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2. Knowledge of the Serological Response to the Third BNT162b2 Vaccination May Influence Compliance of Healthcare Workers to Booster Dose.

Author

Magid, Avi, Hussein, Khetam, Dabaja-Younis, Halima, Szwarcwort-Cohen, Moran, Almog, Ronit, Mekel, Michal, Weissman, Avi, Hyams, Gila, Gepstein, Vardit, Horowitz, Netanel A., Cohen Saban, Hagar, Tarabeia, Jalal, Halberthal, Michael, and Shachor-Meyouhas, Yael

Subjects
MEDICAL personnel, BOOSTER vaccines, COVID-19 vaccines, CONFOUNDING variables, LOGISTIC regression analysis
Abstract

Background: Previous studies showed that the fourth SARS-CoV-2 vaccine dose has a protective effect against infection, as well as against severe disease and death. This study aimed to examine whether knowledge of a high-level antibody after the third dose may reduce compliance to the fourth booster dose among healthcare workers (HCWs). Methods: We conducted a prospective cohort study among HCWs vaccinated with the first three doses at Rambam Healthcare Campus, a tertiary hospital in northern Israel. Participants underwent a serological test before the fourth booster vaccine was offered to all of them, with results provided to participants. The population was divided into two groups, namely those with antibodies below 955 AU/mL and those with 955 AU/mL and higher, a cutoff found protective in a previous study. Multiple logistic regression was carried out to compare the compliance to the fourth booster between the two groups, adjusted for demographic and clinical variables. Results: After adjusting for the confounding variables, the compliance was higher in those with antibody levels below 955 AU/mL (OR = 1.41, p = 0.05, 95% CI 1.10–1.96). In addition, male sex and age of 60 years and above were also associated with higher vaccination rates (OR = 2.28, p < 0.001, 95% CI 1.64–3.17), (OR = 1.14, p = 0.043, 95% CI 1.06–1.75), respectively. Conclusions: Knowledge of the antibody status may affect compliance with the booster dose. Considering waning immunity over time, reduced compliance may affect the protection of HCWs who declined the fourth dose. [ABSTRACT FROM AUTHOR]

Published
2024
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3. 2654. International Multi-Center Study Comparing the Effect of Obinutuzumab or Rituximab Treatment in Hematological Patients on COVID-19 Outcomes During the Omicron Surge

Author

Shafat, Tal, primary, Grupel, Daniel, additional, Porges, Tzvika, additional, Belkin, Ana, additional, Deri, Ofir, additional, Oster, Yonatan, additional, Zahran, Shadi, additional, Horwitz, Ehud, additional, Horowitz, Netanel A, additional, Khatib, Hazim, additional, Batista, Marjorie, additional, Cortez, Anita, additional, Brosh-Nissimov, Tal, additional, Segman, Yafit, additional, Ishay, Linor, additional, Cohen, Regev, additional, Atamna, Alaa, additional, Spallone, Amy, additional, Chemaly, Roy F, additional, Ramos, Juan Carlos, additional, Chowers, Michal, additional, Rogozin, Evgeny, additional, Carmi-Oren, Noga, additional, Keske, Şiran, additional, Barchad, Orit Wolfovitz, additional, and Nesher, Lior, additional

Published
2023
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5. An international multicenter study comparing COVID‐19 omicron outcomes in patients with hematological malignancies treated with obinutuzumab versus rituximab.

Author

Shafat, Tali, Grupel, Daniel, Porges, Tzvika, Abuhasira, Ran, Belkin, Ana, Deri, Ofir, Oster, Yonatan, Zahran, Shadi, Horwitz, Ehud, Horowitz, Netanel A., Khatib, Hazim, Batista, Marjorie Vieira, Cortez, Anita Cassoli, Brosh‐Nissimov, Tal, Segman, Yafit, Ishay, Linor, Cohen, Regev, Atamna, Alaa, Spallone, Amy, and Chemaly, Roy F.

Subjects
HEMATOLOGIC malignancies, SARS-CoV-2 Omicron variant, RITUXIMAB, COVID-19, MONOCLONAL antibodies
Abstract

Objectives: Hematological malignancy (HM) patients treated with anti‐CD20 monoclonal antibodies are at higher risk for severe COVID‐19. A previous single‐center study showed worse outcomes in patients treated with obinutuzumab compared to rituximab. We examined this hypothesis in a large international multicenter cohort. Methods: We included HM patients from 15 centers, from five countries treated with anti‐CD20, comparing those treated with obinutuzumab (O‐G) to rituximab (R‐G) between December 2021 and June 2022, when Omicron lineage was dominant. Results: We collected data on 1048 patients. Within the R‐G (n = 762, 73%), 191 (25%) contracted COVID‐19 compared to 103 (36%) in the O‐G. COVID‐19 patients in the O‐G were younger (61 ± 11.7 vs. 64 ± 14.5, p = 0.039), had more indolent HM diagnosis (aggressive lymphoma: 3.9% vs. 67.0%, p < 0.001), and most were on maintenance therapy at COVID‐19 diagnosis (63.0% vs. 16.8%, p < 0.001). Severe‐critical COVID‐19 occurred in 31.1% of patients in the O‐G and 22.5% in the R‐G. In multivariable analysis, O‐G had a 2.08‐fold increased risk for severe‐critical COVID‐19 compared to R‐G (95% CI 1.13–3.84), adjusted for Charlson comorbidity index, sex, and tixagevimab/cilgavimab (T‐C) prophylaxis. Further analysis comparing O‐G to R‐G demonstrated increased hospitalizations (51.5% vs. 35.6% p = 0.008), ICU admissions (12.6% vs. 5.8%, p = 0.042), but the nonsignificant difference in COVID‐19‐related mortality (n = 10, 9.7% vs. n = 12, 6.3%, p = 0.293). Conclusions: Despite younger age and a more indolent HM diagnosis, patients receiving obinutuzumab had more severe COVID‐19 outcomes than those receiving rituximab. Our findings underscore the need to evaluate the risk–benefit balance when considering obinutuzumab therapy for HM patients during respiratory viral outbreaks. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Clonal Myeloid Dysplasia Following CAR T-Cell Therapy: Chicken or the Egg?

