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An unmanned merchant vessel seems to be escaping from the stage of idea exploration. Once the concept proofs its safety, it may become a part of maritime reality. Although the safety aspect of such a ship has been addressed by a handful of scholars, the problem remains open. This is mainly due to lack of knowledge regarding actual operational circumstances and design of unmanned ships, which are yet to be developed. In the attempt of bridging this gap, the risk analysis associated with unmanned ships needs to be carried out, where all relevant hazards and consequences are assessed and quantified in systematic manner. In this paper we present the results of a first step of such analysis, namely the hazard analysis associated with the unmanned ships. The list of hazards covers various aspects of unmanned shipping originating from both design and operational phases of vessel's life. Subsequently the hazards and related consequences are organized in a casual manner, resulting in the development of a structure of a risk model. [ABSTRACT FROM AUTHOR]

During the course of infection with HIV-1, striking alterations in the subset distribution of peripheral blood γδ T cells are observed. While TCE Vδ2 expression dominates among peripheral blood γδ T cells in healthy adults, there is a clear preponderance of Vδ1 cells in HIV-1 infected persons. In this study, we present the first flow cytometry (FCM) analysis of the complete TCR Vγ gene repertoire in HIV-1-infected individuals using a panel of mAb against all expressed Vγ genes. The quantitative analysis of TCR Vγ transcripts after amplification of cDNA by inverse PCR suggested that Vγ5 usage is increased in HIV-1+ donors. This was confirmed by FCM with a new anti-Vγ5 mAb. In addition, all members of the TCR VγI gene family (i.e. Vγ2, 3, 4, 5 and 8) were expressed on significantly higher percentages of γδ T cells in HIV+ as compared to HIV- donors, whereas VγII (Vγ9) expression was drastically reduced. No preferential association of the expanded Vδ1+ cells with a particular Vγ gene was observed in HIV-1+ donors. These results indicate that the increase in Vδ1+ cells during HIV-1 infection occurs independently of the Vγ gene usage and support the hypothesis that a Vδ1-selective ligand might be involved. [ABSTRACT FROM PUBLISHER]

Background/objectives: The COVID-19 pandemic created a growing need for insights into the mental health of children and youth and their use of coping mechanisms during this period. We assessed mood symptoms and related factors among children and youth in Saskatchewan. We examined if coping abilities mediated the relationship between risk factors and mood states., Methods: "See Us, Hear Us 2.0", a cross-sectional study of 563 child-parent dyads, provided the data. The dependent variable, current mood state, was measured by the CoRonavIruS health Impact Survey (CRISIS) scale. Independent variables included sociodemographics, behaviors, household conditions, and coping ability. Multiple linear regression and mediation analyses were conducted, ensuring sample representativeness with sampling weights and addressing missing data through multiple imputations., Results: The participants reported mood symptoms ("moderate" to "extreme") ranging from 23% to 38% on the CRISIS scale. Factors such as older children, hybrid learning, disrupted activities, and increased screen time worsened moods. The ethnic minority groups (BIPOC) living in mid-sized cities/towns experienced more negative moods compared to Whites residing in cities. Coping ability mediated the relationship between extracurricular activities and mood states., Conclusions: Our results underscore the importance of tailored interventions, recognizing the diverse needs of specific age groups, gender identities, and ethnicities and addressing the adverse effects of the pandemic-related disruptions on the mental health and well-being of school children in Saskatchewan. Our study also suggests prioritizing the diverse needs of children and youth during the planning and implementation of mental health services in the province.

