28 results on '"Guptaroy, P."'
Search Results
2. Light Hadron Production in Proton-Proton Collisions at Different LHC Energies: Measured Data versus a Model
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Guptaroy, P. and Guptaroy, S.
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High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
Experiments involving proton-proton collisions at energies $\sqrt{s_{NN}}$ = 0.9, 2.76 and 7 TeV in Large Hadron Collider (LHC) have produced a vast amount of high-precision data. Here, in this work, we have chosen to analyse the two aspects of the measured data, viz., (i) the $p_T$ -spectra of pions, kaons, proton-antiproton at above-mentioned energies, and (ii) some of their very important ratio-behaviours, in the light of a version of the Sequential Chain Model (SCM). The agreements between the measured data and model-based results are generally found to be modestly satisfactory., Comment: 10 pages, 2 figures. arXiv admin note: substantial text overlap with arXiv:0907.2008
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- 2014
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3. Direct Photon Production at RHIC and LHC-energies: Measured Data Versus a Model
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Guptaroy, P. and Guptaroy, S.
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High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
We attempt, in this paper, to deal with the direct photon production phenomena in $p+p$, $d+Au$ and $Au+Au$ collisions at RHIC energy, $\sqrt{s_{NN}}$ = 200 GeV and in $Pb+Pb$-collisions at LHC energy, $\sqrt{s_{NN}}$ = 2.76 TeV on the basis of a non-standard framework outlined in the text. Comparisons of the model-based results with the measured data on some observables reveal fair agreement; and they are modestly consistent with the results obtained by some other models of `Standard' framework., Comment: 10 pages, 5 figures;To appear in CHIN. PHYS. LETT. Vol. 30, No. 6 (2013) 062502
- Published
- 2013
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4. Production of J/$\Psi$-Particles at RHIC and LHC energies: An Alternative `Psi'-chology
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Guptaroy, P., Sau, Goutam, Biswas, S. K., and Bhattacharyya, S.
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High Energy Physics - Phenomenology - Abstract
We attempt here to understand successfully some crucial aspects of $J/\Psi$-production in some high energy nuclear collisions in the light of a non-standard framework outlined in the text. It is found that the results arrived at with this main working approach here is fairly in good agreement with both the measured data and the results obtained on the basis of some other models of the `standard' variety. Impact and implications of this comparative study have also been precisely highlighted in the end., Comment: 14 pages, 7 figures, to appear in Open Journal of Microphysics. arXiv admin note: substantial text overlap with arXiv:0906.2612, arXiv:1110.5582, and overlap with arXiv:1103.6269, arXiv:1007.4513
- Published
- 2012
- Full Text
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5. On Production of Hadrons in Proton-Proton Collisions at RHIC and LHC Energies and an Approach
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Guptaroy, P., Sau, Goutam, and Bhattacharyya, S.
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High Energy Physics - Phenomenology - Abstract
From the very early days of Particle Physics, both experimental and theoretical studies on proton-proton collisions had occupied the center-stage of attention for very simple and obvious reasons. And this intense interest seems now to be at peak value with the onset of the Large Hadron Collider (LHC)-studies at TeV ranges of energies. In this work, we have chosen to analyse the inclusive cross-sections, the rapidity density, the $K/\pi$ and $p/\pi$-ratio behaviours and the $
$-values, in the light of the Sequential Chain Model (SCM). And the limited successes of the model encourage us to take up further studies on several other aspects of topmost importance in particle physics with the same approach., Comment: 14 pages, 3 tables, 7 figures; to appear in Journal of Modern Physics - Published
- 2011
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6. Ansatzs, Assumptions and Production of J/$\Psi$-Particles: A Non-`Charmed' Approach vs. the `Charmed' Ones
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Guptaroy, P., Sau, Goutam, and Bhattacharyya, S.
- Subjects
High Energy Physics - Phenomenology - Abstract
We would attempt, in this work, at dwelling upon some crucial aspects of $J/\Psi$-production in a few high energy nuclear collisions in the light of a non-standard model which is outlined in the text. The underlying physical ideas, assumptions and ansatzs have also been enunciated in some detail. It is found that the results arrived at with this main working approach here are fairly in good agreement with both the measured data and the results obtained on the basis of some other models of the `standard' variety. Impact and implications of this comparative study have also been precisely highlighted in the end., Comment: 8 pages, 7 figures
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- 2011
- Full Text
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7. Rapidity Spectra of Heavy Baryons in Nuclear Collisions at Various Energies : A Systematic Approach
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Sau, Goutam, Guptaroy, P., Ghosh, A. C. Das, and Bhattacharyya, S.
