Valentina, Pacitti, Francesca, Bartolomeis, Andrea, Gramaglia, Carla, Gambaro, Eleonora, Gattoni, Eleonora, Favaro, Angela, Tenconi, Elena, Meneguzzo, Paolo, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan, Carpita, Barbara, Girardi, Nicoletta, Frascarelli, Marianna, Buzzanca, Antonio, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Corrivetti, Giulio, Cascino, Giammarco, Buono, Gianfranco, Bolognesi, Simone, Fagiolini, Andrea, Goracci, Arianna, Bellino, Silvio, Montemagni, Cristiana, and Brasso, Claudio

Abstract

Improving real‐life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness‐related variables, personal resources, context‐related factors and real‐life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4‐year follow‐up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow‐up. In addition, we compared the network structure of patients who were classified as recovered at follow‐up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow‐up study. The network structure did not change significantly from baseline to follow‐up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow‐up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non‐recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self‐reinforcing networks of symptoms and dysfunctions in people with schizophrenia.

Published
2020
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9. rTMS Reduces Psychopathological Burden and Cocaine Consumption in Treatment-Seeking Subjects With Cocaine Use Disorder: An Open Label, Feasibility Study.

Author

Pettorruso, Mauro, Martinotti, Giovanni, Santacroce, Rita, Montemitro, Chiara, Fanella, Fabrizio, di Giannantonio, Massimo, De Risio, Luisa, Petrucci, Ilaria, Tourjansky, Gaia, Capicotto, Patrizia, Neri, Francesca, Ruggiero, Gianluca, Cassiani, Barbara, Fraticelli, Silvia, and Moroni, Valentina

Subjects
COCAINE-induced disorders, TRANSCRANIAL magnetic stimulation, SUBSTANCE-induced disorders, FEASIBILITY studies, COCAINE, DESIRE, DRUG-seeking behavior
Abstract

Introduction: Cocaine use disorder (CUD) currently represents a notable public health concern, linked with significant disability, high chances of chronicity, and lack of effective pharmacological or psychological treatments. Repetitive transcranial magnetic stimulation (rTMS) is supposed to be a potential therapeutic option for addictive disorders. Aim of this study was to evaluate the feasibility of rTMS on (1) cocaine craving and consumption and (2) other comorbid psychiatric symptoms. Methods: Twenty treatment seeking CUD subjects underwent 2 weeks of intensive rTMS treatment (15Hz; 5 days/week, twice a day for a total of 20 stimulation sessions) of the left dorsolateral prefrontal cortex, followed by 2 weeks of maintenance treatment (15Hz, 1 day/week, twice a day). Sixteen patients completed the study. Patients were evaluated at baseline (T0), after 2 weeks of treatment (T1), and at the end of the study (T2; 4 weeks), with the following scales: Cocaine Selective Severity Assessment (CSSA), Zung Self-Rating Anxiety Scale, Beck Depression Inventory (BDI), Symptom Checklist-90 (SCL-90), and the Insomnia Severity Index. Results: After four weeks of rTMS treatment, 9 out of 16 subjects (56.25%) had a negative urinalysis test, with a significant conversion rate with respect to baseline (Z = −3.00; p = 0.003). Craving scores significantly improved only at T2 (p = 0.020). The overall psychopathological burden, as measured by the SCL-90 Global Severity Index (GSI), significantly decreased during the study period (Z = −2.689; p = 0.007), with a relevant improvement with regards to depressive symptoms, anhedonia, and anxiety. Subjects exhibiting lower baseline scores on the SCL-90 were more likely to be in the positive outcome group at the end of the study (Z = −3.334; p = 0.001). Discussion: Findings from this study are consistent with previous contributions on rTMS use in subjects with cocaine use disorder. We evidenced a specific action on some psychopathological areas and a consequent indirect effect in terms of relapse prevention and craving reduction. A double-blind, sham-controlled, neuro-navigated rTMS study design is needed, in order to confirm the potential benefits of this technique, opening new scenarios in substance use disorders treatment. [ABSTRACT FROM AUTHOR]

Published
2019
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10. Understanding the Complex of Suicide in Depression: from Research to Clinics

Author

Federica Vellante, Domenico De Berardis, Roberto Latini, Silvia Fraticelli, Alessandro Valchera, Sabatino Trotta, Umberto Volpe, Michele Fornaro, Carmine Tomasetti, Maurizio Pompili, Massimo Di Giannantonio, Laura Orsolini, Raffaella La Rovere, Gianluca Serafini, Giovanni Martinotti, Marco Alessandrini, Orsolini, Laura, Latini, Roberto, Pompili, Maurizio, Serafini, Gianluca, Volpe, Umberto, Vellante, Federica, Fornaro, Michele, Valchera, Alessandro, Tomasetti, Carmine, Fraticelli, Silvia, Alessandrini, Marco, La Rovere, Raffaella, Trotta, Sabatino, Martinotti, Giovanni, Di Giannantonio, Massimo, and De Berardis, Domenico

Subjects
Suicidal risk, medicine.medical_specialty, Population, MEDLINE, Psychological intervention, Review Article, Major depressive disorder, Scientific evidence, 03 medical and health sciences, 0302 clinical medicine, medicine, Psychiatry, education, Biological Psychiatry, Depression (differential diagnoses), education.field_of_study, Depression, business.industry, Stressor, medicine.disease, 030227 psychiatry, Assessment of suicide risk, Suicide, Psychiatry and Mental health, business, 030217 neurology & neurosurgery
Abstract