Author

Vainstein, Vladimir, primary, Avni, Batia, additional, Grisariu, Sigal, additional, Kfir-Erenfeld, Shlomit, additional, Asherie, Nathalie, additional, Nachmias, Boaz, additional, Auman, Shlomtzion, additional, Saban, Revital, additional, Zimran, Eran, additional, Assayag, Miri, additional, Filanovsky, Kalman, additional, Horowitz, Netanel A., additional, Lebel, Eyal, additional, Shaulov, Adir, additional, Gur, Michal, additional, Rosenbluh, Chaggai, additional, Krichevsky, Svetlana, additional, Stepensky, Polina, additional, and Gatt, Moshe E., additional

Published
2023
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10. Administration of Obinutuzumab, and Not Rituximab, during Induction and Maintenance for Follicular Lymphoma Increases the Likelihood of Developing Delayed Neutropenia

Author

Harlev, Shimrit, primary, Fadaos, Nashwa, additional, Azoulay, Tehila, additional, Leiba, Ronit, additional, Horesh, Nurit, additional, Inbar, Tsofia, additional, Horowitz, Netanel A., additional, Tsoran-Rosenthal, Inna, additional, Lavi, Noa, additional, Dann, Eldad J., additional, and Zuckerman, Tsila, additional

Published
2022
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11. Central Nervous System Relapse in Patients with Primary Mediastinal Large B-Cell Lymphoma: Incidence and Risk Factors in the Rituximab Era

Author

Vassilakopoulos, Theodoros P., primary, Panitsas, Fotios, additional, Mellios, Zois, additional, Apostolidis, John, additional, Piperidou, Alexia, additional, Michael, Michalis D, additional, Gurion, Ronit, additional, Akay, Meltem, additional, Hatzimichael, Eleftheria, additional, Karakatsanis, Stamatis J., additional, Dimou, Maria, additional, Kalpadakis, Christina, additional, Katodritou, Eirini, additional, Leonidopoulou, Theoni, additional, Kotsianidis, Ioannis, additional, Giatra, Chara, additional, Kanellias, Nikolaos, additional, Sayyed, Ayman, additional, Tadmor, Tamar, additional, Kaynar, Leylagul, additional, Zektser, Miri, additional, Symeonidis, Argiris, additional, Atalar, SC, additional, Verrou, Evgenia, additional, Gutwein, Odit, additional, Ganzel, Chezi, additional, Karianakis, Giorgos, additional, Isenberg, Jonathan, additional, Gainaru, Gabriela, additional, Triantafyllou, Theodora, additional, Vrakidou, Efimia, additional, Palassopoulou, Maria, additional, Ozgur, Mehmet, additional, Paydas, Semra, additional, Tsirigotis, Panagiotis, additional, Tsirogianni, Maria, additional, Tuglular, Tulin, additional, Chatzidimitriou, Chrysovalantou, additional, Kotsopoulou, Maria, additional, Terpos, Evangelos, additional, Zikos, Panagiotis, additional, Koumarianou, Argyro, additional, Poziopoulos, Christos, additional, Boutsis, Dimitrios, additional, Gafter-Gvili, Anat, additional, Karmiris, Themistoklis, additional, Angelopoulou, Maria K., additional, Bakiri Papaioannou, Maria, additional, Pangalis, Gerassimos, additional, Panayiotidis, Panayiotis, additional, Ferhanoglu, Burhan, additional, Horowitz, Netanel A., additional, and Papageorgiou, Sotirios, additional

Published
2022
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12. Mosunetuzumab Monotherapy Continues to Demonstrate Promising Efficacy and Durable Complete Responses in Elderly/Unfit Patients with Previously Untreated Diffuse Large B-Cell Lymphoma

Author

Olszewski, Adam J., primary, Avigdor, Abraham, additional, Babu, Sunil, additional, Levi, Itai, additional, Eradat, Herbert, additional, Abadi, Uri, additional, Holmes, Houston, additional, McKinney, Matthew, additional, Woszczyk, Dariusz, additional, Giannopoulos, Krzysztof, additional, Jurczak, Wojciech, additional, Dunshee, Diana, additional, Yang, Annie, additional, Zhou, Mingzhu, additional, Qayum, Naseer, additional, Sellam, Gila, additional, and Horowitz, Netanel A., additional

Published
2022
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13. Revisiting SARS-CoV-2 environmental contamination by patients with COVID-19: The Omicron variant does not differ from previous strains

Author

Glinert, Itai, primary, Ben-Shmuel, Amir, additional, Szwartcwort-Cohen, Moran, additional, Beth-din, Adi, additional, Laskar, Orly, additional, Barlev-Gross, Moria, additional, Melamed, Sharon, additional, Arbell, Noga, additional, Levy, Haim, additional, Horowitz, Netanel A, additional, and Weiss, Shay, additional

Published
2022
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16. A Phase II Study to Assess the Safety and Efficacy of the Dual mTORC1/2 and PI3K Inhibitor Bimiralisib (PQR309) in Relapsed, Refractory Lymphoma

Author

Collins, Graham P., primary, Eyre, Toby A., additional, Schmitz-Rohmer, Debora, additional, Townsend, William, additional, Popat, Rakesh, additional, Giulino-Roth, Lisa, additional, Fields, Paul A., additional, Krasniqi, Fatime, additional, Soussain, Carole, additional, Stathis, Anastasios, additional, Andjelkovic, Nebojsa, additional, Cunningham, David, additional, Mandic, Danijela, additional, Radulovic, Sinisa, additional, Tijanic, Ivan, additional, Horowitz, Netanel A., additional, Kurtovic, Sabira, additional, Schorb, Elisabeth, additional, Schmidt, Christian, additional, Dimitrijević, Saša, additional, and Dreyling, Martin, additional

Published
2021
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18. Continuous Remote Patient Monitoring Shows Early Cardiovascular Changes in COVID-19 Patients

Author

Eisenkraft, Arik, primary, Maor, Yasmin, additional, Constantini, Keren, additional, Goldstein, Nir, additional, Nachman, Dean, additional, Levy, Ran, additional, Halberthal, Michael, additional, Horowitz, Netanel A., additional, Golan, Ron, additional, Rosenberg, Elli, additional, Lavon, Eitan, additional, Cohen, Ornit, additional, Shapira, Guy, additional, Shomron, Noam, additional, Ishay, Arik Ben, additional, Sand, Efrat, additional, Merin, Roei, additional, Fons, Meir, additional, Littman, Romi, additional, and Gepner, Yftach, additional

