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1. Evaluating a multimodal, clinical and work-directed intervention (RTW-PIA) to support sustainable return to work among employees with mental disorders: study protocol of a multicentre, randomised controlled trial

Author

Fiona Starke, Alexandra Sikora, Ralf Stegmann, Leonie Knebel, Claudia Buntrock, Angelique de Rijk, Inge Houkes, Gregor R. Szycik, Hans-Peter Unger, Jan Ole Schumacher, Heiko Stark, Iris Hauth, Christian Holzapfel, Anna Borgolte, Carlotta Schneller, Sarah-Louise Unterschemmann, Wiebke Paetow, Anna Lena Jung, Matthias Berking, Johannes Zimmermann, and Uta Wegewitz

Subjects
Return to work, Mental disorders, Relapse prevention, RCT, Sickness absence, Multimodal Intervention, Psychiatry, RC435-571
Abstract

Abstract Background Mental disorders (MDs) are one of the leading causes for workforce sickness absence and disability worldwide. The burden, costs and challenges are enormous for the individuals concerned, employers and society at large. Although most MDs are characterised by a high risk of relapse after treatment or by chronic courses, interventions that link medical-psychotherapeutic approaches with work-directed components to facilitate a sustainable return to work (RTW) are rare. This protocol describes the design of a study to evaluate the (cost-)effectiveness and implementation process of a multimodal, clinical and work-directed intervention, called RTW-PIA, aimed at employees with MDs to achieve sustainable RTW in Germany. Methods The study consists of an effectiveness, a health-economic and a process evaluation, designed as a two-armed, multicentre, randomised controlled trial, conducted in German psychiatric outpatient clinics. Sick-listed employees with MDs will receive either the 18-month RTW-PIA treatment in conjunction with care as usual, or care as usual only. RTW-PIA consists of a face-to-face individual RTW support, RTW aftercare group meetings, and web-based aftercare. Assessments will be conducted at baseline and 6, 12, 18 and 24 months after completion of baseline survey. The primary outcome is the employees´ achievement of sustainable RTW, defined as reporting less than six weeks of working days missed out due to sickness absence within 12 months after first RTW. Secondary outcomes include health-related quality of life, mental functioning, RTW self-efficacy, overall job satisfaction, severity of mental illness and work ability. The health-economic evaluation will be conducted from a societal and public health care perspective, as well as from the employer’s perspective in a cost–benefit analysis. The design will be supplemented by a qualitative effect evaluation using pre- and post-interviews, and a multimethod process evaluation examining various predefined key process indicators from different stakeholder perspectives. Discussion By applying a comprehensive, multimethodological evaluation design, this study captures various facets of RTW-PIA. In case of promising results for sustainable RTW, RTW-PIA may be integrated into standard care within German psychiatric outpatient clinics. Trial registration The study was prospectively registered with the German Clinical Trials Register ( DRKS00026232 , 1 September 2021).

Published
2023
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2. The effect of multisensory semantic congruency on unisensory object recognition in schizophrenia

Author

Erfan Ghaneirad, Anna Borgolte, Christopher Sinke, Anja Čuš, Stefan Bleich, and Gregor R. Szycik

Subjects
schizophrenia, multisensory memory, multisensory integration, multisensory object recognition, congruency effect, Psychiatry, RC435-571
Abstract

Multisensory, as opposed to unisensory processing of stimuli, has been found to enhance the performance (e.g., reaction time, accuracy, and discrimination) of healthy individuals across various tasks. However, this enhancement is not as pronounced in patients with schizophrenia (SZ), indicating impaired multisensory integration (MSI) in these individuals. To the best of our knowledge, no study has yet investigated the impact of MSI deficits in the context of working memory, a domain highly reliant on multisensory processing and substantially impaired in schizophrenia. To address this research gap, we employed two adopted versions of the continuous object recognition task to investigate the effect of single-trail multisensory encoding on subsequent object recognition in 21 schizophrenia patients and 21 healthy controls (HC). Participants were tasked with discriminating between initial and repeated presentations. For the initial presentations, half of the stimuli were audiovisual pairings, while the other half were presented unimodal. The task-relevant stimuli were then presented a second time in a unisensory manner (either auditory stimuli in the auditory task or visual stimuli in the visual task). To explore the impact of semantic context on multisensory encoding, half of the audiovisual pairings were selected to be semantically congruent, while the remaining pairs were not semantically related to each other. Consistent with prior studies, our findings demonstrated that the impact of single-trial multisensory presentation during encoding remains discernible during subsequent object recognition. This influence could be distinguished based on the semantic congruity between the auditory and visual stimuli presented during the encoding. This effect was more robust in the auditory task. In the auditory task, when congruent multisensory pairings were encoded, both participant groups demonstrated a multisensory facilitation effect. This effect resulted in improved accuracy and RT performance. Regarding incongruent audiovisual encoding, as expected, HC did not demonstrate an evident multisensory facilitation effect on memory performance. In contrast, SZs exhibited an atypically accelerated reaction time during the subsequent auditory object recognition. Based on the predictive coding model we propose that this observed deviations indicate a reduced semantic modulatory effect and anomalous predictive errors signaling, particularly in the context of conflicting cross-modal sensory inputs in SZ.

Published
2023
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3. Altered brain network organization in adults with Asperger's syndrome: decreased connectome transitivity and assortativity with increased global efficiency

Author

Nooshin Javaheripour, Gerd Wagner, Feliberto de la Cruz, Martin Walter, Gregor R. Szycik, and Fabian-Alexander Tietze

Subjects
autism spectrum disorder (ASD), Asperger's syndrome (AS), graph theory, resting-state functional magnetic resonance imaging (rs-fMRI), autism spectrum traits, Psychiatry, RC435-571
Abstract

IntroductionAutism spectrum disorder (ASD) is a neurodevelopmental disorder that persists into adulthood with both social and cognitive disturbances. Asperger's syndrome (AS) was a distinguished subcategory of autism in the DSM-IV-TR defined by specific symptoms including difficulties in social interactions, inflexible thinking patterns, and repetitive behaviour without any delay in language or cognitive development. Studying the functional brain organization of individuals with these specific symptoms may help to better understand Autism spectrum symptoms.MethodsThe aim of this study is therefore to investigate functional connectivity as well as functional network organization characteristics using graph-theory measures of the whole brain in male adults with AS compared to healthy controls (HC) (AS: n = 15, age range 21–55 (mean ± sd: 39.5 ± 11.6), HC: n = 15, age range 22–57 [mean ± sd: 33.5 ± 8.5]).ResultsNo significant differences were found when comparing the region-by-region connectivity at the whole-brain level between the AS group and HC. However, measures of “transitivity,” which reflect local information processing and functional segregation, and “assortativity,” indicating network resilience, were reduced in the AS group compared to HC. On the other hand, global efficiency, which represents the overall effectiveness and speed of information transfer across the entire brain network, was increased in the AS group.DiscussionOur findings suggest that individuals with AS may have alterations in the organization and functioning of brain networks, which could contribute to the distinctive cognitive and behavioural features associated with this condition. We suggest further research to explore the association between these altered functional patterns in brain networks and specific behavioral traits observed in individuals with AS, which could provide valuable insights into the underlying mechanisms of its symptomatology.

Published
2023
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4. Cognitive control in adults with high-functioning autism spectrum disorder: a study with event-related potentials

Author

Laura Möde, Anna Borgolte, Erfan Ghaneirad, Mandy Roy, Christopher Sinke, Gregor R. Szycik, Stefan Bleich, and Daniel Wiswede

Subjects
high-functioning, autism, cognitive control, flanker task, conflict adaptation, post-error slowing, Psychiatry, RC435-571
Abstract

IntroductionLittle is known about cognitive control in adults with high-functioning forms of autism spectrum disorder because previous research focused on children and adolescents. Cognitive control is crucial to monitor and readjust behavior after errors to select contextually appropriate reactions. The congruency effect and conflict adaptation are measures of cognitive control. Post-error slowing, error-related negativity and error positivity provide insight into behavioral and electrophysiological correlates of error processing. In children and adolescent with autism spectrum disorder deficits in cognitive control and error processing have been shown by changes in post-error slowing, error-related negativity and error positivity in the flanker task.MethodsWe performed a modified Eriksen flanker task in 17 adults with high-functioning autism spectrum disorder and 17 healthy controls. As behavioral measures of cognitive control and error processing, we included reaction times and error rates to calculate congruency effects, conflict adaptation, and post-error slowing. Event-related potentials namely error-related negativity and error positivity were measured to assess error-related brain activity.ResultsBoth groups of participants showed the expected congruency effects demonstrated by faster and more accurate responses in congruent compared to incongruent trials. Healthy controls exhibited conflict adaptation as they obtained performance benefits after incongruent trials whereas patients with autism spectrum disorder did not. The expected slowing in reaction times after errors was observed in both groups of participants. Individuals with autism spectrum disorder demonstrated enhanced electrophysiological error-processing compared to healthy controls indicated by increased error-related negativity and error positivity difference amplitudes.DiscussionOur findings show that adults with high-functioning autism spectrum disorder do not show the expected upregulation of cognitive control in response to conflicts. This finding implies that previous experiences may have a reduced influence on current behavior in these patients which possibly contributes to less flexible behavior. Nevertheless, we observed intact behavioral reactions after errors indicating that adults with high-functioning autism spectrum disorder can flexibly adjust behavior in response to changed environmental demands when necessary. The enhancement of electrophysiological error-processing indicates that adults with high-functioning autism spectrum disorder demonstrate an extraordinary reactivity toward errors reflecting increased performance monitoring in this subpopulation of autism spectrum disorder patients.

Published
2023
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5. Examining the CEO-owner dyad : a dynamic model of interrelationship influences on innovation capability

Author

Schmitt, Gregor R.

Subjects
658, Interrelationship, Innovation, Corporate governance, Ideology
Abstract

Innovation is fundamental to long-term business success in technology medium-sized enterprises (MSEs). The owner-CEO interrelationship is likely to set the culture and be an important influence on the enterprise innovation capability. Previous studies of the owner-CEO interrelationship have produced varying results but few have examined the influence on innovation capability. Agency theory assumes that owners and CEOs have contrasting objectives but it is silent when owners and CEOs are in accord. Companies may have varying dominant ideologies, such as entrepreneurialism, managerialism, and paternalism, which likely influence their innovation capability. Using primary data from three different German MSEs, selected for their contrasting ideologies, this study examines how interrelationship influences of the owner-CEO interrelationship have the potential to influence the innovation capability of MSEs. The results show that the influence of the owner-CEO interrelationship on the innovation capability is associated with social and situational influences. This thesis provides an original contribution by developing an "interrelationship influence model" that captures the interrelationship factors that influence innovation capability, namely: action, support, communication, responsibility, power and autonomy. This study has important implications for researchers in corporate governance as well as in innovation. Enterprises aiming to improve their innovation capability should pay attention to interrelationships and the influence of owners as well as to the CEO and the management team.

