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6. Work-related asthma in France: recent trends for the period 2001–2009

Author

RNV3P, Paris, Christophe, Ngatchou-Wandji, Joseph, Luc, Amandine, McNamee, Roseanne, Bensefa-Colas, Lynda, Larabi, Lynda, Telle-Lamberton, Maylis, Herin, Fabrice, Bergeret, Alain, Bonneterre, Vincent, Brochard, Patrick, Choudat, Dominique, Dupas, Dominique, Garnier, Robert, Pairon, Jean-Claude, Agius, Raymond M, and Ameille, Jacques

Published
2012

7. Post-vaccination SARS-CoV-2 antibody kinetics and protection duration

Author

Dimeglio, Chloé, Herin, Fabrice, Da-Silva, Isabelle, Porcheron, Marion, Martin-Blondel, Guillaume, Chapuy-Regaud, Sabine, and Izopet, Jacques

Subjects
Kinetics, AcademicSubjects/MED00290, SARS-CoV-2, Correspondence, Vaccination, COVID-19, Humans, Antibodies, Viral
Published
2021

10. Occupational asbestos exposure and incidence of colon and rectal cancers in French men: the asbestos-related diseases cohort (ARDCo-Nut)

Author

Paris, Christophe, Thaon, Isabelle, Herin, Fabrice, Clin, Benedicte, Lacourt, Aude, Luc, Amandine, Coureau, Gaelle, Brochard, Patrick, Chammings, Soizick, Gislard, Antoine, Galan, Pilar, Hercberg, Serge, Wild, Pascal, Pairon, Jean-Claude, and Andujar, Pascal

Subjects
Environmental issues, Health
Abstract

BACKGROUND: The relationships between asbestos exposure and colorectal cancer remain controversial. OBJECTIVES: We examined the association between asbestos exposure and colorectal cancer incidence. METHODS: Volunteer retired workers previously exposed to asbestos were invited to participate in the French ARDCo screening program between 2003 and 2005. Additional data on risk factors for colorectal cancer were collected from the ARDCo-Nut subsample of 3,769 participants in 2011. Cases of colon and rectal cancer were ascertained each year through 2014 based on eligibility for free medical care following a cancer diagnosis. Survival regression based on the Cox model was used to estimate the relative risk of colon and rectal cancer separately, in relation to the time since first exposure (TSFE) and cumulative exposure index (CEI) to asbestos, and with adjustment for smoking in the overall cohort and for smoking, and certain risk factors for these cancers in the ARDCo-Nut subsample. RESULTS: Mean follow-up was 10.2 years among 14,515 men, including 181 colon cancer and 62 rectal cancer cases (41 and 17, respectively, in the ARDCo-Nut subsample). In the overall cohort, after adjusting for smoking, colon cancer was significantly associated with cumulative exposure (HR = 1.14; 95% CI: 1.04, 1.26 for a 1-unit increase in In-CEI) and [greater than or equal to] 20-40 years since first exposure (HR = 4.67; 95% CI: 1.92, 11.46 vs. 0-20 years TSFE), and inversely associated with 60 years TSFE (HR = 0.26; 95% CI: 0.10, 0.70). Although rectal cancer was also associated with TSFE 20-40 years (HR = 4.57; 95% CI: 1.14, 18.27), it was not associated with ln-CEI, but these findings must be interpreted cautiously due to the small number of cases. CONCLUSIONS: Our findings provide support for an association between occupational exposure to asbestos and colon cancer incidence in men. http://dx.doi.org/10.1289/EHP153, Introduction Asbestos exposure is associated with several malignancies including lung cancer, mesothelioma, and more recently, ovarian and laryngeal cancers (IARC 2012). However, the role of asbestos in the pathogenesis of [...]

