21 results on '"Giannetti G"'
Search Results
2. Impact of Pregnancy on Weight Loss After Endoscopic Sleeve Gastroplasty
- Author
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Carlino, Giorgio, Benson, A. A., Bove, Vincenzo, Pontecorvi, Valerio, De Siena, Martina, Matteo, Maria Valeria, Farina, A., Polidori, G., Vinti, L., Giannetti, Giulia, Costamagna, Guido, Spada, Cristiano, Boskoski, Ivo, Carlino G., Bove V., Pontecorvi V., De Siena M., Matteo M. V., Giannetti G., Costamagna G. (ORCID:0000-0002-8100-2731), Spada C. (ORCID:0000-0002-5692-0960), Boskoski I. (ORCID:0000-0001-8194-2670), Carlino, Giorgio, Benson, A. A., Bove, Vincenzo, Pontecorvi, Valerio, De Siena, Martina, Matteo, Maria Valeria, Farina, A., Polidori, G., Vinti, L., Giannetti, Giulia, Costamagna, Guido, Spada, Cristiano, Boskoski, Ivo, Carlino G., Bove V., Pontecorvi V., De Siena M., Matteo M. V., Giannetti G., Costamagna G. (ORCID:0000-0002-8100-2731), Spada C. (ORCID:0000-0002-5692-0960), and Boskoski I. (ORCID:0000-0001-8194-2670)
- Abstract
Purpose: Obesity and pregnancy are strictly related: on the one hand, obesity—one of the most common comorbidities in women of reproductive age—contributes to infertility and obesity-related pregnancy complications, whereas pregnancy is a condition in which, physiologically, the pregnant woman undergoes weight gain. Endoscopic sleeve gastroplasty (ESG) may be used for the treatment of obesity in women of childbearing age. Materials and Methods: A retrospective analysis was conducted to evaluate weight trajectories, the evolution of obesity-related comorbidities, and lifestyle modification in women who became pregnant after ESG. A comparison was made between childbearing-age women who became pregnant after ESG and non-pregnant women. Results: A total of 150 childbearing-age women underwent ESG at a large tertiary medical center. Of these, 11 patients (33.4 ± 6.2 years) became pregnant after the procedure, following a mean time interval of 5.5 ± 3.9 months. Three women (two affected by polycystic ovary syndrome) reported difficulty getting pregnant before undergoing ESG. The mean preconception BMI was 31.9±4.0 kg/m2 (−7.24 ± 4.0 kg/m2 after ESG). Total body weight loss (TBWL, %) was 18.08 ± 8.00, 11.00 ± 11.08, and 12.08 ± 8.49, at the beginning of pregnancy, at the delivery, and at the first follow-up (19.6 ± 7.8 months after ESG). TBWL of at least 5% was achieved before pregnancy in all patients (73% reached a TBWL ≥ 10%). No significant differences in weight loss and QoL were found between the pregnancy and non-pregnancy groups up to 24 months after ESG. Conclusions: Endoscopic sleeve gastroplasty allows for adequate weight loss before and after pregnancy in patients with obesity. Graphical Abstract: [Figure not available: see fulltext.]