Purpose: To examine the lived experiences of children and adolescents coping with mental health issues and seeking mental health services in Saskatchewan during the COVID-19 pandemic., Methods: In our descriptive phenomenological qualitative study, we interviewed forty-six individuals, including children aged 8-15 and their parents. Thematic analysis was applied to interpret the interview data., Results: Our analysis identified three key themes: pyscho-behavioural impact, academic impact, and social impact. The pandemic adversely affected children due to factors like changes in behaviours such as increased screen time and decreased physical activity, limited access to mental health services, and disruptions to schooling and social interactions. Coping mechanisms varied, ranging from the utilization of available mental health supports and services to individual and family-based strategies. Disparities in timely access to mental health services were evident, with financially stable families accessing private services, while others struggled, particularly in rural areas. Families demonstrated resilience through parental efforts to seek balance and prioritize safety amidst COVID-19 challenges., Conclusions: Social connectedness served as a crucial buffer against pandemic-induced stress. Children faced difficulty in accessing timely mental health services and supports. Echoing participant experiences, our findings emphasize the urgency of targeted interventions and policy adjustments to address existing gaps in mental health service accessibility and availability.

Over the year of 2015, about 800.000 refugees arrived in Germany, a number which equals around one percent of the total population. This migration process was labelled the refugee crisis and was accompanied by a contested debate. On the one hand, there was a widespread willingness to voluntarily help arriving refugees, on the other hand, the number of xenophobic attacks against refugees drastically increased. Our paper will focus on a specific form of xenophobic violence with a strong symbolic meaning: We analyze how arson attacks against collective accommodation facilities spread. Using a comprehensive web chronicle, we collected temporal and spatial data about arson attacks perpetrated on accommodations or facilities for refugees in Germany between 2015 and 2017. We counted 251 attacks, assigned each incident location to its county, merged county characteristics such as population size, proportion of foreigners, right-wing party support, and-going beyond previous research-added geographically coded media data from two digital archives. Besides newspaper contents of a popular nation-wide tabloid, we use a data base that covers local fake news on refugees. Based on these data, we constructed a balanced panel data set with the counties as geographical units and periods of 14 days as the time dimension. Results indicate that social contagion drives the diffusion process of arson attacks. Spatial proximity of previous attacks increased the propensity of attacks in the neighboring counties. Attacks were more likely to occur in counties with larger populations and fewer foreigners. While local newspaper coverage did not impact the diffusion of xenophobic attacks, fake news were relevant-but only in East Germany. We also considered two particularly salient threatening events that received nation-wide media attention, namely Merkel's "border opening" on the 5th of September 2015 and the sexual assaults occurring during New Year's 2015/16 in Cologne. Both were followed by temporary increases in violence., Competing Interests: NO authors have competing interests., (Copyright: © 2023 Hinz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

For children and youth, the COVID-19 pandemic surfaced at a critical time in their development. Children have experienced extended disruptions to routines including in-person schooling, physical activities, and social interactions-things that bring meaning and structure to their daily lives. We estimated the prevalence of anxiety and depression symptoms of children and youth and their experiences of health-related quality of life (HRQoL), during the first year of the pandemic, and identified factors related to these outcomes. Further, we examined these effects among ethnocultural minority families. We conducted an online survey (March-July 2021) with 510 children and youth aged 8-18 years and their parents/caregivers. The sample was representative of the targeted population. We modelled the relationship between anxiety, depression (measured using the Revised Child Anxiety and Depression Scale), HRQoL (measured using KIDSCREEN-10), and sociodemographic, behavioural, and COVID-19-contributing factors using binary logistic regression. A priori-selected moderating effects of sociodemographic characteristics and self-identified ethnocultural minority groups on the outcomes were tested. The point-in-time prevalence of medium-to-high anxiety symptoms and depression symptoms was 10.19% and 9.26%, respectively. Almost half (49.15%) reported low-to-moderate HRQoL. Children reporting medium-to-high anxiety symptoms, depression symptoms, and low-to-moderate HRQoL were more likely to be aged 8-11 years, 16-18 years, ethnocultural minority participants, living in rural/urban areas, having good/fair MH before COVID-19, experiencing household conflicts, having less physical activity, and having ≥3 h of recreational screen time. Those who had more people living at home and ≥8 h of sleep reported low anxiety and depression symptoms. Ethnocultural minority 16-18-year-olds were more likely to report low-to-moderate HRQoL, compared to 12-15-year-olds. Additionally, 8-11-year-olds, 16-18-year-olds with immigrant parents, and 16-18-year-olds with Canadian-born parents were more likely to report low-moderate HRQoL, compared to 12-15-year-olds. Children and youth MH and HRQoL were impacted during the pandemic. Adverse MH outcomes were evident among ethnocultural minority families. Our results reveal the need to prioritize children's MH and to build equity-driven, targeted interventions.

