1. Moderate to severe leukocytosis with vasopressor use is associated with increased mortality in trauma patients
- Author
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Hasjim, Bima J, Grigorian, Areg, Stopenski, Stephen, Swentek, Lourdes, Sun, Beatrice, Livingston, Joshua K, Williams, Barbara, Nastanski, Frank, and Nahmias, Jeffry
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Hematology ,Prevention ,Good Health and Well Being ,Leukemoid reaction ,leukocytosis ,trauma ,critical care ,white blood cell count ,inflammatory response ,complications ,vasopressors ,emergency medicine ,shock ,sepsis ,Clinical sciences - Abstract
BackgroundLeukocytosis is a rise in white blood cell (WBC) count and clinical outcomes of moderate to severe leukocytosis in trauma patients have not been described. We hypothesized that trauma patients with severe leukocytosis (SL; ≥40.0 × 109 leukocytes/L) have higher rates of in-hospital complications and mortality than those with moderate leukocytosis (ML; 25.0-39 × 109 leukocytes/L).MethodsWe performed a retrospective analysis (2010-2017) on trauma patients developing ML or SL at a single Level-I trauma center. A multivariable logistic regression analysis for risk factors were performed.ResultsFrom 15,807 trauma admissions, 332 (2.1%) had ML or SL. Of these, 308 (92.8%) were ML and 24 (7.2%) were SL. Patients with ML and SL reached their peak WBC count in 1 and 10 days after admission respectively (p
- Published
- 2022