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The main objective of this study was to examine the integration of indigenous knowledge (IK) into the rapidly developing field of rural social work in China. The study demonstrated the incorporation of indigenous elements such as folkways, power structures, values, norms, traditions, and crafts into the practice through collaboration with the local community. The research employed purposive sampling, which included 4 agency directors, 1 head of a social work organization, 6 social workers, 21 social work students, 16 children and teenagers, 13 villagers, 1 folk writer, 5 local families, 3 teacher lecturers, and 6 government officers. Results showed that the integration process involves the identification, extraction, application, and evaluation of IK are closely linked to the indigenous environment, service recipients, and social workers. Nevertheless, further research is required to operationalize and evaluate the effectiveness of this integration. Findings would be important guidelines for policymakers, education and development experts, and service providers. The conclusions drawn from this study offer valuable insights into the effective integration of Indigenous Knowledge (IK) into social work practice. These insights hold significance for policymakers, education and development experts, as well as service providers not only in China but also in a broader international context.

The NLRP3 inflammasome's core and most specific protein, NLRP3, has a variety of functions in inflammation-driven diseases. Costunolide (COS) is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity, but the principal mechanism and molecular target of COS remain unclear. Here, we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3, altering the ATPase activity and assembly of NLRP3 inflammasome. We declare COS's great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome activation. We also reveal that the α -methylene- γ -butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 activation. Taken together, NLRP3 is identified as a direct target of COS for its anti-inflammasome activity. COS, especially the α -methylene- γ -butyrolactone motif in COS structure, might be used to design and produce novel NLRP3 inhibitors as a lead compound. Costunolide covalently binds to cysteine 598 of NLRP3 NACHT domain, inhibiting activation of NLRP3 inflammasome to alleviate NLRP3-driven diseases, such as gouty arthritis, peritonitis, and ulcerative colitis. [Display omitted] [ABSTRACT FROM AUTHOR]