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7. China's pattern of growth moving to sustainability and reducing inequality.

Author

Guo, Yating, Rosland, Anitha, Ishak, Suryati, and Muhamad Senan, Mohamad Khair Afham

Subjects
ECONOMIC conditions in China, LABOR productivity, SUSTAINABILITY, SUSTAINABLE development, ECONOMIC policy, ECONOMIC expansion
Abstract

The objective of this study was to identify the pattern of economic growth of China by identifying the factors that are contributing to sustainability and reducing inequality in the Chinese communities. The role of sustainable development goals has become critical for even the non- democratic country because inequality is also found in China which is rapidly increasing due to overpopulation and other factors. In this study, the questionnaire was developed on the Likert scale to collect the data from the economists to test the relationship between the hypotheses. The sample size for this study was 330 from the selected population of 800 people with a response rate of 45%. The study concludes that there is a critical role of sustainable development goals, sustainable economic policy, and labor productivity in the growth of China's economy. Further, this study also demonstrates that the Chinese government must focus on sustainability to reduce inequality in society. Significantly, this study provides a detailed insight into the relationship of factors that are contributing to China's economic growth that was not discussed earlier in the Chinese economic context. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Bempedoic Acid Unveils Therapeutic Potential in Non-Alcoholic Fatty Liver Disease: Suppression of the Hepatic PXR-SLC13A5/ACLY Signaling Axis

Author

Sun, Qiushuang, Guo, Yating, Hu, Wenjun, Zhang, Mengdi, Wang, Shijiao, Lei, Yuanyuan, Meng, Haitao, Li, Ning, Xu, Pengfei, Li, Zhiyu, Lin, Haishu, Huang, Fang, and Qiu, Zhixia

Abstract

The hepatic SLC13A5/SLC25A1-ATP–dependent citrate lyase (ACLY) signaling pathway, responsible for maintaining the citrate homeostasis, plays a crucial role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Bempedoic acid (BA), an ACLY inhibitor commonly used for managing hypercholesterolemia, has shown promising results in addressing hepatic steatosis. This study aimed to elucidate the intricate relationships in processes of hepatic lipogenesis among SLC13A5, SLC25A1, and ACLY and to examine the therapeutic potential of BA in NAFLD, providing insights into its underlying mechanism. In murine primary hepatocytes and HepG2 cells, the silencing or pharmacological inhibition of SLC25A1/ACLY resulted in significant upregulation of SLC13A5 transcription and activity. This increase in SLC13A5 activity subsequently led to enhanced lipogenesis, indicating a compensatory role of SLC13A5 when the SLC25A1/ACLY pathway was inhibited. However, BA effectively counteracted this upregulation, reduced lipid accumulation, and ameliorated various biomarkers of NAFLD. The disease-modifying effects of BA were further confirmed in NAFLD mice. Mechanistic investigations revealed that BA could reverse the elevated transcription levels of SLC13A5 and ACLY, and the subsequent lipogenesis induced by PXR activation in vitro and in vivo. Importantly, this effect was diminished when PXR was knocked down, suggesting the involvement of the hepatic PXR-SLC13A5/ACLY signaling axis in the mechanism of BA action. In conclusion, SLC13A5-mediated extracellular citrate influx emerges as an alternative pathway to SLC25A1/ACLY in the regulation of lipogenesis in hepatocytes, BA exhibits therapeutic potential in NAFLD by suppressing the hepatic PXR-SLC13A5/ACLY signaling axis, while PXR, a key regulator in drug metabolism may be involved in the pathogenesis of NAFLD.SIGNIFICANCE STATEMENTThis work describes that bempedoic acid, an ATP-dependent citrate lyase (ACLY) inhibitor, ameliorates hepatic lipid accumulation and various hallmarks of non-alcoholic fatty liver disease. Suppression of hepatic SLC25A1-ACLY pathway upregulates SLC13A5 transcription, which in turn activates extracellular citrate influx and the subsequent DNL. Whereas in hepatocytes or the liver tissue challenged with high energy intake, bempedoic acid reverses compensatory activation of SLC13A5 via modulating the hepatic PXR-SLC13A5/ACLY axis, thereby simultaneously downregulating SLC13A5 and ACLY.

