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10. 5-cis-, Trans- and Total Lycopene Plasma Concentrations Inversely Relate to Atherosclerotic Plaque Burden in Newly Diagnosed Type 2 Diabetes Subjects

Author

Chiva-Blanch, Gemma, primary, Jiménez, Claudia, additional, Pinyol, Montserrat, additional, Herreras, Zoe, additional, Catalán, Marta, additional, Martínez-Huélamo, Miriam, additional, Lamuela-Raventos, Rosa M, additional, Sala-Vila, Aleix, additional, Cofán, Montserrat, additional, Gilabert, Rosa, additional, Jiménez, Amanda, additional, and Ortega, Emilio, additional

Published
2020
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13. Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk

Author

Bargalló, Núria, primary, Gilabert, Rosa, additional, Romero-Mamani, Edwin-Saúl, additional, Cofán, Montserrat, additional, Calder, Philip, additional, Fitó, Montserrat, additional, Corella, Dolores, additional, Salas-Salvadó, Jordi, additional, Ruiz-Canela, Miguel, additional, Estruch, Ramon, additional, Ros, Emilio, additional, and Sala-Vila, Aleix, additional

Published
2017
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14. Changes in ultrasound-assessed carotid intima-media thickness and plaque with a mediterranean diet: A substudy of the PREDIMED trial

Author

Sala-Vila, Aleix, Romero-Mamani, Edwin Saúl, Gilabert, Rosa, Núñez, Isabel, Torre, Rafael de la, Corella, Dolores, Ruiz-Gutiérrez, Valentina, López-Sabater, Carmen, Pintó, Xavier, Rekondo, Javier, Martínez-González, Miguel Ángel, Estruch, Ramón, Ros, Emilio, Sala-Vila, Aleix, Romero-Mamani, Edwin Saúl, Gilabert, Rosa, Núñez, Isabel, Torre, Rafael de la, Corella, Dolores, Ruiz-Gutiérrez, Valentina, López-Sabater, Carmen, Pintó, Xavier, Rekondo, Javier, Martínez-González, Miguel Ángel, Estruch, Ramón, and Ros, Emilio

Abstract

OBJECTIVE - : The Prevención con Dieta Mediterránea (PREDIMED) trial showed that a Mediterranean diet (MedDiet) supplemented with either extra virgin olive oil or 30 g/d of mixed nuts reduced incident cardiovascular events compared with a control (low fat) diet. The mechanisms of cardiovascular protection afforded by MedDiets remain to be uncovered. We assessed the effect of both supplemented MedDiets on internal carotid intima-media thickness (ICA-IMT) and plaque height, the ultrasound features that best predict future cardiovascular events, in subjects at high cardiovascular risk. APPROACH AND RESULTS - : In a PREDIMED subcohort (n=175), plaque height and carotid IMT of 3 prespecified segments (ICA, bifurcation, and common) were sonographically assessed at baseline and after intervention for a mean of 2.4 years. We evaluated 164 subjects with complete data. In a multivariate model, mean ICA-IMT progressed in the control diet group (mean [95% confidence interval], 0.052 mm [-0.014 to 0.118 mm]), whereas it regressed in the MedDiet+nuts group (-0.084 mm [-0.158 to -0.010 mm]; P=0.024 versus control). Similar results were observed for maximum ICA-IMT (control, 0.188 mm [0.077 to 0.299 mm]; MedDiet+nuts, -0.030 mm [-0.153 to 0.093 mm]; P=0.034) and maximum plaque height (control, 0.106 mm [0.001 to 0.210 mm]; MedDiet+nuts, -0.091 mm [-0.206 to 0.023 mm]; P=0.047). There were no changes in ICA-IMT or plaque after the MedDiet+extra virgin olive oil. CONCLUSIONS - : Compared with a control diet, consumption of a MedDiet supplemented with nuts is associated with delayed progression of ICA-IMT and plaque. The results contribute mechanistic evidence for the reduction of cardiovascular events observed in the PREDIMED trial. © 2013 American Heart Association, Inc.

