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9 results on '"Hong, Qilan"'

1. Human induced-T-to-natural killer cells have potent anti-tumour activities

Author

Jiang, Zhiwu, Qin, Le, Tang, Yuou, Liao, Rui, Shi, Jingxuan, He, Bingjia, Li, Shanglin, Zheng, Diwei, Cui, Yuanbin, Wu, Qiting, Long, Youguo, Yao, Yao, Wei, Zhihui, Hong, Qilan, Wu, Yi, Mai, Yuanbang, Gou, Shixue, Li, Xiaoping, Weinkove, Robert, Norton, Sam, Luo, Wei, Feng, Weineng, Zhou, Hongsheng, Liu, Qifa, Chen, Jiekai, Lai, Liangxue, Chen, Xinwen, Pei, Duanqing, Graf, Thomas, Liu, Xingguo, Li, Yangqiu, Liu, Pentao, Zhang, Zhenfeng, and Li, Peng

Published
2022
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2. BCL11B and the NuRD complex cooperatively guard T‐cell fate and inhibit OPA1‐mediated mitochondrial fusion in T cells.

Author

Liao, Rui, Wu, Yi, Qin, Le, Jiang, Zhiwu, Gou, Shixue, Zhou, Linfu, Hong, Qilan, Li, Yao, Shi, Jingxuan, Yao, Yao, Lai, Liangxue, Li, Yangqiu, Liu, Pentao, Thiery, Jean Paul, Qin, Dajiang, Graf, Thomas, Liu, Xingguo, and Li, Peng

Subjects
CELL fusion, KILLER cells, T cells, HISTONE deacetylase, MITOCHONDRIA, OXIDATIVE phosphorylation, T cell receptors
Abstract

The nucleosome remodeling and histone deacetylase (NuRD) complex physically associates with BCL11B to regulate murine T‐cell development. However, the function of NuRD complex in mature T cells remains unclear. Here, we characterize the fate and metabolism of human T cells in which key subunits of the NuRD complex or BCL11B are ablated. BCL11B and the NuRD complex bind to each other and repress natural killer (NK)‐cell fate in T cells. In addition, T cells upregulate the NK cell‐associated receptors and transcription factors, lyse NK‐cell targets, and are reprogrammed into NK‐like cells (ITNKs) upon deletion of MTA2, MBD2, CHD4, or BCL11B. ITNKs increase OPA1 expression and exhibit characteristically elongated mitochondria with augmented oxidative phosphorylation (OXPHOS) activity. OPA1‐mediated elevated OXPHOS enhances cellular acetyl‐CoA levels, thereby promoting the reprogramming efficiency and antitumor effects of ITNKs via regulating H3K27 acetylation at specific targets. In conclusion, our findings demonstrate that the NuRD complex and BCL11B cooperatively maintain T‐cell fate directly by repressing NK cell‐associated transcription and indirectly through a metabolic‐epigenetic axis, providing strategies to improve the reprogramming efficiency and antitumor effects of ITNKs. Synopsis: While BCL11b is known to bind the NuRD complex and be required for T cell development, the function of these factors in mature T cells has so far been unclear. This work demonstrates how the NuRD complex and BCL11B together maintain T‐cells from reprogramming into NK cells. T cells are reprogrammed into NK‐like cells upon deletion of MTA2, MBD2, or CHD4.BCL11B associates with the NuRD complex to repress OPA1 expression in T cells.OPA1‐mediated mitochondrial fusion facilitates ITNK reprogramming and cytotoxicity by increasing OXPHOS.Acetyl‐CoA elevated by OXPHOS promotes NK‐cell‐associated genes expression and antitumor effects in ITNKs by regulating H3K27 acetylation. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors

Author

Jiang, Zhiwu, primary, Cheng, Lin, additional, Wu, Zhiping, additional, Zhou, Linfu, additional, Wang, Haitao, additional, Hong, Qilan, additional, Wu, Qiting, additional, Long, Youguo, additional, Huang, Yunlin, additional, Xu, Gaoqi, additional, Yao, Yao, additional, Tang, Zhaoyang, additional, Zhang, Zhenfeng, additional, Yang, Lili, additional, Luo, Wei, additional, Yang, Jie, additional, Gong, Likun, additional, Liu, Pentao, additional, Chen, Xinwen, additional, Cui, Shuzhong, additional, Zhang, Qi, additional, Li, Yinxiong, additional, and Li, Peng, additional

Published
2022
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4. Additional file 11 of Human induced-T-to-natural killer cells have potent anti-tumour activities

Author

Jiang, Zhiwu, Qin, Le, Tang, Yuou, Liao, Rui, Shi, Jingxuan, He, Bingjia, Li, Shanglin, Zheng, Diwei, Cui, Yuanbin, Wu, Qiting, Long, Youguo, Yao, Yao, Wei, Zhihui, Hong, Qilan, Wu, Yi, Mai, Yuanbang, Gou, Shixue, Li, Xiaoping, Weinkove, Robert, Norton, Sam, Luo, Wei, Feng, Weineng, Zhou, Hongsheng, Liu, Qifa, Chen, Jiekai, Lai, Liangxue, Chen, Xinwen, Pei, Duanqing, Graf, Thomas, Liu, Xingguo, Li, Yangqiu, Liu, Pentao, Zhang, Zhenfeng, and Li, Peng

Abstract

Additional file 11: Figure S1. Inactivating BCL11B in human T cells by CRISPR/Cas9. Figure S2. ITNKs are derived from CD4+ and CD8+ T cells. Figure S3. ITNKs are derived from different T cell subsets. Figure S4. Immunophenotypic characteristics of ITNKs using CyTOF. Figure S5. Evaluating antitumor effects of ITNKs. Figure S6. Evaluating antitumor effects of CAR-ITNK cells. Figure S7. Evaluating kinetics and safety of clinical-grade ITNKs. Figure S8. Clinical trial protocol schematic. Figure S9. CONSORT statement/diagram. Figure S10. Immunohistochemistry staining of tumor tissues from patients. Figure S11. Clinical characteristics of patients treated with ITNK cells.