Published
2023
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20. Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

Author

Zou, Yi, primary, Sun, Huaqin, additional, Guo, Yating, additional, Shi, Yidan, additional, Jiang, Zhiyu, additional, Huang, Jingxuan, additional, Li, Li, additional, Jiang, Fengle, additional, Lin, Zeman, additional, Wu, Junling, additional, Zhou, Ruixiang, additional, Liu, Yuncai, additional, and Ao, Lu, additional

Published
2021
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27. Rubber: Upside Room Capped by Downstream, May Turn a Corner in 2H 2020.

Author

Wang Kaifu, Guo Yating, and Zhu Zhiwei

Subjects
*STYRENE-butadiene rubber, *COVID-19 pandemic
Abstract

The article talks about the performance of rubber products industry in China in 2020. It mentions that the prices of major tyre feedstock, including natural rubber and synthetic rubber rose after initially dropping; and crippled demand after China's Lunar New Year holiday triggered consecutive declines in feedstock prices, with butadiene rubber (BR), and carbon black posting a year-on-year fall. It also mentions COVID-19 pandemic pummeled China's tyre and other rubber products industries.

Published
2020

28. gH-Symmetrically Derivative of Interval-Valued Functions and Applications in Interval-Valued Optimization.

Author

Guo, Yating, Ye, Guoju, Zhao, Dafang, and Liu, Wei

Subjects
*EXERCISE
Abstract

In this paper, we present the gH-symmetrical derivative of interval-valued functions and its properties. In application, we apply this new derivative to investigate the Karush–Kuhn–Tucker (KKT) conditions of interval-valued optimization problems. Meanwhile, some examples are worked out to illuminate the obtained results. [ABSTRACT FROM AUTHOR]

Published
2019
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29. Synthetic Rubber: Surplus of Mainstream Products and Short of High-end Ones.

Author

Guo Yating

Subjects
*ARTIFICIAL rubber, *SURPLUS commodities, *ETHYLENE-propylene rubber, *SYNTHETIC products, *BUTYL rubber, *STYRENE-butadiene rubber, *RUBBER
Abstract

The article highlights the market segments or surplus of China's synthetic rubber industry along with its development trend. It mentions the difficulty of the operation of synthetic rubber companies to purchase raw materials that expected to decline; and also highlights the development of green industries and environmentally friendly products.

Published
2020

30. Discovery of Antimicrobial Lysins from the "Dark Matter" of Uncharacterized Phages Using Artificial Intelligence.

Author

Zhang Y, Li R, Zou G, Guo Y, Wu R, Zhou Y, Chen H, Zhou R, Lavigne R, Bergen PJ, Li J, and Li J

Abstract

The rapid rise of antibiotic resistance and slow discovery of new antibiotics have threatened global health. While novel phage lysins have emerged as potential antibacterial agents, experimental screening methods for novel lysins pose significant challenges due to the enormous workload. Here, the first unified software package, namely DeepLysin, is developed to employ artificial intelligence for mining the vast genome reservoirs ("dark matter") for novel antibacterial phage lysins. Putative lysins are computationally screened from uncharacterized Staphylococcus aureus phages and 17 novel lysins are randomly selected for experimental validation. Seven candidates exhibit excellent in vitro antibacterial activity, with LLysSA9 exceeding that of the best-in-class alternative. The efficacy of LLysSA9 is further demonstrated in mouse bloodstream and wound infection models. Therefore, this study demonstrates the potential of integrating computational and experimental approaches to expedite the discovery of new antibacterial proteins for combating increasing antimicrobial resistance., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

Published
2024
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