Published
2021
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20. Humoral serological response to the BNT162b2 vaccine is abrogated in lymphoma patients within the first 12 months following treatment with anti-CD2O antibodies

Author

Gurion, Ronit, primary, Rozovski, Uri, additional, Itchaki, Gilad, additional, Gafter-Gvili, Anat, additional, Leibovitch, Chiya, additional, Raanani, Pia, additional, Ben-Zvi, Haim, additional, Szwarcwort, Moran, additional, Taylor-Abigadol, Mor, additional, Dann, Eldad J., additional, Horesh, Nurit, additional, Inbar, Tsofia, additional, Tzoran, Inna, additional, Lavi, Noa, additional, Fineman, Riva, additional, Ringelstein-Harlev, Shimrit, additional, and Horowitz, Netanel A., additional

Published
2021
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23. CpG methylation in cell-free Epstein-Barr virus DNA in patients with EBV-Hodgkin lymphoma

Author

Shamay, Meir, primary, Kanakry, Jennifer A., primary, Low, John S. W., primary, Horowitz, Netanel A., primary, Journo, Guy, primary, Ahuja, Anuj, primary, Eran, Yonatan, primary, Barzilai, Elinor, primary, Dann, Eldad J., primary, Stone, Jennifer, primary, Woo, Wan Lu, primary, Hsieh, Wen-son, primary, Xian, Rena R., primary, and Ambinder, Richard F., primary

Published
2020
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25. Clinical Characteristics, Treatment Patterns and Outcomes of Solitary Plasmacytoma - a Multicenter Retrospective Cohort Study

Author

Trestman, Svetlana, primary, Ganzel, Chezi, additional, Levi, Shai, additional, Gatt, Moshe E., additional, Lavi, Noa, additional, Vaxman, Iuliana, additional, Rouvio, Ory, additional, Magen, Hila, additional, Horowitz, Netanel A, additional, Leiba, Merav, additional, Tadmor, Tamar, additional, Tzarfati, Katrin Herzog, additional, Surio, Celia, additional, Yeganeh, Shay, additional, Deli, Nagib, additional, Avivi, Irit, additional, and Yael, Cohen, additional

Published
2019
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26. Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial

Author

Dimopoulos, Meletios A., Gay, Francesca, Schjesvold, Fredrik, Beksac, Meral, Hajek, Roman, Weisel, Katja Christina, Goldschmidt, Hartmut, Maisnar, Vladimir, Moreau, Philippe, Min, Chang Ki, Pluta, Agnieszka, Chng, Wee-Joo, Kaiser, Martin, Zweegman, Sonja, Mateos, Maria Victoria, Spencer, Andrew, Iida, Shinsuke, Morgan, Gareth, Suryanarayan, Kaveri, Teng, Zhaoyang, Skacel, Tomas, Palumbo, Antonio, Dash, Ajeeta B., Gupta, Neeraj, Labotka, Richard, Rajkumar, S. Vincent, Bar, Daniel, Basso, Alfredo, Fantl, Dorotea, He, Simon, Horvath, Neomi, Lee, Cindy, Rowlings, Phillip, Taylor, Kerry, Cochrane, Tara, Kwok, Fiona, Ramanathan, Sundreswran, Agis, Hermine, Zojer, Niklas, Kentos, Alain, Offner, Fritz, Van Droogenbroeck, Jan, Wu, Ka Lung, Maiolino, Angelo, Martinez, Gracia, Zanella, Karla, Capra, Marcelo, Araujo, Sergio, Gregora, Evzen, Pour, Ludek, Scudla, Vlastimil, Spicka, Ivan, Abildgaard, Niels, Andersen, Niels, Jensen, Bo Amdi, Helleberg, Carsten, Plesner, Torben, Salomo, Morten, Svirskaite, Asta, Delarue, Richard, Blau, Igor, Schieferdecker, Aneta, Teleanu, Veronica, Munder, Markus, Rollig, Christoph, Salwender, Han-Juergen, Fuhrmann, Stephan, Weisel, Katja, Duerig, Jan, Zeis, Matthias, Klein, Stefan, Reimer, Peter, Schmidt, Christian, Scheid, Christof, Mayer, Karin, Hoffmann, Martin, Sosada, Markus, Dimopoulos, Athanasios, Delimpasi, Sosana, Kyrtsonis, Mary-Christine, Anagnostopoulos, Achilleas, Nagy, Zsolt, Illes, Arpad, Egyed, Miklos, Borbenyi, Zita, Mikala, Gabor, Dally, Najib, Horowitz, Netanel, Gutwein, Odit, Nemets, Anatoly, Vaxman, Iuliana, Shvetz, Olga, Trestman, Svetlana, Ruchlemer, Rosa, Nagler, Arnon, Tadmor, Tamar, Rouvio, Ory, Preis, Meir, Cavo, Michele, De Rosa, Luca, Musto, Pellegrino, Cafro, Anna, Tosi, Patrizia, Offidani, Massimo, Corso, Alessandro, Rossi, Giuseppe, Liberati, Anna Marina, Bosi, Alberto, Suzuki, Kenshi, Nakaseko, Chiaki, Ishikawa, Takayuki, Matsumoto, Morio, Nagai, Hirokazu, Sunami, Kazutaka, Chou, Takaaki, Akashi, Koichi, Takezako, Naoki, Hagiwara, Shotaro, Eom, Hyeon Seok, Jo, Deog-Yeon, Kim, Jin Seok, Lee, Jae Hoon, Yoon, Sung Soo, Yoon, Dok Hyun, Kim, Kihyun, Levin, Mark-David, Vellenga, Edo, Minnema, Monique, Waage, Anders, Haukas, Einar, Grosicki, Sebastian, Pluta, Andrzej, Robak, Tadeusz, Marques, Herlander, Bergantim, Rui, Campilho, Fernando, Chng, Wee Joo, Goh, Yeow Tee, McDonald, Andrew, Rapoport, Bernado, Rivas, Miguel Angel Alvarez, de La Fuente, Felipe De Arriba, Montes, Yolanda Gonzalez, Sanchez, Jesus Martin, Rocafiguera, Albert Oriol, Rosinol, Laura, San Miguel, Jesus, de Oteyza, Jaime Perez, Encinas, Cristina, Alegre-Amor, Adrian, Lopez-Guia, Ana, Axelsson, Per, Carlson, Kristina, Stromberg, Olga, Hansson, Markus, Blimark, Cecile Hveding, Mueller, Rouven, Chen, Chih-Cheng, Liu, Ta-Chih, Huang, Shang-Yi, Wang, Po-Nan, Nakorn, Thanyaphong Na, Prayongratana, Kannadit, Unal, Ali, Goker, Hakan, Sonmez, Mehmet, Korenkova, Sybiryna, Chaidos, Aristeidis, Oakervee, Heather, Sati, Hamdi, Benjamin, Reuben, Wechalekar, Ashutosh, Garg, Mamta, Ramasamy, Karthik, Cook, Gordon, Chantry, Andrew, Jenner, Matthew, Buadi, Francis, Berryman, Robert, Janakiram, Murali, Dimopoulos, Meletios A., Gay, Francesca, Schjesvold, Fredrik, Beksac, Meral, Hajek, Roman, Weisel, Katja Christina, Goldschmidt, Hartmut, Maisnar, Vladimir, Moreau, Philippe, Min, Chang Ki, Pluta, Agnieszka, Chng, Wee-Joo, Kaiser, Martin, Zweegman, Sonja, Mateos, Maria Victoria, Spencer, Andrew, Iida, Shinsuke, Morgan, Gareth, Suryanarayan, Kaveri, Teng, Zhaoyang, Skacel, Tomas, Palumbo, Antonio, Dash, Ajeeta B., Gupta, Neeraj, Labotka, Richard, Rajkumar, S. Vincent, Bar, Daniel, Basso, Alfredo, Fantl, Dorotea, He, Simon, Horvath, Neomi, Lee, Cindy, Rowlings, Phillip, Taylor, Kerry, Cochrane, Tara, Kwok, Fiona, Ramanathan, Sundreswran, Agis, Hermine, Zojer, Niklas, Kentos, Alain, Offner, Fritz, Van Droogenbroeck, Jan, Wu, Ka Lung, Maiolino, Angelo, Martinez, Gracia, Zanella, Karla, Capra, Marcelo, Araujo, Sergio, Gregora, Evzen, Pour, Ludek, Scudla, Vlastimil, Spicka, Ivan, Abildgaard, Niels, Andersen, Niels, Jensen, Bo Amdi, Helleberg, Carsten, Plesner, Torben, Salomo, Morten, Svirskaite, Asta, Delarue, Richard, Blau, Igor, Schieferdecker, Aneta, Teleanu, Veronica, Munder, Markus, Rollig, Christoph, Salwender, Han-Juergen, Fuhrmann, Stephan, Weisel, Katja, Duerig, Jan, Zeis, Matthias, Klein, Stefan, Reimer, Peter, Schmidt, Christian, Scheid, Christof, Mayer, Karin, Hoffmann, Martin, Sosada, Markus, Dimopoulos, Athanasios, Delimpasi, Sosana, Kyrtsonis, Mary-Christine, Anagnostopoulos, Achilleas, Nagy, Zsolt, Illes, Arpad, Egyed, Miklos, Borbenyi, Zita, Mikala, Gabor, Dally, Najib, Horowitz, Netanel, Gutwein, Odit, Nemets, Anatoly, Vaxman, Iuliana, Shvetz, Olga, Trestman, Svetlana, Ruchlemer, Rosa, Nagler, Arnon, Tadmor, Tamar, Rouvio, Ory, Preis, Meir, Cavo, Michele, De Rosa, Luca, Musto, Pellegrino, Cafro, Anna, Tosi, Patrizia, Offidani, Massimo, Corso, Alessandro, Rossi, Giuseppe, Liberati, Anna Marina, Bosi, Alberto, Suzuki, Kenshi, Nakaseko, Chiaki, Ishikawa, Takayuki, Matsumoto, Morio, Nagai, Hirokazu, Sunami, Kazutaka, Chou, Takaaki, Akashi, Koichi, Takezako, Naoki, Hagiwara, Shotaro, Eom, Hyeon Seok, Jo, Deog-Yeon, Kim, Jin Seok, Lee, Jae Hoon, Yoon, Sung Soo, Yoon, Dok Hyun, Kim, Kihyun, Levin, Mark-David, Vellenga, Edo, Minnema, Monique, Waage, Anders, Haukas, Einar, Grosicki, Sebastian, Pluta, Andrzej, Robak, Tadeusz, Marques, Herlander, Bergantim, Rui, Campilho, Fernando, Chng, Wee Joo, Goh, Yeow Tee, McDonald, Andrew, Rapoport, Bernado, Rivas, Miguel Angel Alvarez, de La Fuente, Felipe De Arriba, Montes, Yolanda Gonzalez, Sanchez, Jesus Martin, Rocafiguera, Albert Oriol, Rosinol, Laura, San Miguel, Jesus, de Oteyza, Jaime Perez, Encinas, Cristina, Alegre-Amor, Adrian, Lopez-Guia, Ana, Axelsson, Per, Carlson, Kristina, Stromberg, Olga, Hansson, Markus, Blimark, Cecile Hveding, Mueller, Rouven, Chen, Chih-Cheng, Liu, Ta-Chih, Huang, Shang-Yi, Wang, Po-Nan, Nakorn, Thanyaphong Na, Prayongratana, Kannadit, Unal, Ali, Goker, Hakan, Sonmez, Mehmet, Korenkova, Sybiryna, Chaidos, Aristeidis, Oakervee, Heather, Sati, Hamdi, Benjamin, Reuben, Wechalekar, Ashutosh, Garg, Mamta, Ramasamy, Karthik, Cook, Gordon, Chantry, Andrew, Jenner, Matthew, Buadi, Francis, Berryman, Robert, and Janakiram, Murali