Published
2022
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5. Additional file 6 of Human induced-T-to-natural killer cells have potent anti-tumour activities

Author

Jiang, Zhiwu, Qin, Le, Tang, Yuou, Liao, Rui, Shi, Jingxuan, He, Bingjia, Li, Shanglin, Zheng, Diwei, Cui, Yuanbin, Wu, Qiting, Long, Youguo, Yao, Yao, Wei, Zhihui, Hong, Qilan, Wu, Yi, Mai, Yuanbang, Gou, Shixue, Li, Xiaoping, Weinkove, Robert, Norton, Sam, Luo, Wei, Feng, Weineng, Zhou, Hongsheng, Liu, Qifa, Chen, Jiekai, Lai, Liangxue, Chen, Xinwen, Pei, Duanqing, Graf, Thomas, Liu, Xingguo, Li, Yangqiu, Liu, Pentao, Zhang, Zhenfeng, and Li, Peng

Abstract

Additional file 6: Table S6. Characterizations of patients with autologous ITNK treatment.

Published
2022
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6. Additional file 5 of Human induced-T-to-natural killer cells have potent anti-tumour activities

Author

Jiang, Zhiwu, Qin, Le, Tang, Yuou, Liao, Rui, Shi, Jingxuan, He, Bingjia, Li, Shanglin, Zheng, Diwei, Cui, Yuanbin, Wu, Qiting, Long, Youguo, Yao, Yao, Wei, Zhihui, Hong, Qilan, Wu, Yi, Mai, Yuanbang, Gou, Shixue, Li, Xiaoping, Weinkove, Robert, Norton, Sam, Luo, Wei, Feng, Weineng, Zhou, Hongsheng, Liu, Qifa, Chen, Jiekai, Lai, Liangxue, Chen, Xinwen, Pei, Duanqing, Graf, Thomas, Liu, Xingguo, Li, Yangqiu, Liu, Pentao, Zhang, Zhenfeng, and Li, Peng

Abstract

Additional file 5: Table S5. Whole genome sequencing analysis on predicted on- and off-target sites.

Published
2022
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7. Additional file 4 of Human induced-T-to-natural killer cells have potent anti-tumour activities

Author

Jiang, Zhiwu, Qin, Le, Tang, Yuou, Liao, Rui, Shi, Jingxuan, He, Bingjia, Li, Shanglin, Zheng, Diwei, Cui, Yuanbin, Wu, Qiting, Long, Youguo, Yao, Yao, Wei, Zhihui, Hong, Qilan, Wu, Yi, Mai, Yuanbang, Gou, Shixue, Li, Xiaoping, Weinkove, Robert, Norton, Sam, Luo, Wei, Feng, Weineng, Zhou, Hongsheng, Liu, Qifa, Chen, Jiekai, Lai, Liangxue, Chen, Xinwen, Pei, Duanqing, Graf, Thomas, Liu, Xingguo, Li, Yangqiu, Liu, Pentao, Zhang, Zhenfeng, and Li, Peng

Abstract

Additional file 4: Table S4. Phenotyping characterization of sgRNA-ctrl and sgRNA-BCL11B edited T cells before in vivo infusion.

Published
2022
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8. Additional file 7 of Human induced-T-to-natural killer cells have potent anti-tumour activities

Author

Jiang, Zhiwu, Qin, Le, Tang, Yuou, Liao, Rui, Shi, Jingxuan, He, Bingjia, Li, Shanglin, Zheng, Diwei, Cui, Yuanbin, Wu, Qiting, Long, Youguo, Yao, Yao, Wei, Zhihui, Hong, Qilan, Wu, Yi, Mai, Yuanbang, Gou, Shixue, Li, Xiaoping, Weinkove, Robert, Norton, Sam, Luo, Wei, Feng, Weineng, Zhou, Hongsheng, Liu, Qifa, Chen, Jiekai, Lai, Liangxue, Chen, Xinwen, Pei, Duanqing, Graf, Thomas, Liu, Xingguo, Li, Yangqiu, Liu, Pentao, Zhang, Zhenfeng, and Li, Peng

Abstract

Additional file 7: Table S7. ITNK cell product release specifications.

Published
2022
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9. Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues

Author

Li, Weiyang, primary, Qi, Yanwei, additional, Cui, Xiaofang, additional, Huo, Qing, additional, Zhu, Liangxi, additional, Zhang, Aiping, additional, Tan, Meihua, additional, Hong, Qilan, additional, Yang, Yan, additional, Zhang, Huali, additional, Liu, Chuanxin, additional, Kong, Qingsheng, additional, Geng, Jiazheng, additional, Tian, Yanjun, additional, Kong, Fancong, additional, and Man, Dongmei, additional

Published
2018
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