Published
2017
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11. Work-related asthma in France: recent trends for the period 2001–2009

Author

Paris, Christophe, Ngatchou-Wandji, Joseph, Luc, Amandine, McNamee, Roseanne, Bensefa-Colas, Lynda, Larabi, Lynda, Telle-Lamberton, Maylis, Herin, Fabrice, Bergeret, Alain, Bonneterre, Vincent, Brochard, Patrick, Choudat, Dominique, Dupas, Dominique, Garnier, Robert, Pairon, Jean-Claude, Agius, Raymond M, and Ameille, Jacques

Published
2012
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13. Cancer bronchopulmonaire et expositions professionnelles : données du Réseau national de vigilance et de prévention des pathologies professionnelles (RNV3P) 2001–2016

Author

Paris, Christophe, Baldi, Isabelle, Bensefa-Colas, Lynda, Bloch, Juliette, Bonneterre, Vincent, Brunel, Serge, Clin-Godard, Bénédicte, Durand-Moreau, Quentin, Gain, Muriel, HERIN, Fabrice, Larabi, Lynda, Nisse, Catherine, Nourry, Nathalie, Vanrullen, Isabelle, Vongmany, Natalie, CHU-Hôpitaux de Rouen, CCPPE, Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Environnement et Prédiction de la Santé des Populations (TIMC-IMAG-EPSP), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Universitaire [Grenoble] (CHU), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital Morvan - CHRU de Brest (CHU - BREST ), Service de Pneumologie et de Pathologie Professionnelle, CHI Créteil, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de consultations de pathologies professionnelles [CHU Toulouse], CHU Toulouse [Toulouse], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Les Hôpitaux Universitaires de Strasbourg (HUS)

Subjects
030506 rehabilitation, 03 medical and health sciences, 0302 clinical medicine, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, Exposition professionnelle, 0305 other medical science, 030210 environmental & occupational health, Cancer bronchopulmonaire, Silice, ComputingMilieux_MISCELLANEOUS, Amiante
Abstract

International audience

Published
2018

14. Cancer colorectal et expositions professionnelles : données du Réseau national de vigilance et de prévention des pathologies professionnelles (RNV3P) 2001–2016

Author

CLIN, Benedicte, BALDI, Isabelle, BENSEFA-COLAS, Lynda, BLOCH, Juliette, BONNETERRE, Vincent, BRUNEL, Serge, DURAND-MOREAU, Quentin, GAIN, Murielle, HERIN, Fabrice, LARABI, Lynda, NISSE, Catherine, NOURRY, Nathalie, PARIS, Christophe, VANRULLEN, Isabelle, VONGMANY, Natalie, Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Environnement et Prédiction de la Santé des Populations (TIMC-IMAG-EPSP), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Universitaire [Grenoble] (CHU), Hôpital Morvan - CHRU de Brest (CHU - BREST ), Service de Pneumologie et de Pathologie Professionnelle, CHI Créteil, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de consultations de pathologies professionnelles [CHU Toulouse], CHU Toulouse [Toulouse], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Les Hôpitaux Universitaires de Strasbourg (HUS), and Centre Hospitalier Universitaire [Rennes]

Subjects
Cancer colorectal, 030506 rehabilitation, 03 medical and health sciences, Surveillance, 0302 clinical medicine, Expositions professionnelles, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, 0305 other medical science, 030210 environmental & occupational health, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

15. Cancers et expositions professionnelles : données du Réseau national de vigilance et de prévention des pathologies professionnelles (RNV3P) 2001–2016

Author

PARIS, Christophe, BALDI, Isabelle, BENSEFA-COLAS, Lynda, BLOC, Juliette, BONNETERRE, Vincent, BRUNEL, Serge, CLIN, Benedicte, DURAND-MOREAU, Quentin, GAIN, Muriel, HERIN, Fabrice, LARABI, Lynda, NISSE, Catherine, NOURRY, Nathalie, VANRULLEN, Isabelle, VONGMANY, Natalie, CHU-Hôpitaux de Rouen, CCPPE, Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Environnement et Prédiction de la Santé des Populations (TIMC-IMAG-EPSP), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Universitaire [Grenoble] (CHU), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital Morvan - CHRU de Brest (CHU - BREST ), Service de Pneumologie et Pathologie Professionnelle, CHI Créteil-Faculté de Médecine, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de consultations de pathologies professionnelles [CHU Toulouse], CHU Toulouse [Toulouse], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Les Hôpitaux Universitaires de Strasbourg (HUS)