- Published
- 2023
3. Commissioning and first results of an x-band LLRF system for TEX test facility at LNF-INFN
- Author
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Piersanti, L, primary, Alesini, D, additional, Bellaveglia, M, additional, Bini, S, additional, Buonomo, B, additional, Cardelli, F, additional, Di Giulio, C, additional, Di Pasquale, E, additional, Diomede, M, additional, Faillace, L, additional, Falone, A, additional, Franzini, G, additional, Gallo, A, additional, Giannetti, G, additional, Liedl, A, additional, Moriggi, D, additional, Pioli, S, additional, Quaglia, S, additional, Sabbatini, L, additional, Scampati, M, additional, Scarselletta, G, additional, Stella, A, additional, Tocci, S, additional, and Zelinotti, L, additional
- Published
- 2023
- Full Text
- View/download PDF
4. A new sensitive and accurate model to predict moderate to severe obstructive sleep apnea in patients with obesity
- Author
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Ahlin, Sofie, Manco, M., Panunzi, Simona, Verrastro, Ornella, Giannetti, Giulia, Prete, A., Guidone, C., Berardino, A. D. M., Viglietta, L., Ferravante, A., Mingrone, Geltrude, Mormile, Flaminio, Capristo, Esmeralda, Ahlin S., Panunzi S., Verrastro O., Giannetti G., Mingrone G. (ORCID:0000-0003-2021-528X), Mormile F. (ORCID:0000-0003-0790-3272), Capristo E. (ORCID:0000-0002-5753-3495), Ahlin, Sofie, Manco, M., Panunzi, Simona, Verrastro, Ornella, Giannetti, Giulia, Prete, A., Guidone, C., Berardino, A. D. M., Viglietta, L., Ferravante, A., Mingrone, Geltrude, Mormile, Flaminio, Capristo, Esmeralda, Ahlin S., Panunzi S., Verrastro O., Giannetti G., Mingrone G. (ORCID:0000-0003-2021-528X), Mormile F. (ORCID:0000-0003-0790-3272), and Capristo E. (ORCID:0000-0002-5753-3495)
- Abstract
Obstructive sleep apnea (OSA) has a high prevalence in patients with obesity. Only patients with clinical symptoms of OSA are admitted to polysomnography; however, many patients with OSA are asymptomatic. We aimed to create and validate a population-based risk score that predicts the severity of OSA in patients with obesity.We here report the cross-sectional analysis at baseline of an ongoing study investigating the long-term effect of bariatric surgery on OSA. One-hundred sixty-one patients of the Obesity Center of the Catholic University Hospital in Rome, Italy were included in the study. The patients underwent overnight cardiorespiratory monitoring, blood chemistry analyses, hepatic ultrasound, and anthropometric measurements. The patients were divided into 2 groups according OSA severity assessed by the apnea-hypopnea index (AHI): AHI < 15 = no or mild and AHI ≥ 15 moderate to severe OSA. A statistical prediction model was created and validated. C statistics was used to evaluate the discrimination performance of the model.The prevalence of OSA was 96.3% with 74.5% of the subjects having moderate/severe OSA. Sex, body mass index, diabetes, and age were included in the final prediction model that had excellent discrimination ability (C statistics equals to 83%). An OSA risk chart score for clinical use was created.Patients with severe obesity are at a very high risk for moderate or severe OSA in particular if they are men, older, more obese, and/or with type 2 diabetes. The OSA risk chart can be useful for general practitioners and patients as well as for bariatric surgeons to select patients with high risk of moderate to severe OSA for further polysomnography.
- Published
- 2019
5. Strategies for Disease Prevention and Health Promotion in Urban Areas: The Erice 50 Charter
- Author
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D'Alessandro, D, Arletti, S, Azara, A, Buffoli, M, Capasso, L, Cappuccitti, A, Casuccio, A, Cecchini, A, Costa, G, De Martino, A M, Dettori, M, Di Rosa, E, Fara, G M, Ferrante, M, Giammanco, G, Lauria, A, Melis, G, Moscato, U, Oberti, I, Patrizio, C, Petronio, M G, Rebecchi, A, ROMANO SPICA, Vincenzo, Settimo, G, Signorelli, C, Capolongo, S, Attendees of the 50th Course Urban Health, Alessi, V, Apollonio, F, Barbagallo, E, Bassot, Am, Bernini, D, Borghini, A, Borri, M, Brandimarte, A, Copat, C, Cracchiolo, M, Cribellati, S, Cristaldi, A, D'Agati, P, D'Amico, A, De Marchis, A, Dell'Ovo, M, Donia, Am, Filippini, T, Giannetti, G, Giorgi, S, Gola, M, Grasso, A, Graziano, G, Lanzilotti, C, Laudani, N, Lopuzzo, M, Malfer, M, Marchese, V, Marzella, A, Mascarello, A, Milicia, Gm, Nurchis, P, Ogana, S, Oliveri Conti