Published
2018

8. Deficient Audiovisual Speech Perception in Schizophrenia: An ERP Study

Author

Erfan Ghaneirad, Ellyn Saenger, Gregor R. Szycik, Anja Čuš, Laura Möde, Christopher Sinke, Daniel Wiswede, Stefan Bleich, and Anna Borgolte

Subjects
schizophrenia, multisensory speech perception, audiovisual speech, early sensory processing of speech, EEG, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

In everyday verbal communication, auditory speech perception is often disturbed by background noise. Especially in disadvantageous hearing conditions, additional visual articulatory information (e.g., lip movement) can positively contribute to speech comprehension. Patients with schizophrenia (SZs) demonstrate an aberrant ability to integrate visual and auditory sensory input during speech perception. Current findings about underlying neural mechanisms of this deficit are inconsistent. Particularly and despite the importance of early sensory processing in speech perception, very few studies have addressed these processes in SZs. Thus, in the present study, we examined 20 adult subjects with SZ and 21 healthy controls (HCs) while presenting audiovisual spoken words (disyllabic nouns) either superimposed by white noise (−12 dB signal-to-noise ratio) or not. In addition to behavioral data, event-related brain potentials (ERPs) were recorded. Our results demonstrate reduced speech comprehension for SZs compared to HCs under noisy conditions. Moreover, we found altered N1 amplitudes in SZ during speech perception, while P2 amplitudes and the N1-P2 complex were similar to HCs, indicating that there may be disturbances in multimodal speech perception at an early stage of processing, which may be due to deficits in auditory speech perception. Moreover, a positive relationship between fronto-central N1 amplitudes and the positive subscale of the Positive and Negative Syndrome Scale (PANSS) has been observed.

Published
2023
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9. Photoproduction of {\omega} Mesons off the Proton

Author

Wilson, A., Crede, V., Anisovich, A. V., Bacelar, J. C. S., Bantes, B., Bartholomy, O., Bayadilov, D., Beck, R., Beloglazov, Y. A., Brinkmann, K. T., Castelijns, R., Dutz, H., Elsner, D., Ewald, R., Frommberger, F., Fuchs, M., Funke, Chr., Gregor, R., Gridnev, A., Gutz, E., Hannappel, J., Hillert, W., Hoffmeister, P., Horn, I., Jaegle, I., Jude, T., Junkersfeld, J., Kalinowsky, H., Kleber, V., Klein, Frank, Klein, Friedrich, Klempt, E., Kotulla, M., Krusche, B., Lang, M., Löhner, H., Lopatin, I. V., Lugert, S., Mertens, T., Messchendorp, J. G., Metag, V., Nanova, M., Nikonov, V. A., Novinski, D., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Roy, A., Sarantsev, A. V., Schmidt, C., Schmieden, H., Shende, S., Sokhoyan, V., Sparks, N., Süle, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Wendel, Ch., and Wiedner, U.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

The differential cross sections and unpolarized spin-density matrix elements for the reaction $\gamma p\to p\omega$ were measured using the CBELSA/TAPS experiment for initial photon energies ranging from the reaction threshold to 2.5 GeV. These observables were measured from the radiative decay of the $\omega$ meson, $\omega\to\pi^0\gamma$. The cross sections cover the full angular range and show the full extent of the $t$-channel forward rise. The overall shape of the angular distributions in the differential cross sections and unpolarized spin-density matrix elements are in fair agreement with previous data. In addition, for the first time, a beam of linearly-polarized tagged photons in the energy range from 1150 MeV to 1650 MeV was used to extract polarized spin-density matrix elements. These data were included in the Bonn-Gatchina partial wave analysis (PWA). The dominant contribution to $\omega$ photoproduction near threshold was found to be the $3/2^+$ partial wave, which is primarily due to the sub-threshold $N(1720)\,3/2^+$ resonance. At higher energies, pomeron-exchange was found to dominate whereas $\pi$-exchange remained small. These $t$-channel contributions as well as further contributions from nucleon resonances were necessary to describe the entire dataset: the $1/2^-$, $3/2^-$, and $5/2^+$ partial waves were also found to contribute significantly., Comment: 8 pages, 5 figures, accepted for publication in Physics Letters B

Published
2015
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10. High statistics study of the reaction $\gamma p\to p\;2\pi^0$

Author

Sokhoyan, V., Gutz, E., Crede, V., van Pee, H., Anisovich, A. V., Bacelar, J. C. S., Bantes, B., Bartholomy, O., Bayadilov, D., Beck, R., Beloglazov, Y. A., Castelijns, R., Dutz, H., Elsner, D., Ewald, R., Frommberger, F., Fuchs, M., Funke, Ch., Gregor, R., Gridnev, A. B., Hillert, W., Hoffmeister, Ph., Horn, I., Jaegle, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Kleber, V., Klein, Frank, Klein, Friedrich, Klempt, E., Kotulla, M., Krusche, B., Lang, M., Löhner, H., Lopatin, I. V., Lugert, S., Mertens, T., Messchendorp, J. G., Metag, V., Metsch, B., Nanova, M., Nikonov, V. A., Novinsky, D., Novotny, R., Ostrick, M., Pant, L., Pfeiffer, M., Piontek, D., Roy, A., Sarantsev, A. V., Schmidt, Ch., Schmieden, H., Seifen, T., Shende, S., Süle, A., Sumachev, V. V., Szczepanek, T., Thiel, A., Thoma, U., Trnka, D., Varma, R., Walther, D., Wendel, Ch., and Wilson, A.

Subjects
Nuclear Experiment
Abstract

The photoproduction of 2$\pi^0$ mesons off protons was studied with the Crystal Barrel/TAPS experiment at the electron accelerator ELSA in Bonn. The energy of photons produced in a radiator was tagged in the energy range from 600\,MeV to 2.5\,GeV. Differential and total cross sections and $p\pi^0\pi^0$ Dalitz plots are presented. Part of the data was taken with a diamond radiator producing linearly polarized photons, and beam asymmetries were derived. Properties of nucleon and $\Delta$ resonances contributing to the $p\pi^0\pi^0$ final state were determined within the BnGa partial wave analysis. The data presented here allow us to determine branching ratios of nucleon and $\Delta$ resonances for their decays into $p\pi^0\pi^0$ via several intermediate states. Most prominent are decays proceeding via $\Delta(1232)\pi$, $N(1440)1/2^+\pi$, $N(1520)3/2^-\pi$, $N(1680)5/2^+\pi$, but also $pf_0(500)$, $pf_0(980)$, and $pf_2(1270)$ contribute to the reaction., Comment: 28 pages, 17 figures, 7 tables

Published
2015
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11. The neuroprotective role of Wnt signaling in the retina

Author

Stefan Kassumeh, Gregor R Weber, Matthias Nobl, Siegfried G Priglinger, and Andreas Ohlmann

Subjects
apoptosis, β-catenin, leukemia inhibitory factor, müller cells, neurodegeneration, neuroprotection, norrin, photoreceptors, retina, retinal ganglion cells, wnt, Neurology. Diseases of the nervous system, RC346-429
Abstract

The canonical Wnt/β-catenin signaling pathway has been shown to play a major role during embryonic development and maturation of the central nervous system including the retina. It has a significant impact on retinal vessel formation and maturation, as well as on the establishment of synaptic structures and neuronal function in the central nervous system. Mutations in components of the Wnt/β-catenin signaling cascade may lead to severe retinal diseases, while dysregulation of Wnt signaling can contribute to disease progression. Apart from the angiogenic role of Wnt/β-catenin signaling, research in the last decades leads to the theory of a protective effect of Wnt/β-catenin signaling on damaged neurons. In this review, we focus on the neuroprotective properties of the Wnt/β-catenin pathway as well as its downstream signaling in the retina.

Published
2021
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12. CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte

Author

Andrea E. Dillinger, Gregor R. Weber, Matthias Mayer, Magdalena Schneider, Corinna Göppner, Andreas Ohlmann, Mikhail Shamonin, Gareth J. Monkman, and Rudolf Fuchshofer

Subjects
glaucoma, optic nerve, growth factors, astrocytes, stiffness, extracellar matrix, Biology (General), QH301-705.5
Abstract

In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes, which contribute to its permanent deformation and to degeneration of ON axons. The remodeling process of the ECM causes changes in the biomechanical properties of the ONH and the peripapillary sclera, which is accompanied by an increased reactivity of the resident astrocytes. The molecular factors involved in the remodeling process belong to the Transforming growth factor (TGF)-β superfamily, especially TGF-β2. In previous publications we showed that TGF-β2 induced ECM alterations are mediated by Cellular Communication Network Factor (CCN)2/Connective Tissue Growth Factor (CTGF) and recently we showed that CCN2/CTGF is expressed by astrocytes of the ON under normal conditions. In this study we wanted to get a better understanding of the function of CCN2/CTGF under normal and pathologic conditions. To this end, we analyzed the glial lamina and peripapillary sclera of CCN2/CTGF overexpressing mice and studied the effect of CCN2/CTGF and increasing substratum stiffness on murine ON astrocytes in vitro. We observed enhanced astrocyte reactivity in the ONH, increased ECM protein synthesis in the peripapillary sclera and increased Ccn2/Ctgf expression in the ONH during the pathologic development in situ. CCN2/CTGF treatment of primary murine ON astrocytes induced a higher migration rate, and increase of ECM proteins including fibronectin, elastin and collagen type III. Furthermore, the astrocytes responded to stiffer substratum with increased glial fibrillary acidic protein, vimentin, actin and CCN2/CTGF synthesis. Finally, we observed the reinforced appearance of CCN2/CTGF in the lamina cribrosa of glaucomatous patients. We conclude that reactive changes in ONH astrocytes, induced by the altered biomechanical characteristics of the region, give rise to a self-amplifying process that includes increased TGF-β2/CCN2/CTGF signaling and leads to the synthesis of ECM molecules and cytoskeleton proteins, a process that in turn augments the stiffness at the ONH. Such a scenario may finally result in a vicious circle in the pathogenesis of POAG. The transgenic CTGF-overexpressing mouse model might be an optimal model to study the chronic pathological POAG changes in the ONH.