Subjects
030506 rehabilitation, 03 medical and health sciences, Surveillance, 0302 clinical medicine, Expositions professionnelles, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, 0305 other medical science, 030210 environmental & occupational health, ComputingMilieux_MISCELLANEOUS, Cancer
Abstract

International audience

Published
2018

17. Working with argan cake: a new etiology for hypersensitivity pneumonitis

Author

Paris, Christophe, Herin, Fabrice, Reboux, Gabriel, Penven, Emmanuelle, Barrera, Coralie, Guidat, Cécile, Thaon, Isabelle, Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Centre de consultations de pathologies professionnelles [CHRU Nancy] (CCPP), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Maladies Professionnelles et Environnementales [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de parasitologie et mycologie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Département de Médecine du travail, Association Lorraine de Santé en Milieu de Travail (ALSMT), BMC, BMC, Service des Maladies Professionnelles et Environnementales, Université Fédérale Toulouse Midi-Pyrénées-Centre hospitalier universitaire de Toulouse - CHU Toulouse, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Interactions Gènes-Risques environnementaux et Effets sur la Santé ( INGRES ), Université de Lorraine ( UL ), Centre de consultations de pathologies professionnelles [CHRU Nancy] ( CCPP ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Epidémiologie et anlyses en santé publique: risques, maladies chroniques et handicaps, Université Paul Sabatier - Toulouse 3 ( UPS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Toulouse-Centre hospitalier universitaire de Toulouse - CHU Toulouse, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Service de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), and Association Lorraine de Santé en Milieu de Travail ( ALSMT )

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Sapotaceae, [ SDV ] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], Cosmetics, Argan, [SDV] Life Sciences [q-bio], Occupational diseases, Humans, Pulmonary Diffusing Capacity, Female, Tomography, X-Ray Computed, Bronchoalveolar Lavage Fluid, Lung, Hypersensitivity pneumonitis, Research Article, Alveolitis, Extrinsic Allergic
Abstract

Background Argan is now used worldwide in numerous cosmetic products. Nine workers from a cosmetic factory were examined in our occupational medicine department, following the diagnosis of a case of hypersensitivity pneumonitis (HP) related to handling of argan cakes. Methods Operators were exposed to three forms of argan (crude granulates, powder or liquid) depending on the step of the process. All workers systematically completed standardized questionnaires on occupational and medical history, followed by medical investigations, comprising, in particular, physical examination and chest X-rays, total IgE and a systematic screening for specific serum antibodies directed against the usual microbial agents of domestic and farmer’s HP and antigens derived from microbiological culture and extracts of various argan products. Subjects with episodes of flu-like syndrome several hours after handling argan cakes, were submitted to a one-hour challenge to argan cakes followed by physical examination, determination of Carbon Monoxide Diffusing Capacity (DLCO) and chest CT-scan on day 2, and, when necessary, bronchoalveolar lavage on day 4. Results Six of the nine workers experienced flu-like symptoms within 8 hours after argan handling. After challenge, two subjects presented a significant decrease of DLCO and alveolitis with mild lymphocytosis, and one presented ground glass opacities. These two patients and another patient presented significant arcs to both granulates and non-sterile powder. No reactivity was observed to sterile argan finished product, antigens derived from argan cultures (various species of Bacillus) and Streptomyces marokkonensis (reported in the literature to contaminate argan roots). Conclusions We report the first evidence of hypersensitivity pneumonitis related to argan powder in two patients. This implies preventive measures to reduce their exposure and clinical survey to diagnose early symptoms. As exposure routes are different and antibodies were observed against argan powder and not the sterile form, consumers using argan-based cosmetics should not be concerned. Electronic supplementary material The online version of this article (doi:10.1186/s12890-015-0013-3) contains supplementary material, which is available to authorized users.

