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2. Multiparametric autoantibody analysis: a new paradigm for the diagnosis of connective tissue diseases

Author

Bizzaro, Nicola, Villalta, Danilo, Bini, Vittorio, Migliorini, Paola, Franceschini, Franco, Piantoni, Silvia, Garrafa, Emirena, Riccieri, Valeria, Fioravanti, Antonella, Bellisai, Francesca, Tampoia, Marilina, Fornaro, Marco, Iannone, Florenzo, Ghirardello, Anna, Zen, Margherita, Palterer, Boaz, Parronchi, Paola, Infantino, Maria, Benucci, Maurizio, Rigon, Amelia, Arcarese, Luisa, Del Rosso, Stefania, Canti, Valentina, Bartoloni, Elena, and Gerli, Roberto

Published
2022
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3. Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts

Author

Pezoulas, Vasileios C., Goules, Andreas, Kalatzis, Fanis, Chatzis, Luke, Kourou, Konstantina D., Venetsanopoulou, Aliki, Exarchos, Themis P., Gandolfo, Saviana, Votis, Konstantinos, Zampeli, Evi, Burmeister, Jan, May, Thorsten, Marcelino Pérez, Manuel, Lishchuk, Iryna, Chondrogiannis, Thymios, Andronikou, Vassiliki, Varvarigou, Theodora, Filipovic, Nenad, Tsiknakis, Manolis, Baldini, Chiara, Bombardieri, Michele, Bootsma, Hendrika, Bowman, Simon J., Soyfoo, Muhammad Shahnawaz, Parisis, Dorian, Delporte, Christine, Devauchelle-Pensec, Valérie, Pers, Jacques-Olivier, Dörner, Thomas, Bartoloni, Elena, Gerli, Roberto, Giacomelli, Roberto, Jonsson, Roland, Ng, Wan-Fai, Priori, Roberta, Ramos-Casals, Manuel, Sivils, Kathy, Skopouli, Fotini, Torsten, Witte, A. G. van Roon, Joel, Xavier, Mariette, De Vita, Salvatore, Tzioufas, Athanasios G., and Fotiadis, Dimitrios I.

Published
2022
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4. The management of patients with inflammatory bowel disease-associated spondyloarthritis: Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) and Italian Society of Rheumatology (SIR) recommendations based on a pseudo-Delphi consensus

Author

Macaluso, F, Caprioli, F, Benedan, L, Bezzio, C, Caporali, R, Cauli, A, Chimenti, M, Ciccia, F, D'Angelo, S, Fantini, M, Festa, S, Iannone, F, Lubrano, E, Mariani, P, Papi, C, Provenzano, G, Pugliese, D, Rispo, A, Saibeni, S, Salvarani, C, Variola, A, Zenga, M, Armuzzi, A, Orlando, A, Gerli, R, Macaluso, Fabio Salvatore, Caprioli, Flavio, Benedan, Laura, Bezzio, Cristina, Caporali, Roberto, Cauli, Alberto, Chimenti, Maria Sole, Ciccia, Francesco, D'Angelo, Salvatore, Fantini, Massimo Claudio, Festa, Stefano, Iannone, Florenzo, Lubrano, Ennio, Mariani, Paolo, Papi, Claudio, Provenzano, Giuseppe, Pugliese, Daniela, Rispo, Antonio, Saibeni, Simone, Salvarani, Carlo, Variola, Angela, Zenga, Mariangela, Armuzzi, Alessandro, Orlando, Ambrogio, Gerli, Roberto, Macaluso, F, Caprioli, F, Benedan, L, Bezzio, C, Caporali, R, Cauli, A, Chimenti, M, Ciccia, F, D'Angelo, S, Fantini, M, Festa, S, Iannone, F, Lubrano, E, Mariani, P, Papi, C, Provenzano, G, Pugliese, D, Rispo, A, Saibeni, S, Salvarani, C, Variola, A, Zenga, M, Armuzzi, A, Orlando, A, Gerli, R, Macaluso, Fabio Salvatore, Caprioli, Flavio, Benedan, Laura, Bezzio, Cristina, Caporali, Roberto, Cauli, Alberto, Chimenti, Maria Sole, Ciccia, Francesco, D'Angelo, Salvatore, Fantini, Massimo Claudio, Festa, Stefano, Iannone, Florenzo, Lubrano, Ennio, Mariani, Paolo, Papi, Claudio, Provenzano, Giuseppe, Pugliese, Daniela, Rispo, Antonio, Saibeni, Simone, Salvarani, Carlo, Variola, Angela, Zenga, Mariangela, Armuzzi, Alessandro, Orlando, Ambrogio, and Gerli, Roberto

Abstract

Spondyloarthritis (SpA) is the most frequent extraintestinal manifestation in patients with inflammatory bowel diseases (IBD). When IBD and spondyloarthritis coexist, musculoskeletal and intestinal disease features should be considered when planning a therapeutic strategy. Treatment options for IBD and SpA have expanded enormously over the last few years, but randomized controlled trials with specific endpoints focused on SpA are not available in the IBD setting. To address this important clinical topic, the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) and the Italian Society of Rheumatology (SIR) jointly planned to draw updated therapeutic recommendations for IBD-associated SpA using a pseudo-Delphi method. This document presents the official recommendations of IG-IBD and SIR on the management of IBD-associated SpA in the form of 34 statements and 4 therapeutic algorithms. It is intended to be a reference guide for gastroenterologists and rheumatologists dealing with IBD-associated SpA.

Published
2024

5. Rational approach to the prescription of anti-rheumatic drugs in rheumatoid arthritis: a product leaflet-based strategy in Italy.

Author

Perricone, Carlo, Castellucci, Andrea, Cafaro, Giacomo, Calvacchi, Santina, Bruno, Lorenza, Pozzolo, Roberto Dal, Tromby, Francesco, Colangelo, Anna, Gerli, Roberto, and Bartoloni, Elena

Abstract

The treatment of patients with rheumatoid arthritis (RA) has dramatically changed in the past 30 years. Currently, numerous conventional, biologic, and targeted synthetic DMARDs have been licensed and used following recommendations provided by international and national scientific societies. However, the availability of biosimilars and the increasing necessity of savings impacted on the local/national prescription of these drugs. The information provided by data sheet of every single drug is a decisive factor on the choice of a certain treatment merged with the patient’s profile. Thus, our purpose was to construct a rational algorithm for the treatment strategy in RA according to costs and the product leaflet of the biologic and targeted-synthetic DMARDs currently licensed in Italy. We used the most recent available recommendations and then we performed a review of the literature considering all the factors that are known to influence drug safety/effectiveness. All these factors were considered in the context of the data sheets of currently available originators and biosimilars. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Descriptive analysis of patients positive for anti-phospholipid antibodies included in two Italian registries

