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Objective. The present study aims to investigate the relationship between vitamin D deficiency and renin-angiotensin-aldosterone levels in patients with essential hypertension. Methods. The present study observed two groups of patients from Urumqi, Xinjiang, China, from April 2017 to March 2018. There were two subject groups: the hypertension group (80 patients with essential hypertension selected by random cluster sampling) and the control group (76 healthy adults). The 25-hydroxyvitamin D (25(OH)D or vitamin D) levels were measured through electrolytes; fasting blood glucose, blood lipids, and other biochemical indicators were detected using immune chemiluminescence; and plasma renin activity and angiotensin II concentrations were detected with radio-immunity. Results. Comparison between the hypertension group and control group showed statistically significant differences in the systolic pressure and levels of 25(OH)D, renin, and triglycerides ( P < 0.05 ). The correlation analysis showed that 25(OH)D was negatively correlated with renin (r = –0.185; P = 0.021 ) and positively correlated with systolic pressure (r = –0.105; P = 0.035 ). There were no statistically significant differences in diastolic pressure, fasting blood glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides between the two groups. Conclusions. The results of the present study show that vitamin D deficiency is common in Urumqi, Xinjiang, China and vitamin D levels are negatively correlated with renin levels. Vitamin D plays an important role in regulating blood pressure by affecting renin levels through the renin-angiotensin-aldosterone system.

Cav3.1, a subfamily of T-type calcium channel, is overexpressed in various human cancers and exerts important functions in tumor progression. This study is to identify the expression pattern and clinical significance of Cav3.1 in oral squamous cell carcinoma (OSCC). Firstly, the expression levels of Cav3.1 in oral mucosa (OM), dysplasia and oral squamous cell carcinoma (OSCC) were determined and compared by real-time quantitative PCR and Western blot analysis. After that, human tissue microarrays, containing 29 OM, 23 dysplasia and 122 primary OSCC samples, were applied to investigate the expression levels of Cav3.1, proliferation markers [Ki-67, proliferating cell nuclear antigen (PCNA)] and cellular anti-apoptosis markers [B cell lymphoma 2 (Bcl-2)] by immunohistochemistry and digital pathology analysis. In addition, we determined the function of Cav3.1 using knockdown assays of Cav3.1 in vitro. The results demonstrated that the mRNA and protein expression of Cav3.1 were significantly higher in OSCC specimens, and Cav3.1 expression in primary OSCCs was correlated with tumor size and pathological grade. Statistical analysis of immunohistochemical staining showed that Cav3.1 was closely correlated with Ki-67, PCNA and Bcl-2. Functional studies showed that the knockdown of Cav3.1 in OSCC cell lines using RNA interference influenced cell proliferation and apoptosis in vitro. Taken together, these findings suggested that Cav3.1 is overexpressed in OSCC tissues, also associated with proliferative and anti-apoptotic activity in oral squamous cell carcinoma.

The traditional bored pile technology has some arduous problems, such as the sediment at the pile tip, the mud skin along the pile shaft, and the stress release due to borehole construction. The post-grouted technology at the pile tip of bored pile has emerged because of demand. The grouting migration height (GMH) is of great significance to the strengthen and reinforcement of the pile foundation. This paper derives the calculation formula of the GMH based on the theory of the column hole expansion and Herschel-Bulkley model. The influence of relevant parameters on the GMH is discussed. Aiming at the problem of the grouting migration along the pile shaft in layered soils, the iterative calculation method of the GMH is proposed. The correctness of the GMH is verified by an engineering case, which can guide the engineering practice. The result shows that the GMH increases with the increase of the grouting pressure, the pile diameter and the thickness of the mud skin, and the grouting pressure is positively correlated with the GMH. The GMH decreases with the increase of the buried depth, the consistency coefficient and the rheological index. On this basis, the correctness of the GMH is verified by an engineering case.