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High Energy Physics - Phenomenology - Abstract
This study aims at understanding the nature of measured data on the rapidity spectra of some heavy baryons [$\Lambda$, $\Lambda$bar, $\Xi^-$ & $\Xi$bar$^+$] produced in the nuclear collisions at some modestly high energies. Furthermore, our objective is also to build up a comprehensive and consistent methodology to analyze the data on this specific observable which has a very important place in the domain of High Energy Physics (HEP). On an overall basis, our target here attains a moderate degree of success even for production of such rare secondaries. In addition to this, the limitations of such an approach have also been pointed out., Comment: 19 pages, 14 figures, Accepted for publication in IL Nuovo Cimento B
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- 2010
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8. Analyzing Non-Extensivity of $\eta$-spectra in Relativistic Heavy Ion Collisions at $\sqrt{s_{NN}}=200$ GeV
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De, Bhaskar, Sau, Gautam, Biswas, S. K., Bhattacharyya, S., and Guptaroy, P.
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Nuclear Theory ,High Energy Physics - Phenomenology ,Nuclear Experiment - Abstract
The transverse momentum spectra of secondary $\eta$ particles produced in $P+P$, $D+Au$ and $Au+Au$ interactions at $\sqrt{s_{NN}}=200$ GeV at different centralities have been studied in the light of a non-extensive thermodynamical approach. The results and the possible thermodynamical insights, thus obtained, about the hadronizing process have also been discussed in detail., Comment: 16 pages, 7 figures; Accepted for publication in IJMPA
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- 2009
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9. Understanding the Characteristics of Multiple Production of Light Hadrons in Cu + Cu Interactions at Various RHIC Energies: A Model-based Analysis
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Guptaroy, P., Sau, Goutam, Biswas, S. K., and Bhattacharyya, S.
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High Energy Physics - Phenomenology - Abstract
Experiments involving copper-copper collisions at the RHIC-BNL (USA) at energies $\sqrt{s_{NN}}$ = 22.5, 62 and 200 GeV have produced a vast amount of high-precision data which are to be analysed in the light of various competing models in the domain of multiparicle production scenario. We have chosen to analyse here the measured data on the $p_T$ -spectra of various light and non-strange secondaries at various energies mentioned above, some of their very important ratio-behaviours at the various centralities of the collisions and the nuclear modification factors $R_{AA}$ and $R_{CP}$ in the light of a version of the Sequential Chain Model (SCM). The agreements between the measured data and model-based results are generally found to be modestly satisfactory. Besides, our obtained results have also been compared with results based upon two approaches with strong standard model flavour, of which one is purely pQCD-oriented and is forwarded by Vitev., Comment: 35 pages, 14 Figures, 4 Tables; Title, Abstract and the text changed; To appear in Il Nuovo Cimento B
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- 2009
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10. Understanding the New High Energy Data-sets Measured by BESS, CAPRICE and PAMELA on Antiproton Flux and $\bar{P}/P$ Ratios
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Sau, Goutam, Guptaroy, P., Bhattacharya, A., and Bhattacharyya, S.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Reliable data from the very recent high-precision measurements on the antiproton fluxes and the antiproton-to-proton ratios by the PAMELA Collaboration at relatively much higher energies are now available. The results with regard to antiproton production phenomena spring no special surprises; rather they are sharply in contrast with and contradiction to the case of positron production at the same energy-range. However, the totality of data on antiproton production from the past experiments to the very recent PAMELA outburst seem to be a very challenging exercise for interpretation in terms of the secondary production mechanisms alone, the galactic propagation model etc against the background of the `dark-matter'-related controversy. In the present work we assume the validity of the simple leaky box model, choose a simple particle production model and attempt at providing a comprehensive interpretation of the totality of data on both antiproton flux measurements and the $\overline{P}/P$ ratio-values for the various experiments ranging from BESS, CAPRICE to the latest PAMELA experiment. With the assumption of no contribution from the exotic sources to the antiproton production process, our model and the method describe the totality of the measured data with a fair degree of success., Comment: 16 Pages, 5 Figures. Title changed, Abstract changed, some minor changes in references, typos
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- 2009
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11. Analysing $j/\Psi$ Production in Various RHIC Interactions with a Version of Sequential Chain Model (SCM)
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Guptaroy, P., Garain, Tarun K., Sau, Goutam, Biswas, S. K., and Bhattacharyya, S.