Published
2022
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13. Photoproduction of the $\omega$ meson off the proton near threshold

Author

Strakovsky, I. I., Prakhov, S., Azimov, Y. I., Aguar-Bartolome, P., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V., Berghaeuser, H., Braghieri, A., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Collicott, C., Costanza, S., Demissie, B. T., Downie, E. J., Drexler, P., Fil'kov, L. V., Glazier, D. I., Gregor, R., Hamilton, D. J., Heid, E., Hornidge, D., Jaegle, I., Jahn, O., Jude, T. C., Kashevarov, V. L., Keshelashvili, I., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A., Kruglov, S., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., Marinides, Z., McGeorge, J. C., McNicoll, E. F., Mekterovic, D., Metag, V., Middleton, D. G., Mushkarenkov, A., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ortega, H., Ostrick, M., Otte, P. B., Oussena, B., Pedroni, P., Pheron, F., Polonski, A., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sikora, M. H., Starostin, A., Supek, I., Taragin, M. F., Tarbert, C. M., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Werthmueller, D., and Zehr, F.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

An experimental study of $\omega$ photoproduction on the proton was conducted by using the Crystal Ball and TAPS multiphoton spectrometers together with the photon tagging facility at the Mainz Microtron MAMI. The $\gamma p\to\omega p$ differential cross sections are measured from threshold to the incident-photon energy $E_\gamma=1.40$ GeV ($W=1.87$ GeV for the center-of-mass energy) with 15-MeV binning in $E_\gamma$ and full production-angle coverage. The quality of the present data near threshold gives access to a variety of interesting physics aspects. As an example, an estimation of the $\omega N$ scattering length $\alpha_{\omega p}$ is provided., Comment: 8 pages, 5 figures. Published version; some typos were fixed

Published
2014
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14. A new measurement of the rare decay eta -> pi^0 gamma gamma with the Crystal Ball/TAPS detectors at the Mainz Microtron

Author

Nefkens, B. M. K., Prakhov, S., Aguar-Bartolomé, P., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V., Berghäuser, H., Braghieri, A., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Collicott, C., Costanza, S., Danilkin, I. V., Denig, A., Demissie, B., Dieterle, M., Downie, E. J., Drexler, P., Fil'kov, L. V., Fix, A., Garni, S., Glazier, D. I., Gregor, R., Hamilton, D., Heid, E., Hornidge, D., Howdle, D., Jahn, O., Jude, T. C., Kashevarov, V. L., Käser, A., Keshelashvili, I., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A., Kruglov, S., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Mancel, J., Manley, D. M., McNicoll, E. F., Mekterovic, D., Metag, V., Mushkarenkov, A., Nikolaev, A., Novotny, R., Oberle, M., Ortega, H., Ostrick, M., Ott, P., Otte, P. B., Oussena, B., Pedroni, P., Polonski, A., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sikora, M. H., Starostin, A., Strakovsky, I. I., Strub, T., Suarez, I. M., Supek, I., Tarbert, C. M., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Werthmüller, D., and Witthauer., L.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

A new measurement of the rare, doubly radiative decay eta->pi^0 gamma gamma was conducted with the Crystal Ball and TAPS multiphoton spectrometers together with the photon tagging facility at the Mainz Microtron MAMI. New data on the dependence of the partial decay width, Gamma(eta->pi^0 gamma gamma), on the two-photon invariant mass squared, m^2(gamma gamma), as well as a new, more precise value for the decay width, Gamma(eta->pi^0 gamma gamma) = (0.33+/-0.03_tot) eV, are based on analysis of 1.2 x 10^3 eta->pi^0 gamma gamma decays from a total of 6 x 10^7 eta mesons produced in the gamma p -> eta p reaction. The present results for dGamma(eta->pi^0 gamma gamma)/dm^2(gamma gamma) are in good agreement with previous measurements and recent theoretical calculations for this dependence., Comment: 10 pages, 8 figures, 1 table

Published
2014
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15. Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study

Author

Konstantin Butenko, Ningfei Li, Clemens Neudorfer, Jan Roediger, Andreas Horn, Gregor R. Wenzel, Hazem Eldebakey, Andrea A. Kühn, Martin M. Reich, Jens Volkmann, and Ursula van Rienen

Subjects
Deep brain stimulation, Pathway activation, UPDRS-III score, Pallidothalamic pathway, Computational modeling, Parkinson’s disease, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
Abstract

Background: Deep brain stimulation (DBS) is an established therapy for patients with Parkinson’s disease. In silico computer models for DBS hold the potential to inform a selection of stimulation parameters. In recent years, the focus has shifted towards DBS-induced firing in myelinated axons, deemed particularly relevant for the external modulation of neural activity.Objective: The aim of this project was to investigate correlations between patient-specific pathway activation profiles and clinical motor improvement.Methods: We used the concept of pathway activation modeling, which incorporates advanced volume conductor models and anatomically authentic fiber trajectories to estimate DBS-induced action potential initiation in anatomically plausible pathways that traverse in close proximity to targeted nuclei. We applied the method on two retrospective datasets of DBS patients, whose clinical improvement had been evaluated according to the motor part of the Unified Parkinson’s Disease Rating Scale. Based on differences in outcome and activation levels for intrapatient DBS protocols in a training cohort, we derived a pathway activation profile that theoretically induces a complete alleviation of symptoms described by UPDRS-III. The profile was further enhanced by analyzing the importance of matching activation levels for individual pathways.Results: The obtained profile emphasized the importance of activation in pathways descending from the motor-relevant cortical regions as well as the pallidothalamic pathways. The degree of similarity of patient-specific profiles to the optimal profile significantly correlated with clinical motor improvement in a test cohort.Conclusion: Pathway activation modeling has a translational utility in the context of motor symptom alleviation in Parkinson’s patients treated with DBS.

Published
2022
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16. Neutron skin of $^{208}$Pb from Coherent Pion Photoproduction

Author

Tarbert, C. M., Watts, D. P., Glazier, D. I., Aguar, P., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R., Downie, E. J., Foehl, K., Grabmayr, P., Gregor, R., Heid, E., Hornidge, D., Jahn, O., Kashevarov, V. L., Knezevic, A., Kondratiev, R., Korolija, M., Kotulla, M., Krambrich, D., Krusche, B., Lang, M., Lisin, V., Livingston, K., Lugert, S., MacGregor, I. J. D., Manley, D. M., Martinez, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Owens, R. O., Pedroni, P., Polonski, A., Prakhov, S. N., Price, J. W., Rosner, G., Rost, M., Rostomyan, T., Schadmand, S., Schumann, S., Sober, D., Starostin, A., Supek, I., Thomas, A., Unverzagt, M., Walcher, Th., and Zehr, F.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Information on the size and shape of the neutron skin on $^{208}$Pb has been extracted from coherent pion photoproduction cross sections measured using the Crystal Ball together with the Glasgow tagger at the MAMI electron beam facility. On exploitation of an interpolated fit of a theoretical model to the measured cross sections the half-height radius and diffuseness of the neutron distribution are found to be 6.70$\pm 0.03(stat)$ fm and 0.55$\pm 0.01(stat)$$^{+0.02}_{-0.03}(sys)$ fm respectively, corresponding to a neutron skin thickness $\Delta r_{np}$=0.15$\pm 0.03(stat)$$^{+0.01}_{-0.03}(sys)$ fm. The results give the first successful extraction of a neutron skin with an electromagnetic probe and indicate the skin of $^{208}$Pb has a halo character. The measurement provides valuable new constraints on both the structure of nuclei and the equation of state for neutron-rich matter., Comment: 4 figures 5 pages. Version submitted to journal. Includes additional studies of systematic effects in the extracted diffuseness, which led to a small increase in the quoted systematic error. These additional studies are discussed in the revised manuscript. Also includes minor editorial improvements to the text

Published
2013
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17. Measurement of the $^{1}H$($\vec{\gamma}$, $\vec{p}$)$\pi^{0}$ reaction using a novel nucleon spin polarimeter

Author

Watts, D. P., Glazier, D. I., Aguar-Bartolomé, P., Akasoy, L. K., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V. S., Berghäuser, H., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Demissie, B. T., Downie, E. J., Drexler, P., Fil'kov, L. V., Freehart, B., Gregor, R., Hamilton, D., Heid, E., Hornidge, D., Jaegle, I., Jahn, O., Jude, T. C., Kashevarov, V. L., Keshelashvili, I., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A. A., Kruglov, S. P., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., Marinides, Z., Martinez, M., McGeorge, J. C., McKinnon, B., McNicoll, E. F., Mekterovic, D., Metag, V., Micanovic, S., Middleton, D. G., Mushkarenkov, A., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ostrick, M., Otte, P. B., Oussena, B., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sober, D. I., Starostin, A., Strakovsky, I. I., Suarez, I. M., Supek, I., Thiel, M., Thomas, A., Unverzagt, M., Werthmüller, D., Workman, R. L., Zamboni, I., and Zehr, F.

Subjects
Nuclear Experiment
Abstract

We report the first large-acceptance measurement of polarization transfer from a polarized photon beam to a recoiling nucleon, pioneering a novel polarimetry technique with wide application to future nuclear and hadronic physics experiments. The commissioning measurement of polarization transfer in the $^{1}H$($\vec{\gamma}$,$\vec{p}$)$\pi^{0}$ reaction in the range $0.4

Published
2013
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18. A new determination of the eta transition form factor in the Dalitz decay eta -> e^+ e^- gamma with the Crystal Ball/TAPS detectors at the Mainz Microtron

Author

Aguar-Bartolomé, P., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V., Berghäuser, H., Braghieri, A., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Collicott, C., Costanza, S., Denig, A., Downie, E. J., Drexler, P., Fil'kov, L. V., Fix, A., Glazier, D. I., Gregor, R., Hamilton, D. J., Heid, E., Hornidge, D., Isaksson, L., Jaegle, I., Jahn, O., Jude, T. C., Kashevarov, V. L., Keshelashvili, I., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A., Kruglov, S., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., Masjuan, P., McGeorge, J. C., McNicoll, E. F., Mekterovic, D., Metag, V., Mushkarenkov, A., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ortega, H., Ostrick, M., Ott, P., Otte, P. B., Oussena, B., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sikora, M. H., Sober, D. I., Starostin, A., Strakovsky, I. I., Suarez, I. M., Supek, I., Tarbert, C. M., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Werthmüller, D., and Zehr., F.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The Dalitz decay eta -> e^+ e^- gamma has been measured in the gamma p -> eta p reaction with the Crystal Ball and TAPS multiphoton spectrometers, together with the photon tagging facility at the Mainz Microtron MAMI. The experimental statistic used in this work is one order of magnitude greater than in any previous measurement of eta -> e^+ e^- gamma. The value obtained for the slope parameter 1/Lambda^2 of the eta transition form factor, 1/Lambda^2 = (1.95 +/- 0.15_stat +/- 0.10_syst) [1/GeV^2], is in good agreement with recent measurements conducted in eta -> e^+ e^- gamma and eta -> mu^+ mu^- gamma decays, as well as with recent form-factor calculations. The uncertainty obtained in the value of 1/Lambda^2 is lower compared to results from previous measurements of the eta -> e^+ e^- gamma decay., Comment: 11 pages, 10 figures, 1 table

Published
2013
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19. $K^+\Lambda$ and $K^+\Sigma^0$ photoproduction with fine center-of-mass energy resolution

Author

Jude, T. C., Glazier, D. I., Watts, D. P., Aguar-Bartolome, P., Akasoy, L. K., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V. S., Berghauser, H., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Demissie, B. T., Dieterle, M., Downie, E. J., Fil'kov, L. V., Gregor, R., Heid, E., Hornidge, D., Jaegle, I., Jahn, O., Kashevarov, V. L., Keshelashvili, I., Kondratiev, R., Korolija, M., Koulbardis, A. A., Kruglov, S. P., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., Marinides, Z., Mart, T., Martinez, M., McGeorge, J. C., McNicoll, E. F., Middleton, D. G., Mushkarenkov, A., Nefkens, B. M. K., Nikolaev, A., Nikonov, V. A., Oberle, M., Ostrick, M., Otte, P. B., Oussena, B., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S., Robinson, J., Rosner, G., Rostomyan, T., Sarantsev, A. V., Schumann, S., Sikora, M. H., Sober, D. I., Starostin, A., Strakovsky, I., Suarez, I. M., Supek, I., Thiel, M., Thomas, A., Unverzagt, M., Werthmueller, D., Witthauer, L., and Zehr, F.