Published
2019

27. Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial

Author

MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Dimopoulos, Meletios A., Gay, Francesca, Schjesvold, Fredrik, Beksac, Meral, Hajek, Roman, Weisel, Katja Christina, Goldschmidt, Hartmut, Maisnar, Vladimir, Moreau, Philippe, Min, Chang Ki, Pluta, Agnieszka, Chng, Wee-Joo, Kaiser, Martin, Zweegman, Sonja, Mateos, Maria Victoria, Spencer, Andrew, Iida, Shinsuke, Morgan, Gareth, Suryanarayan, Kaveri, Teng, Zhaoyang, Skacel, Tomas, Palumbo, Antonio, Dash, Ajeeta B., Gupta, Neeraj, Labotka, Richard, Rajkumar, S. Vincent, Bar, Daniel, Basso, Alfredo, Fantl, Dorotea, He, Simon, Horvath, Neomi, Lee, Cindy, Rowlings, Phillip, Taylor, Kerry, Cochrane, Tara, Kwok, Fiona, Ramanathan, Sundreswran, Agis, Hermine, Zojer, Niklas, Kentos, Alain, Offner, Fritz, Van Droogenbroeck, Jan, Wu, Ka Lung, Maiolino, Angelo, Martinez, Gracia, Zanella, Karla, Capra, Marcelo, Araujo, Sergio, Gregora, Evzen, Pour, Ludek, Scudla, Vlastimil, Spicka, Ivan, Abildgaard, Niels, Andersen, Niels, Jensen, Bo Amdi, Helleberg, Carsten, Plesner, Torben, Salomo, Morten, Svirskaite, Asta, Delarue, Richard, Blau, Igor, Schieferdecker, Aneta, Teleanu, Veronica, Munder, Markus, Rollig, Christoph, Salwender, Han-Juergen, Fuhrmann, Stephan, Weisel, Katja, Duerig, Jan, Zeis, Matthias, Klein, Stefan, Reimer, Peter, Schmidt, Christian, Scheid, Christof, Mayer, Karin, Hoffmann, Martin, Sosada, Markus, Dimopoulos, Athanasios, Delimpasi, Sosana, Kyrtsonis, Mary-Christine, Anagnostopoulos, Achilleas, Nagy, Zsolt, Illes, Arpad, Egyed, Miklos, Borbenyi, Zita, Mikala, Gabor, Dally, Najib, Horowitz, Netanel, Gutwein, Odit, Nemets, Anatoly, Vaxman, Iuliana, Shvetz, Olga, Trestman, Svetlana, Ruchlemer, Rosa, Nagler, Arnon, Tadmor, Tamar, Rouvio, Ory, Preis, Meir, Cavo, Michele, De Rosa, Luca, Musto, Pellegrino, Cafro, Anna, Tosi, Patrizia, Offidani, Massimo, Corso, Alessandro, Rossi, Giuseppe, Liberati, Anna Marina, Bosi, Alberto, Suzuki, Kenshi, Nakaseko, Chiaki, Ishikawa, Takayuki, Matsumoto, Morio, Nagai, Hirokazu, Sunami, Kazutaka, Chou, Takaaki, Akashi, Koichi, Takezako, Naoki, Hagiwara, Shotaro, Eom, Hyeon Seok, Jo, Deog-Yeon, Kim, Jin Seok, Lee, Jae Hoon, Yoon, Sung Soo, Yoon, Dok Hyun, Kim, Kihyun, Levin, Mark-David, Vellenga, Edo, Minnema, Monique, Waage, Anders, Haukas, Einar, Grosicki, Sebastian, Pluta, Andrzej, Robak, Tadeusz, Marques, Herlander, Bergantim, Rui, Campilho, Fernando, Chng, Wee Joo, Goh, Yeow Tee, McDonald, Andrew, Rapoport, Bernado, Rivas, Miguel Angel Alvarez, de La Fuente, Felipe De Arriba, Montes, Yolanda Gonzalez, Sanchez, Jesus Martin, Rocafiguera, Albert Oriol, Rosinol, Laura, San Miguel, Jesus, de Oteyza, Jaime Perez, Encinas, Cristina, Alegre-Amor, Adrian, Lopez-Guia, Ana, Axelsson, Per, Carlson, Kristina, Stromberg, Olga, Hansson, Markus, Blimark, Cecile Hveding, Mueller, Rouven, Chen, Chih-Cheng, Liu, Ta-Chih, Huang, Shang-Yi, Wang, Po-Nan, Nakorn, Thanyaphong Na, Prayongratana, Kannadit, Unal, Ali, Goker, Hakan, Sonmez, Mehmet, Korenkova, Sybiryna, Chaidos, Aristeidis, Oakervee, Heather, Sati, Hamdi, Benjamin, Reuben, Wechalekar, Ashutosh, Garg, Mamta, Ramasamy, Karthik, Cook, Gordon, Chantry, Andrew, Jenner, Matthew, Buadi, Francis, Berryman, Robert, Janakiram, Murali, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Dimopoulos, Meletios A., Gay, Francesca, Schjesvold, Fredrik, Beksac, Meral, Hajek, Roman, Weisel, Katja Christina, Goldschmidt, Hartmut, Maisnar, Vladimir, Moreau, Philippe, Min, Chang Ki, Pluta, Agnieszka, Chng, Wee-Joo, Kaiser, Martin, Zweegman, Sonja, Mateos, Maria Victoria, Spencer, Andrew, Iida, Shinsuke, Morgan, Gareth, Suryanarayan, Kaveri, Teng, Zhaoyang, Skacel, Tomas, Palumbo, Antonio, Dash, Ajeeta B., Gupta, Neeraj, Labotka, Richard, Rajkumar, S. Vincent, Bar, Daniel, Basso, Alfredo, Fantl, Dorotea, He, Simon, Horvath, Neomi, Lee, Cindy, Rowlings, Phillip, Taylor, Kerry, Cochrane, Tara, Kwok, Fiona, Ramanathan, Sundreswran, Agis, Hermine, Zojer, Niklas, Kentos, Alain, Offner, Fritz, Van Droogenbroeck, Jan, Wu, Ka Lung, Maiolino, Angelo, Martinez, Gracia, Zanella, Karla, Capra, Marcelo, Araujo, Sergio, Gregora, Evzen, Pour, Ludek, Scudla, Vlastimil, Spicka, Ivan, Abildgaard, Niels, Andersen, Niels, Jensen, Bo Amdi, Helleberg, Carsten, Plesner, Torben, Salomo, Morten, Svirskaite, Asta, Delarue, Richard, Blau, Igor, Schieferdecker, Aneta, Teleanu, Veronica, Munder, Markus, Rollig, Christoph, Salwender, Han-Juergen, Fuhrmann, Stephan, Weisel, Katja, Duerig, Jan, Zeis, Matthias, Klein, Stefan, Reimer, Peter, Schmidt, Christian, Scheid, Christof, Mayer, Karin, Hoffmann, Martin, Sosada, Markus, Dimopoulos, Athanasios, Delimpasi, Sosana, Kyrtsonis, Mary-Christine, Anagnostopoulos, Achilleas, Nagy, Zsolt, Illes, Arpad, Egyed, Miklos, Borbenyi, Zita, Mikala, Gabor, Dally, Najib, Horowitz, Netanel, Gutwein, Odit, Nemets, Anatoly, Vaxman, Iuliana, Shvetz, Olga, Trestman, Svetlana, Ruchlemer, Rosa, Nagler, Arnon, Tadmor, Tamar, Rouvio, Ory, Preis, Meir, Cavo, Michele, De Rosa, Luca, Musto, Pellegrino, Cafro, Anna, Tosi, Patrizia, Offidani, Massimo, Corso, Alessandro, Rossi, Giuseppe, Liberati, Anna Marina, Bosi, Alberto, Suzuki, Kenshi, Nakaseko, Chiaki, Ishikawa, Takayuki, Matsumoto, Morio, Nagai, Hirokazu, Sunami, Kazutaka, Chou, Takaaki, Akashi, Koichi, Takezako, Naoki, Hagiwara, Shotaro, Eom, Hyeon Seok, Jo, Deog-Yeon, Kim, Jin Seok, Lee, Jae Hoon, Yoon, Sung Soo, Yoon, Dok Hyun, Kim, Kihyun, Levin, Mark-David, Vellenga, Edo, Minnema, Monique, Waage, Anders, Haukas, Einar, Grosicki, Sebastian, Pluta, Andrzej, Robak, Tadeusz, Marques, Herlander, Bergantim, Rui, Campilho, Fernando, Chng, Wee Joo, Goh, Yeow Tee, McDonald, Andrew, Rapoport, Bernado, Rivas, Miguel Angel Alvarez, de La Fuente, Felipe De Arriba, Montes, Yolanda Gonzalez, Sanchez, Jesus Martin, Rocafiguera, Albert Oriol, Rosinol, Laura, San Miguel, Jesus, de Oteyza, Jaime Perez, Encinas, Cristina, Alegre-Amor, Adrian, Lopez-Guia, Ana, Axelsson, Per, Carlson, Kristina, Stromberg, Olga, Hansson, Markus, Blimark, Cecile Hveding, Mueller, Rouven, Chen, Chih-Cheng, Liu, Ta-Chih, Huang, Shang-Yi, Wang, Po-Nan, Nakorn, Thanyaphong Na, Prayongratana, Kannadit, Unal, Ali, Goker, Hakan, Sonmez, Mehmet, Korenkova, Sybiryna, Chaidos, Aristeidis, Oakervee, Heather, Sati, Hamdi, Benjamin, Reuben, Wechalekar, Ashutosh, Garg, Mamta, Ramasamy, Karthik, Cook, Gordon, Chantry, Andrew, Jenner, Matthew, Buadi, Francis, Berryman, Robert, and Janakiram, Murali