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High Energy Physics - Phenomenology - Abstract
We have attempted to develop here tentatively a model for $J/\Psi$ production in p+p, d+Au, Cu + Cu and Au + Au collisions at RHIC energies on the basic ansatz that the results of nucleus-nucleus collisions could be arrived at from the nucleon-nucleon (p + p)-interactions with induction of some additional specific features of high energy nuclear collisions. Based on the proposed new and somewhat unfamiliar model, we have tried (i) to capture the properties of invariant $p_T$ -spectra for $J/\Psi$ meson production; (ii) to study the nature of centrality dependence of the $p_T$ -spectra; (iii) to understand the rapidity distributions; (iv) to obtain the characteristics of the average transverse momentum $< p_T >$ and the values of $< p_T^2 >$ as well and (v) to trace the nature of nuclear modification factor. The alternative approach adopted here describes the data-sets on the above-mentioned various observables in a fairly satisfactory manner. And, finally, the nature of $J/\Psi$-production at Large Hadron Collider(LHC)-energies deduced on the basis of our chosen model has been presented in a predictive way against the RHIC-yields, both calculated for the most central collisions and on the same model., Comment: 24 Pages, 14 Figures
- Published
- 2009
12. Transverse Momentum Spectra of Pions in Particle and Nuclear Collisions and Some Ratio-Behaviours: Towards A Combinational Approach
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De, Bhaskar, Bhattacharyya, S., and Guptaroy, P.
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Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
The nature of transverse momentum dependence of the inclusive cross-sections for secondary pions produced in high energy hadronic($PP$), hadronuclear($PA$) and nuclear($AA$) collisions has here been exhaustively investigated for a varied range of interactions in a unified way with the help of a master formula. This formula evolved from a new combination of the basic Hagedorn's model for particle(pion) production in PP scattering at ISR range of energies, a phenomenological approach proposed by Peitzmann for converting the results of $NN(PP)$ reactions to those for either $PA$ or $AA$ collisions, and a specific form of parametrization for mass number-dependence of the nuclear cross sections. This grand combination of models(GCM) is then applied to analyse the assorted extensive data on various high energy collisions. The nature of qualitative agreement between measurements and calculations on both the inclusive cross-sections for production of pions, and some ratios of them as well, is quite satisfactory. The modest successes that we achieve here in dealing with the massive data-sets are somewhat encouraging in view of the diversity of the reactions and the very wide range of interaction energies., Comment: 19 pages, 19 figures
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- 2002
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13. Physics of particle collisions at high energies: limits to phenomenology, Part 3
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Sau, Goutam, Biswas, S.K., De, Bhaskar, Guptaroy, P., Bhattacharya, A., and Bhattacharyya, S.
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Collisions (Physics) -- Analysis ,Physics ,Quotations ,Analysis ,Research - Abstract
In continuation of our series of works on the phenomenological studies on production of particles in various high-energy collisions, we attempt here to deal exclusively with some very crucial aspects of Au-Au collisions at RHIC-BNL. With emphasis on understanding the qualitative and quantitative properties of several important observables related to Au-Au interactions at RHIC, we have also endeavored to analyze and assess, if possible, the limits to the successes and failures of such absolutely phenomenological approaches. As all the models in the domain of high-energy physics are invariably and essentially phenomenological in nature, we have also tried to pinpoint the main and major constrictions of and constraints on these approaches-cum-models. By this yardstick, even the so-called Standard Model (SM), which is too greatly lauded and taken for granted ,cannot escape our critical remarks that are cast on the general framework of what is termed 'phenomenology', in the realm of physics in particular and of science in general. PACS Nos.: 25.75.-q, 13.60.Hb, 13.60.Le, 13.85.Ni Pour continuer notre serie d'articles qui etudient la production de particules dans differentes collisions de haute energie, nous nous penchons ici sur des aspects cruciaux des collisions Au-Au observees au RHIC-BNL. Insistant sur la comprehension des proprietes qualitatives et quantitatives de plusieurs observables relies aux interactions Au-Au au RHIC, nous nous sommes employes a analyser et a evaluer, si possible, les limites des succes et des echecs de telles approches totalement phenomenologiques. Comme tous les modeles en physique des hautes energies sont essentiellement phenomenologiques en nature, nous avons aussi essaye de circonscrire les contraintes et restrictions les plus importantes et centrales de ces approches et modeles. Selon ce point de vue, meme le celebre Modele Standard qui est loue au dela de toute proportion et pris comme acquis ne peut echapper a ce type de critique dans un cadre general des theories phenomenologiques en physique en particulier et en sciences en general. [Traduit par la Redaction], It's not what you don't know that gets you in trouble, it's what you think you know.--Mark Twain. 1. Introduction This study is set in the context of a controversy [...]