Author

Pengo, Vittorio, primary, Sarti, Luca, additional, Antonucci, Emilia, additional, Di Agostino, Stefania, additional, Bison, Elisa, additional, Denas, Gentian, additional, Poli, Daniela, additional, Meroni, Pier Luigi, additional, Gerli, Roberto, additional, Radice, Antonella, additional, Palareti, Gualtiero, additional, and FIRMA group and START collaborators, On behalf of, additional

Published
2023
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7. Exploring the Link between Plasma Levels of PCSK9, Immune Dysregulation and Atherosclerosis in Patients with Primary Sjögren’s Syndrome

Author

Bianconi, Vanessa, primary, Cafaro, Giacomo, additional, Mannarino, Massimo Raffaele, additional, Perricone, Carlo, additional, Cosentini, Elena, additional, Bistoni, Onelia, additional, Paltriccia, Rita, additional, Lombardini, Rita, additional, Gerli, Roberto, additional, Pirro, Matteo, additional, and Bartoloni, Elena, additional

Published
2023
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8. Autoantibody status according to multiparametric assay accurately estimates connective tissue disease classification and identifies clinically relevant disease clusters

Author

Cafaro, Giacomo, primary, Bartoloni, Elena, additional, Baldini, Chiara, additional, Franceschini, Franco, additional, Riccieri, Valeria, additional, Fioravanti, Antonella, additional, Fornaro, Marco, additional, Ghirardello, Anna, additional, Palterer, Boaz, additional, Infantino, Maria, additional, Rigon, Amelia, additional, Del Rosso, Stefania, additional, Gerli, Roberto, additional, Villalta, Danilo, additional, and Bizzaro, Nicola, additional

Published
2023
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9. Management of psoriatic arthritis: a consensus opinion by expert rheumatologists.

Author

D'Angelo, Salvatore, Atzeni, Fabiola, Benucci, Maurizio, Bianchi, Gerolamo, Cantini, Fabrizio, Felice Caporali, Roberto, Carlino, Giorgio, Caso, Francesco, Cauli, Alberto, Ciccia, Francesco, D'Agostino, Maria Antonietta, Dagna, Lorenzo, Dejaco, Christian, Massimiliano Epis, Oscar, Ferrucci, Maria Grazia, Franceschini, Franco, Fusaro, Enrico, Gabini, Marco, Gerli, Roberto, and Giacomelli, Roberto

Published
2023
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10. Early and Late Response and Glucocorticoid-Sparing Effect of Belimumab in Patients with Systemic Lupus Erythematosus with Joint and Skin Manifestations: Results from the Belimumab in Real Life Setting Study—Joint and Skin (BeRLiSS-JS)

Author

Zen, Margherita, primary, Gatto, Mariele, additional, Depascale, Roberto, additional, Regola, Francesca, additional, Fredi, Micaela, additional, Andreoli, Laura, additional, Franceschini, Franco, additional, Urban, Maria Letizia, additional, Emmi, Giacomo, additional, Ceccarelli, Fulvia, additional, Conti, Fabrizio, additional, Bortoluzzi, Alessandra, additional, Govoni, Marcello, additional, Tani, Chiara, additional, Mosca, Marta, additional, Ubiali, Tania, additional, Gerosa, Maria, additional, Bozzolo, Enrica P., additional, Canti, Valentina, additional, Cardinaletti, Paolo, additional, Gabrielli, Armando, additional, Tanti, Giacomo, additional, Gremese, Elisa, additional, De Marchi, Ginevra, additional, De Vita, Salvatore, additional, Fasano, Serena, additional, Ciccia, Francesco, additional, Pazzola, Giulia, additional, Salvarani, Carlo, additional, Negrini, Simone, additional, Di Matteo, Andrea, additional, De Angelis, Rossella, additional, Orsolini, Giovanni, additional, Rossini, Maurizio, additional, Faggioli, Paola, additional, Laria, Antonella, additional, Piga, Matteo, additional, Cauli, Alberto, additional, Scarpato, Salvatore, additional, Rossi, Francesca Wanda, additional, De Paulis, Amato, additional, Brunetta, Enrico, additional, Ceribelli, Angela, additional, Selmi, Carlo, additional, Prete, Marcella, additional, Racanelli, Vito, additional, Vacca, Angelo, additional, Bartoloni, Elena, additional, Gerli, Roberto, additional, Zanatta, Elisabetta, additional, Larosa, Maddalena, additional, Saccon, Francesca, additional, Doria, Andrea, additional, and Iaccarino, Luca, additional

Published
2023
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12. Characterization and outcomes of 414 patients with primary SS who developed haematological malignancies

Author

Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials, Hernández Molina, Gabriela, Kostov, Belchin Adriyanov, Brito Zerón, Pilar, Vissink, Arjan, Mandl, Thomas, Hinrichs, Anneline C., Quartuccio, Luca, Baldini, Chiara, Seror, Raphaèle, Szántó, Antonia, Isenberg, David, Gerli, Roberto, Nordmark, Gunnel, Acar Denizli, Nihan, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials, Hernández Molina, Gabriela, Kostov, Belchin Adriyanov, Brito Zerón, Pilar, Vissink, Arjan, Mandl, Thomas, Hinrichs, Anneline C., Quartuccio, Luca, Baldini, Chiara, Seror, Raphaèle, Szántó, Antonia, Isenberg, David, Gerli, Roberto, Nordmark, Gunnel, and Acar Denizli, Nihan

Abstract

Objective To characterize 414 patients with primary SS who developed haematological malignancies and to analyse how the main SS- and lymphoma-related features can modify the presentation patterns and outcomes. Methods By January 2021, the Big Data Sjögren Project Consortium database included 11¿966 patients fulfilling the 2002/2016 classification criteria. Haematological malignancies diagnosed according to the World Health Organization (WHO) classification were retrospectively identified. Results There were 414 patients (355 women, mean age 57¿years) with haematological malignancies (in 43, malignancy preceded at least one year the SS diagnosis). A total of 376 (91%) patients had mature B-cell malignancy, nearly half had extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT lymphoma) (n¿=¿197), followed by diffuse large B-cell lymphoma (DLBCL) (n¿=¿67), nodal MZL lymphoma (n¿=¿29), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) (n¿=¿19) and follicular lymphoma (FL) (n¿=¿17). Rates of complete response, relapses and death were 80%, 34% and 13%, respectively, with a 5-year survival rate of 86.5% after a mean follow-up of 8¿years. There were significant differences in age at diagnosis (younger in MALT, older in CLL/SLL), predominant clinical presentation (glandular enlargement in MALT lymphoma, peripheral lymphadenopathy in nodal MZL and FL, constitutional symptoms in DLBCL, incidental diagnosis in CLL/SLL), therapeutic response (higher in MALT lymphoma, lower in DLBCL) and survival (better in MALT, nodal MZL and FL, worse in DLBCL). Conclusion In the largest reported study of haematological malignancies complicating primary SS, we confirm the overwhelming predominance of B-cell lymphomas, especially MALT, with the salivary glands being the primary site of involvement. This highly-specific histopathological scenario is linked with the overall good prognosis with a 5-year survival rate of nearly 90%., Peer Reviewed, Postprint (published version)