Background To investigate the relationship between 24-hour urinary microalbumin (24h-UmAlb) and atrial arrhythmia in patients with essential hypertension (EH). Methods From March 2018 to January 2020, 917 EH patients at First Affiliated Hospital of Xinjiang Medical University were enrolled, and divided into nonatrial arrhythmia and atrial arrhythmia groups according to their 24-hour dynamic electrocardiography. The general clinical data and laboratory test parameters were compared. Results Compared with patients without atrial arrhythmia, the 24-UmAlb level was higher in patients with atrial arrhythmia (8.0, 5.0–19.7 vs. 7.5, 4.5–15.5 mg/24 hours, Z = −2.190, P < 0.05). Multivariate regression analysis showed that positive 24-UmAlb (odds ratio = 1.649, 95% confidence interval 1.065–2.554) and supine angiotensin II (odds ratio = 1.407, 95% confidence interval 1.034–1.914) were the risk factor for atrial arrhythmia in patients with EH after adjusted for left atrial diameter, age, course of hypertension, 24-hour systolic and diastolic blood pressure. Conclusions 24h-UmAlb is one of the risk factors for atrial arrhythmia in patients with EH.

Aim. Based on optical coherence tomography (OCT), we aimed to determine the diagnosis, clinical characteristics, and interventions of braid-like coronary arteries, which are rare and tend to be diagnosed as a woven coronary artery (WCA) anomaly. Methods and Results. We identified braid-like lesions on coronary angiography (CAG) in 7 patients (6 men; median age 47 years; age range 26 to 57 years). All patients were heavy smokers. Four patients were diagnosed with an old myocardial infarction and the other 3 with unstable angina. The braid-like lesions were located in the left anterior descending arteries in 2 patients and in the right coronary arteries in the other 5. TIMI grade 2 flow was observed in all involved vessels. OCT findings of all lesions were consistent with recanalization of organized thrombi, which consisted of septa that divided the lumen into multiple small cavities communicating with each other. No separate three-layered structure could be defined. Based on the significance of the stenosis and its related symptoms, drug-eluting stents were implanted in all of the lesions. All patients experienced symptomatic improvement after the intervention and were followed up event-free for 12 months. Conclusions. Braid-like coronary arteries are likely to undergo recanalization of organized thrombi rather than WCA according to our OCT findings. The majority of cases affect men who smoke heavily. Percutaneous stent implantation may be beneficial in selected patients when feasible.

A patch-based method for detecting vehicle logos using prior knowledge is proposed. By representing the coarse region of the logo with the weight matrix of patch intensity and position, the proposed method is robust to bad and complex environmental conditions. The bounding-box of the logo is extracted by a thershloding approach. Experimental results show that 93.58% location accuracy is achieved with 1100 images under various environmental conditions, indicating that the proposed method is effective and suitable for the location of vehicle logo in practical applications.

This article summarizes the current development situation of automotive integrated circuits, the origin of relevant domestic and foreign standards AEC Q100, IEC 61967, IEC 62132. In addition, this article introduces in detail the test methods of IEC 61967 and IEC 62132 standards, that is radiated emissions, radiated immunity, conducted emissions, conducted immunity, and gives a test block diagram of the relevant test methods. Finally, this article summarizes the status of domestic integrated circuit electromagnetic compatibility testing and standards

The pore water pressure of tailings dam has a very great influence on the stability of tailings dam. Based on the assumption of one-dimensional consolidation and small strain, the partial differential equation of pore water pressure is deduced. The obtained differential equation can be simplified based on the parameters which are constants. According to the characteristics of the tailings dam, the pore water pressure of the tailings dam can be divided into the slope dam segment, dry beach segment, and artificial lake segment. The pore water pressure is obtained through solving the partial differential equation by separation variable method. On this basis, the dissipation and accumulation of pore water pressure of the upstream tailings dam are analyzed. The example of typical tailings is introduced to elaborate the applicability of the analytic solution. What is more, the application of pore water pressure in tailings dam is discussed. The research results have important scientific and engineering application value for the stability of tailings dam.

Background subtraction is important process in many automatic video content analysis applications. extracting foreground moving objects from video sequences is a crucial step and also a hot topic in computer vision and image processing . This paper presents a new approach in image processing for detection crack in video. This method involves two main steps: First, we use based on Visual Background Extractor (Vibe) to detection moving crack in video. Second steps: Using a suitable threshold in a binary image and classifies all pixels two groups’ background and foreground. And use filter area and changes the area if less than the specific number to back; and using filtering to elimination of residual noise. This paper describes a method for detection crack in video we use Image Processing Techniques. The advantage of this method is clearly and accurate detection of cracks in video. Experimental work shows that our method is improved relatively to the other widely used techniques.