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- 2009
14. Physics of particle collisions at high energies: Limits to phenomenology, Part 2
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Sau, Goutam, Biswas, S.K., De, Bhaskar, Guptaroy, P., Bhattacharya, A., and Bhattacharyya, S.
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Collisions (Nuclear physics) -- Research ,Relativity (Physics) -- Research ,Phenomenology -- Research ,Gold -- Properties -- Research ,Deuterons -- Properties -- Research ,Physics ,Research ,Properties - Abstract
Our focus in this work would be concentrated on trying to understand the nature of some very important observables measured for deuteron-gold (d + Au) collisions at relativistic heavy ion collider (RHIC) energies in the light of a particular phenomenological model that we had applied earlier in analyzing data for PP collisions at RHIC and Fermi National Accelerator Laboratory (FNAL) energies with a fair degree of success. In this particular case, as well, our observations and conclusions are exactly similar to those in our previous work. The emphatic ending points, on the whole, to some gross limitations of the chosen phenomenological approach in particular and of the phenomenology as such in general. PACS Nos.: 13.60.Hb, 13.60.Le, 13.60.Rj, 13.85.Ni Le present travail vise a ameliorer notre comprehension de la nature de quelques observables importantes mesurees dans les collisions deuteron-or (d + Au) aux energies du RHIC, a la lumiere d'un modele phenomenologique particulier que nous avons precedemment utilise avec succes dans l'analyse des donnees de collisions p-p aux energies du RHIC et de FNAL. Dans le cas present, nos observations et conclusions sont exactement similaires a celles de nos travaux precedents. La conclusion porte sur les limites de l'approche phenomenologique choisie et sur les approches phenomenologiques en general. [Traduit par la Redaction], 1. Introduction Studies on the high-energy particle-particle, particle-nucleus, and nucleus-nucleus reactions have nowadays entered into crucial phase and stage, with the latest well-agreed revelation that a 'new' state (not quark-gluon-plasma [...]
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- 2008
15. Physics of particle collisions at high energies: Limits to phenomenology, Part 1
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Sau, Goutam, Biswas, S.K., De, Bhaskar, Guptaroy, P., Bhattacharya, A., and Bhattacharyya, S.
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Collisions (Nuclear physics) -- Research ,Hadrons -- Properties -- Research ,Phenomenology -- Research ,Physics ,Research ,Properties - Abstract
Interpretation and understanding of high-energy PP data in a clear, consistent, and comprehensive manner is crucial for making valid claims to build up any successful theoretical framework for particle interactions. We have tried here to analyze the various sets of PP data available from the pre-ISR days to the latest PP collisions at the relativistic heavy ion collider (RHIC) experiment at [square root of sNN] = 200 GeV in the light of a power-law model. Both mid-rapidity and high-rapidity data sets have been dealt with by applying the same working formula. It is found that the working formula used provides a good description of these wide ranging data sets; but hardly throws any deep insights into the nature of particle interactions that force us to question the worth and rigour of phenomenological studies. PACS Nos.: 13.60.Hb, 13.60.Le, 13.85.Ni L'interpretation et la comphehension des donnees p-p a haute energie dans un cadre clair, coherent et complet, sont cruciales pour pretendre pouvoir construire un modele theorique valide de l'interaction entre les particules. Nous avons essaye ici d'analyser dans un modele en loi de puissance les differents ensembles de donnees p-p disponibles, debutant avec les donnees pre-ISR jusqu'aux experiences RHIC a [square root of sNN] = 200 GeV. Nous avons utilise les ensembles de rapidite moyenne et elevee en leur appliquant la meme formule de travail. Nous trouvons que la formule de travail utilisee donne une bonne description sur une large gamme de donnees, mais cela ne jette aucune lumiere sur la nature de l'interaction entre particules, ce qui nous pousse a questionner la valeur et la rigueur des modeles phenomenologiques. [Traduit par la Redaction], 1. Introduction and the background Multiparticle production phenomena involving hadron-hadron interactions still constitute a very exciting topic, as the particle production mechanisms are not yet properly understood even for this [...]