Published
2015

18. Occupational Asbestos Exposure and Incidence of Colon and Rectal Cancers in French Men: The Asbestos-Related Diseases Cohort (ARDCo-Nut).

Author

Luc, Amandine, Paris, Christophe, Thaon, Isabelle, Gislard, Antoine, Galan, Pilar, Hercberg, Serge, Wild, Pascal, Pairon, Jean-Claude, Andujar, Pascal, Herin, Fabrice, Clin, Benedicte, Lacourt, Aude, Coureau, Gaelle, Brochard, Patrick, and Chamming's, Soizick

Subjects
OCCUPATIONAL disease prevention, AGE distribution, ASBESTOS, CONFIDENCE intervals, COLON tumors, MEN'S health, PROBABILITY theory, QUESTIONNAIRES, RESEARCH funding, RECTUM tumors, SMOKING, OCCUPATIONAL hazards, ENVIRONMENTAL exposure, RELATIVE medical risk, DISEASE incidence, PROPORTIONAL hazards models, DATA analysis software, DESCRIPTIVE statistics, EARLY detection of cancer, DIAGNOSIS, TUMOR risk factors, CANCER risk factors
Abstract

BACKGROUND: The relationships between asbestos exposure and colorectal cancer remain controversial. OBJECTIVES: We examined the association between asbestos exposure and colorectal cancer incidence. METHODS: Volunteer retired workers previously exposed to asbestos were invited to participate in the French ARDCo screening program between 2003 and 2005. Additional data on risk factors for colorectal cancer were collected from the ARDCo-Nut subsample of 3,769 participants in 2011. Cases of colon and rectal cancer were ascertained each year through 2014 based on eligibility for free medical care following a cancer diagnosis. Survival regression based on the Cox model was used to estimate the relative risk of colon and rectal cancer separately, in relation to the time since first exposure (TSFE) and cumulative exposure index (CEI) to asbestos, and with adjustment for smoking in the overall cohort and for smoking, and certain risk factors for these cancers in the ARDCo-Nut subsample. RESULTS: Mean follow-up was 10.2 years among 14,515 men, including 181 colon cancer and 62 rectal cancer cases (41 and 17, respectively, in the ARDCo-Nut subsample). In the overall cohort, after adjusting for smoking, colon cancer was significantly associated with cumulative exposure (HR = 1.14; 95% CI: 1.04, 1.26 for a 1-unit increase in ln-CEI) and ≥ 20-40 years since first exposure (HR = 4.67; 95% CI: 1.92, 11.46 vs. 0-20 years TSFE), and inversely associated with 60 years TSFE (HR = 0.26; 95% CI: 0.10, 0.70). Although rectal cancer was also associated with TSFE 20-40 years (HR = 4.57; 95% CI: 1.14, 18.27), it was not associated with ln-CEI, but these findings must be interpreted cautiously due to the small number of cases. CONCLUSIONS: Our findings provide support for an association between occupational exposure to asbestos and colon cancer incidence in men. CITATION: Paris C, Thaon I, Hérin F, Clin B, Lacourt A, Luc A, Coureau G, Brochard P, Chamming's S, Gislard A, Galan P, Hercberg S, Wild P, Pairon JC, Andujar P. 2017. Occupational asbestos exposure and incidence of colon and rectal cancers in French men: the Asbestos-Related Diseases Cohort (ARDCo-Nut). Environ Health Perspect 125:409-45; http://dx.doi. org/10.1289/EHP153 [ABSTRACT FROM AUTHOR]

Published
2017
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