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3. The Interdisciplinary Stem Cell Institute’s Use of Food and Drug Administration-Expanded Access Guidelines to Provide Experimental Cell Therapy to Patients With Rare Serious Diseases

Author

Khan, Aisha, primary, Bellio, Michael A., additional, Schulman, Ivonne H., additional, Levi, Allan D., additional, Longsomboon, Bangon, additional, Brooks, Adriana, additional, Valasaki, Krystalenia, additional, DiFede, Darcy L., additional, Pujol, Marietsy V., additional, Yavagal, Dileep R., additional, Bates, Karen E., additional, Si, Ming-Sing, additional, Kaushal, Sunjay, additional, Green, Barth A., additional, Anderson, Kimberly D., additional, Guest, James D., additional, Burks, Stephen Shelby, additional, Silvera, Risset, additional, Santamaria, Andrea J., additional, Lalwani, Anil, additional, Dietrich, W. Dalton, additional, and Hare, Joshua M., additional

Published
2021
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6. Imaging characteristics of chronic spinal cord injury identified during screening for a cell transplantation clinical trial

Author

Burks, Joshua D., primary, Gant, Katie L., additional, Guest, James D., additional, Jamshidi, Aria G., additional, Cox, Efrem M., additional, Anderson, Kim D., additional, Dietrich, W. Dalton, additional, Bunge, Mary Bartlett, additional, Green, Barth A., additional, Khan, Aisha, additional, Pearse, Damien D., additional, Saraf-Lavi, Efrat, additional, and Levi, Allan D., additional

Published
2019
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9. MRI Measures of Posterior Cranial Fossa Morphology and CSF Physiology in Chiari Malformation Type I

Author

Alperin, Noam, Loftus, James Ryan, Oliu, Carlos J., Bagci, Ahmet, Lee, Sang H., Ertl-Wagner, Birgit, Green, Barth, and Sekula, Raymond

Subjects
Adult, Male, Cranial Fossa, Posterior, Humans, Female, Magnetic Resonance Imaging, Article, Arnold-Chiari Malformation, Encephalocele
Abstract

It has been well documented that, along with tonsillar herniation, Chiari Malformation Type I (CMI) is associated with smaller posterior cranial fossa (PCF) and altered cerebrospinal fluid (CSF) flow and tissue motion in the craniocervical junction.This study assesses the relationship between PCF volumetry and CSF and tissue dynamics toward a combined imaging-based morphological-physiological characterization of CMI. Multivariate analysis is used to identify the subset of parameters that best discriminates CMI from a healthy cohort.Eleven length and volumetric measures of PCF, including crowdedness and 4th ventricle volume, 4 measures of CSF and cord motion in the craniocervical junction, and 5 global intracranial measures, including intracranial compliance and pressure, were measured by magnetic resonance imaging (MRI) in 36 symptomatic CMI subjects (28 female, 37 ± 11 years) and 37 control subjects (24 female, 36 ± 12 years). The CMI group was further divided based on symptomatology into "typical" and "atypical" subgroups.Ten of the 20 morphologic and physiologic measures were significantly different between the CMI and the control cohorts. These parameters also had less variability and stronger significance in the typical CMI compared with the atypical. The measures with the most significance were clival and supraocciput lengths, PCF crowdedness, normalized PCF volume, 4th ventricle volume, maximal cord displacement (P.001), and MR measure of intracranial pressure (P = .007). Multivariate testing identified cord displacement, PCF crowdedness, and normalized PCF as the strongest discriminator subset between CMI and controls. MR measure of intracranial pressure was higher in the typical CMI cohort compared with the atypical.The identified 10 complementing morphological and physiological measures provide a more complete and symptomatology-relevant characterization of CMI than tonsillar herniation alone.

Published
2014

17. Surgical treatment for acute spinal cord injury study pilot study #2: evaluation of protocol for decompressive surgery within 8 hours of injury

Author

Ng, Wai Pui, primary, Fehlings, Michael G., additional, Cuddy, Brian, additional, Dickman, Curtis, additional, Fazl, Mahmood, additional, Green, Barth, additional, Hitchon, Patrick, additional, Northrup, Bruce, additional, Sonntag, Volker, additional, Wagner, Frank, additional, and Tator, Charles H., additional

Published
1999
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22. Circuit resistance training in persons with complete paraplegia.

Author

Jacobs, Patrick L., Mahoney, Edward T., Nash, Mark S., and Green, Barth A.

