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21 results on '"Gu, Li ‐ Juan"'

6. Distributed optical fiber acoustic sensor for in situmonitoring of marine natural gas hydrates production for the first time in the Shenhu Area, China

Author

He, Xiang-ge, Wu, Xue-min, Wang, Lei, Liang, Qian-yong, Gu, Li-juan, Liu, Fei, Lu, Hai-long, Zhang, Yi, and Zhang, Min

Abstract

The distributed acoustic sensor (DAS) uses a single optical cable as the sensing unit, which can capture the acoustic and vibration signals along the optical cable in real-time. So it is suitable for monitoring downhole production activities in the process of oil and gas development. The authors applied the DAS system in a gas production well in the South China Sea for in situmonitoring of the whole wellbore for the first time and obtained the distributed acoustic signals along the whole wellbore. These signals can clearly distinguish the vertical section, curve section, and horizontal production section. The collected acoustic signal with the frequency of approximately 50 Hz caused by the electric submersible pump exhibit a signal-to-noise ratio higher than 27 dB. By analyzing the acoustic signals in the production section, it can be located the layers with high gas production rates. Once an accurate physical model is built in the future, the gas production profile will be obtained. In addition, the DAS system can track the trajectory of downhole tools in the wellbore to guide the operation. Through the velocity analysis of the typical signals, the type of fluids in the wellbore can be distinguished. The successful application of the system provides a promising whole wellbore acoustic monitoring tool for the production of marine gas hydrate, with a good application prospect.

Published
2022
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7. Perspectives of Alopecia behind the Regulation of Foxn1 Gene Exposes the Human Nude Phenotype

Author

Begum, Shahnaz, Hossain, Md Jamil, Gu, Li Juan, Sung, Chang Keun, Begum, Shahnaz, Hossain, Md Jamil, Gu, Li Juan, and Sung, Chang Keun

Abstract

The hair follicle (HF) is remarkable for its dynamic structure and one of the most prominent mini organs of the skin. The most visible end product formed by the hair follicle known as “hair shaft”- a tissue with a highly keratinized protein. Therefore, alopecia or baldness issue largely depends on the equilibrium between keratinocyte growth and differentiation of the HF. However, molecular nature in mice, rats, and humans, loss of transcription factor Foxn1 the keratinization processes is significantly impaired. Hence, this nude gene lack of function makes very similar hair pattern baldness in both human and nude mice (Foxn1nu/Foxn1nu). Thus highlighting the usefulness of mouse mutants and mouse genomics as a research tool for better molecular controls of human hair biology. To enhance research efforts of Foxn1 target gene regulation and the pharmacological manipulation of the nude phenotype are important open questions for promising research strategies related with Foxn1 biology. Taken together these issues may open the discovery of the investigative dermatology that promises the controls of epithelial differentiation in mammalian skin.

Published
2018
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8. Myxoid adrenocortical adenoma with a pseudoglandular pattern: a case report and literature review

Author

Zeng, Zhi, Gu, Li-Juan, Zhou, Zi-Ying, Liu, Lin, Yan, Hong-Lin, Huang, Ya-Bing, Wang, Ze-Sheng, Chen, Jun, and Yuan, Jing-Ping

Subjects
Case Report
Abstract

Adrenocortical adenoma is a benign neoplasm derived from cells of the adrenal cortex. The myxoid variant of this tumor is extremely rare. To our knowledge, only 23 cases of myxoid adrenocortical adenoma have been reported so far and 19 of them mentioned the pseudoglandular pattern. We reported a new case of 56-year-old Chinese female patient whose left adrenal gland was shown a neoplastic lesion by computed tomography (CT) and magnetic resonance (MR) imaging. Histopathological study showed that the mass was a myxoid adrenocortical adenoma with a pseudoglandular pattern. Then, we performed immunohistochemistry with 28 biomarkers to make differential diagnosis and found that tumor cells were diffusely positive for vimentin, melan-A, CD56, NSE and USP10, and focally positive for cytokeratin pan, cytokeratin 8/18 and VEGF. The labeling index of Ki-67 and Cyclin D1 were about 1% and 50%, respectively. No immunoreactivity was found for EMA, cytokeratin 7, HMB45, S-100, alpha-inhibin, calretinin, synaptophysin, chromogranin A, P53, EGFR, MMP2, DNA topo II alpha, CA125, E-cadherin, P63, P16 and Her-2. The patient has been followed up for 37 months after tumor resection and no evidence was found to suggest any local recurrence or any metastatic disease. Myxoid adrenocortical adenoma with a pseudoglandular pattern is extremely rare. The accurate diagnosis should be based on combined consideration of clinical characteristics, CT, MR imaging and pathological features, and should be distinguished from other retroperitoneal myxoid tumors.