Published
2023

13. Characterization and outcomes of 414 patients with primary SS who developed haematological malignancies

Author

Hernandez-Molina, Gabriela, Kostov, Belchin, Brito-Zeron, Pilar, Vissink, Arjan, Mandl, Thomas, Hinrichs, Anneline C., Quartuccio, Luca, Baldini, Chiara, Seror, Raphaele, Szanto, Antonia, Isenberg, David, Gerli, Roberto, Nordmark, Gunnel, Rasmussen, Astrid, Solans-Laque, Roser, Hofauer, Benedikt, Sene, Damien, Pasoto, Sandra G., Rischmueller, Maureen, Praprotnik, Sonja, Gheita, Tamer A., Danda, Debashish, Armagan, Berkan, Suzuki, Yasunori, Valim, Valeria, Devauchelle-Pensec, Valerie, Retamozo, Soledad, Kvarnstrom, Marika, Sebastian, Agata, Atzeni, Fabiola, Giacomelli, Roberto, Carsons, Steven E., Kwok, Seung-Ki, Nakamura, Hideki, Moca Trevisani, Virginia Fernandes, Flores-Chavez, Alejandra, Mariette, Xavier, Ramos-Casals, Manuel, Hernandez-Molina, Gabriela, Kostov, Belchin, Brito-Zeron, Pilar, Vissink, Arjan, Mandl, Thomas, Hinrichs, Anneline C., Quartuccio, Luca, Baldini, Chiara, Seror, Raphaele, Szanto, Antonia, Isenberg, David, Gerli, Roberto, Nordmark, Gunnel, Rasmussen, Astrid, Solans-Laque, Roser, Hofauer, Benedikt, Sene, Damien, Pasoto, Sandra G., Rischmueller, Maureen, Praprotnik, Sonja, Gheita, Tamer A., Danda, Debashish, Armagan, Berkan, Suzuki, Yasunori, Valim, Valeria, Devauchelle-Pensec, Valerie, Retamozo, Soledad, Kvarnstrom, Marika, Sebastian, Agata, Atzeni, Fabiola, Giacomelli, Roberto, Carsons, Steven E., Kwok, Seung-Ki, Nakamura, Hideki, Moca Trevisani, Virginia Fernandes, Flores-Chavez, Alejandra, Mariette, Xavier, and Ramos-Casals, Manuel

Abstract

Objective To characterize 414 patients with primary SS who developed haematological malignancies and to analyse how the main SS- and lymphoma-related features can modify the presentation patterns and outcomes. Methods By January 2021, the Big Data Sjögren Project Consortium database included 11 966 patients fulfilling the 2002/2016 classification criteria. Haematological malignancies diagnosed according to the World Health Organization (WHO) classification were retrospectively identified. Results There were 414 patients (355 women, mean age 57 years) with haematological malignancies (in 43, malignancy preceded at least one year the SS diagnosis). A total of 376 (91%) patients had mature B-cell malignancy, nearly half had extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT lymphoma) (n = 197), followed by diffuse large B-cell lymphoma (DLBCL) (n = 67), nodal MZL lymphoma (n = 29), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) (n = 19) and follicular lymphoma (FL) (n = 17). Rates of complete response, relapses and death were 80%, 34% and 13%, respectively, with a 5-year survival rate of 86.5% after a mean follow-up of 8 years. There were significant differences in age at diagnosis (younger in MALT, older in CLL/SLL), predominant clinical presentation (glandular enlargement in MALT lymphoma, peripheral lymphadenopathy in nodal MZL and FL, constitutional symptoms in DLBCL, incidental diagnosis in CLL/SLL), therapeutic response (higher in MALT lymphoma, lower in DLBCL) and survival (better in MALT, nodal MZL and FL, worse in DLBCL). Conclusion In the largest reported study of haematological malignancies complicating primary SS, we confirm the overwhelming predominance of B-cell lymphomas, especially MALT, with the salivary glands being the primary site of involvement. This highly-specific histopathological scenario is linked with the overall good prognosis with a 5-year survival rate of nearly 90%.

Published
2022
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14. Fibromyalgia severity according to age categories: results of a cross-sectional study from a large national database

Author

Di Carlo, Marco, Farah, Sonia, Bazzichi, Laura, Atzeni, Fabiola, Govoni, Marcello, Biasi, Giovanni, Di Franco, Manuela, Mozzani, Flavio, Gremese, Elisa, Dagna, Lorenzo, Batticciotto, Alberto, Fischetti, Fabio, Giacomelli, Roberto, Guiducci, Serena, Guggino, Giuliana, Bentivegna, Mario, Gerli, Roberto, Salvarani, Carlo, Bajocchi, Gianluigi, Ghini, Marco, Iannone, Florenzo, Giorgi, Valeria, Cirillo, Mariateresa, Bonazza, Sara, Barbagli, Stefano, Gioia, Chiara, Marino, Noemi Giuliana, Capacci, Annunziata, Cavalli, Giulio, Cappelli, Antonella, Carubbi, Francesco, Nacci, Francesca, Riccucci, Ilenia, Cutolo, Maurizio, Sinigaglia, Luigi, Sarzi-Puttini, Piercarlo, Salaffi, Fausto, Gremese, Elisa (ORCID:0000-0002-2248-1058), Di Carlo, Marco, Farah, Sonia, Bazzichi, Laura, Atzeni, Fabiola, Govoni, Marcello, Biasi, Giovanni, Di Franco, Manuela, Mozzani, Flavio, Gremese, Elisa, Dagna, Lorenzo, Batticciotto, Alberto, Fischetti, Fabio, Giacomelli, Roberto, Guiducci, Serena, Guggino, Giuliana, Bentivegna, Mario, Gerli, Roberto, Salvarani, Carlo, Bajocchi, Gianluigi, Ghini, Marco, Iannone, Florenzo, Giorgi, Valeria, Cirillo, Mariateresa, Bonazza, Sara, Barbagli, Stefano, Gioia, Chiara, Marino, Noemi Giuliana, Capacci, Annunziata, Cavalli, Giulio, Cappelli, Antonella, Carubbi, Francesco, Nacci, Francesca, Riccucci, Ilenia, Cutolo, Maurizio, Sinigaglia, Luigi, Sarzi-Puttini, Piercarlo, Salaffi, Fausto, and Gremese, Elisa (ORCID:0000-0002-2248-1058)