CG, Pacifico, C, Paduano, S, Paglione, L, Palmeri, S, Pieve, G, Raffo, M, Raguzzoni, G, Raia, Dd, Righi, A, Rochira, Andrea, Rondinelli, L, Salvia, C, Sciaraffa, R, Trogu, F, Ubiali, A, Valt, R, Vantaggiato, V, Ventura, G, Zuccarello, P, D'Alessandro, D, Arletti, S, Azara, A, Buffoli, M, Capasso, L, Cappuccitti, A, Casuccio, A, Cecchini, A, Costa, G, De Martino, A M, Dettori, M, Di Rosa, E, Fara, G M, Ferrante, M, Giammanco, G, Lauria, A, Melis, G, Moscato, U, Oberti, I, Patrizio, C, Petronio, M G, Rebecchi, A, Romano Spica, V, Settimo, G, Signorelli, C, Capolongo, S, D'Alessandro, D., Arletti, S., Azara, A., Buffoli, M., Capasso, L., Cappuccitti, A., Casuccio, A., Cecchini, A., Costa, G., De Martino, A. M., Dettori, M., Di Rosa, E., Fara, G. M., Ferrante, M., Giammanco, G., Lauria, A., Melis, G., Moscato, U., Oberti, I., Patrizio, C., Petronio, M. G., Rebecchi, A., Romano Spica, V., Settimo, G., Signorelli, C., Capolongo, S., Alessi, V., Apollonio, F., Barbagallo, E., Bassot, A. M., Bernini, D., Borghini, A., Borri, M., Brandimarte, A., Copat, C., Cracchiolo, M., Cribellati, S., Cristaldi, A., D'Agati, P., D'Amico, A., De Marchis, A., Dell'Ovo, M., Donia, A. M., Filippini, T., Giannetti, G., Giorgi, S., Gola, M., Grasso, A., Graziano, G., Lanzilotti, C., Laudani, N., Lopuzzo, M., Malfer, M., Marchese, V., Marzella, A., Mascarello, A., Milicia, G. M., Nurchis, P., Ogana, S., Oliveri Conti, C. G., Pacifico, C., Paduano, S., Paglione, L., Palmeri, S., Pieve, G., Raffo, M., Raguzzoni, G., Raia, D. D., Righi, A., Rochira, A., Rondinelli, L., Salvia, C., Sciaraffa, R., Trogu, F., Ubiali, A., Valt, R., Vantaggiato, V., Ventura, G., and Zuccarello, P.
- Subjects
Planning and Designing Strategies ,Urban Health ,Health Promotion ,Urban Health, Public Health, Built Environment, Planning and Designing Strategies, Health Promotion ,Primary Prevention ,Italy ,Planning and Designing Strategie ,built environment ,health promotion ,planning and designing strategies ,public health ,urban health ,public health environmental and occupational health ,infectious diseases ,Humans ,Public Health ,Built Environment ,Health promotion - Abstract
The Erice 50 Charter titled "Strategies for Diseases Prevention and Health Promotion in Urban Areas" was unanimously approved at the conclusion of the 50th Residential Course "Urban Health. Instruments for promoting health and for assessing hygienic and sanitary conditions in urban areas", held from 29th March to 2nd April 2017 in Erice, at the "Ettore Majorana" Foundation and Centre for Scientific Culture and promoted by the International School of Epidemiology and Preventive Medicine "G. D'Alessandro" and the Study Group "Building Hygiene" of the Italian Society of Hygiene, Preventive Medicine and Public Health (SItI). At the conclusion of the intense learning experience during the Course, with more than 20 lectures, workshops and long-lasting discussions between Professors and Students, the participants identified the major points connecting urban features and Public Health, claiming the pivotal role of urban planning strategies for the management of Diseases Prevention and Health Promotion activities. The Erice 50 Charter is configured as a Decalogue for Healthy Cities and as a Think Tank for designing effective strategic actions and best practices to develop urban regeneration interventions and improve the urban quality of contemporary cities. The Decalogue is structured into the following key strategic objectives: 1. Promoting urban planning interventions that address citizens towards healthy behaviours; 2. Improving living conditions in the urban context; 3. Building an accessible and inclusive city, with a special focus on the frail population; 4. Encouraging the foundation of resilient urban areas; 5. Supporting the development of new economies and employment through urban renewal interventions; 6. Tackling social inequalities; 7. Improving stakeholders' awareness of the factors affecting Public Health in the cities; 8. Ensuring a participated urban governance; 9. Introducing qualitative and quantitative performance tools, capable of measuring the city's attitude to promote healthy lifestyles and to monitor the population's health status; 10. Encouraging sharing of knowledge and accessibility to informations. Finally, all the participants underlined that a multidisciplinary team, composed of Physicians specialized in Hygiene, Preventive Medicine, Public Health and Technicians as Architects, Urban planners and Engineers, is needed to deepen the research topic of Urban Health.