Subjects
Nuclear Experiment
Abstract

Measurements of $\gamma p \rightarrow K^{+} \Lambda$ and $\gamma p \rightarrow K^{+} \Sigma^0$ cross-sections have been obtained with the photon tagging facility and the Crystal Ball calorimeter at MAMI-C. The measurement uses a novel $K^+$ meson identification technique in which the weak decay products are characterized using the energy and timing characteristics of the energy deposit in the calorimeter, a method that has the potential to be applied at many other facilities. The fine center-of-mass energy ($W$) resolution and statistical accuracy of the new data results in a significant impact on partial wave analyses aiming to better establish the excitation spectrum of the nucleon. The new analyses disfavor a strong role for quark-diquark dynamics in the nucleon., Comment: 7 pages, 8 figures

Published
2013
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20. Measurement of the g p -> K^0 Sigma^+ reaction with the Crystal Ball/TAPS detectors at the Mainz Microtron

Author

Aguar-Bartolomé, P., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V., Berghäuser, H., Braghieri, A., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Collicott, C., Demissie, B., Dieterle, M., Downie, E. J., Drexler, P., Fil'kov, L. V., Fix, A., Glazier, D. I., Gregor, R., Hamilton, D., Heid, E., Hornidge, D., Howdle, D., Isaksson, L., Jaegle, I., Jahn, O., Jude, T. C., Kashevarov, V. L., Keshelashvili, I., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A., Kruglov, S., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Mancel, J., Manley, D. M., McNicoll, E. F., Mekterovic, D., Metag, V., Mushkarenkov, A., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Oberle, M., Ortega, H., Ostrick, M., Ott, P., Otte, P. B., Oussena, B., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sikora, M. H., Sober, D. I., Starostin, A., Strakovsky, I. I., Suarez, I. M., Supek, I., Tarbert, C. M., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Werthmüller, D., Witthauer, L., and Zehr., F.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The g p -> K^0 Sigma^+ reaction has been measured from threshold to Eg=1.45 GeV (W_cm=1.9 GeV) using the Crystal Ball and TAPS multiphoton spectrometers together with the photon tagging facility at the Mainz Microtron MAMI. In the present experiment, this reaction was searched for in the 3pi^0 p final state, by assuming K^0_S -> pi^0 pi^0 and Sigma^+ -> pi^0 p. The experimental results include total and differential cross sections as well as the polarization of the recoil hyperon. The new data significantly improve empirical knowledge about the g p -> K^0 Sigma^+ reaction in the measured energy range. The results are compared to previous measurements and model predictions. It is demonstrated that adding the present g p -> K^0 Sigma^+ results to existing data allowed a better description of this reaction with various models., Comment: 12 pages, 10 figures, 4 tables

Published
2013
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21. Double pion photoproduction off nuclei - are there effects beyond final-state interaction?

Author

Maghrbi, Y., Gregor, R., Lugert, S., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R., Downie, E. J., Dexler, P., Fil'kov, L. V., Fix, A., Glazier, D. I., Heid, E., Hornidge, D., Jahn, O., Jaegle, I., Kashevarov, V. L., Keshelashvili, I., Knezevic, A., Kondratiev, A., Korolija, M., Kotulla, M., Krambrich, D., Krusche, B., Lang, M., Lisin, V., Livingston, K., MacGregor, I. J. D., Manley, D. M., Martinez, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ostrick, M., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S. N., Price, J. W., Rosner, G., Rost, M., Rostomyan, T., Schadmand, S., Schumann, S., Sober, D., Starostin, S., Supek, I., Thomas, A., Unverzagt, M., Watts, D. P., Werthmueller, D., and Zehr, F.

Subjects
Nuclear Experiment
Abstract

Photoproduction of $\pi^{0}\pi^{0}$ and $\pi^{0}\pi^{\pm}$ pairs from nuclei has been measured over a wide mass range ($^2$H, $^{7}$Li, $^{12}$C, $^{40}$Ca, and $^{\rm nat}$Pb) for photon energies from threshold to 600 MeV. The experiments were performed at the MAMI accelerator in Mainz, using the Glasgow photon tagging spectrometer and a 4$\pi$ electromagnetic calorimeter consisting of the Crystal Ball and TAPS detectors. A shift of the pion-pion invariant mass spectra for heavy nuclei to small invariant masses has been observed for $\pi^0$ pairs but also for the mixed-charge pairs. The precise results allow for the first time a model-independent analysis of the influence of pion final-state interactions. The corresponding effects are found to be large and must be carefully considered in the search for possible in-medium modifications of the $\sigma$-meson. Results from a transport model calculation reproduce the shape of the invariant-mass distributions for the mixed-charge pairs better than for the neutral pairs, but also for the latter differences between model results and experiment are not large, leaving not much room for $\sigma$-in-medium modification., Comment: accepted for publication in Phys. Lett. B

Published
2013
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22. Coherent photoproduction of pi^0- and eta-mesons off 7Li

Author

Maghrbi, Y., Krusche, B., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Downie, E. J., Drexler, P., Fil'kov, L. V., Fix, A., Glazier, D. I., Gregor, R., Heid, E., Hornidge, D., Jaegle, I., Jahn, O., Kashevarov, V. L., Keshelashvili, I., Knezevic, A., Kondratiev, R., Korolija, M., Krambrich, D., Lang, M., Lisin, V., Livingston, K., Lugert, S., MacGregor, I. J. D., Manley, D. M., Martinez, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ostrick, M., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S., Price, J. W., Rosner, G., Rost, M., Rostomyan, T., Schadmand, S., Schumann, S., Sober, D., Starostin, A., Supek, I., Tarbert, C. M., Thomas, A., Unverzagt, M., Watts, D. P., Werthmueller, D., and Zehr, F.

Subjects
Nuclear Experiment
Abstract

Coherent photoproduction of $\pi^0$-mesons from threshold ($E_{th} \approx$ 136 MeV) throughout the $\Delta$-resonance region and of $\eta$-mesons close to the production threshold ($E_{th} \approx$ 570 MeV for $\eta$) has been measured for $^7$Li nuclei. The experiment was performed using the tagged-photon beam of the Mainz MAMI accelerator with the Crystal Ball and TAPS detectors combined to give an almost 4$\pi$ solid-angle electromagnetic calorimeter. The reactions were identified by a combined invariant-mass and missing-energy analysis. A comparison of the pion data to plane-wave impulse modelling tests the nuclear mass form factor. So far coherent $\eta$-production had been only identified for the lightest nuclear systems ($^2$H and $^3$He). For $^3$He a large enhancement of the cross section above plane-wave approximations had been reported, indicating the formation of a quasi-bound state. The present Li-data for $\eta$-production agree with a plane-wave approximation. Contrary to $^3$He, neither a threshold enhancement of the total cross section nor a deviation of the angular distributions from the expected form-factor dependence were observed., Comment: accepted for publication in Eur. Phys. J. A

Published
2013
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23. Determination of the {\eta} mass with the Crystal Ball at MAMI-B

Author

Nikolaev, A., Aguar-Bartolomé, P., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J. W., Cherepnya, S., Codling, R., Dehn, M., Downie, E. J., Fil'kov, L. V., Glazier, D. I., Gregor, R., Heid, E., Hornidge, D., Jahn, O., Jankowiak, A., Kaiser, K. -H., Kashevarov, V. L., Kondratiev, R., Korolija, M., Kotulla, M., Krambrich, D., Krusche, B., Lang, M., Lisin, V., Livingston, K., Ludwig-Mertin, U., Lugert, S., MacGregor, I. J. D., Manley, D. M., Martinez-Fabregate, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Novotny, R., Owens, R. O., Pedroni, P., Polonski, A., Prakhov, S. N., Price, J. W., Reiter, A., Rosner, G., Rost, M., Rostomyan, T., Schumann, S., Sober, D., Starostin, A., Supek, I., Tarbert, C. M., Thomas, A., Unverzagt, M., Walcher, Th., Watts, D. P., and Zehr, F.

Subjects
Nuclear Experiment
Abstract

A new precise determination of the {\eta} meson mass is presented. It is based on a measurement of the threshold for the {\gamma}p -> p{\eta} reaction using the tagger focal-plane microscope detector at the MAMI-B facility in Mainz. The tagger microscope has a higher energy resolution than the standard tagging spectrometer and, hence, allowed an improvement in the accuracy compared to the previous {\eta} mass measurement at MAMI-B. The result m{\eta} = (547.851 +- 0.031 stat. +- 0.062 syst.) MeV agrees very well with the precise values of the NA48, KLOE and CLEO collaborations and deviates by about 5{\sigma} from the smaller, but also very precise value obtained by the GEM collaboration at COSY., Comment: Submitted for publication in EPJA

Published
2012

24. Photoproduction of pi0pi0 and pi0pi+-pairs off the proton from threshold to the second resonance region

Author

Zehr, F., Krusche, B., Aguar, P., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Downie, E. J., Drexler, P., Glazier, D. I., Fil'kov, L. V., Gregor, R., Heid, E., Hornidge, D., Jaegle, I., Jahn, O., Kashevarov, V. L., Knezevic, A., Kondratiev, R., Korolija, M., Kotulla, M., Krambrich, D., Kulbardis, A., Lang, M., Lisin, V., Livingston, K., Lugert, S., MacGregor, I. J. D., Manley, D. M., Maghrbi, Y., Martinez, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Nikolaev, A., Ostrick, M., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S., Price, J. W., Rosner, G., Rost, M., Rostomyan, T., Schumann, S., Sober, D., Starostin, A., Supek, I., Tarbert, C. M., Thomas, A., Unverzagt, M., Walcher, Th., and Watts, D. P.

Subjects
Nuclear Experiment
Abstract

Precise total cross-sections and invariant-mass distributions have been measured for photoproduction of pion pairs off the proton producing $p\pi^0\pi^0$ and $n\pi^+\pi^0$ final states from the threshold region up to 800 MeV incident photon energy. Additionally, beam helicity asymmetries have been measured in the second resonance region (550 MeV - 820 MeV). The experiment was performed at the tagged photon beam of the Mainz MAMI accelerator with the Crystal Ball and TAPS detectors combined to give an almost 4$\pi$ solid-angle electromagnetic calorimeter. The results are much more precise than any previous measurements and confirm the chiral perturbation theory predictions for the threshold behavior of these reactions. In the second resonance region, the invariant-mass distributions of meson-meson and meson-nucleon pairs are in reasonable agreement with model predictions, but none of the models reproduce the asymmetries for the mixed-charge channel., Comment: accepted for publication in Eur. Phys. J. A

Published
2012
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25. Study of the gamma p --> pi0 pi0 p reaction with the Crystal Ball/TAPS at the Mainz

Author

Kashevarov, V. L., Fix, A., Prakhov, S., Aguar-Bartolomé, P., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V., Berghäuser, H., Braghieri, A., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Downie, E. J., Drexler, P., Fil'kov, L. V., Glazier, D. I., Gregor, R., Heid, E., Hornidge, D., Isaksson, L., Jaegle, I., Jahn, O., Jude, T. C., Keshelashvili, I., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A., Kruglov, S., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., McGeorge, J. C., McNicoll, E. F., Mekterovic, D., Metag, V., Mushkarenkov, A., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ortega, H., Ostrick, M., Ott, P., Otte, P. B., Oussena, B., Pedroni, P., Pheron, F., Polonski, A., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sikora, M. H., Sober, D. I., Starostin, A., Strakovsky, I. I., Suarez, I. M., Supek, I., Tarbert, C. M., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Werthmüller, D., and Zehr, F.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, Nuclear Theory
Abstract

The gamma p --> pi0 pi0 p reaction has been measured from threshold to 1.4 GeV using the Crystal Ball and TAPS photon spectrometers together with the photon tagging facility at the Mainz Microtron. The experimental results include total and differential cross sections as well as specific angular distributions, which were used to extract partial-wave amplitudes. In particular, the energy region below the D13(1520) resonance was studied., Comment: 12 pages, 13 figures, corrected version, published in PRC

Published
2012
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26. Transparency ratio in \gamma A -> \eta' A' and the in-medium \eta' width

Author

Nanova, M., Metag, V., Ramos, A., Oset, E., Jaegle, I., Makonyi, K., Brinkmann, K., Bartholomy, O., Bayadilov, D., Beloglazov, Y. A., Crede, V., Dutz, H., Ehmanns, A., Elsner, D., Essig, K., Ewald, R., Fabry, I., Fuchs, M., Funke, Ch., Gregor, R., Gridnev, A. B., Gutz, E., Höffgen, S., Hoffmeister, P., Horn, I., Junkersfeld, J., Kalinowsky, H., Klein, Frank, Klein, Friedrich, Klempt, E., Konrad, M., Kopf, B., Krusche, B., Langheinrich, J., Löhner, H., Lopatin, I. V., Lotz, J., Lugert, S., Menze, D., Mertens, T., Messchendorp, J. G., Morales, C., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Roy, A., Radkov, A., Schadmand, S., Schmidt, Ch., Schmieden, H., Schoch, B., Süle, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., and Wendel, Ch.

