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1. A Food Impaction in Crohn’s Ileal Stricture

Author

Hokama, Akira, Kishimoto, Kazuto, Ihama, Yasushi, Chinen, Hiroshi, Kinjo, Fukunori, and Fujita, Jiro

Subjects
Crohn's disease, computed tomography, small bowel obstruction., Medicine, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Published
2010

2. Pneumococcal meningitis in adults in 2014–2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan

Author

Chang, Bin, Tamura, Kosuke, Fujikura, Hiroyuki, Watanabe, Hiroshi, Tanabe, Yoshinari, Kuronuma, Koji, Fujita, Jiro, Oshima, Kengo, Maruyama, Takaya, Abe, Shuichi, Kasahara, Kei, Nishi, Junichiro, Kubota, Tetsuya, Kinjo, Yuki, Serizawa, Yusuke, Shimbashi, Reiko, Fukusumi, Munehisa, Shimada, Tomoe, Sunagawa, Tomimasa, Suzuki, Motoi, and Oishi, Kazunori

Published
2022
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3. Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan

Author

Oka, Keisuke, Matsumoto, Akane, Tetsuka, Nobuyuki, Morioka, Hiroshi, Iguchi, Mitsutaka, Ishiguro, Nobuhisa, Nagamori, Tsunehisa, Takahashi, Satoshi, Saito, Norihiro, Tokuda, Koichi, Igari, Hidetoshi, Fujikura, Yuji, Kato, Hideaki, Kanai, Shinichiro, Kusama, Fumiko, Iwasaki, Hiromichi, Furuhashi, Kazuki, Baba, Hisashi, Nagao, Miki, Nakanishi, Masaki, Kasahara, Kei, Kakeya, Hiroshi, Chikumi, Hiroki, Ohge, Hiroki, Azuma, Momoyo, Tauchi, Hisamichi, Shimono, Nobuyuki, Hamada, Yohei, Takajo, Ichiro, Nakata, Hirotomo, Kawamura, Hideki, Fujita, Jiro, and Yagi, Tetsuya

Published
2022
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5. Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013-2017

Author

Shimbashi, Reiko, Suzuki, Motoi, Chang, Bin, Watanabe, Hiroshi, Tanabe, Yoshinari, Kuronuma, Koji, Oshima, Kengo, Maruyama, Takaya, Takeda, Hiroaki, Kasahara, Kei, Fujita, Jiro, Nishi, Junichiro, Kubota, Tetsuya, Tanaka-Taya, Keiko, Matsui, Tamano, Sunagawa, Tomimasa, and Oishi, Kazunori

Subjects
Vaccines, Polysaccharides, Adults, Health
Abstract

Streptococcus pneumoniae is a major cause of illness and death among adults (1). Pneumonia is the most common form of pneumococcal disease in adults, whereas invasive pneumococcal disease (IPD), including [...]

Published
2020
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6. Subcutaneous epcoritamab monotherapy in Japanese adults with relapsed/refractory diffuse large B‐cell lymphoma

Author

Izutsu, Koji, primary, Kumode, Takahiro, additional, Yuda, Junichiro, additional, Nagai, Hirokazu, additional, Mishima, Yuko, additional, Suehiro, Youko, additional, Yamamoto, Kazuhito, additional, Fujisaki, Tomoaki, additional, Ishitsuka, Kenji, additional, Ishizawa, Kenichi, additional, Ikezoe, Takayuki, additional, Nishikori, Momoko, additional, Akahane, Daigo, additional, Fujita, Jiro, additional, Dinh, Minh, additional, Soong, David, additional, Noguchi, Hidehisa, additional, Buchbjerg, Jeppe Klint, additional, Favaro, Elena, additional, and Fukuhara, Noriko, additional

Published
2023
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8. “Whirl Sign” of Primary Small Bowel Volvulus

Author

Tamura, Jiro, Kuniyoshi, Nobuo, Maruwaka, Shuichi, Shiroma, Joji, Miyagi, Sunao, Orita, Hitoshi, Sakugawa, Hiroshi, Kinjo, Fukunori, Fujita, Jiro, and Hokama, Akira

Subjects
whirl sign, primary small bowel volvulus
Abstract

[West J Emerg Med. 2014;15(4):359–360.]

Published
2014

11. “Playboy Bunny” Sign of Congestive Heart Failure

Author

Hokama, Akira, Arakaki, Shingo, Shibata, Daisuke, Maeshiro, Tatsuji, Kinjo, Fukunori, and Fujita, Jiro

Subjects
ultrasound, congestive heart failure, Cardiology, Emergency Medicine, Hepatology
Abstract

In emergency, ultrasound has been widely used as a non-invasive and effective examination to evaluate congestive heart failure. We highlight “Playboy Bunny” sign as a reliable marker and an important clue to the diagnosis of passive hepatic congestion, caused by congestive heart failure. [West J Emerg Med. 2011;12(4):433–434.]

