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8. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas

Author

Yamada, Shin-ichi, Ohira, Miki, Horie, Hiroshi, Ando, Kiyohiro, Takayasu, Hajime, Suzuki, Yutaka, Sugano, Sumio, Hirata, Takahiro, Goto, Takeshi, Matsunaga, Tadashi, Hiyama, Eiso, Hayashi, Yutaka, Ando, Hisami, Suita, Sachiyo, Kaneko, Michio, Sasaki, Fumiaki, Hashizume, Kohei, Ohnuma, Naomi, and Nakagawara, Akira

Published
2004
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10. Two cases of a non-progressive hepatic form of glycogen storage disease type IV with atypical liver pathology

Author

Ichimoto, Keiko, primary, Fujisawa, Tomoo, additional, Shimura, Masaru, additional, Fushimi, Takuya, additional, Tajika, Makiko, additional, Matsunaga, Ayako, additional, Ogawa-Tominaga, Minako, additional, Akiyama, Nana, additional, Naruke, Yuki, additional, Horie, Hiroshi, additional, Fukuda, Tokiko, additional, Sugie, Hideo, additional, Inui, Ayano, additional, and Murayama, Kei, additional

Published
2020
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12. Thin-film quasi-SOI power MOSFET fabricated by reversed silicon wafer direct bonding

Author

Matsumoto, Satoshi, Yachi, Toshiaki, Horie, Hiroshi, and Arimoto, Yoshihiro

Subjects
Thin film devices -- Research, Field-effect transistors -- Research, Business, Electronics, Electronics and electrical industries
Abstract

The fabrication of a thin-film quasi-silicon-on-insulator power MOSFET has been achieved using a reversed silicon wafer direct bonding technique. The MOSFET device has a low base resistance to the parasitic npn bipolar transistor, has a specific on-resistance of 86 micro ohms per millimeter squared and an on-state breakdown voltage of 30 volts.

Published
1998

13. Scaling theory for double-gate SOI MOSFET's

Author

Suzuki, Kunihiro, Tanaka, Tetsu, Tosaka, Yoshiharu, Horie, Hiroshi, and Arimoto, Yoshihiro

Subjects
Metal oxide semiconductor field effect transistors -- Research, Gates (Electronics) -- Research, Electronic instruments -- Design and construction, Business, Electronics, Electronics and electrical industries
Abstract

Studies on a scaling theory for double-gate SOI MOSFET's reveal that the theory enables the design of SOI devices with proper subthreshold factor. The design involves selection of SOI silicon and gate oxide thicknesses, tsi and tox, respectively, for a specified gate length. Experimental results reveal that the shortest gate length depends upon the thinnest tsi value.

Published
1993

15. Metabolic profiling of urine and blood plasma in rat models of drug addiction on the basis of morphine, methamphetamine, and cocaine-induced conditioned place preference

Author

Zaitsu, Kei, primary, Miyawaki, Izuru, additional, Bando, Kiyoko, additional, Horie, Hiroshi, additional, Shima, Noriaki, additional, Katagi, Munehiro, additional, Tatsuno, Michiaki, additional, Bamba, Takeshi, additional, Sato, Takako, additional, Ishii, Akira, additional, Tsuchihashi, Hitoshi, additional, Suzuki, Koichi, additional, and Fukusaki, Eiichiro, additional

Published
2013
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25. CHANGES OF X-RAY PHOTOELECTRON SPECTRA BY ION SPUTTERING

Author

Hashimoto, Satoshi, primary, Hirokawa, Kichinosuke, additional, Fukuda, Yasuo, additional, Suzuki, Keni-chi, additional, Suzuki, Toshiko, additional, Usuki, Noriaki, additional, Gennai, Norio, additional, Yoshida, Sizuo, additional, Koda, Mitsuru, additional, Sezaki, Hiroshi, additional, Horie, Hiroshi, additional, Tanaka, Akihiro, additional, and Ohtsubo, Takashi, additional

Published
1991
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27. Binding of Porphyromonas gingivalisFimbriae to Proline-Rich Glycoproteins in Parotid Saliva via a Domain Shared by Major Salivary Components

Author

Amano, Atsuo, Shizukuishi, Satoshi, Horie, Hiroshi, Kimura, Shigenobu, Morisaki, Ichijiro, and Hamada, Shigeyuki

Abstract

ABSTRACTPorphyromonas gingivalis, a putative periodontopathogen, can bind to human saliva through its fimbriae. We previously found that salivary components from the submandibular and sublingual glands bind to P. gingivalisfimbriae and that acidic proline-rich protein (PRP) and statherin function as receptor molecules for fimbriae. In this study, we investigated the fimbria-binding components in parotid saliva. Fractionated human parotid saliva by gel-filtration chromatography was immobilized onto nitrocellulose membranes for the overlay assay following sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The salivary components on the membrane were allowed to interact with fimbriae purified fromP. gingivalisATCC 33277, and the interacted fimbriae were probed with anti-fimbria antibodies. The fimbriae were shown to bind to two forms of proline-rich glycoproteins (PRGs) as well as to acidic PRPs and statherin. Moreover, fimbriae bound to several components of smaller molecular size which appeared to be acidic PRP variants and basic PRPs. Fimbriae bound strongly to the purified PRGs adsorbed onto hydroxyapatite (HAP) beads. In contrast, PRGs in solution failed to inhibit the fimbrial binding to the immobilized PRGs on the HAP beads. These findings suggest that the appearance of binding site(s) of PRGs can be ascribed to their conformational changes. We previously identified the distinct segments within PRP and statherin molecules that are involved in fimbrial binding. The peptides analogous to the binding regions of PRP and statherin (i.e., PRP-C and STN-C) markedly inhibit the binding of fimbriae to PRP and statherin immobilized on the HAP beads, respectively. The PRP-C significantly inhibited the binding of fimbriae to PRG-coated HAP beads as well as to PRP on HAP beads. The peptide did not affect the binding of fimbriae to statherin, whereas the STN-C showed no effect on the fimbrial binding to PRPs or PRGs. In the overlay assay, the PRP-C clearly diminished the interactions between the fimbriae and the various salivary components, including PRPs, the PRGs, and the components with smaller molecular sizes but not statherin. These results strongly suggest that fimbriae bind to salivary components (except statherin) via common peptide segments. It is also suggested that fimbriae bind to saliva through the two distinct binding domains of receptory salivary components: (i) PRGs and PRPs and (ii) statherin.

Published
1998
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