Subjects
Nuclear Experiment
Abstract

The photoproduction of \eta'-mesons off different nuclei has been measured with the CBELSA/TAPS detector system for incident photon energies between 1500 - 2200 MeV. The transparency ratio has been deduced and compared to theoretical calculations describing the propagation of \eta'-mesons in nuclei. The comparison indicates a width of the \eta' -meson of the order of \Gamma= 15-25 MeV at \rho =\rho_0 for an average momentum p_{\eta'} = 1050 MeV/c, at which the \eta'-meson is produced in the nuclear rest frame. The inelastic \eta' N cross section is estimated to be 3 - 10 mb. Parameterizing the photoproduction cross section of \eta'-mesons by \sigma(A) = \sigma_0 A^{\alpha}, a value of \alpha = 0.84\pm0.03 has been deduced., Comment: 14 pages, 6 figures

Published
2012
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27. Quasi-free photoproduction of eta-mesons off the deuteron

Author

Jaegle, I., Krusche, B., Anisovich, A. V., Bacelar, J. C. S., Bantes, B., Bartholomy, O., Bayadilov, D. E., Beck, R., Beloglazov, Y. A., Castelijns, R., Crede, V., Dieterle, M., Dutz, H., Elsner, D., Ewald, R., Frommberger, F., Funke, C., Gothe, R., Gregor, R., Gridnev, A. B., Gutz, E., Hillert, W., Hoeffgen, S., Hoffmeister, P., Horn, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Keshelashvili, I., Kleber, V., Klein, Frank, Klein, Friedrich, Klempt, E., Konrad, M., Kotulla, M., Lang, M., Loehner, H., Lopatin, I. V., Lugert, S., Maghrbi, Y., Menze, D., Mertens, T., Messchendorp, J. G., Metag, V., Nikonov, V. A., Nanova, M., Novinski, D. V., Novotny, R., Oberle, M., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Pheron, F., Roy, A., Sarantsev, A. V., Schadmand, S., Schmidt, C., Schmieden, H., Schoch, B., Shende, S. V., Sokhoyan, V., Suele, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Wendel, C., Werthmueller, D., and Witthauer, L.

Subjects
Nuclear Experiment
Abstract

Precise data for quasi-free photoproduction of $\eta$ mesons off the deuteron have been measured at the Bonn ELSA accelerator with the combined Crystal Barrel/TAPS detector for incident photon energies up to 2.5 GeV. The $\eta$-mesons have been detected in coincidence with recoil protons and neutrons. Possible nuclear effects like Fermi motion and re-scattering can be studied via a comparison of the quasi-free reaction off the bound proton to $\eta$-production off the free proton. No significant effects beyond the folding of the free cross section with the momentum distribution of the bound protons have been found. These Fermi motion effects can be removed by an analysis using the invariant mass of the $\eta$-nucleon pairs reconstructed from the final state four-momenta of the particles. The total cross section for quasi-free $\eta$-photoproduction off the neutron reveals even without correction for Fermi motion a pronounced bump-like structure around 1 GeV of incident photon energy, which is not observed for the proton. This structure is even narrower in the invariant mass spectrum of the $\eta$-neutron pairs. Position and width of the peak in the invariant mass spectrum are $W\approx 1665$ MeV and FWHM $\Gamma\approx 25$ MeV. The data are compared to the results of different models., Comment: accepted for publication in Eur. Phys. J. A

Published
2011
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28. Photoproduction of Neutral Pions off Protons

Author

Collaboration, The CBELSA/TAPS, Crede, V., Sparks, N., Wilson, A., Anisovich, A. V., Bacelar, J. C. S., Bantes, R., Bartholomy, O., Bayadilov, D., Beck, R., Beloglazov, Y. A., Castelijns, R., Dutz, H., Elsner, D., Ewald, R., Frommberger, F., Funke, Chr., Gregor, R., Gridnev, A., Gutz, E., Hillert, W., Hoffmeister, P., Jaegle, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Klein, Frank, Klein, Friedrich, Klempt, E., Kotulla, M., Krusche, B., Loehner, H., Lopatin, I. V., Lugert, S., Menze, D., Mertens, T., Messchendorp, J. G., Metag, V., Nanova, M., Nikonov, V. A., Novinski, D., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Roy, A., Sarantsev, A. V., Schadmand, S., Schmidt, C., Schmieden, H., Schoch, B., Shende, S., Sokhoyan, V., Suele, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., and Wendel, Ch.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Photoproduction of neutral pions has been studied with the CBELSA/TAPS detector in the reaction $\gamma p\to p\pi^0$ for photon energies between 0.85 and 2.50 GeV. The $\pi^0$ mesons are observed in their dominant neutral decay mode: $\pi^0\to\gamma\gamma$. For the first time, the differential cross sections cover the very forward region, $\theta_{\rm c.m.}<60^\circ$. A partial-wave analysis of these data within the Bonn-Gatchina framework observes the high-mass resonances $G_{17}$(2190), $D_{13}$(2080), and $D_{15}$(2070)., Comment: 12 pages, 9 figures, minor modifications to PWA section

Published
2011
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29. Measurement of 3pi^0 photoproduction on the proton from threshold to 1.4 GeV

Author

Starostin, A., Suarez, I. M., Nefkens, B. M. K., Ahrens, J., Annand, J. R. M., Arends, H. J., Bantawa, K., Bartolome, P. A., Beck, R., Bekrenev, V., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Dieterle, M., Downie, E. J., Fil'kov, L. V., Glazier, D. I., Gregor, R., Heid, E., Hornidge, D., Jaegle, I., Jahn, O., Jude, T. C., Kashevarov, V. L., Keshelashvili, I., Kondratiev, R., Korolija, M., Koulbardis, A., Kruglov, S., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Manley, D. M., Martinez, M., McGeorge, J. C., McNicoll, E. F., Metag, V., Mushkarenkov, A., Oberle, M., Ostrick, M., Pedroni, P., Polonski, A., Prakhov, S., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sikora, M. H., Sober, D., Supek, I., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Wertmueller, D., and Witthauer, L.

Subjects
Nuclear Experiment
Abstract

The total cross section for gamma p -> 3pi0 p has been measured for the first time from threshold to 1.4 GeV using the tagged photon beam of the Mainz Microtron. The equipment utilized the Crystal Ball multiphoton spectrometer, the TAPS forward detector and a particle identification detector. The gamma p -> 3pi0 p total cross section has two broad enhancements at sqrt{s}~1.5 GeV and 1.7 GeV. We obtained the ratio of the total cross sections gamma p -> 3pi0 p to gamma p -> eta p equal to 0.014 \pm 0.001 at sqrt{s}~1.5 GeV., Comment: submitted to Physical Review C

Published
2011

30. Photoproduction of $\eta '$-mesons off the deuteron

Author

Jaegle, I., Mertens, T., Fix, A., Huang, F., Nakayama, K., Tiator, L., Anisovich, A. V., Bacelar, J. C. S., Bantes, B., Bartholomy, O., Bayadilov, D. E., Beck, R., Beloglazov, Y. A., Castelijns, R., Crede, V., Dutz, H., Elsner, D., Ewald, R., Frommberger, F., Funke, C., Gregor, R., Gridnev, A. B., Gutz, E., Hillert, W., Hoeffgen, S., Junkersfeld, J., Kalinowsky, H., Kammer, S., Kleber, V., Klein, Frank, Klein, Friedrich, Klempt, E., Kotulla, M., Krusche, B., Lang, M., Loehner, H., Lopatin, I. V., Lugert, S., Menze, D., Messchendorp, J. G., Metag, V., Nikonov, V. A., Nanova, M., Novinski, D. V., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Roy, A., Sarantsev, A. V., Schadmand, S., Schmidt, C., Schmieden, H., Schoch, B., Shende, S. V., Sokhoyan, V., Suele, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., and Wendel, C.

Subjects
Nuclear Experiment
Abstract

Quasi-free photoproduction of $\eta '$ mesons off nucleons bound in the deuteron has been measured with the combined Crystal Barrel - TAPS detector. The experiment was done at a tagged photon beam of the ELSA electron accelerator in Bonn for incident photon energies from the production threshold up to 2.5 GeV. The $\eta '$-mesons have been detected in coincidence with recoil protons and recoil neutrons. The quasi-free proton data are in good agreement with the results for free protons, indicating that nuclear effects have no significant impact. The coincidence with recoil neutrons provides the first data for the $\gamma n \rightarrow n\eta '$ reaction. In addition, also first estimates for coherent $\eta '$-production off the deuteron have been obtained. In agreement with model predictions, the total cross section for this channel is found to be very small, at most at the level of a few nb. The data are compared to model calculations taking into account contributions from nucleon resonances and $t$-channel exchanges., Comment: Accepted for publication in Eur. Phys. J. A

Published
2010
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31. First measurement of the circular beam asymmetry in the gamma p --> pi0 eta p reaction

Author

Kashevarov, V. L., Fix, A., Aguar-Bartolomé, P., Akasoy, L. K., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V., Berghäuser, H., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Demissie, B. T., Downie, E. J., Drexler, P., Fil'kov, L. V., Glazier, D. I., Gregor, R., Hamilton, D., Heid, E., Hornidge, D., Jaegle, I., Jahn, O., Jude, T. C., Kellie, J. D., Keshelashvili, I., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A., Kruglov, S., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., Martinez-Fabregate, M., McGeorge, J. C., McNicoll, E. F., Mekterovic, D., Metag, V., Micanovic, S., Middleton, D., Mushkarenkov, A., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ostrick, M., Otte, P. B., Oussena, B., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S. N., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sikora, M. H., Sober, D., Starostin, A., Stakovsky, I. I., Suarez, I. M., Supek, I., Tarbert, C., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Werthmüller, D., Zamboni, I., and Zehr., F.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, Nuclear Theory
Abstract

The circular photon asymmetry for pi0 eta photoproduction on the proton was measured for the first time at the tagged photon facility of the MAMI C accelerator using the Crystal Ball/TAPS photon spectrometer. The experimental results are interpreted within a phenomenological isobar model that confirms the dominant role of the Delta(1700)D33 resonance. The measured asymmetry allows us to identify small contributions from positive-parity resonances via interference terms with the dominant D33 amplitude., Comment: 11 pages, 3 figures, submitted to Phys.Lett. B

Published
2010
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32. Photoproduction of $\omega$ mesons on nuclei near the production threshold

Author

Nanova, M., Weil, J., Friedrich, S., Metag, V., Mosel, U., Anton, G., Bacelar, J. C. S., Bartholomy, O., Bayadilov, D., Beloglazov, Y. A., Bogendörfer, R., Castelijns, R., Crede, V., Dutz, H., Ehmanns, A., Elsner, D., Essig, K., Ewald, R., Fabry, I., Fuchs, M., Funke, Ch., Gothe, R., Gregor, R., Gridnev, A. B., Gutz, E., Höffgen, S., Hoffmeister, P., Horn, I., Hössl, J., Jaegle, I., Junkersfeld, J., Kalinowsky, H., Klein, Frank, Klein, Friedrich, Klempt, E., Konrad, M., Kopf, B., Kotulla, M., Krusche, B., Langheinrich, J., Löhner, H., Lopatin, I. V., Lotz, J., Lugert, S., Menze, D., Mertens, T., Messchendorp, J. G., Morales, C., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Roy, A., Radkov, A., Schadmand, S., Schmidt, Ch., Schmieden, H., Schoch, B., Shende, S., Suft, G., Süle, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Weinheimer, Ch., and Wendel, Ch.