The literature on social and wealth inequality has long acknowledged the importance of intergenerational wealth transmission (IWT) to inequality in homeownership tenure. However, it has paid insufficient attention to the institutional structures that moderate these inequalities. Therefore, in this study, we ask how institutional factors via differential housing finance systems and governmental housing policies, moderate the association between IWT and homeownership tenure. This is done by using the framework of housing regime configurations and mortgage market financialization. To do so, we pooled data for 20 European countries from the European Central Bank's Household Finance and Consumption Survey (HFCS) for 2010-2017, for household heads aged 25-40. Our main findings show consistent contradiction to the welfare state-homeownership "trade-off" hypothesis: that is, when the rental market is more heavily regulated, it is actually young adults who benefited from IWT or who received higher value of IWT have a higher probability of mortgaged homeownership. Paradoxically, when housing finance institutions are more active and generous, the wealthiest young adults hold an advantage in mortgaged homeownership. Therefore, liberal mortgage markets actually serve to enable wealthier young adults to reproduce and preserve their parental wealth status. Further, when housing prices are less affordable (median mortgage-to-income ratio), those who have received a higher amount of IWT hold an advantage in mortgaged homeownership. We discuss the implications of our findings, which cut across the socioeconomic, spatial, and demographical arenas., Competing Interests: The authors have declared that no competing interests exist.

Unlimited paid time off policies are currently fashionable and widely discussed by HR professionals around the globe. While on the one hand, paid time off is considered a key benefit by employees and unlimited paid time off policies (UPTO) are seen as a major perk which may help in recruiting and retaining talented employees, on the other hand, early adopters reported that employees took less time off than previously, presumably leading to higher burnout rates. In this conceptual review, we discuss the theoretical and empirical evidence regarding the potential effects of UPTO on leave utilization, well-being and performance outcomes. We start out by defining UPTO and placing it in a historical and international perspective. Next, we discuss the key role of leave utilization in translating UPTO into concrete actions. The core of our article constitutes the description of the effects of UPTO and the two pathways through which these effects are assumed to unfold: autonomy need satisfaction and detrimental social processes. We moreover discuss the boundary conditions which facilitate or inhibit the successful utilization of UPTO on individual, team, and organizational level. In reviewing the literature from different fields and integrating existing theories, we arrive at a conceptual model and five propositions, which can guide future research on UPTO. We conclude with a discussion of the theoretical and societal implications of UPTO., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 de Bloom, Syrek, Kühnel and Vahle-Hinz.)

Childhood and adolescence are important life periods for the development of health status and physical activity (PA) behaviours. This study analyses the stability and potential changes of self-rated health status, overweight and PA behaviour over time, specifically focusing on the age and the socioeconomic status of children and adolescents. We employ representative longitudinal data for German children and adolescents from the Motorik-Modul Study and the German Health Interview and Examination Survey. Using four different dichotomous health status and PA indicators (self-rated health status [SRHS]; overweight; moderate-to-vigorous PA; and leisure sports engagement), we report within-person transition rates across the panel waves when the survey was taken (2003-2006, 2009-2012, and 2014-2017). Additionally, we report results of logistic regressions estimating the impact of children's age, gender, migration background, and their parents' socioeconomic status on these transition rates. The transition rates show mixed results. While children and adolescents from highly problematic states reporting bad SRHS and no leisure sports engagement at an early stage tend to improve later on, overweight children mostly stay overweight. Age and social inequality indicators correlate with some of the chances of improving or worsening the health and PA states. Most clearly, high parental status prevents the health status and PA from worsening over all transitions, particularly becoming overweight, representing a ratchet effect. The results of the present study underline that health policy needs to target specific groups to reduce social inequality in the health status and PA of children and adolescents., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Rittsteiger, Hinz, Oriwol, Wäsche, Schmidt, Kolb and Woll.)

