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2. Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis

Author

Tominaga, Kentaro, Tsuchiya, Atsunori, Mizusawa, Takeshi, Matsumoto, Asami, Minemura, Ayaka, Oka, Kentaro, Takahashi, Motomichi, Yosida, Tomoaki, Kawata, Yuzo, Takahashi, Kazuya, Sato, Hiroki, Ikarashi, Satoshi, Hayashi, Kazunao, Mizuno, Ken-ichi, Tajima, Yosuke, Nakano, Masato, Shimada, Yoshifumi, Kameyama, Hitoshi, Yokoyama, Junji, Wakai, Toshifumi, and Terai, Shuji

Published
2021
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9. Machine learning prediction model for treatment responders in patients with primary biliary cholangitis.

Author

Kimura, Naruhiro, Takahashi, Kazuya, Setsu, Toru, Goto, Shu, Miida, Suguru, Takeda, Nobutaka, Kojima, Yuichi, Arao, Yoshihisa, Hayashi, Kazunao, Sakai, Norihiro, Watanabe, Yusuke, Abe, Hiroyuki, Kamimura, Hiroteru, Sakamaki, Akira, Yokoo, Takeshi, Kamimura, Kenya, Tsuchiya, Atsunori, and Terai, Shuji

Subjects
MACHINE learning, CHOLANGITIS, MEDICAL forecasting, URSODEOXYCHOLIC acid, RANDOM forest algorithms
Abstract

Background and Aim: Treatment response to ursodeoxycholic acid may predict the prognosis of patients with primary biliary cholangitis (PBC). Recent studies have suggested the benefits of using machine learning (ML) to forecast complex medical predictions. We aimed to predict treatment response in patients with PBC using ML and pretreatment data. Methods: We conducted a single‐center retrospective study and collected data from 194 patients with PBC who were followed up for at least 12 months after treatment initiation. Patient data were analyzed with five ML models, namely random forest, extreme gradient boosting (XGB), decision tree, naïve Bayes, or logistic regression, to predict treatment response using the Paris II criteria. The established models were assessed using an out‐of‐sample validation. The area under the curve (AUC) was used to evaluate the efficacy of each algorithm. Overall survival and liver‐related deaths were analyzed using Kaplan–Meier analysis. Results: Compared to logistic regression (AUC = 0.595, P = 0.0219, 0.031 models), ML analyses showed significantly high AUC in the random forest (AUC = 0.84) and XGB (AUC = 0.83) models; however, the AUC was not significantly high for decision tree (AUC = 0.633) or naïve Bayes (AUC = 0.584) models. Kaplan–Meier analysis showed significantly improved prognoses in patients predicted to achieve the Paris II criteria by XGB (log‐rank = 0.005 and 0.007). Conclusion: ML algorithms could improve treatment response prediction using pretreatment data, which could lead to better prognoses. In addition, the ML model using XGB could predict the prognosis of patients before treatment initiation. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Utility of autologous fecal microbiota transplantation and elucidation of microbiota in diversion colitis

Author

Tominaga, Kentaro, primary, Tsuchiya, Atsunori, additional, Mizusawa, Takeshi, additional, Matsumoto, Asami, additional, Minemura, Ayaka, additional, Oka, Kentaro, additional, Takahashi, Motomichi, additional, Yoshida, Tomoaki, additional, Kojima, Yuichi, additional, Ogawa, Kohei, additional, Kawata, Yuzo, additional, Nakajima, Nao, additional, Kimura, Naruhiro, additional, Abe, Hiroyuki, additional, Setsu, Toru, additional, Takahashi, Kazuya, additional, Sato, Hiroki, additional, Ikarashi, Satoshi, additional, Hayashi, Kazunao, additional, Mizuno, Ken‐ichi, additional, Yokoyama, Junji, additional, Tajima, Yosuke, additional, Nakano, Masato, additional, Shimada, Yoshifumi, additional, Kameyama, Hitoshi, additional, Wakai, Toshifumi, additional, and Terai, Shuji, additional

Published
2021
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12. Novel Strategy for Diagnosis of Focal Nodular Hyperplasia Using Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid: Enhanced Magnetic Resonance Imaging and Magnetic Resonance Elastography

Author

Takeda, Nobutaka, primary, Tsuchiya, Atsunori, additional, Natsui, Kazuki, additional, Ishii, Yui, additional, Arao, Yoshihisa, additional, Kimura, Naruhiro, additional, Tominaga, Kentaro, additional, Takeuchi, Suguru, additional, Hayashi, Kazunao, additional, Takamura, Masaaki, additional, and Terai, Shuji, additional