- Published
- 2008
16. N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux.
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Habibeh Khoshbouei, Namita Sen, Bipasha Guptaroy, L 'Aurelle Johnson, David Lund, Margaret E Gnegy, Aurelio Galli, and Jonathan A Javitch
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Biology (General) ,QH301-705.5 - Abstract
Amphetamine (AMPH) elicits its behavioral effects by acting on the dopamine (DA) transporter (DAT) to induce DA efflux into the synaptic cleft. We previously demonstrated that a human DAT construct in which the first 22 amino acids were truncated was not phosphorylated by activation of protein kinase C, in contrast to wild-type (WT) DAT, which was phosphorylated. Nonetheless, in all functions tested to date, which include uptake, inhibitor binding, oligomerization, and redistribution away from the cell surface in response to protein kinase C activation, the truncated DAT was indistinguishable from the full-length WT DAT. Here, however, we show that in HEK-293 cells stably expressing an N-terminal-truncated DAT (del-22 DAT), AMPH-induced DA efflux is reduced by approximately 80%, whether measured by superfusion of a population of cells or by amperometry combined with the patch-clamp technique in the whole cell configuration. We further demonstrate in a full-length DAT construct that simultaneous mutation of the five N-terminal serine residues to alanine (S/A) produces the same phenotype as del-22-normal uptake but dramatically impaired efflux. In contrast, simultaneous mutation of these same five serines to aspartate (S/D) to simulate phosphorylation results in normal AMPH-induced DA efflux and uptake. In the S/A background, the single mutation to Asp of residue 7 or residue 12 restored a significant fraction of WT efflux, whereas mutation to Asp of residues 2, 4, or 13 was without significant effect on efflux. We propose that phosphorylation of one or more serines in the N-terminus of human DAT, most likely Ser7 or Ser12, is essential for AMPH-induced DAT-mediated DA efflux. Quite surprisingly, N-terminal phosphorylation shifts DAT from a "reluctant" state to a "willing" state for AMPH-induced DA efflux, without affecting inward transport. These data raise the therapeutic possibility of interfering selectively with AMPH-induced DA efflux without altering physiological DA uptake.
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- 2004
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17. Power laws and production of direct photons in high-energy physics
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Biswas, S K, Sau, G, Guptaroy, P, De, B, Bhattacharya, A, and Bhattacharyya, S
- Published
- 2008
18. Mnogobrojna tvorba piona i kaona u visokoenergijskim sudarima jezgra-jezgra: ishodi mjerenja i posebni modeli
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Guptaroy, P., De, Bh., Bhattacharyya, S., and Bhattacharyya, D. P.
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relativistic heavy ion collisions ,inclusive production ,quark gluon plasm - Abstract
The pion and kaon rapidity densities and the nature of kaon-pion ratios offer two very prominent and crucial physical observables on which modestly sufficient data for heavy nucleus collisions are available to date. In the light of two sets of models - one purely phenomenological and the other with a modest degree of a dynamical basis - we try to examine the state of agreement between calculations and experimental results obtainable from the past and the latest measurements. Impact and implications of all these would also finally be spelt out., Gustoće rapidnosti piona i kaona i narav omjera kaona i piona pružaju dvije vrlo važne fizičke opservable za koje su dosada postignuti brojni podaci mjerenjem sudara teških jezgri. Ispitujemo skladnost teorije polazeći od dva skupa modela, jednog potpuno fenomenološkog i drugog s umjerenim stupnjem dinamike, i eksperimentalnih podataka poznatih iz ranijih i nedavnih mjerenja. Raspravlja se njihova važnost i sljedbe.
- Published
- 2002
19. Prinosi čestica, skaliranje antiprotona i prosječni poprečni impulsi u sudarima olovo–olovo na visokoj energiji: modelska studija
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Guptaroy, P., Bhattacharyya, S., Deand, B., and Bhattacharyya, D. P.