Generative adversarial networks conditioned on textual image descriptions are capable of generating realistic-looking images. However, current methods still struggle to generate images based on complex image captions from a heterogeneous domain. Furthermore, quantitatively evaluating these text-to-image models is challenging, as most evaluation metrics only judge image quality but not the conformity between the image and its caption. To address these challenges we introduce a new model that explicitly models individual objects within an image and a new evaluation metric called Semantic Object Accuracy (SOA) that specifically evaluates images given an image caption. The SOA uses a pre-trained object detector to evaluate if a generated image contains objects that are mentioned in the image caption, e.g., whether an image generated from "a car driving down the street" contains a car. We perform a user study comparing several text-to-image models and show that our SOA metric ranks the models the same way as humans, whereas other metrics such as the Inception Score do not. Our evaluation also shows that models which explicitly model objects outperform models which only model global image characteristics.

Background: Participation in sports and physical activity (PA) is a critical resource for children's health and social development. This study analyzes how the parental socioeconomic status (SES) of children and adolescents affects their PA in sports clubs (organized sports) and outside of sports clubs (unorganized sports) and tests whether the potential impact of parental SES is mediated by the opportunity structure of their residential area (walkability, infrastructure, etc.) and by family and peer support for PA. Furthermore, PA is analyzed respecting differences by gender and migration background., Methods: Using representative data from the MoMo/KiGGS study (2009-2012 and 2014-2017), we take into account about 8000 measurements from about 7000 subjects. We estimate hurdle regression models to analyze the minutes per week spent on sports activities., Results: Results show that children with a higher parental SES, children living in areas with many opportunities for PA, and children receiving family and peer support are more physically active than children without these features. Controlled for opportunities and support, status effects are small but visible. The differences regarding parental SES are much more apparent for organized sports than for unorganized sports, indicating the relevance of economic resources. Boys are more active than girls, whereas there is no clear effect of migration background., Conclusions: The coefficient of parental SES on organized sports most probably relates to the resources needed to participate in sports clubs, including fees and equipment. Lower membership fees might potentially help to integrate children with low parental SES into sports clubs and thereby make organized sports more accessible to all social classes., (© 2021. The Author(s).)

Human infants are able to acquire natural language seemingly easily at an early age. Their language learning seems to occur simultaneously with learning other cognitive functions as well as with playful interactions with the environment and caregivers. From a neuroscientific perspective, natural language is embodied, grounded in most, if not all, sensory and sensorimotor modalities, and acquired by means of crossmodal integration. However, characterizing the underlying mechanisms in the brain is difficult and explaining the grounding of language in crossmodal perception and action remains challenging. In this paper, we present a neurocognitive model for language grounding which reflects bio-inspired mechanisms such as an implicit adaptation of timescales as well as end-to-end multimodal abstraction. It addresses developmental robotic interaction and extends its learning capabilities using larger-scale knowledge-based data. In our scenario, we utilize the humanoid robot NICO in obtaining the EMIL data collection, in which the cognitive robot interacts with objects in a children's playground environment while receiving linguistic labels from a caregiver. The model analysis shows that crossmodally integrated representations are sufficient for acquiring language merely from sensory input through interaction with objects in an environment. The representations self-organize hierarchically and embed temporal and spatial information through composition and decomposition. This model can also provide the basis for further crossmodal integration of perceptually grounded cognitive representations., (Copyright © 2020 Heinrich, Yao, Hinz, Liu, Hummel, Kerzel, Weber and Wermter.)