Published
2021
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15. Usefulness of ultrasonography to assess the response to steroidal therapy for the rare case of type 2b immunoglobulin G4-related sclerosing cholangitis without pancreatitis: A case report

Author

Tanaka, Yuto, primary, Kamimura, Kenya, additional, Nakamura, Ryota, additional, Ohkoshi-Yamada, Marina, additional, Koseki, Yohei, additional, Mizusawa, Takeshi, additional, Ikarashi, Satoshi, additional, Hayashi, Kazunao, additional, Sato, Hiroki, additional, Sakamaki, Akira, additional, Yokoyama, Junji, additional, and Terai, Shuji, additional

Published
2020
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18. Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review

Author

Tominaga, Kentaro, primary, Tsuchiya, Atsunori, additional, Sato, Hiroki, additional, Mizusawa, Takeshi, additional, Morita, Shinichi, additional, Ishii, Yui, additional, Takeda, Nobutaka, additional, Natsui, Kazuki, additional, Kawata, Yuzo, additional, Kimura, Naruhiro, additional, Arao, Yoshihisa, additional, Takahashi, Kazuya, additional, Hayashi, Kazunao, additional, Yokoyama, Junji, additional, and Terai, Shuji, additional

Published
2020
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20. Rare case of circumferential esophageal peeling

Author

Tominaga, Kentaro, primary, Tsuchiya, Atsunori, additional, Sato, Hiroki, additional, Ishii, Yui, additional, Takeda, Nobutaka, additional, Natsui, Kazuki, additional, Kawata, Yuzo, additional, Kimura, Naruhiro, additional, Arao, Yoshihisa, additional, Takeuchi, Suguru, additional, Hayashi, Kazunao, additional, Yokoyama, Junji, additional, and Terai, Shuji, additional

Published
2020
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26. Sa1391 - Risk Factors for Walled-Off Necrosis Associated with Severe Acute Pancreatitis: A Multicenter Retrospective Observational Study

Author

Ikarashi, Satoshi, primary, Hayashi, Kazunao, additional, Kawai, Hirokazu, additional, Kohisa, Junji, additional, Sato, Toshifumi, additional, Nozawa, Yujiro, additional, Morita, Shinichi, additional, Oka, Hiromitsu, additional, Sato, Munehiro, additional, Aruga, Yukio, additional, Yoshikawa, Seiichi, additional, and Terai, Shuji, additional

Published
2018
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27. Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor

Author

Hayashi, Kazunao, primary, Kamimura, Kenya, additional, Hosaka, Kazunori, additional, Ikarashi, Satoshi, additional, Kohisa, Junji, additional, Takahashi, Kazuya, additional, Tominaga, Kentaro, additional, Mizuno, Kenichi, additional, Hashimoto, Satoru, additional, Yokoyama, Junji, additional, Yamagiwa, Satoshi, additional, Takizawa, Kazuyasu, additional, Wakai, Toshifumi, additional, Umezu, Hajime, additional, and Terai, Shuji, additional

Published
2017
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30. A Mesenteric Desmoid Tumor with Rapid Progression

Author

Hayashi, Kazunao, primary, Takamura, Masaaki, additional, Yokoyama, Hisashi, additional, Sato, Yuichi, additional, Yamagiwa, Satoshi, additional, Nogami, Hitoshi, additional, Wakai, Toshifumi, additional, Hasegawa, Go, additional, and Terai, Shuji, additional

Published
2017
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31. Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis

Author

Sato, Hiroki, primary, Nakajima, Nao, additional, Takahashi, Kazuya, additional, Hasegawa, Go, additional, Mizuno, Ken-ichi, additional, Hashimoto, Satoru, additional, Ikarashi, Satoshi, additional, Hayashi, Kazunao, additional, Honda, Yutaka, additional, Yokoyama, Junji, additional, Sato, Yuichi, additional, and Terai, Shuji, additional

Published
2017
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32. Giant Hepatic Cyst with Septal Structure: Diagnosis and Management

Author

Sato, Toshihiro, Imai, Michitaka, Hayashi, Kazunao, Isokawa, Osamu, Nomura, Tatsuya, Tsuchiya, Yoshiaki, and Kawasaki, Takashi