Objective Amongst psychiatric disorders, major depressive disorder (MDD) is the most prevalent, by affecting approximately 15–17% of the population and showing a high suicide risk rate equivalent to around 15%. The present comprehensive overview aims at evaluating main research studies in the field of MDD at suicide risk, by proposing as well as a schematic suicide risk stratification and useful flow-chart for planning suicide preventive and therapeutic interventions for clinicians.Methods A broad and comprehensive overview has been here conducted by using PubMed/Medline, combining the search strategy of free text terms and exploded MESH headings for the topics of ‘Major Depressive Disorder’ and ‘Suicide’ as following: ((suicide [Title/Abstract]) AND (major depressive disorder [Title/Abstract])). All articles published in English through May 31, 2019 were summarized in a comprehensive way.Results Despite possible pathophysiological factors which may explain the complexity of suicide in MDD, scientific evidence supposed the synergic role of genetics, exogenous and endogenous stressors (i.e., interpersonal, professional, financial, as well as psychiatric disorders), epigenetic, the hypothalamic-pituitary-adrenal stress-response system, the involvement of the monoaminergic neurotransmitter systems, particularly the serotonergic ones, the lipid profile, neuro-immunological biomarkers, the Brain-derived neurotrophic factor and other neuromodulators.Conclusion The present overview reported that suicide is a highly complex and multifaceted phenomenon in which a large plethora of mechanisms could be variable implicated, particularly amongst MDD subjects. Beyond these consideration, modern psychiatry needs a better interpretation of suicide risk with a more careful assessment of suicide risk stratification and planning of clinical and treatment interventions.

Published
2020

11. Religious Coping, Hopelessness, and Suicide Ideation in Subjects with First-Episode Major Depression: An Exploratory Study in the Real World Clinical Practice

Author

Federica Vellante, Nicola Serroni, Domenico De Berardis, Luigi Olivieri, Gabriella Rapini, Maurizio Pompili, Massimiliano Bustini, Massimo Di Giannantonio, Gianluca Serafini, Antonio Ventriglio, Michele Fornaro, Alessandro Carano, Silvia Fraticelli, Giampaolo Perna, Alessandro Valchera, Giovanni Martinotti, RS: MHeNs - R2 - Mental Health, De Berardis, Domenico, Olivieri, Luigi, Rapini, Gabriella, Serroni, Nicola, Fornaro, Michele, Valchera, Alessandro, Carano, Alessandro, Vellante, Federica, Bustini, Massimiliano, Serafini, Gianluca, Pompili, Maurizio, Ventriglio, Antonio, Perna, Giampaolo, Fraticelli, Silvia, Martinotti, Giovanni, and Di Giannantonio, Massimo

Subjects
life, Coping (psychology), STRESS, CROATIAN WAR VETERANS, Protective factor, Exploratory research, INTRINSIC RELIGIOSITY, lcsh:RC321-571, scale, Religiosity, 03 medical and health sciences, 0302 clinical medicine, religious coping, prevention, high-risk, Rating scale, mental disorders, hopelessness, medicine, resilience, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, First episode, Communication, General Neuroscience, association, social support, medicine.disease, religiosity, 030227 psychiatry, hopelessne, mental-health, suicide ideation, depression, Beck Hopelessness Scale, Major depressive disorder, Psychology, Depression, Hopelessness, Prevention, Religious coping, Suicide ideation, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Background. This study aimed to evaluate the potential relationships between religious coping, hopelessness, and suicide ideation in adult outpatients with the first episode of major depressive disorder (MDD). Methods. Ninety-four adult outpatients with MDD were assessed through the Hamilton Depression Rating Scale (HAM-D), the Beck Hopelessness Scale (BHS), and the Scale of Suicide Ideation (SSI). Religious coping was assessed with the Italian version of the Brief RCOPE scale, consisting of seven positive coping items (PosCop) and seven negative coping items (NegCop). Results. The results showed that the Brief RCOPE PosCop scale exhibited a strong inverse correlation with HAM-D, BHS, and SSI, whereas HAM-D and BHS were positively correlated with SSI. Brief RCOPE NegCop scores were positively correlated only with SSI. Regression analysis with SSI as the dependent variable showed that higher Brief RCOPE PosCop scores were associated with lower suicide ideation, whereas higher HAM-D and BHS scores were associated with higher suicide ideation. Conclusion. Positive religious coping may be a protective factor against the development of suicide ideation, perhaps counteracting the severity of depressive symptoms and hopelessness. The evaluation of religious coping should be performed in all subjects with MDD in everyday clinical practice. However, this study was preliminary, and limitations must be considered.

Published
2020

12. Overcoming the Use of Mechanical Restraints in Psychiatry: A New Challenge in the Everyday Clinical Practice at the Time of COVID-19

Author

Domenico De Berardis, Michele Fornaro, Massimo Di Giannantonio, Antonio Ventriglio, Silvia Fraticelli, Giovanni Martinotti, Federica Vellante, De Berardis, Domenico, Ventriglio, Antonio, Fornaro, Michele, Vellante, Federica, Martinotti, Giovanni, Fraticelli, Silvia, and Di Giannantonio, Massimo

Subjects
2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), lcsh:R, Psychological intervention, MEDLINE, lcsh:Medicine, General Medicine, Mental health, 030227 psychiatry, Clinical Practice, 03 medical and health sciences, Editorial, n/a, 0302 clinical medicine, Family medicine, medicine, 030212 general & internal medicine, business
Abstract

Restraining interventions, which comprise physical (PR) and mechanical restraint (MR), have a long history in mental health services [...]

Published
2020

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