Abstract

Objectives: The role of age in influencing the severity of fibromyalgia (FM) is still controversial. The aim of this study is to define the contribution of age in the severity of FM from data from a large national database. Methods: This cross-sectional study included adult patients with FM diagnosed according to the 2010/2011 American College of Rheumatology criteria. Disease severity was assessed with the revised Fibromyalgia Impact Questionnaire (FIQR) and the modified Fibromyalgia Assessment Status (FAS 2019mod). Patients were grouped into five age categories (between 18-40 years, between 41-50 years, between 51-60 years, between 61-70 years, and ≥71 years). Differences in disease severity between groups were assessed by one-way analysis of variance (ANOVA). Results: The study included 2889 patients (199 males and 2690 females), mean age of 52.58 (±11.82) years, with a mean FIQR score of 59.22 (±22.98) and a mean FAS 2019mod of 25.50 (±8.66). Comparing the mean values of the various indices between age categories, there were no statistically significant differences between the groups for FIQR total score and FAS 2019mod. However, the 60-70 years category showed the lowest scores for both scales. The main difference emerged for the FIQR physical function subscale, where the ≥71 years category showed significantly higher scores (p<0.05) compared the 18-40 years category. Conclusions: The severity of FM has a significant level of stationarity according to age categories. Patients between 60-70 years have a lower disease burden. Physical function is the health domain with the most significant difference between the groups.

Published
2022

15. Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts

Author

Pezoulas, Vasileios C, Goules, Andreas, Kalatzis, Fanis, Chatzis, Luke, Kourou, Konstantina D, Venetsanopoulou, Aliki, Exarchos, Themis P, Gandolfo, Saviana, Votis, Konstantinos, Zampeli, Evi, Baurmeister, Jan, Thorsten, May, Pérez, Manuel M, Lishchuk, Iryna, Chondrogiannis, Thymios, Andronikou, Vassiliki, Varvarigou, Theodora, Filipovic, Nenad, Tsiknakis, Manolis, Baldini, Chiara, Bombardieri, Michele, Bootsma, Hendrika, Bowman, Simon, Soyfoo, Muhammad Shahnawaz, Parisis, Dorian, Delporte, Christine, Devauchelle-Pensec, Valérie, Pers, Jacques-Olivier, Dörner, Thomas, Bartolini, Elena, Gerli, Roberto, Giacomelli, Roberto, Johnsson, Roland, Ng, Wan-Fai, Priori, Roberta, Casals, Manuel Ramos, Sivils, Kathy, Skopouli, Fotini, Witte, Torsten, Van Roon, Joel AG, Mariette, Xavier, De Vita, Salvatore, Tzioufas, Athanasios, Fotiadis, Dimitrios Ioannis, Pezoulas, Vasileios C, Goules, Andreas, Kalatzis, Fanis, Chatzis, Luke, Kourou, Konstantina D, Venetsanopoulou, Aliki, Exarchos, Themis P, Gandolfo, Saviana, Votis, Konstantinos, Zampeli, Evi, Baurmeister, Jan, Thorsten, May, Pérez, Manuel M, Lishchuk, Iryna, Chondrogiannis, Thymios, Andronikou, Vassiliki, Varvarigou, Theodora, Filipovic, Nenad, Tsiknakis, Manolis, Baldini, Chiara, Bombardieri, Michele, Bootsma, Hendrika, Bowman, Simon, Soyfoo, Muhammad Shahnawaz, Parisis, Dorian, Delporte, Christine, Devauchelle-Pensec, Valérie, Pers, Jacques-Olivier, Dörner, Thomas, Bartolini, Elena, Gerli, Roberto, Giacomelli, Roberto, Johnsson, Roland, Ng, Wan-Fai, Priori, Roberta, Casals, Manuel Ramos, Sivils, Kathy, Skopouli, Fotini, Witte, Torsten, Van Roon, Joel AG, Mariette, Xavier, De Vita, Salvatore, Tzioufas, Athanasios, and Fotiadis, Dimitrios Ioannis

Abstract

info:eu-repo/semantics/published

Published
2022

16. Emerging of a new CD3+CD31HCD184+ tang cell phenothype in Sjögren's syndrome induced by microencapsulated human umbilical cord matrix-derived multipotent stromal cells.

Author

Montanucci, Pia, Bistoni, Onelia, Antonucci, Matteo, Pescara, Teresa, Greco, Alessia, Basta, Giuseppe, Bartoloni, Elena, Gerli, Roberto, and Calafiore, Riccardo

Subjects
SJOGREN'S syndrome, STROMAL cells, MONONUCLEAR leukocytes, REGULATORY B cells, UMBILICAL cord
Abstract

Background: Sjögren's syndrome (SS) is an autoimmune disease hallmarked by infiltration and destruction of exocrine glands. Currently, there is no therapy that warrants full recovery of the affected tissues. Umbilical cord-derived multipotent stromal cells, microincapsulated in an endotoxin-free alginate gel (CpS-hUCMS), were shown to modulate the inflammatory activity of PBMCs in SS patients in vitro, through release of soluble factors (TGFb1, IDO1, IL6, PGE2, VEGF). These observations led us to set up the present study, aimed at defining the in vitro effects of CpS-hUCMS on pro- and anti-inflammatory lymphocyte subsets involved in the pathogenesis of SS. Methods and results: Peripheral blood mononuclear cells (PBMCs) upon collection from SS patients and matched healthy donors, were placed in coculture with CpS-hUCMS for five days. Cellular proliferation and T-(Tang, Treg) and B-(Breg, CD19+) lymphocyte subsets were studied by flow cytometry, while Multiplex, Real-Time PCR, and Western Blotting techniques were employed for the analysis of transcriptome and secretome. IFNg pre-treated hUCMS were assessed with a viability assay and Western Blotting analysis before co-culture. After five days co-culture, CpS-hUCMS induced multiple effects on PBMCs, with special regard to decrease of lymphocyte proliferation, increase of regulatory B cells and induction of an angiogenic T cell population with high expression of the surface marker CD31, that had never been described before in the literature. Conclusion: We preliminarily showed that CpS-hUCMS can influence multiple pro- and anti-inflammatory pathways that are deranged in SS. In particular, Breg raised and a new Tang phenothype CD3+CD31HCD184+ emerged. These results may considerably expand our knowledge on multipotent stromal cell properties and may open new therapeutic avenues for the management of this disease, by designing ad hoc clinical studies. [ABSTRACT FROM AUTHOR]

Published
2023
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19. The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus

