1. Inclusion or Exclusion of Intratumoral Vessels in Relative Cerebral Blood Volume Characterization in Low-Grade Gliomas: Does It Make a Difference?
- Author
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Jeremy Rees, Christopher E. Benton, John S. Thornton, Adam D. Waldman, Tarek A. Yousry, Hans Rolf Jäger, and G Brasil Caseiras
- Subjects
Pathology ,medicine.medical_specialty ,Blood volume ,Sensitivity and Specificity ,Central nervous system disease ,Glioma ,Image Interpretation, Computer-Assisted ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Blood Volume ,Neovascularization, Pathologic ,Brain Neoplasms ,business.industry ,Reproducibility of Results ,Brain ,medicine.disease ,Magnetic Resonance Imaging ,Proton mr spectroscopy ,medicine.anatomical_structure ,Cerebral blood volume ,Cerebrovascular Circulation ,Neurology (clinical) ,business ,Blood vessel - Abstract
SUMMARY: We assessed the influence of inclusion (method 1) and exclusion (method 2) of intratumoral vessels when determining maximum relative cerebral blood volume (rCBVmax) in 3 types of low-grade gliomas (LGGs): astrocytomas, oligoastrocytomas, and oligodendrogliomas. Method 1 yielded significantly higher mean rCBVmax than method 2. However, only method 2 demonstrated a significant (P = .026) association between rCBVmax and membership of a differently ranked histologic category. Exclusion of intratumoral vessels appears, therefore, preferable when determining rCBVmax in LGGs.
- Published
- 2008
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