Aims - The objective of this study was to investigate the effect of a berberine derivative, berberine8998, on serum cholesterol and lipid levels in-vivo and to explore the mechanisms involved.Methods - Lipid lowering effect of berberine and berberine8998 was determined by high fat diet model on hamsters. Total cholesterol, low-density lipoprotein and triglycerides were analyzed. The potential target proteins on hamster liver were screened by iTRAQ labeled proteomics. The effect of berberine and berberine8998 on ACOX1 and ACSL1 was determined by western blot. Non-esterified fatty acids were analyzed to demonstrate its effect on triglyceride and fatty acid. Pharmacokinetics of berberine 8998 was conducted on SD rats.Results - Berberine8998 significant lowered the total cholesterol, triglycerides (TG) and LDL-c levels in hamsters. Bioinformatics revealed that berberine and berberine8998 shared similar metabolic pathways where fatty acid metabolism was the most dominant one. Western blot validation results showed that peroxisomal acyl-coenzyme A oxidase 1 (ACOX1), Long-chain-fatty-acid—CoA ligase 1 (ACSL1) a protein involved in fatty acid metabolism, expressed differently in berberine8998 group comparing with both model group and berberine treatment group. Further biochemistry results showed that berberine8998 significantly lowered the non-esterified fatty acid (NEFA), which may lead to the reduction of TG levels in berberine8998 treatment groups and the difference in proteomics. Pharmacokinetic study showed that berberine8998, could remarkably improve absorption by 6.7 times, comparing with berberine.Conclusion - These findings suggest that berberine8998 lowers both cholesterol and lipid with different mechanisms from berberine and is a promising therapeutic candidate for treating hypercholesterolemia and obesity.

The courses of computer programming language are important basic specialty courses for majors of science and technology in universities. These courses are often both highly abstract and practical, and many works involved in the teaching process are worth exploring and researching. Focusing on teaching methods of “C++ programming language” course, this paper presents our ideas and practice in performing teaching work in the course. In the paper, we discusses some important works in different teaching links, including textbook selection, courseware preparation, classroom teaching, practical ability training. Our practice has proved that, by adopting appropriate teaching methods to adapt to the actual situation in the teaching process, the teachers can control teaching process flexibly and improve teaching effectiveness and quality.

Background Accumulating evidence suggests that low concentrations of serum 25(OH)D is coupled with increased risks of hypertension, obesity, and cardiovascular disease. However, this relationship has not been established in populations with very low levels of 25(OH)D. Therefore, the aim of our study was to clarify the associations between 25(OH)D and blood pressure, obesity, sex, and lipid profiles in the Kazak ethnic population, who have an extremely low level of 25(OH)D. Material/Methods A multistage-cluster sampling survey was carried out for residents with Kazak ethnicity in Xinjiang, China. Anthropometric measurements of each participant were taken and the concentrations of 25(OH)D, calcium, alkaline phosphatase, and lipid profiles were measured. Individuals were classified into different groups in terms of vitamin D status, degree of adiposity, presence of hypertension, and other comorbidities. Results The madian concentration of 25(OH)D was 16.2 (11.8–20.5) ng/mL and the prevalence of vitamin D deficiency was 72.4% in this Kazak population (n=928, 59.0% women). Females had a lower 25(OH)D concentration than males – 14.6 (10.5–19.4) ng/mL vs. 17.7 (14.8–22.5) ng/mL, P

With continuous increase of the high tailings dam, it has an important practical and theoretical significance to study the mechanical characteristics of the tailings material under high pressures. It is indicated that strength envelopes of the tailings material have a remarkable nonlinear characteristics through the triaxial test under high pressures. A further study stated that the particle crushing has a critical effect on the mechanical behavior of the tailings material. In order to quantitatively research its influence, the grain size distribution of the tailings material is analyzed for pre-and post-test and the particle crushing of the tailings material is measured. The particle flow code is employed to simulate and monitor the sample during testing. Firstly, a model which considers the particle crushing is built under the plane strain condition. Then, a series of biaxial numerical tests of the tailings specimen are simulated by using the model. It is found that the simulation result agrees with the triaxial test. Finally, a law between the particle crushing and strain of the tailings material under different confining pressures is obtained.