- Published
- 2017
6. Esiste un rischio di contaminazione da gas anestetici negli ambienti non chirurgici del blocco operatorio?
- Author
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Moscato, U, Di Donato, M, Contegiacomo, P, Sessa, M, Wachocka, M, Poscia, A, Giannetti, G, Cerabona, V, and Ricciardi, W
- Subjects
operating rooms ,anaesthetic gases ,operating rooms pollution - Published
- 2010
7. Un percorso assistenziale per le donne vittime di violenza sessuale e domestica
- Author
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Giannetti, G, Di Donato, M, Poscia, A, Wachocka, M, Cerabona, V, Ricciardi, G, Fontana, A, and Moscato, U.
- Subjects
donne ,Violenza femminile ,Percorso assistenziale ,Sanità Pubblica moderna ,Percorsi ,Settore MED/42 - IGIENE GENERALE E APPLICATA - Published
- 2010
8. Studio RM di mano e polso con gadolinio DTPA nell’artrite reumatoide in fase precoce: risultati preliminari
- Author
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Caiazza, L., Cortese, Andrea, Messineo, Daniela, Guerrisi, Raffaele, Marini, Mario, Villani, Marcello, and Giannetti, G.
- Published
- 1996
9. Laser flow measurements of scattering and fluorescence from cell nuclei in the presence of increasing Mg++ concentrations
- Author
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Grattarola, M., Carlo, P., Giannetti, G., Finollo, R., Viviani, R., and Chiabrera, A.
- Published
- 1985
- Full Text
- View/download PDF
10. Treatment of canine leishmaniasis: Long term molecular and serological observations
- Author
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Ariti, G., Simona Nardoni, ROBERTO AMERIGO PAPINI, Mugnaini, L., Giannetti, G., MARCO BIZZETI, Fanetti, N., and Francesca Mancianti
- Subjects
canine leishmaniasis, treatment, IFAT, PCR ,PCR ,treatment ,canine leishmaniasis ,IFAT
11. Cell adhesion to silicon substrata: characterization by means of optical and acoustic cytometric techniques
- Author
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Grattarola, M., primary, Tedesco, M., additional, Cambiaso, A., additional, Perlo, G., additional, Giannetti, G., additional, and Sanguineti, A., additional
- Published
- 1988
- Full Text
- View/download PDF
12. A mobile laminar airflow unit to reduce air bacterial contamination at surgical area in a conventionally ventilated operating theatre
- Author
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P. Vitali, Pietro Cortellini, Giuliano Sansebastiano, G. Giannetti, Samanta Fornia, Stefania Ferretti, Umberto Moscato, M. Fanti, C Pasquarella, Elisa Saccani, Carlo Signorelli, Pasquarella, C., Sansebastiano, G. E., Ferretti, S., Saccani, E., Fanti, M., Moscato, U., Giannetti, G., Fornia, S., Cortellini, P., Vitali, P., and Signorelli, C.
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,Operating Rooms ,Operating theatres ,Instrument table ,Colony Count, Microbial ,Environment controlled ,law.invention ,law ,Medicine ,Humans ,Surgical Wound Infection ,Cross Infection ,business.industry ,Significant difference ,General Medicine ,Contamination ,Environment, Controlled ,Mobile laminar airflow unit ,Surgery ,Infectious Diseases ,Ventilation (architecture) ,Colony count ,Particulate Matter ,business ,Biomedical engineering ,Environmental Monitoring - Abstract
The aim of this study was to evaluate the efficacy of a mobile laminar airflow (LAF) unit in reducing bacterial contamination at the surgical area in an operating theatre supplied with turbulent air ventilation. Bacterial sedimentation was evaluated during 76 clean urological laparotomies; in 34 of these, a mobile LAF unit was added. During each operation, settle plates were placed at four points in the operating theatre (one at the patient area and three at the perimeter), a nitrocellulose membrane was placed on the instrument table and an additional membrane near the wound. During four operations, particle counting was performed to detect particles > or =0.5 microm. Mean bacterial sedimentation on the nitrocellulose membrane on the instrument table was 2730 cfu/m(2)/h under standard ventilation conditions, whereas it decreased significantly to a mean of 305 cfu/m(2)/h when the LAF unit was used, i.e. within the suggested limit for ultraclean operating theatres (P=0.0001). The membrane near the wound showed a bacterial sedimentation of 4031 cfu/m(2)/h without the LAF unit and 1608 cfu/m(2)/h with the unit (P=0.0001). Particle counts also showed a reduction when the LAF unit was used. No significant difference was found at the four points in the operating theatre between samplings performed with, and without, the LAF unit. Use of a mobile LAF unit with turbulent air ventilation can reduce bacterial contamination at the surgical area in high-risk operations (e.g. prosthesis implant).
