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In this paper, the boundary-based finite element method (BFEM) is developed for the bending-extension coupling analysis of shear deformable laminated composite curved beams with non-uniform thickness. The curved beams are discretized into a series of uniform straight segments. Based upon the first order shear deformation theory and the reciprocal theorem of Betti and Rayleigh, the boundary integral equations (BIEs) associated with each beam segment are derived and expressed in explicit form. The fundamental solutions required in the BIEs are obtained explicitly from the associated Green's function. Since no singular integrals, numerical integrations and function interpolations are involved in the BIEs, our proposed BFEM provides an exact solution for a straight beam with uniform thickness, and only one single element with two end nodes is required for our analysis. Even only an approximate solution is provided for a curved beam with non-uniform thickness, BFEM converges faster than the conventional finite element method, and the results are in well agreement with those obtained by the commercial finite element software. Through the illustrated numerical examples, its generality is shown by: (1) stacking sequence of laminates: symmetric or unsymmetric; (2) beam geometries: straight, stepped, or curvilinear with uniform or non-uniform thickness; (3) loading types: axial force, transverse force and/or bending moment; distributed or concentrated; and (4) supporting conditions: clamped, simply supported, or free; with or without internal supports. • Incorporate with bending-extensional coupling and transverse shear deformations. • Develop BFEM for composite laminated curved beams with non-uniform thickness. • Solve all involved integrals and construct element stiffness matrices explicitly. • Derive explicit-form analytical solutions for straight uniform laminated beams. • Provide more efficient and accurate results than conventional finite element method. [ABSTRACT FROM AUTHOR]

Risk factors were examined for subgroups of breast cancer characterized by estrogen receptor (ER) and progesterone receptor (PR) status. Data from the Carolina Breast Cancer Study, a population-based, North Carolina case-control study of 862 breast cancer cases aged 20–74 years diagnosed during 1993–1996 and 790 controls frequency matched on race and age, were obtained by personal interview. ER and PR status was retrieved from medical records (80%) or was determined in the authors' laboratory (11%) but was missing for 9% of cases. The receptor status distribution was as follows: 53% ER+PR+, 11% ER+PR−, 8% ER−PR+, and 28% ER−PR−. Several hormone-related factors were associated with stronger increased risks for ER+PR+ than for ER−PR− breast cancer: the elevated odds ratios were strongest for ER+PR+ breast cancer among postmenopausal women who had an early age at menarche (odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.4), nulliparity/late age at first full-term pregnancy (OR = 1.7, 95% CI: 0.9, 3.2 and OR = 1.6, 95% CI: 1.0, 2.7, respectively), or a high body mass index (OR = 1.6, 95% CI: 0.9, 3.0) and among pre-/perimenopausal women who had a high waist-hip ratio (OR = 1.9, 95% CI: 1.2, 3.1). In contrast, family history of breast or ovarian cancer and medical radiation exposure to the chest produced higher odds ratios for ER−PR− than for ER+PR+ breast cancer, especially among pre-/perimenopausal women. Am J Epidemiol 2000;151:703–14. [ABSTRACT FROM PUBLISHER]

Background Bacillus cereus is a ubiquitous gram-positive rod-shaped bacterium that can cause sepsis and neuroinvasive disease in patients with acute leukemia or neutropenia. Methods A single-center retrospective review was conducted to evaluate patients with acute leukemia, positive blood or cerebrospinal fluid test results for B cereus , and abnormal neuroradiographic findings between January 2018 and October 2022. Infection control practices were observed, environmental samples obtained, a dietary case-control study completed, and whole genome sequencing performed on environmental and clinical Bacillus isolates. Results Five patients with B cereus neuroinvasive disease were identified. All patients had acute myeloid leukemia (AML), were receiving induction chemotherapy, and were neutropenic. Neurologic involvement included subarachnoid or intraparenchymal hemorrhage or brain abscess. All patients were treated with ciprofloxacin and survived with limited or no neurologic sequelae. B cereus was identified in 7 of 61 environmental samples and 1 of 19 dietary protein samples—these were unrelated to clinical isolates via sequencing. No point source was identified. Ciprofloxacin was added to the empiric antimicrobial regimen for patients with AML and prolonged or recurrent neutropenic fevers; no new cases were identified in the ensuing year. Conclusions B cereus is ubiquitous in the hospital environment, at times leading to clusters with unrelated isolates. Fastidious infection control practices addressing a range of possible exposures are warranted, but their efficacy is unknown and they may not be sufficient to prevent all infections. Thus, including B cereus coverage in empiric regimens for patients with AML and persistent neutropenic fever may limit the morbidity of this pathogen. [ABSTRACT FROM AUTHOR]

Background: Some researchers have reported that Toxoplasma gondii can cause serious reproductive impairment in male animals. Specifically, T. gondii destroy the quality of sperm in the epididymis, which affects their sexual ability. However, among such studies, none have investigated the male reproductive transcriptome. Therefore, to investigate the relationship between T. gondii and sperm maturation, we infected mice with T. gondii prugniaud (PRU) strain and performed transcriptome sequencing of the epididymis. Results: Compared with the control group, 431 upregulated and 229 downregulated differentially expressed genes (DEGs) were found (P-value < 0.05, false discovery rate (FDR) < 0.05 and |log2 (fold change)| ≥ 1). According to results of a bioinformatics analysis, Gene Ontology (GO) function is divided into three categories: cellular component, molecular function and biological process. Upon performing GO analysis, we found that some DEGs correlated with an integral part of membrane, protein complex, cell surface, ATP binding, immune system process, signal transduction and metabolic process which are responsible for the epididymal injury. DEGs were mapped to 101 unique KEGG pathways. Pathways such as cytokine-cytokine receptor interaction, glycolysis/gluconeogenesis and apoptosis are closely related to sperm quality. Moreover, Tnfsf10 and spata18 can damage the mitochondria in sperm, which decreases sperm motility and morphology. Conclusions: We sequenced the reproductive system of male mice chronically infected with T. gondii, which provides a new direction for research into male sterility caused by Toxoplasma infection. This work provides valuable information and a comprehensive database for future studies of the interaction between T. gondii infection and the male reproductive system. [ABSTRACT FROM AUTHOR]