Workplace incivility is a low-intensity, counterproductive work behavior associated with negative health outcomes and organizational consequences (e.g., turnover intention). In the present study, I used a daily diary design to investigate the short-term within-person effects of workplace incivility on work-related rumination. Time pressure was included in the present study to underline the importance of workplace incivility for off-work ruminative thoughts beyond the known effects of a stressful workday. Additionally, I propose mood at the end of the workday as a mediator for the proposed relationships. The results of my study corroborate the existence of the daily within-person and the more stable weekly between-person effect of workplace incivility on off-work ruminative thoughts. These results suggest that the experience of short-term and fluctuating workplace incivility has an impact on off-work ruminative thinking even when controlling for the known effects of time pressure. With regard to my proposed mediational effect, my hypothesis was not confirmed. In an additional analysis, however, mediation was confirmed when time pressure was excluded from the model. Further, the within-person relationship between time pressure and work-related rumination was mediated by mood.

Drawing on social resource theory and the norm of equity, this research proposes fairness of task distribution as a mediating mechanism of the well-established relationship between transformational leadership and followers' well-being, conceptualizing the latter as low emotional exhaustion. Using data from 479 German employees in a three-wave longitudinal study, we found transformational leadership to be related to fair task distribution over time. The perceived fairness of task distribution mediated the relationship between transformational leadership and follower emotional exhaustion (structural equation modeling) when excluding stabilities. Our results also show a reverse causation effect for emotional exhaustion and transformational leadership over a longer time period (within 20 months), suggesting a circular process, as well as a mediation by fairness of task distribution when excluding stabilities. The findings emphasize the importance of fair task distribution by leaders for followers' well-being., (Copyright © 2019 Scheel, Otto, Vahle-Hinz, Holstad and Rigotti.)

The problem of generating structured Knowledge Graphs (KGs) is difficult and open but relevant to a range of tasks related to decision making and information augmentation. A promising approach is to study generating KGs as a relational representation of inputs (e.g., textual paragraphs or natural images), where nodes represent the entities and edges represent the relations. This procedure is naturally a mixture of two phases: extracting primary relations from input, and completing the KG with reasoning. In this paper, we propose a hybrid KG builder that combines these two phases in a unified framework and generates KGs from scratch. Specifically, we employ a neural relation extractor resolving primary relations from input and a differentiable inductive logic programming (ILP) model that iteratively completes the KG. We evaluate our framework in both textual and visual domains and achieve comparable performance on relation extraction datasets based on Wikidata and the Visual Genome. The framework surpasses neural baselines by a noticeable gap in reasoning out dense KGs and overall performs particularly well for rare relations., (Copyright © 2019 Mao, Yao, Heinrich, Hinz, Weber, Wermter, Liu and Sun.)

This paper describes an extension of the high efficiency video coding (HEVC) standard for coding of multi-view video and depth data. In addition to the known concept of disparity-compensated prediction, inter-view motion parameter, and inter-view residual prediction for coding of the dependent video views are developed and integrated. Furthermore, for depth coding, new intra coding modes, a modified motion compensation and motion vector coding as well as the concept of motion parameter inheritance are part of the HEVC extension. A novel encoder control uses view synthesis optimization, which guarantees that high quality intermediate views can be generated based on the decoded data. The bitstream format supports the extraction of partial bitstreams, so that conventional 2D video, stereo video, and the full multi-view video plus depth format can be decoded from a single bitstream. Objective and subjective results are presented, demonstrating that the proposed approach provides 50% bit rate savings in comparison with HEVC simulcast and 20% in comparison with a straightforward multi-view extension of HEVC without the newly developed coding tools.

Optical coherence tomography (OCT) is a new imaging method with promising results for several dermatological indications, including preoperative skin tumour characterization. While high-frequency ultrasound (HFUS) is frequently used for this purpose, overestimation of tumour thickness is a problem, due to subtumoral inflammatory infiltration that cannot be differentiated from tumour tissue. The aim of this single-centre study was to describe OCT features of basal cell carcinoma (BCC) and to determine vertical tumour thickness accurately, including a comparison with HFUS and histopathology. Tumour thickness values of 10 BCCs measured by OCT did not differ significantly from those measured by histopathology (median difference 0.12 mm). By contrast, the difference between HFUS and histopathology was greater (median difference 0.3 mm). A Pearson's correlation coefficient of 0.83 showed a stronger correlation of OCT in measuring tumour thickness compared with HFUS (0.59). Bland-Altman plots revealed a better agreement of OCT and histopathology concerning tumour thickness measurements. On the basis of this explorative study cohort, OCt was more exact than HFUS in preoperative tumour thickness estimation of BCCs compared with histopathological measurements.

