1. Neuroimaging of Peptide-based Vaccine Therapy in Pediatric Brain Tumors Initial Experience
- Author
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Furtado, Andre D, Ceschin, Rafael, Blüml, Stefan, Mason, Gary, Jakacki, Regina I, Okada, Hideho, Pollack, Ian F, and Panigrahy, Ashok
- Subjects
Biomedical and Clinical Sciences ,Immunology ,Cancer ,Orphan Drug ,Brain Cancer ,Brain Disorders ,Rare Diseases ,Neurosciences ,Vaccine Related ,Immunization ,Pediatric ,Pediatric Cancer ,Prevention ,Biomedical Imaging ,4.2 Evaluation of markers and technologies ,Neurological ,Good Health and Well Being ,Brain ,Brain Neoplasms ,Child ,Diffusion Magnetic Resonance Imaging ,Humans ,Immunotherapy ,Active ,Magnetic Resonance Imaging ,Magnetic Resonance Spectroscopy ,Neuroimaging ,Peptides ,Treatment Outcome ,Pseudoprogression ,Vaccine therapy ,Pediatric brain tumors ,MR spectroscopy ,Nuclear Medicine & Medical Imaging - Abstract
The potential benefits of peptide-based immunotherapy for pediatric brain tumors are under investigation. Treatment-related heterogeneity has resulted in radiographic challenges, including pseudoprogression. Conventional MR imaging has limitations in assessment of different forms of treatment-related heterogeneity, particularly regarding distinguishing true tumor progression from efficacious treatment responses. Advanced neuroimaging techniques, including diffusion magnetic resonance (MR), perfusion MR, and MR spectroscopy, may add value in the assessment of treatment-related heterogeneity. Observations suggest that recent delineation of specific response criteria for immunotherapy of adult brain tumors is likely relevant to the pediatric population and further validation in multicenter pediatric brain tumor peptide-based vaccine studies is warranted.
- Published
- 2017