1. Association of Health Status Scores With Cardiovascular and Limb Outcomes in Patients With Symptomatic Peripheral Artery Disease: Insights From the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) Trial
- Author
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Rymer, Jennifer A, Mulder, Hillary, Smolderen, Kim G, Hiatt, William R, Conte, Michael S, Berger, Jeffrey S, Norgren, Lars, Mahaffey, Kenneth W, Baumgartner, Iris, Fowkes, F Gerry, Katona, Brian G, Rockhold, Frank, Jones, W Schuyler, and Patel, Manesh R
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Trials and Supportive Activities ,Cardiovascular ,Clinical Research ,Good Health and Well Being ,Cardiovascular Diseases ,Double-Blind Method ,Female ,Health Status Indicators ,Humans ,Lower Extremity ,Male ,Middle Aged ,Outcome Assessment ,Health Care ,Peripheral Arterial Disease ,Platelet Aggregation Inhibitors ,Quality of Life ,Surveys and Questionnaires ,Symptom Assessment ,Ticagrelor ,Vascular Surgical Procedures ,Visual Analog Scale ,health status instruments ,peripheral artery disease ,quality of life ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Background There are limited data on health status instruments in patients with peripheral artery disease and cardiovascular and limb events. We evaluated the relationship between health status changes and cardiovascular and limb events. Methods and Results In an analysis of the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) trial, we examined the characteristics of 13 801 patients by tertile of health status instrument scores collected in the trial (EuroQol 5-Dimensions [EQ-5D], EQ visual analog scale [VAS], and peripheral artery questionnaire). We assessed the association between the baseline health status measurements and major adverse cardiovascular events, major adverse limb events, and lower-extremity revascularization procedures during trial follow-up and the association between 12-month health status change scores and subsequent end points during follow-up. There were 13 217 (95%) patients with EQ-5D scores, 13 533 (98%) with VAS scores, and 4431 (32%) with peripheral artery questionnaire scores. Patients in the lowest baseline EQ-5D tertile (0 to
- Published
- 2020