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lead-lead collisions ,sequential chain model ,cascading and rescattering ,transverse momenta - Abstract
The study aims at explaining the behaviour of some of the very important observables measured in the latest lead-lead collisions at CERN in the light of a variety of the sequential chain model. Calculated values, to our surprise, are in excellent agreement with the measurements, especially when the effect of cascading and rescattering is empirically introduced in the calculations of the average transverse momenta. Implications of the results are discussed., Pokušavamo objasniti svojstva nekih vrlo važnih opservabli koje su u CERNu mjerili u najnovijim sudarima olovo–olovo i to na osnovi inačice modela lančastih nizova. Na naše iznenađenje, izračunate su vrijednosti u izvrsnom skladu s ishodima mjerenja, posebice kada se kaskade i višestruko raspršenje iskustveno uvedu u račun poprečnih impulsa. Raspravljaju se posljedice usporedbi.
- Published
- 2001
20. Production of J/$\Psi$-Particles at RHIC and LHC energies: An Alternative 'Psi'-chology
- Author
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Guptaroy, P., Sau, Goutam, Biswas, S. K., Bhattacharyya, S., Guptaroy, P., Sau, Goutam, Biswas, S. K., and Bhattacharyya, S.
- Abstract
We attempt here to understand successfully some crucial aspects of $J/\Psi$-production in some high energy nuclear collisions in the light of a non-standard framework outlined in the text. It is found that the results arrived at with this main working approach here is fairly in good agreement with both the measured data and the results obtained on the basis of some other models of the `standard' variety. Impact and implications of this comparative study have also been precisely highlighted in the end., Comment: 14 pages, 7 figures, to appear in Open Journal of Microphysics. arXiv admin note: substantial text overlap with arXiv:0906.2612, arXiv:1110.5582, and overlap with arXiv:1103.6269, arXiv:1007.4513
- Published
- 2012
- Full Text
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21. Ansatzs, Assumptions and Production of J/$\Psi$-Particles: A Non-'Charmed' Approach vs. the 'Charmed' Ones
- Author
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Guptaroy, P., Sau, Goutam, Bhattacharyya, S., Guptaroy, P., Sau, Goutam, and Bhattacharyya, S.
- Abstract
We would attempt, in this work, at dwelling upon some crucial aspects of $J/\Psi$-production in a few high energy nuclear collisions in the light of a non-standard model which is outlined in the text. The underlying physical ideas, assumptions and ansatzs have also been enunciated in some detail. It is found that the results arrived at with this main working approach here are fairly in good agreement with both the measured data and the results obtained on the basis of some other models of the `standard' variety. Impact and implications of this comparative study have also been precisely highlighted in the end., Comment: 8 pages, 7 figures
- Published
- 2011
- Full Text
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22. Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects
- Author
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Carpenter, Colleen, Zestos, Alexander G, Altshuler, Rachel, Sorenson, Roderick J, Guptaroy, Bipasha, Showalter, Hollis D, Kennedy, Robert T, Jutkiewicz, Emily, and Gnegy, Margaret E
- Abstract
Amphetamines (AMPHs) are globally abused. With no effective treatment for AMPH addiction to date, there is urgent need for the identification of druggable targets that mediate the reinforcing action of this stimulant class. AMPH-stimulated dopamine efflux is modulated by protein kinase C (PKC) activation. Inhibition of PKC reduces AMPH-stimulated dopamine efflux and locomotor activity. The only known CNS-permeant PKC inhibitor is the selective estrogen receptor modulator tamoxifen. In this study, we demonstrate that a tamoxifen analog, 6c, which more potently inhibits PKC than tamoxifen but lacks affinity for the estrogen receptor, reduces AMPH-stimulated increases in extracellular dopamine and reinforcement-related behavior. In rat striatal synaptosomes, 6c was almost fivefold more potent at inhibiting AMPH-stimulated dopamine efflux than [3H]dopamine uptake through the dopamine transporter (DAT). The compound did not compete with [3H]WIN 35,428 binding or affect surface DAT levels. Using microdialysis, direct accumbal administration of 1 μM 6c reduced dopamine overflow in freely moving rats. Using LC-MS, we demonstrate that 6c is CNS-permeant. Systemic treatment of rats with 6 mg/kg 6c either simultaneously or 18 h prior to systemic AMPH administration reduced both AMPH-stimulated dopamine overflow and AMPH-induced locomotor effects. Finally, 18 h pretreatment of rats with 6 mg/kg 6c s.c. reduces AMPH-self administration but not food self-administration. These results demonstrate the utility of tamoxifen analogs in reducing AMPH effects on dopamine and reinforcement-related behaviors and suggest a new avenue of development for therapeutics to reduce AMPH abuse.