- Published
- 2007
13. Endothelial microparticles correlate with endothelial dysfunction in obese women
- Author
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Bruno Schisano, Roberto Gualdiero, Katherine Esposito, Giovanni Giannetti, Lucio Misso, Dario Giugliano, Luigi Sardelli, Miryam Ciotola, Esposito, Katherine, Ciotola, M., Schisano, B., Gualdero, R., Sardelli, L., Misso, L., Giannetti, G., and Giugliano, Dario
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CD31 ,Adult ,medicine.medical_specialty ,Endothelium ,Brachial Artery ,Endocrinology, Diabetes and Metabolism ,Vasodilator Agents ,Clinical Biochemistry ,Context (language use) ,circulating microparticles ,Biochemistry ,Body Mass Index ,Nitroglycerin ,Endocrinology ,Waist–hip ratio ,medicine.artery ,Internal medicine ,medicine ,Humans ,Obesity ,Endothelial dysfunction ,Brachial artery ,Reactive hyperemia ,business.industry ,Waist-Hip Ratio ,Biochemistry (medical) ,Endothelial Cells ,Middle Aged ,medicine.disease ,Vasodilation ,medicine.anatomical_structure ,Cell-derived microparticle ,Female ,business ,Body mass index - Abstract
Context: Cell-derived microparticles are supposed to be involved in atherogenesis. Objective: This study aimed to evaluate circulating microparticles in obese women and their relation with anthropometric measures and endothelial dysfunction. Design, Setting, and Participants: Forty-one obese [body mass index (BMI) > 30 kg/m2] women and 40 normal weight (BMI < 25 kg/m2) age-matched women were studied. Flow cytometry was used to assess microparticles by quantification of circulating endothelial microparticles (EMP, CD31+/CD42b–) and platelet microparticles (PMP, CD31+/CD42b+) in peripheral blood; endothelium-dependent flow-mediated vasodilation (FMD) was evaluated in the right brachial artery after reactive hyperemia. Results: Compared with lean women, obese women presented significantly higher numbers of EMP and PMP, and reduced FMD. BMI did not correlate with either EMP (r = 0.02, P = 0.9) or PMP (r = –0.07, P = 0.645), whereas waist-to-hip ratio (WHR) showed significant correlation with both microparticles (r = 0.699, P < 0.001; r = 0.373, P = 0.016, respectively). Both EMP and PMP counts positively correlated with impairment of FMD in obese women. Multivariate analysis correcting for age, anthropometric indices, lipid parameters, and PMP identified EMP as the only independent predictor for impaired endothelial-dependent vasodilation (P = 0.003). Conclusions: EMP are elevated in obese women and independently involved in the pathogenesis of endothelial dysfunction. WHR is the anthropometric measure more closely related to EMP and endothelial dysfunction.
- Published
- 2006
14. Insulin therapy corrects NK cells abnormality in type I diabetes mellitus patients
- Author
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C Cuomo, T Cerciello, F Sessa, Salvatore Guastafierro, G Giannetti, Guastafierro, Salvatore, Sessa, F, Cerciello, T, Cuomo, C, and Giannetti, G.