Subjects
PHYSICAL fitness for people with disabilities, PATIENTS with spinal cord injuries, PARAPLEGIA, CIRCUIT training
Abstract

Assesses the physiological responses of persons with spinal cord injury paraplegia to a single session of circuit resistance training (CRT) and the caloric cost of the exercise. Significance of exercise to people with spinal cord injury; Information on the peak physiological responses to graded arm ergonometry of the subjects; Analysis of the acute cardiorespiratory responses of the subjects to exercise maneuvers during a single session of CRT.

Published
2002

24. University of miami neuro-spinal index (UMNI): a quantitative method for determining spinal cord function

Author

Klose, K John, Green, Barth A, Smith, Robin S, Adkins, Rodney H, and MacDonald, Anne M

Abstract

At the University of Miami we have developed a quantitative scale for assessing spinal cord function and have utilised this scale in evaluating acute spinal cord injury patients over the last year. The assessments are performed by specially trained physical therapists who see the patients within an hour of their arrival at the hospital emergency room. The University of Miami Neuro-Spinal Index (UMNI) utilises standard methods of spinal cord functional assessment to produce a numerical value which can be used to determine change in a patient's status, even when the change is minimal. The UMNI yields both a sensory and motor scale which can be dealt with individually or in combination. This scale permits one to compare across patients, quantitative changes in status regardless of the initial level of injury. The UMNI is sensitive to small changes. We are in the process of determining the UMNI's potential as a predictor of outcome.

Published
1980
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26. Analysis of swimming pool accidents resulting in spinal cord injury

Author

Green, Barth A, Gabrielsen, M Alexander, Hall, Wiley J, and O'Heir, James

Abstract

This paper is a summary of a study of 72 cases of swimming-pool accidents resulting in serious injuries with the potential of permanent disability. Sixty-four of the 72 cases resulted in spinal cord injuries, 57 of which involved quadriplegic lesions. The authors observed that the majority of these injuries resulted from a lack of good judgement and common sense rather than from intoxication or pool structural deficiencies. Also of note was the lack of appropriate first-aid and extrication rendered, as well as the absence of uniform treatment and care received by the majority of the patients.

Published
1980
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27. Cervical Spinal Cord Injury After Traumatic Breech Delivery

Author

Castillo, Mauricio, Quencer, Robert M., and Green, Barth A.

Subjects
Pregnancy, Child, Preschool, Birth Injuries, Humans, Female, Case Reports, Breech Presentation, Magnetic Resonance Imaging, Spinal Cord Injuries
Published
1989

28. Clinical application of modest hypothermia after spinal cord injury.

Author

Levi AD, Green BA, Wang MY, Dietrich WD, Brindle T, Vanni S, Casella G, Elhammady G, and Jagid J

Subjects
Adolescent, Adult, Catheterization, Cerebrospinal Fluid physiology, Cervical Vertebrae injuries, Female, Heart Rate physiology, Humans, Hypothermia, Induced adverse effects, Hypothermia, Induced statistics & numerical data, Injections, Spinal, Male, Middle Aged, Pilot Projects, Postoperative Complications etiology, Postoperative Complications physiopathology, Retrospective Studies, Spinal Cord metabolism, Spinal Cord Injuries cerebrospinal fluid, Time Factors, Treatment Outcome, Young Adult, Body Temperature physiology, Hypothermia, Induced methods, Spinal Cord physiopathology, Spinal Cord Injuries physiopathology, Spinal Cord Injuries therapy
Abstract

There is widespread interest in the use of hypothermia in the treatment of CNS injury. While there is considerable experience in the use of cooling for a variety of brain pathologies, limited data exist after spinal cord injury. In the past few years, technological advances in the induction and maintenance of cooling have been achieved and can potentially allow for a more accurate evaluation of this form of treatment. We report a series of 14 patients with an average age of 39.4 years (range, 16-62 years) with acute, complete (AIS A) cervical spinal cord injuries who underwent a protocol using an intravascular cooling catheter to achieve modest (33 degrees C) systemic hypothermia. There was an excellent correlation between intravascular and intrathecal cerebrospinal fluid temperature. The average time between injury and induction of hypothermia was 9.17 +/- 2.24 h (mean +/- SEM); the time to target temperature was 2.72 +/- 0.42 h; the duration of cooling at target temperature was 47.6 +/- 3.1 h; the average total length of time of cooling was 93.6 +/- 4 h. There was a positive correlation between temperature and heart rate. Most documented adverse events were respiratory in nature. We were able to effectively deliver systemic cooling using the cooling catheters with minimal variation in body temperature. The study represents the largest, modern series of hypothermia treatment of acute spinal cord injury with intravascular cooling techniques and provides needed baseline data for outcome studies to include larger multi-center, randomized trials.

Published
2009
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