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- 2017
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23. Transverse momentum spectra of pions in particle and nuclear collisions and some ratio behaviours: towards a combinational approach
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De, Bhaskar, primary, Bhattacharyya, S, additional, and Guptaroy, P, additional
- Published
- 2002
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24. Hadronic total cross sections at high and superhigh energies: updating some old models in the light of new data
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De, Bhaskar, primary, Bhattacharyya, S, additional, and Guptaroy, P, additional
- Published
- 2001
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25. Physics of particle collisions at high energies: Limits to phenomenology, Part 1.
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Goutam Sau, Biswas, S. K., De, Bhaskar, Guptaroy, P., Bhattacharya, A., and Bhattacharyya, S.
- Subjects
IONS ,LIGHT ,PHYSICS ,COLLISIONS (Nuclear physics) ,PHENOMENOLOGY ,PARTICLES (Nuclear physics) - Abstract
Copyright of Canadian Journal of Physics is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2008
- Full Text
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26. Physics of particle collisions at high energies: Limits to phenomenology, Part 2.
- Author
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Goutam Sau, Biswas, S. K., Bhaskar De, Guptaroy, P., Bhattacharya, A., and Bhattacharyya, S.
- Subjects
NUCLEAR physics ,IONS ,COLLISIONS (Nuclear physics) ,GOLD ,NICKEL ,PHENOMENOLOGY - Abstract
Copyright of Canadian Journal of Physics is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2008
- Full Text
- View/download PDF
27. Functional Diversity of Alternatively Spliced Isoforms of DrosophilaCa2+/Calmodulin-dependent Protein Kinase II
- Author
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GuptaRoy, Bipasha, Beckingham, Kathy, and Griffith, Leslie C.
- Abstract
Isoforms of calcium/calmodulin-dependent protein kinase II from Drosophila(R1-R6 and R3A) showed differential activation by two series of mutant calmodulins, B1K-B4K and B1Q-B4Q. These mutant calmodulins were generated by changing a glutamic acid in each of the four calcium binding sites to either glutamine or lysine, altering their calcium binding properties. All mutations produced activation defects, with the binding site 4 and B1Q mutants the most severe. Activation differed substantially between isoforms. R4, R5, and R6 were the least sensitive to mutations in calmodulin, while R1, R3, and R3A were the most sensitive. Activation of R1 and R2 by B4K and activation of R3 and R3A by B2K and B2Q produced significant (6-fold and almost 3-fold, respectively) differences in Kactbetween isoforms that differ structurally by a single amino acid. These differences could not be accounted for by differential binding, as all isoforms showed almost identical binding patterns with the mutants. High binding affinity did not always correlate with ability to increase enzyme activity, implying that activation occurs in at least two steps. The isoform-specific differences seen in this study reflect a role for the COOH-terminal variable region in activation of CaM kinase II.
- Published
- 1996
- Full Text
- View/download PDF
28. Functional diversity of alternatively spliced isoforms of Drosophila Ca2+/calmodulin-dependent protein kinase II. A role for the variable domain in activation.
- Author
-
GuptaRoy, B, Beckingham, K, and Griffith, L C
- Abstract
Isoforms of calcium/calmodulin-dependent protein kinase II from Drosophila (R1-R6 and R3A) showed differential activation by two series of mutant calmodulins, B1K-B4K and B1Q-B4Q. These mutant calmodulins were generated by changing a glutamic acid in each of the four calcium binding sites to either glutamine or lysine, altering their calcium binding properties. All mutations produced activation defects, with the binding site 4 and B1Q mutants the most severe. Activation differed substantially between isoforms. R4, R5, and R6 were the least sensitive to mutations in calmodulin, while R1, R3, and R3A were the most sensitive. Activation of R1 and R2 by B4K and activation of R3 and R3A by B2K and B2Q produced significant (6-fold and almost 3-fold, respectively) differences in Kact between isoforms that differ structurally by a single amino acid. These differences could not be accounted for by differential binding, as all isoforms showed almost identical binding patterns with the mutants. High binding affinity did not always correlate with ability to increase enzyme activity, implying that activation occurs in at least two steps. The isoform-specific differences seen in this study reflect a role for the COOH-terminal variable region in activation of CaM kinase II.
- Published
- 1996
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