Published
2011

17. Confounding effects of microbiome on the susceptibility of TNFSF15 to Crohn’s disease in the Ryukyu Islands

Author

Nakagome, Shigeki, Chinen, Hiroshi, Iraha, Atsushi, Hokama, Akira, Takeyama, Yasuaki, Sakisaka, Shotaro, Matsui, Toshiyuki, Kidd, Judith R., Kidd, Kenneth K., Said, Heba S., Suda, Wataru, Morita, Hidetoshi, Hattori, Masahira, Hanihara, Tsunehiko, Kimura, Ryosuke, Ishida, Hajime, Fujita, Jiro, Kinjo, Fukunori, Mano, Shuhei, and Oota, Hiroki

Published
2017
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20. Phase 1/2 study evaluating the safety and efficacy of DSP‐7888 dosing emulsion in myelodysplastic syndromes

Author

Ueda, Yasunori, primary, Usuki, Kensuke, additional, Fujita, Jiro, additional, Matsumura, Itaru, additional, Aotsuka, Nobuyuki, additional, Sekiguchi, Naohiro, additional, Nakazato, Tomonori, additional, Iwasaki, Hiromi, additional, Takahara‐Matsubara, Mariko, additional, Sugimoto, Saori, additional, Goto, Masashi, additional, Naoe, Tomoki, additional, Kizaki, Masahiro, additional, Miyazaki, Yasushi, additional, and Aakashi, Koichi, additional

Published
2022
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23. Whole-Genome Analysis-Based Phylogeographic Investigation of Streptococcus pneumoniae Serotype 19A Sequence Type 320 Isolates in Japan

Author

Nakano, Satoshi, primary, Fujisawa, Takao, additional, Chang, Bin, additional, Ito, Yutaka, additional, Akeda, Hideki, additional, Fujita, Jiro, additional, Matsumura, Yasufumi, additional, Yamamoto, Masaki, additional, Suga, Shigeru, additional, Oishi, Kazunori, additional, Nagao, Miki, additional, and Ohnishi, Makoto, additional

Published
2022
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25. Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement

Author

Suga, Makiko, primary, Fukushima, Kentaro, additional, Ueda, Tomoaki, additional, Arai, Yasuyuki, additional, Nakagawa, Shunsaku, additional, Minami, Yosuke, additional, Toda, Jun, additional, Hino, Akihisa, additional, Fujita, Jiro, additional, Yokota, Takafumi, additional, and Hosen, Naoki, additional

Published
2022
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31. Radiation Ileitis Leading to Enterovesical Fistula

Author

Hokama, Akira, primary, Kanemoto, Moemi, additional, Hagiwara, Keita, additional, Ikemura, Akihito, additional, Koga, Erika, additional, Tameda, Shigehito, additional, Oishi, Yuiko, additional, Tabata, Souhei, additional, Miyazato, Kouya, additional, and Fujita, Jiro, additional

Published
2022
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32. Inotuzumab ozogamicin and blinatumomab sequential therapy for relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia

Author

Ueda, Tomoaki, primary, Fukushima, Kentaro, additional, Kusakabe, Shinsuke, additional, Yoshida, Koki, additional, Suga, Makiko, additional, Nakai, Ritsuko, additional, Koike, Midori, additional, Hino, Akihisa, additional, Akuta, Keigo, additional, Toda, Jun, additional, Nagate, Yasuhiro, additional, Doi, Yukiko, additional, Fujita, Jiro, additional, Yokota, Takafumi, additional, and Hosen, Naoki, additional

Published
2022
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34. A Case Report of Cerebral Meningitis Caused by Penicillin-Non-Susceptible Group B Streptococcus in an Immunocompromised Adult Patient

Author

Hirai, Jun, Kinjo, Takeshi, Haranaga, Shusaku, and Fujita, Jiro

Subjects
adult, PRGBS, meningitis, Case Report, serotype Ib, Streptococcus agalactiae, corticosteroids
Abstract

Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is the leading cause of bacteremia and meningitis in neonates; however, it also causes meningitis in adults, although much less frequently. After the detection of penicillin-non-susceptible GBS (PRGBS) for the first time in 2008 by Japanese researchers, clinical PRGBS isolates have been reported worldwide. These isolates need to be given due attention for being non-susceptible to multiple drugs. Herein, we present the first clinical report of meningitis caused by PRGBS. A 41-year-old Japanese male receiving an immunosuppressant visited hospital complaining of fever. Although he did not have meningitis-related symptoms or physical findings, determination of the cause of fever by Gram-staining of the spinal fluid revealed gram-positive cocci in pairs and chains. Initially, he was hospitalized on the diagnosis of cerebral meningitis caused by Streptococcus pneumoniae. However, culture of the spinal fluid revealed the β-hemolytic colonies on blood agar. Biochemical testing and mass spectrometry revealed the isolated organism as GBS (serotype Ib). The minimum inhibitory concentration (MIC) of penicillin G for the isolated strain was 0.5 μg/mL, which is greater than the MIC criteria for “susceptibility” to penicillin G for beta-hemolytic streptococci according to Clinical and Laboratory Standards Institute standards. The isolated strain was also resistant to macrolide (MIC ≥ 8 μg/mL) and fluoroquinolone (MIC ≥ 8 μg/mL). The patient recovered without neurologic sequelae upon treatment with ceftriaxone, vancomycin, and corticosteroids for 4 days, and subsequently with ampicillin for 17 days. The rate of isolation of PRGBS in the clinics has gradually increased, particularly in Japan. Although PRGBS isolated in the present case was susceptible to ampicillin and cephalosporins, strains not susceptible to ampicillin, cefotaxime, and ceftriaxone have already been isolated, indicating the prospects for limited range of effective antibiotics against PRGBS infections, including meningitis, in the near future.

Published
2020

35. The First Case of Community-Acquired Pneumonia Due to Capsular Genotype K2-ST86 Hypervirulent Klebsiella pneumoniae in Okinawa, Japan: A Case Report and Literature Review

Author

Hirai, Jun, Sakanashi, Daisuke, Kinjo, Takeshi, Haranaga, Shusaku, and Fujita, Jiro

Subjects
hypervirulent Klebsiella pneumoniae, community-acquired pneumonia, Streptococcus pneumoniae, lobar pneumonia, Case Report, serotype K2, sequence type 86
Abstract

Hypervirulent Klebsiella pneumoniae (HV-KP) typically causes pyogenic liver abscess and bacteremia with metastatic infections. Community-acquired pneumonia (CAP) due to HV-KP is uncommon and details of its clinical and microbiological features are limited. We report the first case of CAP due to capsular genotype K2-ST86 HV-KP in Okinawa, Japan and review infections caused by the K2-ST86 strain. A 79-year-old woman presenting with fever and productive cough persisting for the past three days was admitted to hospital. Her vital signs indicated septic shock. Lung examination by auscultation revealed holo-crackle and lobar pneumonia in chest radiography, and Streptococcus pneumoniae was suspected. However, sputum and blood cultures revealed Gram-negative coccus identified as K. pneumoniae. Genetic analysis identified the isolated strain as the K2 serotype harboring rmpA, iutA, entB, and mrkD. Therefore, we identified the isolated strain as hypervirulent. The isolate belonged to ST86 as determined by multilocus sequence typing. The case was not complicated by predisposing factors such as diabetes mellitus and malignancy related to HV-KP infection; thus, this CAP-causing HV-KP strain may differ from the typical HV-KP strain that induces liver abscess. A literature review identified only nine cases with CAP due to HV-KP. In all cases, the disease mainly occurred in older males with diabetes mellitus, which makes the present case unusual, and had high rates of septic shock and death. No case, including ours, was complicated by metastatic infection, suggesting that CAP due to HV-KP poses little distant metastasis risk, even in patients with bloodstream infection. In our review, consistent with our case, K2-ST86 was the most common strain of HV-KP in patients with CAP. Therefore, studies are needed to elucidate the clinical and microbiological features of HV-KP CAP, with a focus on the K2-ST86 strain. Physicians should always consider K. pneumoniae in cases of sepsis CAP with lobar pneumonia.

Published
2020

36. Case Report of Primary Lung Abscesses Due to Hypervirulent Klebsiella pneumoniae (Serotype K2, Sequence Type 375): an Emerging Isolate in Okinawa, Japan

Author

Hirai, Jun, Sakanashi, Daisuke, Momose, Masashi, Koga, Tomomi, Kinjo, Takeshi, Haranaga, Shusaku, Motonaga, Eiji, and Fujita, Jiro

Subjects
hypervirulent Klebsiella pneumoniae, Okinawa, Japan, Case Report, sequence type 375, serotype K2, primary lung abscess
Abstract