Published
2014

24. Changes in Ultrasound-Assessed Carotid Intima-Media Thickness and Plaque With a Mediterranean Diet

Author

Sala-Vila, Aleix, primary, Romero-Mamani, Edwin-Saúl, additional, Gilabert, Rosa, additional, Núñez, Isabel, additional, de la Torre, Rafael, additional, Corella, Dolores, additional, Ruiz-Gutiérrez, Valentina, additional, López-Sabater, María-Carmen, additional, Pintó, Xavier, additional, Rekondo, Javier, additional, Martínez-González, Miguel-Ángel, additional, Estruch, Ramon, additional, and Ros, Emilio, additional

Published
2014
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30. Renal Failure in Patients With Cirrhosis and Sepsis Unrelated to Spontaneous Bacterial Peritonitis: Value of MELD Score

Author

Terra, Carlos, primary, Guevara, Mónica, additional, Torre, Aldo, additional, Gilabert, Rosa, additional, Fernández, Javier, additional, Martín-Llahí, Marta, additional, Baccaro, Maria E., additional, Navasa, Miquel, additional, Bru, Conxita, additional, Arroyo, Vicente, additional, Rodés, Juan, additional, and Ginès, Pere, additional

Published
2005
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33. Preoperative staging and tumor resectability assessment in pancreatic cancer. Prospective study comparing endoscopic ultrasonography (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and angiography

Author

Soriano, Antonio, primary, Carmen Ayuso, M., additional, Ayuso, Juan Ramon, additional, Caralt, Maria Teresa De, additional, Gilabert, Rosa, additional, Gines, Angels, additional, Isabel Real, M., additional, Salvador, Laura, additional, Feu, Faust, additional, Femandez-Cruz, Laureano, additional, Castells, Antoni, additional, and Navarro, Salvador, additional

Published
2001
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35. Clinical events after transjugular intrahepatic portosystemic shunt: Correlation with hemodynamic findings

Author

Casado, Marta, primary, Bosch, Jaume, additional, García-Pagán, Juan Carlos, additional, Bru, Conxita, additional, Bañares, Rafael, additional, Bandi, Juan Carlos, additional, Escorsell, Angels, additional, Rodríguez-Láiz, José Manuel, additional, Gilabert, Rosa, additional, Feu, Faust, additional, Schorlemer, Carlos, additional, Echenagusia, Antonio, additional, and Rodés, Joan, additional

Published
1998
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36. Preclinical arterial disease in patients with type 1 diabetes without other major cardiovascular risk factors or micro-/ macrovascular disease.

Author

Giménez, Marga, Gilabert, Rosa, Lara, Mercè, and Conget, Ignacio

Abstract

We aimed to investigate preclinical atherosclerosis in T1D and its relationship with glucose profile and endothelial/ inflammatory markers. Thirty-eight T1D patients without additional cardiovascular risk factors or micro-/macrovascular complications and 22 healthy matched subjects were included. FMD and cIMT/fIMT were performed in addition to 72-h continuous glucose monitoring and the measurement of endothelial/inflammatory markers. Lower FMD percentages and greater cIMT/fIMT were observed in patients with T1D in comparison with controls (FMD 7.0±3.1% vs. 9.6±2.2%; p<0.005; cIMT 0.523±0.091 mm vs. 0.471±0.061 mm; p<0.05 and fIMT 0.512±0.172mm vs. 0.394±0.061mm; p<0.01, for patients and controls, respectively). T1D subjects in the highest tertile of cIMT were older than those in the lowest group (39.9±9.5 vs. 29.6±4.7 years; p<0.005) and had a longer duration of the disease (18.7±5.4 years vs. 11.8±6.4 years). The higher the cIMT tertile, the greater the fIMT (0.397±0.114 mm vs. 0.431±0.082 mm vs. 0.583±0.197 mm; p<0.05). MAGE was negatively correlated to FMD (r=-0.328; p<0.05) and positively to cIMT (r=0.322; p<0.05). There were no differences between cIMT tertiles in terms of metabolic parameters or endothelial and inflammatory markers. Signals of preclinical atherosclerosis in T1D even in the absence of cardiovascular risk factors and micro- / macrovascular disease are reported. Our findings suggest that daily glucose instability could negatively impact vascular function and structure. [ABSTRACT FROM PUBLISHER]

Published
2011
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