Author

Giacomelli, Roberto, Afeltra, Antonella, Bartoloni, Elena, Berardicurti, Onorina, Bombardieri, Michele, Bortoluzzi, Alessandra, Carubbi, Francesco, Caso, Francesco, Cervera, Ricard, Ciccia, Francesco, Cipriani, Paola, Coloma-Bazán, Emmanuel, Conti, Fabrizio, Costa, Luisa, D'Angelo, Salvatore, Distler, Oliver, Feist, Eugen, Foulquier, Nathan, Gabini, Marco, Gerber, Vanessa, Gerli, Roberto, Grembiale, Rosa Daniela, Guggino, Giuliana, Hoxha, Ariela, Iagnocco, Annamaria, Jordan, Suzana, Kahaleh, Bashar, Lauper, Kim, Liakouli, Vasiliki, Lubrano, Ennio, Margiotta, Domenico, Naty, Saverio, Navarini, Luca, Perosa, Federico, Perricone, Carlo, Perricone, Roberto, Prete, Marcella, Pers, Jacques-Olivier, Pitzalis, Costantino, Priori, Roberta, Rivellese, Felice, Ruffatti, Amelia, Ruscitti, Piero, Scarpa, Raffaele, Shoenfeld, Yehuda, Triolo, Giovanni, Tzioufas, Athanasios, D’Angelo, Salvatore, Giacomelli, Roberto, Afeltra, Antonella, Bartoloni, Elena, Berardicurti, Onorina, Bombardieri, Michele, Bortoluzzi, Alessandra, Carubbi, Francesco, Caso, Francesco, Cervera, Ricard, Ciccia, Francesco, Cipriani, Paola, Coloma-Bazán, Emmanuel, Conti, Fabrizio, Costa, Luisa, D'Angelo, Salvatore, Distler, Oliver, Feist, Eugen, Foulquier, Nathan, Gabini, Marco, Gerber, Vanessa, Gerli, Roberto, Grembiale, Rosa Daniela, Guggino, Giuliana, Hoxha, Ariela, Iagnocco, Annamaria, Jordan, Suzana, Kahaleh, Bashar, Lauper, Kim, Liakouli, Vasiliki, Lubrano, Ennio, Margiotta, Domenico, Naty, Saverio, Navarini, Luca, Perosa, Federico, Perricone, Carlo, Perricone, Roberto, Prete, Marcella, Pers, Jacques-Olivier, Pitzalis, Costantino, Priori, Roberta, Rivellese, Felice, Ruffatti, Amelia, Ruscitti, Piero, Scarpa, Raffaele, Shoenfeld, Yehuda, Triolo, Giovanni, Tzioufas, Athanasios, Clinical Unit of Rheumatology, L'Aquila, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Department of Medicine [Perugia, Italy] (Rheumatology, Unit), Università degli Studi di Perugia (UNIPG), The London School of Medicine & Dentistry, Queen Mary University London, London, UK, Sant'Anna University Hospital, Partenaires INRAE, University of L'Aquila [Italy] (UNIVAQ), 'Federico II' University of Naples Medical School, Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain, Department of Medicine, Universitat Autonòma, Barcelona, University of the Study of Campania Luigi Vanvitelli, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Hospital Clínico San Carlos [Madrid, Spain], Department of Rheumatology [Zürich], Balgrist University Hospital, Helios Department of Rheumatology, Sophie-v.-Boetticher-Straße 1, 39245 Gommern, Germany, Laboratoire de Traitement de l'Information Medicale (LaTIM), Institut National de la Santé et de la Recherche Médicale (INSERM)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), UOC Reumatologia, Presidio Ospedaliero 'Santo Spirito', Pescara, Italy, University hospital of Zurich [Zurich], University of Perugia, University of Catanzaro, University of Palermo, Italy, San Bortolo Hospital, University of Padova [Padova, Italy], Rheumatology Unit, Torino, Department of Chemistry, University of Toledo, University of Toledo, Division of Rheumatology [Geneva, Switzerland], Geneva University Hospital, Geneva-Department of Internal Medicine [Genève], University of Barcelona, University of Molise [Campobasso] (UNIMOL), University of Molise, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy., Università degli studi di Bari Aldo Moro (UNIBA), University of Rome TorVergata, LabEX IGO Immunothérapie Grand Ouest, Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Queen Mary University of London, Barts and The London School of Medicine and Dentistry, School of Medicine and Dentistry, Queen Mary University of London, Institute of cancer, Department of Medicine (DIMED), University of Naples Federico II, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University [Tel Aviv], Sechenov First Moscow State Medical University, Università degli studi di Palermo - University of Palermo, National and Kapodistrian University of Athens (NKUA), Department of Pathophysiology, Medical School, University of Athens, Giacomelli, R., Afeltra, A., Bartoloni, E., Berardicurti, O., Bombardieri, M., Bortoluzzi, A., Carubbi, F., Caso, F., Cervera, R., Ciccia, F., Cipriani, P., Coloma-Bazan, E., Conti, F., Costa, L., D'Angelo, S., Distler, O., Feist, E., Foulquier, N., Gabini, M., Gerber, V., Gerli, R., Grembiale, R. D., Guggino, G., Hoxha, A., Iagnocco, A., Jordan, S., Kahaleh, B., Lauper, K., Liakouli, V., Lubrano, E., Margiotta, D., Naty, S., Navarini, L., Perosa, F., Perricone, C., Perricone, R., Prete, M., Pers, J. -O., Pitzalis, C., Priori, R., Rivellese, F., Ruffatti, A., Ruscitti, P., Scarpa, R., Shoenfeld, Y., Triolo, G., and Tzioufas, A.

Subjects
0301 basic medicine, rheumatoid arthritis, medicine.medical_specialty, antiphospholipid syndrome, precision medicine, primary sjogren's syndrome, spondyloarthritides, systemic lupus erythematosus, systemic sclerosis, consensus, humans, autoimmune diseases, lupus erythematosus, systemic, sjogren's syndrome, Consensus, spondyloarthritide, Immunology, systemic lupus erythematosu, Sjogren's Syndrome, Context (language use), Consensu, primary Sjogren's syndrome, Autoimmune Disease, Treatment failure, Autoimmune Diseases, NO, Efficacy, 03 medical and health sciences, 0302 clinical medicine, primary Sjogren’s syndrome, Acquired immunodeficiency syndrome (AIDS), medicine, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, In patient, Intensive care medicine, Adverse effect, 030203 arthritis & rheumatology, business.industry, Precision medicine, Environmental exposure, rheumatoid arthriti, medicine.disease, 3. Good health, 030104 developmental biology, [SDV.IMM]Life Sciences [q-bio]/Immunology, business, systemic sclerosi, Human
Abstract

International audience; Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. In this work, the growing body of evidence is summarized regarding the predictive factors for drug response in patients with AIDs, applying the precision medicine principles to provide high-quality evidence for therapeutic opportunities in improving the management of these patients.