Published
2019

28. Bone marrow blast elimination by the fifth day of 7 + 3 induction is the strongest predictor of potential cure in patients with acute myeloid leukemia younger than 61 years of age: A long‐term follow‐up of a multi‐center prospective study

Author

Ofran, Yishai, primary, Hayun, Michal, additional, Leiba, Ronit, additional, Zuckerman, Tsila, additional, Horowitz, Netanel, additional, Hoffman, Ron, additional, Ringelstein, Shimrit, additional, Lavi, Noa, additional, Frisch, Avraham, additional, Henig, Israel, additional, Gatt, Moshe E., additional, Hellmann, Ilana, additional, Arad, Ariela, additional, Bulvik, Shlomo, additional, Ram, Ron, additional, Gino‐Moor, Sharon, additional, Saban, Revital, additional, Tvito, Ariella, additional, Rowe, Jacob M., additional, and Ganzel, Chezi, additional

Published
2019
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29. Characteristics, management and outcome of DLBCL patients, presenting with simultaneous systemic and CNS disease at diagnosis: A retrospective multicenter study

Author

Perry, Chava, primary, Ben Barouch, Sharon, additional, Goldschmidt, Neta, additional, Sarid, Nadav, additional, Herishanu, Yair, additional, Shvidel, Lev, additional, Bairey, Osnat, additional, Lavi, Noa, additional, Horowitz, Netanel, additional, Avigdor, Avraham, additional, Lebel, Eyal, additional, Sofer, Orit, additional, Ram, Ron, additional, and Avivi, Irit, additional

Published
2019
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33. Rambam Health Care Campus Research Day Organizing Committee