- Subjects
Pharmacology ,Adult ,medicine.medical_specialty ,Adolescent ,business.industry ,Type i diabetes mellitus ,Insulin ,medicine.medical_treatment ,General Medicine ,Killer Cells, Natural ,Endocrinology ,Diabetes Mellitus, Type 1 ,Internal medicine ,medicine ,Humans ,Hypoglycemic Agents ,Lymphocyte Count ,Abnormality ,business - Published
- 1996
15. Elucidating the role of water in collagen self-assembly by isotopically modulating collagen hydration.
- Author
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Giubertoni G, Feng L, Klein K, Giannetti G, Rutten L, Choi Y, van der Net A, Castro-Linares G, Caporaletti F, Micha D, Hunger J, Deblais A, Bonn D, Sommerdijk N, Šarić A, Ilie IM, Koenderink GH, and Woutersen S
- Subjects
- Thermodynamics, Hydrogen, Water chemistry, Collagen
- Abstract
Water is known to play an important role in collagen self-assembly, but it is still largely unclear how water-collagen interactions influence the assembly process and determine the fibril network properties. Here, we use the H[Formula: see text]O/D[Formula: see text]O isotope effect on the hydrogen-bond strength in water to investigate the role of hydration in collagen self-assembly. We dissolve collagen in H[Formula: see text]O and D[Formula: see text]O and compare the growth kinetics and the structure of the collagen assemblies formed in these water isotopomers. Surprisingly, collagen assembly occurs ten times faster in D[Formula: see text]O than in H[Formula: see text]O, and collagen in D[Formula: see text]O self-assembles into much thinner fibrils, that form a more inhomogeneous and softer network, with a fourfold reduction in elastic modulus when compared to H[Formula: see text]O. Combining spectroscopic measurements with atomistic simulations, we show that collagen in D[Formula: see text]O is less hydrated than in H[Formula: see text]O. This partial dehydration lowers the enthalpic penalty for water removal and reorganization at the collagen-water interface, increasing the self-assembly rate and the number of nucleation centers, leading to thinner fibrils and a softer network. Coarse-grained simulations show that the acceleration in the initial nucleation rate can be reproduced by the enhancement of electrostatic interactions. These results show that water acts as a mediator between collagen monomers, by modulating their interactions so as to optimize the assembly process and, thus, the final network properties. We believe that isotopically modulating the hydration of proteins can be a valuable method to investigate the role of water in protein structural dynamics and protein self-assembly., Competing Interests: Competing interests statement:The authors declare no competing interest.
- Published
- 2024
- Full Text
- View/download PDF
16. Modelling and Experimental Study of Power Losses in Toothed Wheels.
- Author
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Giannetti G, Meli E, and Rindi A
- Abstract
In recent decades, the request for more efficient performances in the aeronautical sector moved researchers to pay particular attention to all the related mechanisms and systems, especially with respect to the saving of power. In this context, the bearing modeling and design, as well as gear coupling, play a fundamental role. Moreover, the need for low power losses also concerns the study and the implementation of advanced lubrication systems, especially for high peripheral speed. With the previous aims, this paper presents a new validated model for toothed gears, added to a bearing model; with the link of these different submodels, the whole model describes the system's dynamic behavior, taking into account the different kinds of power losses (windage losses, fluid dynamic losses, etc.) generated by the mechanical system parts (especially rolling bearings and gears). As the bearing model, the proposed model is characterized by high numerical efficiency and allows the investigation of different rolling bearings and gears with different lubrication conditions and frictions. A comparison between the experimental and simulated results is also presented in this paper. The analysis of the results is encouraging and shows a good agreement between experiments and model simulations, with particular attention to the power losses in the bearing and gears.