Published
2021

21. Characterization and outcomes of 414 patients with primary SS who developed haematological malignancies.

Author

Hernández-Molina, Gabriela, Kostov, Belchin, Brito-Zerón, Pilar, Vissink, Arjan, Mandl, Thomas, Hinrichs, Anneline C, Quartuccio, Luca, Baldini, Chiara, Seror, Raphaele, Szántó, Antonia, Isenberg, David, Gerli, Roberto, Nordmark, Gunnel, Rasmussen, Astrid, Solans-Laque, Roser, Hofauer, Benedikt, Sène, Damien, Pasoto, Sandra G, Rischmueller, Maureen, and Praprotnik, Sonja

Subjects
LYMPHOID tissue, DISEASE relapse, HEMATOLOGIC malignancies, SJOGREN'S syndrome, LYMPHOMAS, LYMPHOPROLIFERATIVE disorders, SYMPTOMS
Abstract

Objective To characterize 414 patients with primary SS who developed haematological malignancies and to analyse how the main SS- and lymphoma-related features can modify the presentation patterns and outcomes. Methods By January 2021, the Big Data Sjögren Project Consortium database included 11 966 patients fulfilling the 2002/2016 classification criteria. Haematological malignancies diagnosed according to the World Health Organization (WHO) classification were retrospectively identified. Results There were 414 patients (355 women, mean age 57 years) with haematological malignancies (in 43, malignancy preceded at least one year the SS diagnosis). A total of 376 (91%) patients had mature B-cell malignancy, nearly half had extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT lymphoma) (n  = 197), followed by diffuse large B-cell lymphoma (DLBCL) (n  = 67), nodal MZL lymphoma (n  = 29), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) (n  = 19) and follicular lymphoma (FL) (n  = 17). Rates of complete response, relapses and death were 80%, 34% and 13%, respectively, with a 5-year survival rate of 86.5% after a mean follow-up of 8 years. There were significant differences in age at diagnosis (younger in MALT, older in CLL/SLL), predominant clinical presentation (glandular enlargement in MALT lymphoma, peripheral lymphadenopathy in nodal MZL and FL, constitutional symptoms in DLBCL, incidental diagnosis in CLL/SLL), therapeutic response (higher in MALT lymphoma, lower in DLBCL) and survival (better in MALT, nodal MZL and FL, worse in DLBCL). Conclusion In the largest reported study of haematological malignancies complicating primary SS, we confirm the overwhelming predominance of B-cell lymphomas, especially MALT, with the salivary glands being the primary site of involvement. This highly-specific histopathological scenario is linked with the overall good prognosis with a 5-year survival rate of nearly 90%. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Quality of life and unmet needs in patients with inflammatory arthropathies: results from the multicentre, observational RAPSODIA study

Author

Giacomelli, Roberto, Gorla, Roberto, Trotta, Francesco, Tirri, Rosella, Grassi, Walter, Bazzichi, Laura, Galeazzi, Mauro, Matucci-Cerinic, Marco, Scarpa, Raffaele, Cantini, Fabrizio, Gerli, Roberto, Lapadula, Giovanni, Sinigaglia, Luigi, Ferraccioli, Gianfranco, Olivieri, Ignazio, Ruscitti, Piero, and Sarzi-Puttini, Piercarlo

Published
2015
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30. Indoleamine 2,3-Dioxygenase 1 (IDO1) Is Up-Regulated in Thyroid Carcinoma and Drives the Development of an Immunosuppressant Tumor Microenvironment

Author

Moretti, Sonia, Menicali, Elisa, Voce, Pasquale, Morelli, Silvia, Cantarelli, Sara, Sponziello, Marialuisa, Colella, Renato, Fallarino, Francesca, Orabona, Ciriana, Alunno, Alessia, de Biase, Dario, Bini, Vittorio, Mameli, Maria Grazia, Filetti, Sebastiano, Gerli, Roberto, Macchiarulo, Antonio, Melillo, Rosa Marina, Tallini, Giovanni, Santoro, Massimo, Puccetti, Paolo, Avenia, Nicola, and Puxeddu, Efisio

Published
2014

32. Peripheral Nervous System Involvement in Sjögren’s Syndrome: Analysis of a Cohort From the Italian Research Group on Sjögren’s Syndrome

Author

Cafaro, Giacomo, primary, Perricone, Carlo, additional, Carubbi, Francesco, additional, Baldini, Chiara, additional, Quartuccio, Luca, additional, Priori, Roberta, additional, Berardicurti, Onorina, additional, Ferro, Francesco, additional, Gandolfo, Saviana, additional, Gattamelata, Angelica, additional, Giacomelli, Roberto, additional, De Vita, Salvatore, additional, Gerli, Roberto, additional, and Bartoloni, Elena, additional

Published
2021
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33. Epidemiological profile and north–south gradient driving baseline systemic involvement of primary Sjögren’s syndrome

Author

Brito-Zeron, Pilar, Acar-Denizli, Nihan, Ng, Wan-Fai, Horvath, Ildiko Fanny, Rasmussen, Astrid, Seror, Raphaele, Li, Xiaomei, Baldini, Chiara, Gottenberg, Jacques-Eric, Danda, Debashish, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, Gabriela, Armagan, Berkan, Kruize, Aike A., Kwok, Seung-Ki, Kvarnstrom, Marika, Praprotnik, Sonja, Sene, Damien, Gerli, Roberto, Solans, Roser, Rischmueller, Maureen, Mandl, Thomas, Suzuki, Yasunori, Isenberg, David, Valim, Valeria, Wiland, Piotr, Nordmark, Gunnel, Fraile, Guadalupe, Bootsma, Hendrika, Nakamura, Hideki, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Trevisani, Virginia Fernandes Moca, Hammenfors, Daniel, Pasoto, Sandra G., Retamozo, Soledad, Gheita, Tamer A., Atzeni, Fabiola, Morel, Jacques, Vollenweider, Cristina, Zeher, Margit, Sivils, Kathy, Xu, Bei, Bombardieri, Stefano, Sandhya, Pulukool, De Vita, Salvatore, Minniti, Antonina, Sanchez-Guerrero, Jorge, Kilic, Levent, van der Heijden, Eefje, Park, Sung-Hwan, Wahren-Herlenius, Marie, Mariette, Xavier, Ramos-Casals, Manuel, Brito-Zeron, Pilar, Acar-Denizli, Nihan, Ng, Wan-Fai, Horvath, Ildiko Fanny, Rasmussen, Astrid, Seror, Raphaele, Li, Xiaomei, Baldini, Chiara, Gottenberg, Jacques-Eric, Danda, Debashish, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, Gabriela, Armagan, Berkan, Kruize, Aike A., Kwok, Seung-Ki, Kvarnstrom, Marika, Praprotnik, Sonja, Sene, Damien, Gerli, Roberto, Solans, Roser, Rischmueller, Maureen, Mandl, Thomas, Suzuki, Yasunori, Isenberg, David, Valim, Valeria, Wiland, Piotr, Nordmark, Gunnel, Fraile, Guadalupe, Bootsma, Hendrika, Nakamura, Hideki, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Trevisani, Virginia Fernandes Moca, Hammenfors, Daniel, Pasoto, Sandra G., Retamozo, Soledad, Gheita, Tamer A., Atzeni, Fabiola, Morel, Jacques, Vollenweider, Cristina, Zeher, Margit, Sivils, Kathy, Xu, Bei, Bombardieri, Stefano, Sandhya, Pulukool, De Vita, Salvatore, Minniti, Antonina, Sanchez-Guerrero, Jorge, Kilic, Levent, van der Heijden, Eefje, Park, Sung-Hwan, Wahren-Herlenius, Marie, Mariette, Xavier, and Ramos-Casals, Manuel