Author

Blazer, Shraga, Giladi, Hadar Zigdon, Avraham, Karen B., Skorecki, Karl, Beyar, Rafael, Paul, Mical, Koppel, Fidi, Bitterman, Roni, Neuberger, Ami, Ghanem-Zoubi, Nesrin, Stern, Anat, Dickstein, Yaakov, Zbu-Zayyad, Hiba, Mussini, Cristina, Leibovici, Leonard, Yahav, Dafna, Yehudai-Reshef, Shlomit, Sabah, Rawan, Fridman-Dror, Anna, Gabay, Tal, Turgeman, Shira, Zuckerman, Tsila, Cohen-Vaizer, Mauricio, Fridman, Eran, Dakhlallah, Shifaa, Federman, Moria, Khamaysi, Iyad, Ben Hemo, Dalit, Bhattacharya, Udayan, Kinaneh, Safa, Ilan, Neta, Vlodavsky, Israel, Abassi, Zaid, Shinnawi, Rami, Shaheen, Naim, Huber, Irit, Shiti, Assad, Arbel, Gil, Gepstein, Amira, Tijsen, Anke, Borggrefe, Marin, Gepstein, Lior, Solt, Ido, Caspi, Or, Beloosesky, Ron, Weiner, Zeev, Avdor, Eyal, Rechtman, Hilla Korach, Hreish, Maysaa, Fried, Carmit, Gerassy-Vainberg, Shiran, Azzam, Zaher S., Kashi, Yechezkel, Berger, Gidon, Duek, Ori Samuel, Ben Naftali, Yeela, Ullmann, Yehuda, Ullman, Yehuda, Kuperman, Pora, Bosak, Noam, Granovsky, Yelena, Granot, Michal, Bahouth, Hany, Fadel, Shiri, Ben-Lulu, Hen, Marco, Avihu, Buxbaum, Chen, Sprecher, Elliot, Yarnitsky, David, Gelber, Pazit Shachar, Halil, Adnan, Gorelik, Yuri, Hag, Eisa, Hananya, Tomer, Leiba, Ronit, Half, Elizabeth, Fares, Basem, Perets, Ruth, Kurolap, Alina, Naoum, Nadine Damouny, Palacios-Zambrano, Sara, Mory, Adi, Paperna, Tamar, Garesse, Rafael, Mandel, Hanna, Zohar, Yaniv, Fernández-Moreno, Miguel A., Feldman, Hagit Baris, Ofir, Ayala, Pollack, Shirley, Eisenstein, Israel, Tzur, Shay, Magen, Daniella, Beck-Razi, Nira, Gaitini, Diana, Besser, Ziva, Halevi, Dorit, Javitt, Marcia, Horowitz, Netanel, Giryes, Sami, Nasser, Roni, Sharon, Rivka, Azoulay, David, Doppelt, Ofri, Cohen, Gal, Book, Reut, Elimelech, Rina, Tamari, Tal, Zigdon, Hadar, Hochberg, Irit, Alon, Raviv, Yom-Tov, Elad, Lauterbach, Roy, Matanes, Emad, Ben David, Chen, Mor, Omer, Linder, Revital, Cohen-Halbertal, Adi, Zipori, Yaniv, Ginsberg, Yuval, Ilan, Lena, Kabha, Ahmad, Zussman, Eyal, Amiel, Gilad, Mabariki, Therese Shehadeh, Sabo, Edmond, Kremer, Ran, Haverfeld, Ori, Sarig, Galit, Blich, Miry, Oron, Hodaya, Darawsha, Wisam, Suleiman, Mahmoud, Boulos, Monther, Luko, Liel, Parush, Avi, Lowenstein, Lior, Haklai, Ziona, Mendelovic, Joseph, Lavie, Gil, Mustafa-Mikhail, Susana, Amit, Amnon, Weiss, Karin, Steinberg, Maya, Hershkovitz, Tova, Ekhilevitch, Nina, Baris, Hagit N., Dabajah, Hanin, Gruenwald, Ilan, Aharoni, Saar, Tal, Raanan, Appel, Boaz, Ghannam-Shahbari, Dima, Jacob, Eyal, Kakun, Reli Rachel, Wasserman, Tanya, Korsensky, Lina, Sternfeld, Ofir, Kagan, Juliana, Bublik, Debora Rosa, Aviel-Ronen, Sarit, Levanon, Keren, Larisch, Sarit, Oren, Moshe, Hershkovitz, Dov, Zur, Gil, Litvin, Maria, Berkovich, Eyal, Andreus, Maisa, Beck, Nira, Na’ara, Shorook, Amit, Moran, Billan, Salem, Shinnawi, Shadi, Gil, Ziv, Amir, Moran, Yehieli-Cohen, Ravit, Masarwa, Omar, Ginini, Lana, Milman, Neta, and Namora, Khalil

Subjects
Guest Lecturers, Oral Presentations, Selected Abstracts from Rambam Research Day, Supplement
Published
2019

35. BST-236, a Novel Cytarabine Pro-Drug, Enables Safe and Effective Administration of High Dose Cytarabine to Older or Unfit Patients with Acute Leukemia. Results of a Phase I/II Study

Author

Zuckerman, Tsila, primary, Ram, Ron, additional, Koren-Michowitz, Maya, additional, Akria, Luiza, additional, Hoffman, Ron, additional, Henig, Israel, additional, Ofran, Yishai, additional, Lavi, Noa, additional, Horowitz, Netanel A, additional, Nudelman, Olga, additional, Yeganeh, Shay, additional, Gengrinovitch, Stela, additional, Flaishon, Liat, additional, Ben Yakar, Ruth, additional, and Rowe, Jacob M., additional

Published
2017
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36. Diffuse Large B Cell Lymphoma Mimicking Granulomatosis with Polyangiitis

Author

Naffaa, Mohammad E., Rozin, Alexander P., Horowitz, Netanel, Ben-Itzhak, Ofer, Braun-Moscovici, Yolanda, and Balbir-Gurman, Alexandra

Subjects
Article Subject, hemic and lymphatic diseases
Abstract

In a patient with systemic multiorgan disease with overlapping features, the differential diagnosis included infectious diseases, malignancies, and systemic autoimmune or inflammatory diseases. We present an unusual case of a young male with B cell lymphoma who presented with symptoms mimicking systemic vasculitis and review the existing literature.

Published
2016
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38. Astarabine, a Novel Leukemia-Targeted Cytarabine Composition Allows, for the First Time, the Delivery of High Cytarabine Doses for Older or Unfit Patients with Acute Leukemia. Results of an Ongoing Phase I/IIa Study

Author

Zuckerman, Tsila, primary, Gengrinovitch, Stela, additional, Ben-Yakar, Ruth, additional, Hoffman, Ron, additional, Henig, Israel, additional, Lavi, Noa, additional, Akria, Luiza, additional, Ofran, Yishai, additional, Horowitz, Netanel A, additional, Nudelman, Olga, additional, Koren-Michowitz, Maya, additional, Yeganeh, Shay, additional, Tallman, Martin S., additional, and Rowe, Jacob M., additional

Published
2016
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39. Primary Plasma Cell Leukemia Has a Poor Prognosis Even in the Era of Novel Agents - a Multicenter Case Series

Author

Ganzel, Chezi, primary, Rouvio, Ory, additional, Magen, Hila, additional, Jarchowsky, Osnat, additional, Avivi, Irit, additional, Herzog, Katrin, additional, Yossi, Cohen, additional, Tadmor, Tamar, additional, Horowitz, Netanel A, additional, Leiba, Merav, additional, Nagler, Arnon, additional, Cohen, Yael, additional, Bulvik, Shlomo, additional, Ben Yehuda, Dina, additional, Rowe, Jacob M., additional, and Gatt, Moshe E., additional

Published
2016
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40. Can We Improve the Predictive Value of Interim PET/CT Using a New Prognostic Model for Advanced Hodgkin Lymphoma?

