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5. Efficient label-free chemiluminescent immunosensor based on dual functional cupric oxide nanorods as peroxidase mimics

Author

Li, Juan, Cao, Yue, Hinman, Samuel S, McKeating, Kristy S, Guan, Yiwen, Hu, Xiaoya, Cheng, Quan, and Yang, Zhanjun

Subjects
Analytical Chemistry, Chemical Sciences, Prevention, Antibodies, Immobilized, Biomimetic Materials, Biomimetics, Biosensing Techniques, Carcinoembryonic Antigen, Copper, Humans, Immunoassay, Limit of Detection, Luminescent Measurements, Nanotubes, Peroxidase, Dual-functionalization, Cupric oxide nanorods, Inununosensor, Peroxidase mimetics, Chemiluminescence, Carcinoembryonic antigen, Immunosensor, Biomedical Engineering, Nanotechnology, Bioinformatics, Analytical chemistry, Biomedical engineering
Abstract

Dual-functional cupric oxide nanorods (CuONRs) as peroxidase mimics are proposed for the development of a flow-through, label-free chemiluminescent (CL) immunosensor. Forming the basis of this cost-efficient, label-free immunoassay, CuONRs, synthesized using a simple hydrothermal method, were deposited onto epoxy-activated standard glass slides, followed by immobilization of biotinylated capture antibodies through a streptavidin bridge. The CuONRs possess excellent catalytic activity, along with high stability as a solid support. Antigens could then be introduced to the sensing system, forming large immunocomplexes that prevent CL substrate access to the surface, thereby reducing the CL signal in a concentration dependent fashion. Using carcinoembryonic antigen (CEA) as a model analyte, the proposed label-free immunosensor was able to rapidly determine CEA with a wide linear range of 0.1-60ngmL-1 and a low detection limit of 0.05ngmL-1. This nanozyme-based immunosensor is simple, sensitive, cost-efficient, and has the potential to be a very promising platform for fast and efficient biosensing applications.

Published
2018

16. Amphiphilic Polymer Capped Perovskite Compositing with Nano Zr‐MOF for Nanozyme‐Involved Biomimetic Cascade Catalysis.

Author

Ye, Qiuyu, Yuan, Enxian, Shen, Jin, Ye, Mingli, Xu, Qin, Hu, Xiaoya, Shu, Yun, and Pang, Huan

Subjects
PEROVSKITE, CATALYSIS, OPTICAL materials, POLYMERS, PRUSSIAN blue, VITAMIN C, ZIRCONIUM compounds, PEROXIDASE
Abstract

CsPbX3 perovskite nanocrystal (NC) is considered as an excellent optical material and is widely applied in optoelectronics. However, its poor water stability impedes its study in enzyme‐like activity, and further inhibits its application in biomimetic cascade catalysis. Herein, for the first time, the oxidase‐like and ascorbate oxidase‐like activities of an amphiphilic polymer capped CsPbX3 are demonstrated, and its catalytic mechanism is further explored. Furthermore, an all‐nanozyme cascade system (multifunctional CsPbBr3@Zr‐metal organic framework (Zr‐MOF) and Prussian blue as oxidase‐like and peroxidase‐like nanozyme) is constructed with a portable paper‐based device for realizing the dual‐mode (ratiometric fluorescence and colorimetric) detection of ascorbic acid in a point‐of‐care (POC) fashion. This is the first report on the utilization of all‐inorganic CsPbX3 perovskite NC in biomimetic cascade catalysis, which opens a new avenue for POC clinical disease diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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20. The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis

Author

Weng, Yiyun, primary, Gao, Yufan, additional, Zhao, Mingyue, additional, Zeng, Tian, additional, Huang, Jiaqi, additional, Xie, Haobo, additional, Huang, Jiexi, additional, Chen, Yiqun, additional, Hu, Xiaoya, additional, Xu, Jiahan, additional, Zhu, Jinrong, additional, Lin, Suichai, additional, Ke, Tingting, additional, Li, Xiang, additional, and Zhang, Xu, additional

Published
2022
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28. Design of privacy-preserving control strategy for data opacity of industrial internet (面向工业互联网中数据不透明性的 隐私保护控制策略设计)

Author

Shen, Yi, Zhou, ChunJie, Hu, XiaoYa, Cheng, Cheng, He, Xin, Tai, RuoChen, and School of Electrical and Electronic Engineering

Subjects
Industrial Internet, Electrical and electronic engineering [Engineering], Networked Discrete-Event Systems
Abstract

With the continuous development of information and communication technologies (ICT) as well as their applications in the industrial environment, industrial internet comes into being. In comparison to the relatively closed and secure production environment of traditional industries, the industrial internet faces significant security challenges in terms of data privacy. This paper investigates the privacy-preserving control problem for data opacity of the industrial internet to provide a resilient defending strategy against cyber threats, where the system to be controlled is modeled as a networked discrete-event system (DES) and malicious eavesdroppers exist to infer the system secret based on its observations. We here aim at designing a networked supervisor to achieve the following two objectives: (1) eavesdroppers cannot infer the system secret based on its observations, which is formulated as the requirement of opacity enforcement, (2) under the control of the designed networked supervisor, the system could still achieve the predetermined control requirement. To solve the previously mentioned privacy-preserving supervisory control problem, this paper first proposes a privacy-preserving control architecture for networked DES, in which each component is modeled as a finite-state automaton to simulate its dynamics. We design an algorithm based on the constructed models to synthesize the networked supervisor by transforming the original privacy-preserving control problem into a classical Ramadge-Wonham supervisory control problem. Furthermore, this paper proves (1) the designed synthesis algorithm is sound and complete, and (2) the existence of the supremal networked supervisor for this privacy-preserving supervisory control problem. 国家重点研发计划 (编号: 2018YFB1701202) 和国家自然科学基金青年基金 (批准号: 51905197) 资助项目.

Published
2022

47. Electrochemical determination of purine and pyrimidine DNA bases based on the recognition properties of azocalix[4]arene

Author

Xu Qin, Yin Li-na, Xiaoxian Liu, Hu Xiaoya, and Li Hongbo

Subjects
Purine, Pyrimidine, Chemistry, Guanine, Inorganic chemistry, Biomedical Engineering, Biophysics, General Medicine, Biosensing Techniques, DNA, Electrochemical Techniques, Electrochemistry, Carbon, Nucleobase, Thymine, chemistry.chemical_compound, Pyrimidines, Purines, Microscopy, Electron, Scanning, Organic chemistry, Differential pulse voltammetry, Electrodes, Cytosine, Biotechnology
Abstract

The azocalix[4]arene film modified glassy carbon electrode was established for the convenient and sensitive detection of four DNA bases (guanine, adenine, thymine and cytosine). Field emission scanning electron microscopy, attenuated total reflectance-FTIR and X-ray photoelectron spectroscopy were used to characterize the film. The azocalix[4]arene film exhibited excellent electrocatalytic activity toward the oxidation of all bases. Well-separated voltammetric peaks were obtained among guanine, adenine, thymine and cytosine, which lead to the feasibility for the simultaneous determination of all of them in a mixture without separation or pretreatment. Linear calibration curves were obtained from 0.125 to 200.0 μM for adenine, 0.125 to 175.0 μM for guanine, 2.50 to 650.0 μM for thymine, and 2.50 to 650.0 μM for cytosine. This sensor also exhibits good stability, reproducibility and long lifetime.

Published
2012

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