Subjects
Article Subject
Abstract

The hepatic cyst is a common benign liver tumor, and no surgical treatment is necessary. However, it is difficult to correctly diagnose the giant hepatic cyst containing the solid septal structures inside, from the malignant cystadenocarcinomas. The various imaging modalities such as computed tomography, magnetic resonance imaging, and ultrasonography, have been developed and are useful for the diagnosis of these liver tumors. Reviewing the other reports in this paper, the combination of more than 2 modalities will help to diagnose these tumors; however, the malignant potential is unable to be excluded if the tumor is huge. Therefore, the surgical resection should be considered for the huge hepatic cysts with septal structures if the correct diagnosis is unable to be made. For example, when the hemorrhages cause the granulation in the septa which often shows neovascularization, the imaging modalities are unable to define this situation from the malignant tissue with hypervascularity. Therefore, with the careful review of other reports, we conclude that if the imaging studies show the possible malignant potential or the sizing-up is marked, the surgical treatment should be considered with the consent from the patients.

Published
2013
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33. Endoscopic Removal of Ingested Dentures and Dental Instruments: A Retrospective Analysis

Author

Mizuno, Ken-ichi, primary, Takahashi, Kazuya, additional, Tominaga, Kentaro, additional, Nishigaki, Yuki, additional, Sato, Hiroki, additional, Ikarashi, Satoshi, additional, Hayashi, Kazunao, additional, Yamamoto, Takashi, additional, Honda, Yutaka, additional, Hashimoto, Satoru, additional, Kamimura, Kenya, additional, Takeuchi, Manabu, additional, Yokoyama, Junji, additional, Sato, Yuichi, additional, Kobayashi, Masaaki, additional, and Terai, Shuji, additional

Published
2016
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34. The Combination Therapy of Dissolution Using Carbonated Liquid and Endoscopic Procedure for Bezoars: Pragmatical and Clinical Review

Author

Ogawa, Kohei, primary, Kamimura, Kenya, additional, Mizuno, Ken-ichi, additional, Shinagawa, Yoko, additional, Kobayashi, Yuji, additional, Abe, Hiroyuki, additional, Watanabe, Yukari, additional, Takahashi, Shunsaku, additional, Hayashi, Kazunao, additional, Yokoyama, Junji, additional, Takeuchi, Manabu, additional, Kobayashi, Masaaki, additional, Yamagiwa, Satoshi, additional, Sato, Yuichi, additional, and Terai, Shuji, additional

Published
2016
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35. The factors influencing long-term outcomes of stenting for malignant colorectal obstruction in elderly group in community medicine.

Author

Imai, Michitaka, Kamimura, Kenya, Takahashi, Yoshifumi, Sato, Toshihiro, Isokawa, Osamu, Maruyama, Masaki, Kobayashi, Takamasa, Hayashi, Kazunao, and Terai, Shuji

Subjects
COLON cancer treatment, PROCTOLOGY, ONCOLOGIC surgery complications, SURGICAL stents, BOWEL obstructions
Abstract

Purpose: Malignant bowel obstruction is a complication of colorectal carcinoma or metastasis from other carcinoma, and it causes significant damage on the condition of elderly patients; however, the self-expandable metallic stents (SEMSs) have been effectively used either for palliation or for bridging to the surgical procedure for this condition. The aim of this study was to investigate the factors influencing long-term outcomes of old-aged patients with SEMS for large bowel obstruction to develop the strategy for those patients in the community medicine. Methods: We performed a retrospective review of 42 patients with a median age of 83.0 years (range, 65-99 years), who underwent SEMS placement for malignant colorectal obstruction between 2006 and 2015 in our hospital. Univariate and multivariate logistic regressions were performed on data from the patients to assess the factors affecting 6-month survival without stent dysfunction. Results: The study population comprised 24 females (57.1%) and 18 males (42.9%). Of these, 38 patients (90.5%) received SEMS as palliation, whereas 4 patients (9.5%) underwent subsequent surgery. SEMSs were successfully inserted in 97.6% of patients. The median duration of follow-up was 205.0 days (range, 20-1377 days). On multivariate analysis, shorter stents (< 10 cm) yielded better outcomes than longer stents (≥ 10 cm) ( P = 0.041), and the Cox proportional hazard model also indicated that shorter stents ( P = 0.036) predicted longer event-free survival. Conclusions: Elderly patients with malignant bowel obstruction receiving shorter stents had longer event-free survival after stenting with better general condition. [ABSTRACT FROM AUTHOR]