Author

Dann, Eldad J., primary, Bairey, Osnat, additional, Bar-Shalom, Rachel, additional, Mashiach, Tanya, additional, Barzilai, Elinor, additional, Korenberg, Abraham, additional, Akria, Luiza, additional, Tadmor, Tamar, additional, Filanovsky, Kalman, additional, Abadi, Uri, additional, Kagna, Olga, additional, Ruchlemer, Rosa, additional, Goldschmidt, Neta, additional, Horowitz, Netanel A., additional, Lavie, David, additional, Ben-Yehuda, Dina, additional, Shpilberg, Ofer, additional, and Paltiel, Ora B., additional

Published
2016
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43. Psychological burden and depressive symptoms in caregivers of hemato-oncological patients: the role of medical visits

Author

Abed al Wahad, Ali, Elran-Barak, Roni, Furer, Marina, Abu Kamir, Gihan, and Horowitz, Netanel A.

Abstract

•In the ambulatory hematology setting, frequency of patient medical visits is linked to burden and depressive symptoms of family caregivers.•Reduction in the number and duration of such visits should be considered to decrease caregiver burden and depressive symptoms.

Published
2024
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44. Mosunetuzumab and Polatuzumab Vedotin Demonstrates Preliminary Efficacy in Elderly Unfit/Frail Patients with Previously Untreated Diffuse Large B-Cell Lymphoma

Author

Olszewski, Adam J, Eradat, Herbert, Avigdor, Abraham, Horowitz, Netanel A., Babu, Sunil, Levi, Itai, McKinney, Matthew, Lee, Seung Tae, Bergua Burgues, Juan Miguel, Rodriguez Izquierdo, Antonia, Bastos-Oreiro, Mariana, Ganzel, Chezi, Kim, Tae Min, Jeon, Youngwoo, Taszner, Michal, Narkhede, Mayur, Kim, Won Seog, Shin, Ho-Jin, Lavie, David, Woszczyk, Dariusz, Dunshee, Diana, Kapp, Amy V., Zhou, Mingzhu, Batlevi, Connie Lee, Ead, Wahib, Sellam, Gila, and Jurczak, Wojciech

Abstract

Background:Treatment options for elderly unfit/frail (U/F) patients (pts) with diffuse large B-cell lymphoma (DLBCL) are often limited due to comorbidities or functional decline. Less toxic, efficacious alternatives to full-dose chemoimmunotherapy (CIT) are needed. Mosunetuzumab (Mosun) is a first-in-class CD20xCD3 T-cell engaging bispecific antibody that redirects T cells to eliminate B cells. Mosun monotherapy has demonstrated efficacy, durable complete responses (CR), and manageable safety in U/F pts with untreated DLBCL (NCT03677154; Olszewski et al. ASH 2022). Subgroup analysis from an ongoing Phase Ib/II study (NCT03671018) of Mosun plus polatuzumab vedotin (Pola; M-Pola) in pts with relapsed/refractory DLBCL demonstrated efficacy and a manageable safety profile in pts ≥65 years (yrs) (Olszewski et al. ASH 2022). We report preliminary efficacy and safety data from the M-Pola cohort of study NCT03677154 in elderly U/F pts with newly diagnosed DLBCL.

Published
2023
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45. Efficacy and Safety of Glofitamab in Patients with R/R DLBCL in Real Life Setting - a Retrospective Study

Author

Gurion, Ronit, Guz, Dmitri, Kedmi, Meirav, Perry, Chava, Avivi Mazza, Irit, Horowitz, Netanel A., Abadi, Uri, Gafter-Gvili, Anat, Raanani, Pia, Goldschmidt, Neta, Nachmias, Boaz, and Aumann, Shlomzion

Abstract

Introduction- Glofitamab is a CD20-directed CD3 T-cell engager that has recently been approved by the FDA for relapsed and refractory diffuse large B cell lymphoma (R/R DLBCL). The approval was based on a pivotal phase II study including 154 patients with a median of 3 lines of treatment (a third post chimeric antigen receptor T (CAR-T) cell therapy) demonstrating an overall response rate (ORR) and complete response (CR) rate of 52% and 39%, respectively 1. However real-life data is still lacking. The present study was aimed to determine the efficacy and safety of glofitamab in real-life settings.

Published
2023
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46. Bone marrow blast elimination by the fifth day of 7 + 3 induction is the strongest predictor of potential cure in patients with acute myeloid leukemia younger than 61 years of age: A long‐term follow‐up of a multi‐center prospective study

Author

Ofran, Yishai, Hayun, Michal, Leiba, Ronit, Zuckerman, Tsila, Horowitz, Netanel, Hoffman, Ron, Ringelstein, Shimrit, Lavi, Noa, Frisch, Avraham, Henig, Israel, Gatt, Moshe E., Hellmann, Ilana, Arad, Ariela, Bulvik, Shlomo, Ram, Ron, Gino‐Moor, Sharon, Saban, Revital, Tvito, Ariella, Rowe, Jacob M., and Ganzel, Chezi

Published
2020
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50. Prospective comparison of early bone marrow evaluation on day 5 versus day 14 of the “3 + 7” induction regimen for acute myeloid leukemia

Author

Ofran, Yishai, primary, Leiba, Ronit, additional, Ganzel, Chezi, additional, Saban, Revital, additional, Gatt, Moshe, additional, Ram, Ron, additional, Arad, Ariela, additional, Bulvik, Shlomo, additional, Hellmann, Ilana, additional, Gino-Moor, Sharon, additional, Zuckerman, Tsila, additional, Hoffman, Ron, additional, Horowitz, Netanel, additional, Lavi, Noa, additional, Ringelstein, Shimrit, additional, Henig, Israel, additional, Hayun, Michal, additional, and Rowe, Jacob M., additional

Published
2015
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