Abstract

Objective: To characterize the systemic phenotype of primary Sjögren’s syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores. Methods: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren’s syndrome from the five continents. Results: The cohort included 10 007 patients (9352 female, mean 53 years) with recorded ESSDAI scores available. At diagnosis, the mean total ESSDAI score was 6.1; 81.8% of patients had systemic activity (ESSDAI score ≥1). Males had a higher mean ESSDAI (8.1 vs 6.0, P < 0.001) compared with females, as did patients diagnosed at <35 years (6.7 vs 5.6 in patients diagnosed at >65 years, P < 0.001). The highest global ESSDAI score was reported in Black/African Americans, followed by White, Asian and Hispanic patients (6.7, 6.5, 5.4 and 4.8, respectively; P < 0.001). The frequency of involvement of each systemic organ also differed between ethnic groups, with Black/African American patients showing the highest frequencies in the lymphadenopathy, articular, peripheral nervous system, CNS and biological domains, White patients in the glandular, cutaneous and muscular domains, Asian patients in the pulmonary, renal and haematological domains and Hispanic patients in the constitutional domain. Systemic activity measured by the ESSDAI, clinical ESSDAI (clinESSDAI) and disease activity states was higher in patients from southern countries (P < 0.001). Conclusion: The systemic phenotype of primary Sjögren’s syndrome is strongly influenced by personal determinants such as age, gender, ethnicity and place of residence, which are key geoepidemiological players in driving the expression of systemic disease at diagnosis.

Published
2020
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34. The Italian Fibromyalgia Registry: a new way of using routine real-world data concerning patient-reported disease status in healthcare research and clinical practice

Author

Salaffi, Fausto, Farah, Sonia, Di Carlo, Marco, Sinigaglia, Luigi, Galeazzi, Mauro, Gerli, Roberto, Sonnati, Massimo, Giorgi, Valeria, Sarzi-Puttini, Piercarlo, and Masullo, Maurizio

Subjects
Adult, Male, Fibromyalgia, Italy, Surveys and Questionnaires, Quality of Life, Humans, Female, Health Services Research, Patient Reported Outcome Measures, Registries, Middle Aged
Abstract

Fibromyalgia (FM), the most frequently encountered cause of widespread musculoskeletal pain, affects an estimated 2% of the general Italian population. However, it is not a homogeneous clinical entity, and a number of interacting factors can influence patient prognosis and the outcomes of standardised treatment programmes. Registries are a source of high-quality data for clinical research, but relating this information to individual patients is technically challenging. The aim of this article is to describe the structure and objectives of the first Italian Fibromyalgia Registry (IFR), a new web-based registry of patients with FM.The IFR was developed to collect, store, and share information electronically entered by physicians throughout Italy who are members of the Italian Society of Rheumatology and have a particular interest in FM. It has a web-based architecture that uses two separate servers and an encryption algorithm to ensure the confidentiality and integrity of the exchanged data. The questionnaires included on the platform are the Revised Fibromyalgia Impact Questionnaire (FIQR), the modified Fibromyalgia Assessment Status (ModFAS), and the Polysymptomatic Distress Scale (PDS).The registry includes data relating to 2,339 patients (93.2% female) who satisfied the 1990 or 2010/2011 American College of Rheumatology Classification Criteria for Fibromyalgia at the time of diagnosis. At the time of this analysis, the patients had a mean age of 51.9 years (SD 11.5) and a mean disease duration of 7.3 years (SD 6.9). The majority were married (71.3%), and generally well educated. The overall median FIQR, ModFAS and PDS scores and 25th-75th percentiles were respetively 61.16 (41.16-77.00), 8.91 (41.16-77.00), and 19.0 (13.00-24.00). The six highest scoring items indicating the greatest impact of the disease on the patients related to fatigue/energy (7.18), sleep quality (6.87), tenderness (6.69), pain (6.68), stiffness (6.66), and environmental sensitivity (6.35). A high proportion of the responding patients reported experiencing pain in the neck (80.46%), upper back (68.36%), and lower back (75.05%).The IFR is the most comprehensive FM registry in Italy, and provides healthcare professionals with a secure, reliable, and easy-to-use means of monitoring the patients' clinical progression, treatment history and treatment responses. This can help clinicians to plan patient management, facilitates research study patient recruitment, and provides the participating pain clinics with statistics based on real-world data. It also helps address the Italian Ministry of Health long-term goal of using precision medicine for chronic pain prevention and treatment. It is hoped that the IFR will enhance both scientific research and clinical practice.

Published
2019

37. Presence of anti-acetylated peptide antibodies (AAPA) in inflammatory arthritis and other rheumatic diseases suggests discriminative diagnostic capacity towards early rheumatoid arthritis

Author

Studenic, Paul, primary, Alunno, Alessia, additional, Sieghart, Daniela, additional, Bang, Holger, additional, Aletaha, Daniel, additional, Blüml, Stephan, additional, Haslacher, Helmuth, additional, Smolen, Josef S, additional, Gerli, Roberto, additional, and Steiner, Günter, additional

Published
2021
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38. Unattended compared to traditional blood pressure measurement in patients with rheumatoid arthritis: a randomised cross-over study

Author

Bartoloni, Elena, primary, Angeli, Fabio, additional, Marcucci, Elisa, additional, Perricone, Carlo, additional, Cafaro, Giacomo, additional, Riccini, Clara, additional, Spighi, Lorenzo, additional, Gildoni, Benedetta, additional, Cavallini, Claudio, additional, Verdecchia, Paolo, additional, and Gerli, Roberto, additional

Published
2021
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39. The association between body mass index and fibromyalgia severity: data from a cross-sectional survey of 2339 patients