Subjects
Nuclear Experiment
Abstract

The photoproduction of $\omega$ mesons on LH_2, C and Nb has been studied for incident photon energies from 900 to 1300 MeV using the CB/TAPS detector at ELSA. The $\omega$ line shape does not show any significant difference between the LH_2 and the Nb targets. The data are compared with results of transport calculations that predict a sensitivity of the $\omega$ line shape to in-medium modifications near the production threshold on a free nucleon of $E_{\gamma}^{lab}$ = 1109 MeV.}, Comment: 5 pages, 3 figures

Published
2010
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33. Study of the gp-->etap reaction with the Crystal Ball detector at the Mainz Microtron(MAMI-C)

Author

McNicoll, E. F., Prakhov, S., Strakovsky, I. I., Aguar-Bartolomepmainz, P., Akasoy, L. K., Annand, J. R. M., Arends, H. J., Arndt, R. A., Azimov, Ya. I., Bantawa, K., Beck, R., Bekrenev, V. S., Berghaeuser, H., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Demissie, B. T., Downie, E. J., Drexler, P., Fil'kov, L. V., Fix, A., Freehart, B., Glazier, D. I., Gregor, R., Hamilton, D., Heid, E., Hornidge, D., Jaegle, I., Jahn, O., Jude, T. C., Kashevarov, V. L., Kellie, J. D., Keshelashvili, I., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A. A., Kruglov, S. P., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., Marinides, Z., Martinez, M., McGeorge, J. C., McKinnon, B., Mekterovic, D., Metag, V., Micanovic, S., Middleton, D., Mushkarenkov, A., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ostrick, M., Otte, P. B., Oussena, B., Paris, M. W., Pedroni, P., Pheron, F., Polonski, A., Robinson, J., Rosner, G., Rostomyan, T., Schumann, S., Sikora, M. H., Sober, D. I., Starostin, A., Suarez, I. M., Supek, I., Thiel, M., Thomas, A., Tiator, L., Unverzagt, M., Watts, D. P., Werthmueller, D., Workman, R. L., Zamboni, I., and Zehr, F.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

The gp-->etap reaction has been measured with the Crystal Ball and TAPS multiphoton spectrometers in the energy range from the production threshold of 707 MeV to 1.4 GeV (1.49 =< W >= 1.87 GeV). Bremsstrahlung photons produced by the 1.5-GeV electron beam of the Mainz Microtron MAMI-C and momentum analyzed by the Glasgow Tagging Spectrometer were used for the eta-meson production. Our accumulation of 3.8 x 10^6 gp-->etap-->3pi0p-->6gp events allows a detailed study of the reaction dynamics. The gp-->etap differential cross sections were determined for 120 energy bins and the full range of the production angles. Our data show a dip near W = 1680 MeV in the total cross section caused by a substantial dip in eta production at forward angles. The data are compared to predictions of previous SAID and MAID partial-wave analyses and to thelatest SAID and MAID fits that have included our data., Comment: 15 pages, 12 figures

Published
2010
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34. In-medium $\omega$ mass from the $\gamma + Nb \to \pi^{0}\gamma + X$ reaction

Author

Collaboration, The The CBELSA/TAPS, Nanova, M., Metag, V., Anton, G., Bacelar, J. C. S., Bartholomy, O., Bayadilov, D., Beloglazov, Y. A., Bogendörfer, R., Castelijns, R., Crede, V., Dutz, H., Ehmanns, A., Elsner, D., Essig, K., Ewald, R., Fabry, I., Fuchs, M., Funke, Ch., Gothe, R., Gregor, R., Gridnev, A. B., Gutz, E., Höffgen, S., Hoffmeister, P., Horn, I., Hössl, J., Jaegle, I., Junkersfeld, J., Kalinowsky, H., Klein, Frank, Klein, Friedrich, Klempt, E., Konrad, M., Kopf, B., Kotulla, M., Krusche, B., Langheinrich, J., Löhner, H., Lopatin, I. V., Lotz, J., Lugert, S., Menze, D., Mertens, T., Messchendorp, J. G., Morales, C., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Roy, A., Radkov, A., Schadmand, S., Schmidt, Ch., Schmieden, H., Schoch, B., Shende, S., Suft, G., Süle, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Weinheimer, Ch., and Wendel, Ch.

Subjects
Nuclear Experiment
Abstract

Data on the photoproduction of $\omega$ mesons on nuclei have been re-analyzed in a search for in-medium modifications. The data were taken with the Crystal Barrel(CB)/TAPS detector system at the ELSA accelerator facility in Bonn. First results from the analysis of the data set were published by D. Trnka et al. in Phys. Rev. Lett 94 (2005) 192303 \cite{david}, claiming a lowering of the $\omega$ mass in the nuclear medium by 14$%$ at normal nuclear matter density. The extracted $\omega$ line shape was found to be sensitive to the background subtraction. For this reason a re-analysis of the same data set has been initiated and a new method has been developed to reduce the background and to determine the shape and absolute magnitude of the background directly from the data. Details of the re-analysis and of the background determination are described. The $\omega$ signal on the $Nb$ target, extracted in the re-analysis, does not show a deviation from the corresponding line shape on a $LH_2$ target, measured as reference. The earlier claim of an in-medium mass shift is thus not confirmed. The sensitivity of the $\omega$ line shape to different in-medium modification scenarios is discussed., Comment: 13 pages and 11 figures, submitted for publication

Published
2010
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35. Measurement of the Beam Asymmetry $\Sigma$ in the Forward Direction for pi0 Photoproduction

Author

Sparks, N., Crede, V., Anisovich, A. V., Bacelar, J. C. S., Bantes, R., Bartholomy, O., Bayadilov, D., Beck, R., Beloglazov, Y. A., Castelijns, R., Elsner, D., Ewald, R., Frommberger, F., Funke, C., Gregor, R., Gridnev, A., Gutz, E., Hillert, W., Hoffmeister, P., Jaegle, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Klein, Frank, Klein, Friedrich, Klempt, E., Kotulla, M., Krusche, B., Loehner, H., Lopatin, I. V., Lugert, S., Menze, D., Mertens, T., Messchendorp, J. G., Metag, V., Nanova, M., Nikonov, V. A., Novinski, D., Novotny, R., Ostrick, M., Pant, L. M., Pee, H., Pfeiffer, M., Roy, A., Sarantsev, A. V., Schadmand, S., Schmidt, C., Schmieden, H., Schoch, B., Shende, S., Sokhoyan, V., Suele, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Wendel, C., and Wilson, A.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

Photoproduction of neutral pions has been studied with the CBELSA/TAPS detector for photon energies between 0.92 and 1.68~GeV at the electron accelerator ELSA. The beam asymmetry~$\Sigma$ has been extracted for $115^\circ < \theta_{\rm c.m.} < 155^\circ$ of the $\pi^0$~meson and for $\theta_{\rm c.m.} < 60^\circ$. The new beam asymmetry data improve the world database for photon energies above 1.5~GeV and, by covering the very forward region, extend previously published data for the same reaction by our collaboration. The angular dependence of $\Sigma$ shows overall good agreement with the SAID parameterization., Comment: 11 pages, 10 figures, published in Phys. Rev. C, included LEPS data and MAID 2007 predictions for comparison with our data

Published
2010
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36. Radiative pi0 photoproduction on protons in the Delta+(1232) region

Author

Schumann, S., Boillat, B., Downie, E. J., Aguar-Bartolomé, P., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J. W., Cherepnya, S., Codling, R., Drexler, P., Fil'kov, L. V., Glazier, D. I., Gregor, R., Heid, E., Hornidge, D., Jahn, O., Kashevarov, V. L., Kondratiev, R., Korolija, M., Kotulla, M., Krambrich, D., Krusche, B., Lang, M., Lisin, V., Livingston, K., Lugert, S., MacGregor, I. J. D., Manley, D. M., Martinez-Fabregate, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ostrick, M., Owens, R. O., Pedroni, P., Polonski, A., Prakhov, S. N., Price, J. W., Rosner, G., Rost, M., Rostomyan, T., Sober, D., Starostin, A., Supek, I., Tarbert, C. M., Thomas, A., Unverzagt, M., Walcher, Th., Watts, D. P., and Zehr, F.

Subjects
High Energy Physics - Experiment
Abstract

The reaction gamma p -> p pi0 gamma' has been measured with the Crystal Ball / TAPS detectors using the energy-tagged photon beam at the electron accelerator facility MAMI-B. Energy and angular differential cross sections for the emitted photon gamma' and angular differential cross sections for the pi0 have been determined with high statistics in the energy range of the Delta+(1232) resonance. Cross sections and the ratio of the cross section to the non-radiative process gamma p -> p pi0 are compared to theoretical reaction models, having the anomalous magnetic moment kappa_Delta+ as free parameter. As the shape of the experimental distributions is not reproduced in detail by the model calculations, currently no extraction of kappa_Delta+ is feasible., Comment: 14 pages, 19 figures

Published
2010
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37. Photoproduction of meson pairs: First measurement of the polarization observable I^s

Author

Gutz, E., Sokhoyan, V., van Pee, H., Anisovich, A. V., Bacelar, J. C. S., Bantes, B., Bartholomy, O., Bayadilov, D., Beck, R., Beloglazov, Yu., Castelijns, R., Crede, V., Dutz, H., Elsner, D., Ewald, R., Frommberger, F., Fuchs, M., Funke, Ch., Gregor, R., Gridnev, A., Hillert, W., Hoffmeister, Ph., Horn, I., Jaegle, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Kleber, V., Klein, Frank, Klein, Friedrich, Klempt, E., Kotulla, M., Krusche, B., Lang, M., Loehner, H., Lopatin, I., Lugert, S., Menze, D., Mertens, T., Messchendorp, J. G., Metag, V., Nanova, M., Nikonov, V., Novinski, D., Novotny, R., Ostrick, M., Pant, L., Pfeiffer, M., Piontek, D., Roberts, W., Roy, A., Sarantsev, A., Schadmand, S., Schmidt, Ch., Schmieden, H., Schoch, B., Shende, S., Suele, A., Sumachev, V., Szczepanek, T., Thiel, A., Thoma, U., Trnka, D., Varma, R., Walther, D., Weinheimer, Ch., and Wendel, Ch.