- Published
- 2023
- Full Text
- View/download PDF
17. A new sensitive and accurate model to predict moderate to severe obstructive sleep apnea in patients with obesity.
- Author
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Ahlin S, Manco M, Panunzi S, Verrastro O, Giannetti G, Prete A, Guidone C, Berardino ADM, Viglietta L, Ferravante A, Mingrone G, Mormile F, and Capristo E
- Subjects
- Adult, Age Factors, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus epidemiology, Female, Humans, Male, Middle Aged, Models, Statistical, Obesity, Morbid epidemiology, Prevalence, ROC Curve, Regression Analysis, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Sex Factors, Obesity, Morbid physiopathology, Sleep Apnea, Obstructive diagnosis, Sleep Apnea, Obstructive epidemiology
- Abstract
Obstructive sleep apnea (OSA) has a high prevalence in patients with obesity. Only patients with clinical symptoms of OSA are admitted to polysomnography; however, many patients with OSA are asymptomatic. We aimed to create and validate a population-based risk score that predicts the severity of OSA in patients with obesity.We here report the cross-sectional analysis at baseline of an ongoing study investigating the long-term effect of bariatric surgery on OSA. One-hundred sixty-one patients of the Obesity Center of the Catholic University Hospital in Rome, Italy were included in the study. The patients underwent overnight cardiorespiratory monitoring, blood chemistry analyses, hepatic ultrasound, and anthropometric measurements. The patients were divided into 2 groups according OSA severity assessed by the apnea-hypopnea index (AHI): AHI < 15 = no or mild and AHI ≥ 15 moderate to severe OSA. A statistical prediction model was created and validated. C statistics was used to evaluate the discrimination performance of the model.The prevalence of OSA was 96.3% with 74.5% of the subjects having moderate/severe OSA. Sex, body mass index, diabetes, and age were included in the final prediction model that had excellent discrimination ability (C statistics equals to 83%). An OSA risk chart score for clinical use was created.Patients with severe obesity are at a very high risk for moderate or severe OSA in particular if they are men, older, more obese, and/or with type 2 diabetes. The OSA risk chart can be useful for general practitioners and patients as well as for bariatric surgeons to select patients with high risk of moderate to severe OSA for further polysomnography.
- Published
- 2019
- Full Text
- View/download PDF
18. Modeling thermophoretic effects in solid-state nanopores.
- Author
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Belkin M, Chao SH, Giannetti G, and Aksimentiev A
- Abstract
Local modulation of temperature has emerged as a new mechanism for regulation of molecular transport through nanopores. Predicting the effect of such modulations on nanopore transport requires simulation protocols capable of reproducing non-uniform temperature gradients observed in experiment. Conventional molecular dynamics (MD) method typically employs a single thermostat for maintaining a uniform distribution of temperature in the entire simulation domain, and, therefore, can not model local temperature variations. In this article, we describe a set of simulation protocols that enable modeling of nanopore systems featuring non-uniform distributions of temperature. First, we describe a method to impose a temperature gradient in all-atom MD simulations based on a boundary-driven non-equilibrium MD protocol. Then, we use this method to study the effect of temperature gradient on the distribution of ions in bulk solution (the thermophoretic effect). We show that DNA nucleotides exhibit differential response to the same temperature gradient. Next, we describe a method to directly compute the effective force of a thermal gradient on a prototypical biomolecule-a fragment of double-stranded DNA. Following that, we demonstrate an all-atom MD protocol for modeling thermophoretic effects in solid-state nanopores. We show that local heating of a nanopore volume can be used to regulate the nanopore ionic current. Finally, we show how continuum calculations can be coupled to a coarse-grained model of DNA to study the effect of local temperature modulation on electrophoretic motion of DNA through plasmonic nanopores. The computational methods described in this article are expected to find applications in rational design of temperature-responsive nanopore systems.
- Published
- 2014
- Full Text
- View/download PDF
19. A case of feline primary inflammatory mammary carcinoma: clinicopathological and immunohistochemical findings.
- Author
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Millanta F, Verin R, Asproni P, Giannetti G, and Poli A
- Subjects
- Adenocarcinoma pathology, Animals, Cats, Female, Immunohistochemistry, Adenocarcinoma veterinary, Cat Diseases pathology, Mammary Neoplasms, Animal pathology
- Abstract
The clinicopathological and immunohistochemical findings of a primary feline mammary tumour with features similar to human and canine primary inflammatory carcinoma are described for the first time. The cat presented to the clinic for the rapid onset of oedema, severe erythema, local pain and warmth of the inguinal region, with a pustular-to-nodular cutaneous lesion in association with an ill-defined underlying mass. An epithelial malignant tumour was diagnosed by cytological investigation. Necropsy revealed a thickening of the skin with oedema of the subcutis in the right inguinal area, and regional and distant metastases. Histology showed an unencapsulated tubulopapillary proliferation of malignant epithelial cells, with a massive embolisation in the dermal lymphatics and a mild inflammatory infiltrate. Through immunohistochemistry, the tumour was found to be oestrogen (ER)-alpha-, androgen (AR)- and progesterone (PR)-negative; neoplastic cells were ER-alpha, AR-negative and focally PR-positive. An irregular, mild and focal HER-2 immunoreactivity was present (score +1, non-HER-2 overexpressing). The neoplastic cells were cyclo-oxygenase-2 and vascular endothelial growth factor positive.