Author

Atzeni, Fabiola, primary, Alciati, Alessandra, additional, Salaffi, Fausto, additional, Di Carlo, Marco, additional, Bazzichi, Laura, additional, Govoni, Marcello, additional, Biasi, Giovanni, additional, Di Franco, Manuela, additional, Mozzani, Flavio, additional, Gremese, Elisa, additional, Dagna, Lorenzo, additional, Batticciotto, Alberto, additional, Fischetti, Fabio, additional, Giacomelli, Roberto, additional, Guiducci, Serena, additional, Guggino, Giuliana, additional, Bentivegna, Mario, additional, Gerli, Roberto, additional, Salvarani, Carlo, additional, Bajocchi, Gianluigi, additional, Ghini, Marco, additional, Iannone, Florenzo, additional, Giorgi, Valeria, additional, Farah, Sonia, additional, Bonazza, Sara, additional, Barbagli, Stefano, additional, Gioia, Chiara, additional, Marino, Noemi Giuliana, additional, Capacci, Annunziata, additional, Cavalli, Giulio, additional, Cappelli, Antonella, additional, Carubbi, Francesco, additional, Nacci, Francesca, additional, Riccucci, Ilenia, additional, Cutolo, Maurizio, additional, Sinigaglia, Luigi, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2021
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42. Detection of anti-IFI16 antibodies by ELISA: clinical and serological associations in systemic sclerosis

Author

Costa, Silvia, Mondini, Michele, Caneparo, Valeria, Afeltra, Antonella, Airò, Paolo, Bellisai, Francesca, Faggioli, Paola, Gerli, Roberto, Lotzniker, Milvia, Meroni, Pier L., Morozzi, Gabriella, Radice, Antonella, Riccieri, Valeria, Scarsi, Mirko, Sebastiani, Gian D., Sinico, Renato A., Tincani, Angela, Gariglio, Marisa, and Landolfo, Santo

Published
2011
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47. Definition of fibromyalgia severity: findings from a cross-sectional survey of 2339 Italian patients

Author

Salaffi, Fausto, primary, Di Carlo, Marco, additional, Bazzichi, Laura, additional, Atzeni, Fabiola, additional, Govoni, Marcello, additional, Biasi, Giovanni, additional, Di Franco, Manuela, additional, Mozzani, Flavio, additional, Gremese, Elisa, additional, Dagna, Lorenzo, additional, Batticciotto, Alberto, additional, Fischetti, Fabio, additional, Giacomelli, Roberto, additional, Guiducci, Serena, additional, Guggino, Giuliana, additional, Bentivegna, Mario, additional, Gerli, Roberto, additional, Salvarani, Carlo, additional, Bajocchi, Gianluigi, additional, Ghini, Marco, additional, Iannone, Florenzo, additional, Giorgi, Valeria, additional, Farah, Sonia, additional, Cirillo, Mariateresa, additional, Bonazza, Sara, additional, Barbagli, Stefano, additional, Gioia, Chiara, additional, Santilli, Daniele, additional, Capacci, Annunziata, additional, Cavalli, Giulio, additional, Carubbi, Francesco, additional, Nacci, Francesca, additional, Riccucci, Ilenia, additional, Sinigaglia, Luigi, additional, Masullo, Maurizio, additional, Polizzi, Bianca Maria, additional, Cutolo, Maurizio, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2020
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48. Early Disease and Low Baseline Damage as Predictors of Response to Belimumab in Patients With Systemic Lupus Erythematosus in a Real‐Life Setting

Author

Gatto, Mariele, primary, Saccon, Francesca, additional, Zen, Margherita, additional, Regola, Francesca, additional, Fredi, Micaela, additional, Andreoli, Laura, additional, Tincani, Angela, additional, Urban, Maria Letizia, additional, Emmi, Giacomo, additional, Ceccarelli, Fulvia, additional, Conti, Fabrizio, additional, Bortoluzzi, Alessandra, additional, Govoni, Marcello, additional, Tani, Chiara, additional, Mosca, Marta, additional, Ubiali, Tania, additional, Gerosa, Maria, additional, Bozzolo, Enrica, additional, Canti, Valentina, additional, Cardinaletti, Paolo, additional, Gabrielli, Armando, additional, Tanti, Giacomo, additional, Gremese, Elisa, additional, De Marchi, Ginevra, additional, De Vita, Salvatore, additional, Fasano, Serena, additional, Ciccia, Francesco, additional, Pazzola, Giulia, additional, Salvarani, Carlo, additional, Negrini, Simone, additional, Puppo, Francesco, additional, Di Matteo, Andrea, additional, De Angelis, Rossella, additional, Orsolini, Giovanni, additional, Rossini, Maurizio, additional, Faggioli, Paola, additional, Laria, Antonella, additional, Piga, Matteo, additional, Mathieu, Alessandro, additional, Scarpato, Salvatore, additional, Rossi, Francesca W., additional, Paulis, Amato, additional, Brunetta, Enrico, additional, Ceribelli, Angela, additional, Selmi, Carlo, additional, Prete, Marcella, additional, Racanelli, Vito, additional, Vacca, Angelo, additional, Bartoloni, Elena, additional, Gerli, Roberto, additional, Larosa, Maddalena, additional, Iaccarino, Luca, additional, and Doria, Andrea, additional

Published
2020
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49. Comparison of Early vs. Delayed Anakinra Treatment in Patients With Adult Onset Still's Disease and Effect on Clinical and Laboratory Outcomes

Author

Vitale, Antonio, primary, Cavalli, Giulio, additional, Ruscitti, Piero, additional, Sota, Jurgen, additional, Colafrancesco, Serena, additional, Priori, Roberta, additional, Valesini, Guido, additional, Argolini, Lorenza Maria, additional, Baldissera, Elena, additional, Bartoloni, Elena, additional, Cammelli, Daniele, additional, Canestrari, Giovanni, additional, Cavallaro, Elena, additional, Massaro, Maria Grazia, additional, Cipriani, Paola, additional, De Marchi, Ginevra, additional, De Vita, Salvatore, additional, Emmi, Giacomo, additional, Frassi, Micol, additional, Gerli, Roberto, additional, Gremese, Elisa, additional, Iannone, Florenzo, additional, Fornaro, Marco, additional, Paladini, Anna, additional, Lopalco, Giuseppe, additional, Manna, Raffaele, additional, Mathieu, Alessandro, additional, Montecucco, Carlomaurizio, additional, Mosca, Marta, additional, Piazza, Ilaria, additional, Piga, Matteo, additional, Pontikaki, Irene, additional, Romano, Micol, additional, Rossi, Silvia, additional, Rossini, Maurizio, additional, Silvestri, Elena, additional, Stagnaro, Chiara, additional, Talarico, Rosaria, additional, Frediani, Bruno, additional, Tincani, Angela, additional, Viapiana, Ombretta, additional, Vitiello, Gianfranco, additional, Galozzi, Paola, additional, Sfriso, Paolo, additional, Gaggiano, Carla, additional, Grosso, Salvatore, additional, Rigante, Donato, additional, Dagna, Lorenzo, additional, Giacomelli, Roberto, additional, and Cantarini, Luca, additional

Published
2020
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