Hypervirulent Klebsiella pneumoniae (HV-KP) is typically associated with community-acquired liver abscess and bacteremia with metastatic infection; however, primary lung abscess (PLA) caused by HV-KP is rare, with only one such case report to date. A 69-year-old man with a history of diabetes mellitus (DM) was admitted to hospital complaining of slight bloody sputum. Chest imaging showed multiple consolidations with cavities in both lung fields. A culture of bronchoalveolar lavage fluid confirmed the presence of K. pneumoniae. Genetic analyses identified the isolate as serotype K2 and sequence type 375 (K2-ST375), and that it harbored the rmpA gene. The patient was an Asian middle-aged male with DM, all of which are risk factors for HV-KP infection. Although complicating DM and the presence of the rmpA gene are more likely to induce disseminated infection, metastatic infections were not found in this patient. The clinical and microbiological characteristics of our patient were different from those of a previous reported case, although in both cases the patient was from Asia and had DM. Therefore, DM appears to be one of the predisposing factors for HV-KP lung abscesses and physicians should pay attention to emerging HV-KP lung abscess infection, particularly in Asian countries. Previous studies have also revealed that K2-ST375 is one of the major clones causing HV-KP infection, and that it is mainly isolated from patients with liver abscess. Interestingly, including the present case, most of the infectious cases caused by K2-ST375 have been reported from Okinawa Prefecture in Japan. Therefore, the trend of the K2-ST375 strain should be carefully monitored, particularly in Okinawa, Japan. The serotype of HV-KP that causes PLA is still unknown and further study is needed to elucidate the etiology of PLA due to HV-KP and the relationship between the strain K2-ST375 and PLA.

Published
2020

44. Hepatocellular Carcinoma in a Patient With Crohn’s Disease

Author

Hokama, Akira, primary, Arakaki, Shingo, additional, Ishino, Shinichiro, additional, Nakagawa, Yutaka, additional, Tabata, Souhei, additional, Agarie, Daiki, additional, Kuwae, Satoshi, additional, Zukeyama, Ryuta, additional, Maeshiro, Tatsuji, additional, Tsuruta, Yuma, additional, Matsuzaki, Akiko, additional, Wada, Naoki, additional, Takatsuki, Mitsuhisa, additional, and Fujita, Jiro, additional

Published
2021
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46. Phase II study of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T‐cell lymphoma

Author

Kawai, Hidetsugu, primary, Ando, Kiyoshi, additional, Maruyama, Dai, additional, Yamamoto, Kazuhito, additional, Kiyohara, Eiji, additional, Terui, Yasuhito, additional, Fukuhara, Noriko, additional, Miyagaki, Tomomitsu, additional, Tokura, Yoshiki, additional, Sakata‐Yanagimoto, Mamiko, additional, Igarashi, Tadahiko, additional, Kuroda, Junya, additional, Fujita, Jiro, additional, Uchida, Toshiki, additional, Ishikawa, Takayuki, additional, Yonekura, Kentaro, additional, Kato, Koji, additional, Nakanishi, Tadashi, additional, Nakai, Kenya, additional, Matsunaga, Risa, additional, and Tobinai, Kensei, additional

Published
2021
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48. Bloating in a supine position

Author

Hokama, Akira, primary, Nakada, Yasuka, additional, Yanagida, Aki, additional, Koga, Erika, additional, Hoshino, Kunikazu, additional, and Fujita, Jiro, additional

Published
2021
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49. Critical respiratory failure in pregnancy complicated with COVID-19: A case report

Author

Chinen, Yukiko, primary, Kinjyo, Yoshino, additional, Mekaru, Keiko, additional, Kinjo, Tadatsugu, additional, Higure, Yuuri, additional, Kinjo, Takeshi, additional, Miyagi, Kazuya, additional, Yamada, Hisako, additional, Masamoto, Hitoshi, additional, Goya, Hideki, additional, Yoshida, Tomohide, additional, Maeshiro, Sakiko, additional, Nakamatsu, Masashi, additional, Fujita, Jiro, additional, and Aoki, Yoichi, additional

Published
2021
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50. Distribution and Variation of Serotypes and Pneumococcal Surface Protein A Clades of Streptococcus pneumoniae Strains Isolated From Adult Patients With Invasive Pneumococcal Disease in Japan

Author

Chang, Bin, primary, Kinjo, Yuki, additional, Morita, Masatomo, additional, Tamura, Kosuke, additional, Watanabe, Hiroshi, additional, Tanabe, Yoshinari, additional, Kuronuma, Koji, additional, Fujita, Jiro, additional, Oshima, Kengo, additional, Maruyama, Takaya, additional, Abe, Shuichi, additional, Kasahara, Kei, additional, Nishi, Junichiro, additional, Kubota, Tetsuya, additional, Ohnishi, Makoto, additional, Suga, Shigeru, additional, and Oishi, Kazunori, additional

Published
2021
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