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5. Therapy-associated polyposis – a novel form of acquired gastrointestinal polyposis

Author

Yurgelun, Matthew B., Hornick, Jason L., Curry, Victoriana K., Ukaegbu, Chinedu I., Brown, Emily K., Hiller, Elaine, Chittenden, Anu, Goldberg, Joel E., and Syngal, Sapna

Subjects
Adult, Male, Adolescent, Genotype, Radiotherapy, Intestinal Polyposis, Adenomatous Polyposis Coli Protein, Infant, Antineoplastic Agents, Middle Aged, Article, DNA Glycosylases, Young Adult, Neoplasms, Humans, Female
Abstract

Survivors of childhood cancers are at increased risk of developing secondary gastrointestinal cancers, including colorectal cancer, later in life, possibly from exposure to abdominopelvic radiotherapy and/or alkylating chemotherapy. Profuse gastrointestinal polyposis is associated with rare, inherited colorectal cancer predisposition syndromes, most commonly caused by mutations in the adenomatous polyposis coli (APC) or mutY homolog (MUTYH) genes. We describe 5 patients who developed gastrointestinal polyposis many years after radiotherapy and chemotherapy for a childhood cancer. Genetic analysis of all 5 subjects did not identify pathogenic germline mutations in APC or MUTYH. Chemotherapy and/or radiotherapy therefore might cause gastrointestinal polyposis in some patients by undiscovered mechanisms.

Published
2013

6. Data on Medicare eligibility and cancer screening utilization

Author

Meyer, Christian P., primary, Allard, Christopher B., additional, Sammon, Jesse D., additional, Hanske, Julian, additional, McNabb-Baltar, Julia, additional, Goldberg, Joel E., additional, Reznor, Gally, additional, Lipsitz, Stuart R., additional, Choueiri, Toni K., additional, Nguyen, Paul L., additional, Weissman, Joel S., additional, and Trinh, Quoc-Dien, additional

Published
2016
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7. 894 Racial Disparities in Colorectal Cancer Screening - More Equitable Outcomes in the Equal-Access Military Health System

Author

Changoor, Navin R., primary, Zogg, Cheryl K., additional, Ranjit, Anju, additional, Ortega, Gezzer, additional, Nguyen, Louis L., additional, Schneider, Eric, additional, Bleday, Ronald, additional, Trinh, Quoc-Dien R., additional, Learn, Peter A., additional, Haider, Adil H., additional, and Goldberg, Joel E., additional

Published
2016
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12. Rapidly Expanding Infectious Aortic Aneurysm Caused by Perforated Colon Cancer.

Author

Rajab TK, Rinewalt DE, Belkin M, Goldberg JE, and Zhou H

Abstract

A 50-year-old male smoker presented with a perforated colon cancer and underwent an extended right colectomy. Feculent peritonitis was treated with empiric antibiotics. Postoperatively he developed severe back pain and rising leukocytosis. Serial computed tomography revealed a rapidly expanding infrarenal aortic aneurysm. He was urgently treated with extra-anatomic bypasses and aortic resection. No organisms grew from the resected aortic wall. He was discharged in stable condition, and the ileostomy was reversed 9 months later.

Published
2016
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