Published
2018
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36. ヒト組織と神経芽腫におけるGATA-2の発現に関する研究

Author

林, 和直, Hayashi, Kazunao, 林, 和直, and Hayashi, Kazunao

Abstract

Globin transcription factor 2 (GATA-2) は造血細胞, 神経細胞, 泌尿生殖器細胞, 血管内皮細胞などに発現する転写調節因子 GATA family の一員である. 本研究では新たに作成された抗ヒトGATA-2抗体を用いて免疫組織学的染色を行い, ヒト成人において骨髄の前赤芽球, 骨髄芽球, 末梢血の肥満細胞, 血管内皮, 腎遠位尿細管上皮にGATA-2の発現を認めた. ヒト胎児では血管内皮, 副腎, 腎臓, 肝内造血細胞, 中枢神経細胞にGATA-2の発現を認めた. 神経芽腫ではロゼット構造をなす円形細胞の核にGATA-2の発現が高く, 分化が進んだ細線維型細胞ではGATA-2の発現は低下する傾向が強いことから, GATA-2の発現は予後を予想する因子となる可能性が示唆された. また, 4種の神経芽腫細胞株 (SH-SY5Y, GOTO, IMR-32, NB-1) の蛍光染色では核にGATA-2の発現を認めたが, GATAS-2発現のもっとも強いSH-SY5Yはオールトランスレチノイン酸を用いた分化誘導によって, GATA-2の蛋白とmRNAの発現は変化せず, 神経芽腫における分化度とGATA-2の発現の関係を再現することはできなかった. 本抗体を用いた免疫染色は神経芽腫の診断及び神経細胞や血球の分化の解析に有用と思われる.

Published
2011

37. Primary Malignant Mesothelioma of the Appendix

Author

Hayashi, Kazunao, primary, Takamura, Masaaki, additional, Sato, Yuichi, additional, Takahashi, Kumiko, additional, Sato, Hiromi, additional, Youkou, Kazumi, additional, Yokoyama, Hisashi, additional, Nomoto, Minoru, additional, Inoue, Chihiro, additional, Hasegawa, Go, additional, and Aoyagi, Yutaka, additional

Published
2012
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38. Comparison of Oral and Esophageal Microbiota in Patients with Achalasia Before and After Peroral Endoscopic Myotomy.

Author

Takahashi K, Sato H, Mizusawa T, Tominaga K, Ikarashi S, Hayashi K, Mizuno KI, Hashimoto S, Yokoyama J, and Terai S

Subjects
Adult, Aged, Aged, 80 and over, Esophageal Sphincter, Lower surgery, Esophagus microbiology, Female, Humans, Male, Middle Aged, Mouth microbiology, Postoperative Period, Preoperative Period, Prospective Studies, RNA, Ribosomal, 16S genetics, Treatment Outcome, Esophageal Achalasia microbiology, Esophageal Achalasia surgery, Esophageal Neoplasms microbiology, Esophageal Squamous Cell Carcinoma microbiology, Gastrointestinal Microbiome genetics, Myotomy methods, Natural Orifice Endoscopic Surgery methods
Abstract

Background/aims: Patients with achalasia have a high incidence of esophageal squamous cell carcinoma (ESCC), which may be associated with alterations in oral and esophageal microbiota caused by food stasis. This study compared the oral and esophageal microbiota of patients with achalasia before and after peroral endoscopic myotomy (POEM). It also compared patients with achalasia to those with ESCC., Materials and Methods: The study prospectively examined 6 patients with achalasia and 14 with superficial ESCC. Oral samples obtained from the buccal mucosa using a swab and esophageal samples obtained from the mid-esophagus using a brush via endoscopy were analyzed by 16S rRNA metagenome sequencing. Additionally, endoscopic and histological findings of patients with achalasia before and after POEM were prospectively compared., Results: In patients with achalasia, Streptococcus was most abundant in both the oral and the esophageal microbiota, and these microbiota were significantly different. Although the overall structure of the oral and esophageal microbiota did not change after POEM, the relative abundance rate of Haemophilus and Neisseria increased in the esophagus, and endoscopic findings of inflammation improved after POEM (P = .04). The relative abundance of microbiota was not different among patients with achalasia from those with ESCC., Conclusions: The oral and esophageal microbiota were significantly different in patients with achalasia, and some of the composition of the esophageal microbiota changed after POEM. However, these findings and disease-specific microbiota should be further evaluated in large-scale studies.

Published
2021
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