- Published
- 2012
- Full Text
- View/download PDF
20. [Availability and quality of vaccines information on the Web: a systematic review and implication in Public Health].
- Author
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Poscia A, Santoro A, Collamati A, Giannetti G, de Belvis AG, Ricciardi W, and Moscato U
- Subjects
- Child, Evidence-Based Medicine, Health Knowledge, Attitudes, Practice, Humans, Treatment Refusal, Health Education standards, Information Dissemination, Internet, Parents education, Public Health, Vaccines adverse effects
- Abstract
Adherence to vaccination campaigns can be negatively influenced by Web presence of unreliable information. Aim of study is qualitative and quantitative evaluation of Italian WebPages contents about vaccinations to address prevention strategies in countries that, like Italy, wouldn't like vaccination to be mandatory any longer In August 2011 two researchers conducted a Systematic Review in Italian WebPages about vaccination risks. First 100 results of 9 common search engines have been combined; pro and against pages were compared (CHI2, p <0,05). 144 WebPages were analysed: 67% of them, often on top positions, was against vaccinations and 24% of them was written by Medical Doctors. All institutional pages (12%) were pro vaccinations but they resulted in less important positions. Against WebPages were different from pro ones in terms of use of emotional images, personal negative experiences, advertising purposes (books or alternative medicine products). Main criticism was: inefficacy, low safety profile and stakeholder's interests. This study would like to represent a useful tool for parents and Medical Doctors, especially because many of them are progressively more sceptical about vaccination practises. The great number of anti-vaccination movements on Italian Web should improve public health strategies in terms of "Evidence-Based prevention".
- Published
- 2012
21. Endothelial microparticles correlate with endothelial dysfunction in obese women.
- Author
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Esposito K, Ciotola M, Schisano B, Gualdiero R, Sardelli L, Misso L, Giannetti G, and Giugliano D
- Subjects
- Adult, Body Mass Index, Brachial Artery physiopathology, Female, Humans, Middle Aged, Nitroglycerin pharmacology, Obesity physiopathology, Vasodilation physiology, Vasodilator Agents pharmacology, Waist-Hip Ratio, Endothelial Cells pathology, Endothelium physiopathology, Obesity blood
- Abstract
Context: Cell-derived microparticles are supposed to be involved in atherogenesis., Objective: This study aimed to evaluate circulating microparticles in obese women and their relation with anthropometric measures and endothelial dysfunction., Design, Setting, and Participants: Forty-one obese [body mass index (BMI) > 30 kg/m(2)] women and 40 normal weight (BMI < 25 kg/m(2)) age-matched women were studied. Flow cytometry was used to assess microparticles by quantification of circulating endothelial microparticles (EMP, CD31+/CD42b-) and platelet microparticles (PMP, CD31+/CD42b+) in peripheral blood; endothelium-dependent flow-mediated vasodilation (FMD) was evaluated in the right brachial artery after reactive hyperemia., Results: Compared with lean women, obese women presented significantly higher numbers of EMP and PMP, and reduced FMD. BMI did not correlate with either EMP (r = 0.02, P = 0.9) or PMP (r = -0.07, P = 0.645), whereas waist-to-hip ratio (WHR) showed significant correlation with both microparticles (r = 0.699, P < 0.001; r = 0.373, P = 0.016, respectively). Both EMP and PMP counts positively correlated with impairment of FMD in obese women. Multivariate analysis correcting for age, anthropometric indices, lipid parameters, and PMP identified EMP as the only independent predictor for impaired endothelial-dependent vasodilation (P = 0.003)., Conclusions: EMP are elevated in obese women and independently involved in the pathogenesis of endothelial dysfunction. WHR is the anthropometric measure more closely related to EMP and endothelial dysfunction.
- Published
- 2006
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