Subjects
Nuclear Experiment
Abstract

The polarization observable I^s, a feature exclusive to the acoplanar kinematics of multi-meson final states produced via linearly polarized photons, has been measured for the first time. Results for the reaction g p -> p pi0 eta are presented for incoming photon energies between 970 MeV and 1650 MeV along with the beam asymmetry I^c. The comparably large asymmetries demonstrate a high sensitivity of I^s to the dynamics of the reaction. Fits using Bonn-Gatchina partial wave analysis demonstrate that the new polarization observables carry significant information on the contributing partial waves., Comment: 11 pages, 6 figures, v2 to appear in Phys. Lett. B

Published
2009
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38. Photoproduction of $\eta$ and $\eta\prime$ Mesons off Protons

Author

CBELSA, The, Collaboration, TAPS, Crede, Volker, McVeigh, A., Anisovich, A., Bacelar, J., Bantes, R., Bartholomy, O., Bayadilov, D., Beck, R., Beloglazov, Y., Castelijns, R., Ehmanns, A., Elsner, D., Essig, K., Ewald, R., Fabry, I., Fuchs, M., Funke, C., Gothe, R., Gregor, R., Gridnev, A., Gutz, E., Hoeffgen, S., Hoffmeister, P., Horn, I., Jaegle, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Klein, Frank, Klein, Friedrich, Klempt, E., Konrad, M., Kotulla, M., Krusche, B., Langheinrich, J., Loehner, H., Lopatin, I., Lotz, J., Lugert, S., Menze, D., Mertens, T., Messchendorp, J., Metag, V., Nanova, M., Nikonov, V., Novinski, D., Novotny, R., Ostrick, M., Pant, L., van Pee, H., Pfeiffer, M., Roy, A., Sarantsev, A., Schadmand, S., Schmidt, C., Schmieden, H., Schoch, B., Shende, S., Sparks, N., Suele, A., Sumachev, V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Weinheimer, C., Wendel, C., and Wilson, A.

Subjects
Nuclear Experiment
Abstract

Total and differential cross sections for $\eta$ and $\eta ^\prime$ photoproduction off the proton have been determined with the CBELSA/TAPS detector for photon energies between 0.85 and 2.55 GeV. The $\eta$ mesons are detected in their two neutral decay modes, $\eta\to\gamma\gamma$ and $\eta\to 3\pi^0\to 6\gamma$, and for the first time, cover the full angular range in $\rm cos \theta_{cm}$ of the $\eta$ meson. These new $\eta$ photoproduction data are consistent with the earlier CB-ELSA results. The $\eta ^\prime$ mesons are observed in their neutral decay to $\pi^0\pi^0\eta\to 6\gamma$ and also extend the coverage in angular range., Comment: 13 pages, 21 figures, updated author list, submitted to PRC

Published
2009
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39. Beam-Helicity Asymmetries in Double Pion Photoproduction off the Proton

Author

Krambrich, D., Zehr, F., Fix, A., Roca, L., Aguar, P., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R., Downie, E. J., Dexler, P., Glazier, D. I., Grabmayr, P., Gregor, R., Heid, E., Hornidge, D., Jahn, O., Kashevarov, V. L., Knezevic, A., Kondratiev, R., Korolija, M., Kotulla, M., Krusche, B., Kulbardis, A., Lang, M., Lisin, V., Livingston, K., Lugert, S., MacGregor, I. J. D., Manley, D. M., Martinez, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Nikolaev, A., Pedroni, P., Pheron, F., Polonski, A., Prakhov, S. N., Price, J. W., Rosner, G., Rost, M., Rostomyan, T., Schumann, S., Sober, D., Starostin, A., Supek, I., Tarbert, C. M., Thomas, A., Unverzagt, M., Walcher, Th., and Watts, D. P.

Subjects
Nuclear Experiment
Abstract

Beam-helicity asymmetries have been measured at the MAMI accelerator in Mainz in the three isospin channels $\vec{\gamma}p\to \pi^{+}\pi^0n$, $\vec{\gamma}p\to \pi^{0}\pi^0p$ and $\vec{\gamma}p\to \pi^{+}\pi^{-}p$ . The circularly polarized photons, produced from bremsstrahlung of longitudinally polarized electrons, were tagged with the Glasgow magnetic spectrometer. Charged pions and the decay photons of $\pi^0$ mesons were detected in a $~4\pi$ electromagnetic calorimeter which combined the Crystal Ball detector with the TAPS detector. The precisely measured asymmetries are very sensitive to details of the production processes and are thus key observables in the modeling of the reaction dynamics., Comment: accepted for publication in Phys. Rev. Lett

Published
2009
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40. Photoproduction of pi^0 eta on protons and the Delta(1700)D_{33} resonance

Author

Kashevarov, V. L., Fix, A., Aguar-Bartolome, P., Akasoy, L. K., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V., Berghauser, H., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Downie, E. J., Drexler, P., Fil'kov, L. V., Glazier, D. I., Gregor, R., Heid, E., Hornidge, D., Jahn, O., Jude, T. C., Knezevic, A., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A., Kruglov, S., Krusche, B., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., Martinez-Fabregate, M., McGeorge, J. C., McNicoll, E. F., Mekterovic, D., Metag, V., Micanovic, S., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Ostrick, M., Owens, R. O., Pedroni, P., Pheron, F., Polonski, A., Robinson, J., Prakhov, S. N., Rosner, G., Rostomyan, T., Schumann, S., Sober, D., Starostin, A., Suarez, I. M., Supek, I., Tarbert, C. M., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Zamboni, I., and Zehr, F.

Subjects
High Energy Physics - Experiment
Abstract

Total and differential cross sections for the reaction gamma p -> pi^o eta p have been measured with the Crystal Ball/TAPS detector using the tagged photon facility at the MAMI C accelerator in Mainz. In the energy range E_gamma=0.95-1.4 GeV the reaction is dominated by the excitation and sequential decay of the Delta(1700)D33 resonance. Angular distributions measured with high statistics allow us to determine the ratio of hadronic decay widths \Gamma_{\eta \Delta}/\Gamma_{\pi S11} and the ratio of the helicity amplitudes A_{3/2}/A_{1/2} for this resonance., Comment: 9 pages, 11 figures

Published
2009
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42. Determination of the Dalitz plot parameter alpha for the decay eta->3pi^0 with the Crystal Ball at MAMI-B

Author

Unverzagt, M., Aguar-Bartolome, P., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J. W., Cherepnya, S., Codling, R., Downie, E. J., Filkov, L. V., Glazier, D. I., Gregor, R., Heid, E., Hornidge, D., Jahn, O., Kashevarov, V. L., Kondratiev, R., Korolija, M., Kotulla, M., Krambrich, D., Krusche, B., Lang, M., Lisin, V., Livingston, K., Lugert, S., MacGregor, I. J. D., Manley, D. M., Martinez-Fabregate, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Owens, R. O., Pedroni, P., Polonski, A., Prakhov, S. N., Price, J. W., Rosner, G., Rost, M., Rostomyan, T., Schumann, S., Sober, D., Starostin, A., Supek, I., Tarbert, C. M., Thomas, A., Walcher, Th., Watts, D. P., and Zehr, F.

Subjects
High Energy Physics - Experiment
Abstract

A precise measurement of the Dalitz plot parameter, alpha, for the eta->3pi^0 decay is presented. The experiment was performed with the Crystal Ball and TAPS large acceptance photon detectors at the tagged photon beam facility of the MAMI-B electron accelerator in Mainz. High statistics of 1.8*10^6 eta->3pi^0 events were obtained, giving the result alpha = -0.032 +/- 0.002(stat) +/- 0.002(syst)., Comment: 9 pages, 6 figures, published in the online-first section of EPJ A, included changes referees asked for, added DOI

Published
2008
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43. Measurement of the Slope Parameter $\alpha$ for the $\eta\to 3\pi^0$ decay with the Crystal Ball detector at the Mainz Microtron (MAMI-C)

Author

Prakhov, S., Nefkens, B. M. K., Aguar-Bartolome, P., Akasoy, L. K., Annand, J. R. M., Arends, H. J., Bantawa, K., Beck, R., Bekrenev, V., Berghauser, H., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R. F. B., Downie, E. J., Drexler, P., Fil'kov, L. V., Glazier, D. I., Gregor, R., Heid, E., Hornidge, D., Jahn, O., Jude, T. C., Kashevarov, V. L., Kellie, J. D., Kondratiev, R., Korolija, M., Kotulla, M., Koulbardis, A., Krambrich, D., Kruglov, S., Krusche, B., Lang, M., Lisin, V., Livingston, K., MacGregor, I. J. D., Maghrbi, Y., Manley, D. M., Martinez, M., McGeorge, J. C., McNicoll, E. F., Mekterovic, D., Metag, V., Micanovic, S., Nikolaev, A., Novotny, R., Ostrick, M., Otte, P. B., Pedroni, P., Pheron, F., Polonski, A., Robinson, J., Rosner, G., Rost, M., Rostomyan, T., Schumann, S., Sikora, M. H., Sober, D. I., Starostin, A., Suarez, I. M., Supek, I., Tarbert, C. M., Thiel, M., Thomas, A., Unverzagt, M., Watts, D. P., Zamboni, I., and Zehr, F.

Subjects
High Energy Physics - Experiment
Abstract

The dynamics of the $\eta\to 3\pi^0$ decay have been studied with the Crystal Ball multiphoton spectrometer and the TAPS calorimeter. Bremsstrahlung photons produced by the 1.5-GeV electron beam of the Mainz microtron MAMI-C and tagged by the Glasgow photon spectrometer were used for $\eta$-meson production. The analysis of $3 \times 10^6$ $\gamma p \to \eta p \to 3\pi^0 p \to 6\gamma p$ events yields the value $\alpha=-0.032\pm0.003$ for the $\eta\to 3\pi^0$ slope parameter, which agrees with the majority of recent experimental results and has the smallest uncertainty. The $\pi^0\pi^0$ invariant-mass spectrum was investigated for the occurrence of a cusplike structure in the vicinity of the $\pi^+\pi^-$ threshold. The observed effect is small and does not affect our measured value for the slope parameter.

