Author: "Gartner, S. E." / Search Limiters: Full Text - Searchworks@Jio Institute Digital Library Search Results

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Author: Silverman, K. C., Cascales, C., Genilloud, O., Sigmund, J. M., Gartner, S. E., Koch, G. E., Gagliardi, M. M., Heimbuch, B. K., Nallin-Omstead, M., Sanchez, M., Diez, M. T., Martin, I., Garrity, G. M., Hirsch, C. F., Gibbs, J. B., Singh, S. B., and Lingham, R. B.
Published: 1995
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Author: Lingham RB, Silverman KC, Bills GF, Cascales C, Sanchez M, Jenkins RG, Gartner SE, Martin I, Diez MT, and Peláez F
Subjects: Fermentation, Maleates isolation & purification, Maleates pharmacology, Alkyl and Aryl Transferases, Maleates metabolism, Mitosporic Fungi metabolism, Transferases antagonists & inhibitors
Abstract: Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.
Published: 1993
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