The human T-cell death-associated gene 51 (TDAG51) is upregulated upon lymphocyte stimulation and in the context of ER stress. Moreover, TDAG51 plays a role in programmed cell death and tumorigenesis. We performed an extensive TDAG51 promoter analysis and found a strong CpG-rich bidirectional promoter within the first 582 nucleotides of the TDAG51 reference DNA complementary to RNA (cDNA). Upon stimulation of primary human T cells, this promoter modulated the downregulation of a newly detected head-to-head oriented transcript. Mapping of the transcription start points revealed that the 5' regions of the TDAG51 mRNA and of the newly identified transcript did not overlap in T cells. Thus, the TDAG51 locus shows an operon-like organization of two head-to-head oriented transcripts that are inversely regulated in T lymphocytes by a CpG-rich bidirectional promoter.

Inverse RT-PCR was used for detecting doxycycline-induced mRNA expression after viral transduction with a retroviral vector harboring human TDAG51. After the circularization of double-stranded cDNA, induced transcripts originating from integrated vector genomes were selectively amplified, even in the presence of DNA templates. Thus, DNase treatment before amplification was unnecessary.

This study examines the conditions under which an intervening lineup affects identification accuracy on a subsequent lineup. One hundred and sixty adults observed a photograph of one target individual for 60 s. One week later, they viewed an intervening target-absent lineup and were asked to identify the target individual. Two days later, participants were shown one of three 6-person lineups that included a different photograph of the target face (present or absent), a foil face from the intervening lineup (present or absent), plus additional foil faces. The hit rate was higher when the foil face from the intervening lineup was absent from the test lineup and the false alarm rate was greater when the target face was absent from the test lineup. The results suggest that simply being exposed to an innocent suspect in an intervening lineup, whether that innocent suspect is identified by the witness or not, increases the probability of misidentifying the innocent suspect and decreases the probability of correctly identifying the true perpetrator in a subsequent test lineup. The implications of these findings both for police lineup procedures and for the interpretation of lineup results in the courtroom are discussed.

Background and Objectives: Hepatosplenic gd T-cell lymphoma is a rare entity of peripheral T-cell lymphomas. We characterized in detail the first case of hepatosplenic gd -T-cell lymphoma following acute myeloid leukemia., Design and Methods: Hepatosplenic gd -T-cell lymphoma was diagnosed in a woman who had been in complete remission (CR) of acute myeloid leukemia (AML) for two years. Improvement but no objective response of the disease was observed after various types of chemotherapy. CR was achieved after related donor stem cell transplantation. Thirteen months later relapse of hepatosplenic gd T-cell lymphoma was diagnosed. While being prepared for a second transplantation the patient developed meningeal lymphoma and died. The patient's lymphoma cells were studied by immunologic, functional and molecular techniques., Results: Lymphoma cells expressed the gd T-cell receptor (TCR), CD2, CD3, CD5, CD7, CD38, CD45, CD161 (NKR-P1), TIA and Ki67. Further analysis revealed expression of Vd1 and two distinct TCRg chains, Vg3 and Vg9, by the malignant cell clone. The clonality of the T-cells was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) followed by sequencing of TCR Vg3, Vg9 and Vd1 junctional regions. Clone-specific PCR was negative at diagnosis of AML and was positive at all times during follow-up of the hepatosplenic gd T-cell lymphoma. The lymphoma cells mediated strong natural killer cell-like cytotoxic activity, possibly explained by expression of CD161 and a lack of killer inhibitory receptor., Interpretation and Conclusions: Several so far undescribed features were observed in this case of hepatosplenic gd T-cell lymphoma, such as T-cell lymphoma following AML, expression of two distinct T-cell receptor g-chains, and an unexpected cytotoxic phenotype.