Published
2008
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44. Photoproduction of eta-mesons off nuclei for Eg < 2.2 GeV

Author

Mertens, T., Jaegle, I., Muehlich, P., Bacelar, J. C. S., Bantes, B., Bartholomy, O., Bayadilov, D. E., Beck, R., Beloglazov, Y. A., Castelijns, R., Crede, V., Dutz, H., Ehmanns, A., Elsner, D., Essig, K., Ewald, R., Fabry, I., Fornet-Ponse, K., Fuchs, M., Funke, C., Gothe, R., Gregor, R., Gridnev, A. B., Gutz, E., Hoeffgen, S., Hoffmeister, P., Horn, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Kleber, V., Klein, Frank, Klein, Friedrich, Klempt, E., Konrad, M., Kotulla, M., Krusche, B., Lang, M., Langheinrich, J., Loehner, H., Lopatin, I. V., Lotz, J., Lugert, S., Menze, D., Messchendorp, J. G., Metag, V., Morales, C., Mosel, U., Nanova, M., Novinski, D. V., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Radkov, A. K., Roy, A., Schadmand, S., Schmidt, C., Schmieden, H., Schoch, B., Shende, S., Sokhoyan, V., Suele, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Weinheimer, C., and Wendel, C.

Subjects
Nuclear Experiment
Abstract

Photoproduction of $\eta$ mesons off $^{12}$C, $^{40}$Ca, $^{93}$Nb, and $^{nat}$Pb nuclei has been measured with a tagged photon beam with energies between 0.6 and 2.2 GeV. The experiment was performed at the Bonn ELSA accelerator with the combined setup of the Crystal Barrel and TAPS calorimeters. It aimed at the in-medium properties of the S$_{11}$(1535) nucleon resonance and the study of the absorption properties of nuclear matter for $\eta$ mesons. Careful consideration was given to contributions from $\eta\pi$ final states and secondary production mechanisms of $\eta$-mesons e.g. from inelastic $\pi N$ reactions of intermediate pions. The analysis of the mass number scaling shows that the nuclear absorption cross section $\sigma_{N\eta}$ for $\eta$ mesons is constant over a wide range of the $\eta$ momentum. The comparison of the excitation functions to data off the deuteron and to calculations in the framework of a BUU-model show no unexplained in-medium modifications of the S$_{11}$(1535)., Comment: Accepted for publication in Eur. Phys. J. A

Published
2008
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45. Quasi-free photoproduction of eta-mesons of the neutron

Author

Jaegle, I., Mertens, T., Anisovich, A. V., Bacelar, J. C. S., Bantes, B., Bartholomy, O., Bayadilov, D., Beck, R., Beloglazov, Y. A., Castelijns, R., Crede, V., Dutz, H., Ehmanns, A., Elsner, D., Essig, K., Ewald, R., Fabry, I., Fuchs, M., Funke, C., Gothe, R., Gregor, R., Gridnev, A. B., Gutz, E., Hoeffgen, S., Hoffmeister, P., Horn, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Kleber, V., Klein, Frank, Klein, Friedrich, Klempt, E., Konrad, M., Kotulla, M., Krusche, B., Lang, M., Langheinrich, J., Loehner, H., Lopatin, I. V., Lotz, J., Lugert, S., Menze, D., Messchendorp, J. G., Metag, V., Morales, C., Nanova, M., Nikonov, V. A., Novinski, D. V., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Radkov, A. K., Roy, A., Sarantsev, A. V., Schadmand, S., Schmidt, C., Schmieden, H., Schoch, B., Shende, S., Sokhoyan, V., Suele, A., Sumachev, V. V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Weinheimer, C., and Wendel, C.

Subjects
Nuclear Experiment
Abstract

Quasi-free photoproduction of eta-mesons off nucleons bound in the deuteron has been measured with the CBELSA/TAPS detector for incident photon energies up to 2.5 GeV at the Bonn ELSA accelerator. The eta-mesons have been detected in coincidence with recoil protons and recoil neutrons, which allows a detailed comparison of the quasi-free n(gamma,eta)n and p(gamma,eta)p reactions. The excitation function for eta-production off the neutron shows a pronounced bump-like structure at W=1.68 GeV (E_g ~ 1 GeV), which is absent for the proton., Comment: accepted for publication in Phys. Rev. Lett

Published
2008
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46. Modification of the $\omega$-Meson Lifetime in Nuclear Matter

Author

Kotulla, M., Trnka, D., Mühlich, P., Anton, G., Bacelar, J. C. S., Bartholomy, O., Bayadilov, D., Beloglazov, Y. A., Bogendörfer, R., Castelijns, R., Crede, V., Dutz, H., Ehmanns, A., Elsner, D., Ewald, R., Fabry, I., Fuchs, M., Essig, K., Funke, Ch., Gothe, R., Gregor, R., Gridnev, A. B., Gutz, E., Höffgen, S., Hoffmeister, P., Horn, I., Hössl, J., Jaegle, I., Junkersfeld, J., Kalinowsky, H., Klein, Frank, Klein, Fritz, Klempt, E., Konrad, M., Kopf, B., Krusche, B., Langheinrich, J., Löhner, H., Lopatin, I. V., Lotz, J., Lugert, S., Menze, D., Messchendorp, J. G., Mertens, T., Metag, V., Mosel, U., Nanova, M., Novotny, R., Ostrick, M., Pant, L. M., van Pee, H., Pfeiffer, M., Roy, A., Radkov, A., Schadmand, S., Schmidt, Ch., Schmieden, H., Schoch, B., Shende, S., Suft, G., Sumachev, V. V., Szczepanek, T., Süle, A., Thoma, U., Varma, R., Walther, D., Weinheimer, Ch., and Wendel, Ch.

Subjects
Nuclear Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

The photo production of $\omega$ mesons on the nuclei C, Ca, Nb and Pb has been measured using the Crystal Barrel/TAPS detector at the ELSA tagged photon facility in Bonn. The dependence of the $\omega$ meson cross section on the nuclear mass number has been compared with three different types of models, a Glauber analysis, a BUU analysis of the Giessen theory group and a calculation by the Valencia theory group. In all three cases, the inelastic $\omega$ width is found to be $130-150 \rm{MeV/c^2}$ at normal nuclear matter density for an average 3-momentum of 1.1 GeV/c. In the restframe of the $\omega$ meson, this inelastic $\omega$ width corresponds to a reduction of the $\omega$ lifetime by a factor $\approx 30$. For the first time, the momentum dependent $\omega$N cross section has been extracted from the experiment and is in the range of 70 mb., Comment: 5 pages, 4 figures

Published
2008
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47. Incoherent pion photoproduction on $^{12}$C

Author

Tarbert, C. M., Watts, D. P., Aguar, P., Ahrens, J., Annand, J. R. M., Arends, H. J., Beck, R., Bekrenev, V., Boillat, B., Braghieri, A., Branford, D., Briscoe, W. J., Brudvik, J., Cherepnya, S., Codling, R., Downie, E. J., Foehl, K., Glazier, D. I., Grabmayr, P., Gregor, R., Heid, E., Hornidge, D., Jahn, O., Kashevarov, V. L., Knezevic, A., Kondratiev, R., Korolija, M., Kotulla, M., Krambrich, D., Krusche, B., Lang, M., Lisin, V., Livingston, K., Lugert, S., MacGregor, I. J. D., Manley, D. M., Martinez, M., McGeorge, J. C., Mekterovic, D., Metag, V., Nefkens, B. M. K., Nikolaev, A., Novotny, R., Owens, R. O., Pedroni, P., Polonski, A., Prakhov, S. N., Price, J. W., Rosner, G., Rost, M., Rostomyan, T., Schadmand, S., Schumann, S., Sober, D., Starostin, A., Supek, I., Thomas, A., Unverzagt, M., Walcher, Th., and Zehr, F.

Subjects
Nuclear Experiment
Abstract

We present the first detailed measurement of incoherent photoproduction of neutral pions to a discrete state of a residual nucleus. The $^{12}$C$(\gamma,\pi^{0})^{12}$C$^{*}_{4.4MeV}$ reaction has been studied with the Glasgow photon tagger at MAMI employing a new technique which uses the large solid angle Crystal Ball detector both as a $\pi^{0}$ spectrometer and to detect decay photons from the excited residual nucleus. The technique has potential applications to a broad range of future nuclear measurements with the Crystal Ball and similar detector systems elsewhere. The data are sensitive to the propagation of the $\Delta$ in the nuclear medium and will give the first information on matter transition form factors from measurements with an electromagnetic probe. The incoherent cross sections are compared to two theoretical predictions including a $\Delta$-hole model., Comment: 4 pages, 8 figures, submitted to Physical Review Letters

Published
2007
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48. A case series of serious and unexpected adverse drug reactions under treatment with cariprazine

Author

Johannes Heck, Johanna Seifert, Dirk O. Stichtenoth, Christoph Schroeder, Adrian Groh, Gregor R. Szycik, Detlef Degner, Ivana Adamovic, Michael Schneider, Catherine Glocker, Eckart Rüther, Stefan Bleich, Renate Grohmann, and Sermin Toto

Subjects
adverse drug reactions, cariprazine, dopamine supersensitivity psychosis, drug safety, hyperprolactinemia, Medicine, Medicine (General), R5-920
Abstract

Abstract Reporting of new or unexpected adverse drug reactions of medicines that are subject to additional monitoring (“black triangle” label), such as the antipsychotic drug cariprazine, is of paramount importance to improve pharmacotherapy safety.

Published
2021
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49. A Randomized Study of Food Pictures-Influenced Decision-Making Under Ambiguity in Individuals With Morbid Obesity

Author

Marek Lescher, Elisa Wegmann, Silke M. Müller, Nora M. Laskowski, Ruth Wunder, Susana Jiménez-Murcia, Gregor R. Szycik, Martina de Zwaan, and Astrid Müller

Subjects
obesity, craving, cue-reactivity, food addiction, decision-making, Iowa Gambling task, Psychiatry, RC435-571
Abstract

Background and AimsIn addition to craving responses to salient food cues, the anticipation of short-term rewarding consumption of palatable food may overrun the anticipation of long-term negative consequences of obesity. The present investigation addressed the potential interplay of food cravings and decision-making abilities in individuals with obesity.MethodStudy 1 included 107 bariatric surgery candidates with class 2/3 obesity (OB-group) and study 2 included 54 individuals with normal weight/pre-obesity (nonOB-group). In both studies, standardized questionnaires concerning food cravings, food addiction, and psychopathology were administered. A cue-reactivity paradigm was used to measure craving responses toward semi-individualized images of highly palatable, processed food/fruit (appetitive food cues) compared to images of raw vegetables (non-appetitive food cues). Decision-making was measured with a modified computerized version of the Iowa Gambling Task (IGT) with food pictures. Both groups were divided into two subgroups that were randomized to different IGT conditions. In one IGT condition the advantageous IGT card decks were covered by pictures of palatable, processed food or fruit and the disadvantageous decks by images of raw vegetables (= congruent condition), and in the other IGT condition vice versa.ResultsParticipants in the OB-group admitted on average higher craving responses toward palatable, processed food or fruit cues compared to pictures of raw vegetables. This was not the case in the nonOB-group. Contrary to our hypothesis, decision-making performance in both groups was worse when pictures of palatable, processed food or fruit were associated with advantageous IGT card decks compared to performance when those pictures were linked to the disadvantageous decks. The interference effect of food pictures processing on advantageous decision-making has been observed particularly in those individuals of the OB-group who exhibited high craving responses toward palatable, processed food cues or high levels of food addiction.DiscussionThe results indicate that food pictures processing interferes with decision-making, regardless of weight status. Opposed to the hypothesis, stronger tendencies to avoid than to approach pictures presenting processed, tasty food were observed. Further research should examine how cognitive avoidance tendencies toward processed, high energy food and approach tendencies toward healthy food can be transferred to real life situations.

Published
2020
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