Published
2017

9. Isolation and Purification of Novel Anti-Fungal Peptides from Hemolymph of Immunized Larvae of Housefly, Musca domestica

Author

Gu Li-Juan, Su Xiao-Qing, Sung Chang-Keun, and Wu Jian-Wei

Subjects
animal structures, biology, media_common.quotation_subject, fungi, Insect, biology.organism_classification, High-performance liquid chromatography, Biochemistry, Immunology, Hemolymph, Solid phase extraction, Housefly, Candida albicans, Defensin, Musca, media_common
Abstract

To isolate and purify anti-fungal active substances from immunized housefly (Musca domestica), low dose of Candida albicans was injected into the larvae of the housefly to induce the appearance of potent anti-fungal active substances in the hemolymph. This purification work was performed by the routine isolation and purification processes of protein, namely, solid phase extraction (SPE), SDS-PAGE electrophoresis, HPLC purification. Three 4~16 kDa peptides which exhibited antifungal activity against Candida albican and other fungi were isolated from induced hemolymph. Consequently, further anti-fungal activity study showed that these three peptides were different either in molecular weight or in anti-fungal activity. All isolated substances were proved to be active and resistant to high-temperature. It was deduced that these peptides isolated from induced housefly were novel members of the insect defensin family and they were inducible.

Published
2006

16. Evaluation of the Oral Acute Toxicity of Black Ginseng in Rats

Author

Lee, Mi-Ra, primary, Oh, Chang-Jin, additional, Li, Zheng, additional, Li, Jing-Jie, additional, Wang, Chun-Yan, additional, Wang, Zhen, additional, Gu, Li-Juan, additional, Lee, Sang-Hwa, additional, Lee, Jae-Il, additional, Lim, Beong-Ou, additional, and Sung, Chang-Keun, additional

Published
2011
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19. Microbial Conversion of Rare Ginsenoside Rf to 20(S)-Protopanaxatriol by Aspergillus niger

Author

LIU, Lei, GU, Li-Juan, ZHANG, Dong-Liang, WANG, Zhen, WANG, Chun-Yan, LI, Zheng, and SUNG, Chang-Keun

Abstract

In this study, rare ginsenoside Rf was transformed into 20(S)-protopanaxatriol (PPT(S)) by glycosidase from Aspergillus niger. By investing the reaction conditions, the optimal conditions were obtained, as follows: pH 5.0, temperature 55 °C, and substrate concentration 1.25 mmol/l. Under optimal conditions, PPT(S) (1.13 μmol) prepared from 1.25 μmol Rf showed a higher yield (90.4%). The enzymatic reaction was analyzed by reversed-phase HPLC, suggesting the transformation pathway: Rf→Rh1(S)→PPT(S).

Published
2010
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20. Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice.

Author

Begum S, Lee MR, Gu LJ, Hossain J, and Sung CK

Subjects
Animals, Cell Differentiation drug effects, Hair Follicle cytology, Humans, Keratinocytes cytology, Mice, Mice, Inbred BALB C, Mice, Nude, Plant Extracts chemistry, Cell Proliferation drug effects, Eclipta chemistry, Gene Expression Regulation drug effects, Hair Follicle metabolism, Keratinocytes metabolism, Plant Extracts pharmacology, Transforming Growth Factor beta1 biosynthesis
Abstract

Eclipta alba (L.) Hassk (E. alba) is a traditionally acclaimed medicinal herb used for the promotion of hair growth. However, to the best of our knowledge, no report has been issued to date on its effects on genetically distorted hair follicles (HFs). In this study, we aimed to identify an agent (stimuli) that may be beneficial for the restoration of human hair loss and which may be used as an alternative to synthetic drugs. We investigated the effects of petroleum ether extract (PEE) and different solvent fractions of E. alba on HFs of nude mice. Treatment was performed by topical application on the backs of nude mice and the changes in hair growth patterns were evaluated. Histological analysis was carried out to evaluate the HF morphology and the structural differences. Immunohistochemical (IHC) staining was performed to visualize follicular keratinocyte proliferation. The histological assessments revealed that the PEE-treated skin specimens exhibited prominent follicular hypertrophy. Subsequently, IHC staining revealed a significant increase (p<0.001) in the number of follicular keratinocytes in basal epidermal and matrix cells. Our results also demonstrated that PEE significantly (p<0.001) reduced the levels of transforming growth factor-β1 (TGF-β1) expression during early anagen and anagen-catagen transition. Our results suggest that PEE of E. alba acts as an important exogenous mediator that stimulates follicular keratinocyte proliferation and delays terminal differentiation by downregulating TGF-β1 expression. Thus, this study highlights the potential use of PEE of E. alba in the treatment of certain types of alopecia.

Published
2015
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21. Aqueous extract of red deer antler promotes hair growth by regulating the hair cycle and cell proliferation in hair follicles.

Author

Li JJ, Li Z, Gu LJ, Wang YB, Lee MR, and Sung CK

Subjects
Animals, Hair Follicle cytology, Hair Follicle physiology, Mice, Antlers chemistry, Biological Products pharmacology, Cell Proliferation, Hair Follicle drug effects
Abstract

Deer antlers are the only mammalian appendage capable of regeneration. We aimed to investigate the effect of red deer antler extract in regulating hair growth, using a mouse model. The backs of male mice were shaved at eight weeks of age. Crude aqueous extracts of deer antler were prepared at either 4 °C or 100 °C and injected subcutaneously to two separate groups of mice (n = 9) at 1 mL/day for 10 consecutive days, with water as a vehicle control group. The mice skin quantitative hair growth parameters were measured and 5-bromo-2-deoxyuridine was used to identify label-retaining cells. We found that, in both the 4 °C and the 100 °C deer antler aqueous extract-injection groups, the anagen phase was extended, while the number of BrdU-incorporated cells was dramatically increased. These results indicate that deer antler aqueous extract promotes hair growth by extending the anagen phase and regulating cell proliferation in the hair follicle region.

Published
2014
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