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Purpose: Previous suicide behavior predicts future suicide risk. Studies of suicide repetition are important for suicide prevention. This study examined the clinical characteristics and psychiatric comorbidities of pesticide self-harm as associated with suicide attempt repetition status. Patients and Methods: This retrospective, observational study included patients admitted to a medical center in northern Taiwan between 2000 and 2015 following suicide attempts by pesticide. Diagnoses were made by a consultation-liaison psychiatry team based on the DSM IV-TR criteria. Independent samples t-test was used to analyze the quantitative variables and Pearson's Chi-squared test with a Bonferroni adjustment for categorical variables. Univariate binary logistic regression analysis was conducted to determine the predictors for repeated suicide attempt and multivariate binary logistic regression analysis to identify significant associated factors. Results: Among 151 patients, organophosphate pesticides were the most used (80.8%). The average age was 52.9± 17.2 years. Most patients were married males from rural areas, with depressive disorder most often diagnosed (40.4%). Nearly one-third of them were suicide repeaters (n=43, 28.5%); these patients were less likely to be married (53.5%, p=0.001), had previously used psychiatric services (72.1%, p< 0.001) and chose complex suicide (46.5%, p=0.014) more often compared to nonrepeaters. No significant differences were found between repeaters and nonrepeaters regarding psychiatric comorbidities. Multivariate logistic regression analysis revealed that marital status (odds ratio: 2.916, 95% confidence interval: 1.234– 6.891, p=0.015) and previous psychiatric services usage (odds ratio: 6.897, 95% confidence interval: 3.012– 15.625, p< 0.001) were significant risk factors associated with suicide repetition. Conclusion: Pesticide suicide repeaters were characterized by less likely to be married and more likely to use psychiatric services before suicide attempts. These features help ensuring that the needs of people who have made a suicide attempt are addressed, and it reduces the likelihood of repetition. [ABSTRACT FROM AUTHOR]

Owing to global competition, integrated circuit (IC) design houses are facing challenges in the optimal use of capacity and resources to fulfill customer demands and maximize profit. A hybrid make-to-stock (MTS) and make-to-order (MTO) model is generally used. Wafer procurement is made according to customers’ long-term demand forecast based on MTS. Limited wafer fab resources and back-end capacity are first allocated to on-hand orders and then to forecast demand. In production planning, several factors need to be considered to determine the production quantity and inventory level, such as the material, capacity, substitute, technical constraint, and order tardiness. This study considers a typical multi-stage supply chain network of semiconductor back-end production with turnkey service for IC design houses. The objective is to maximize the total profit with the constraints of equipment capacity, the flexibility of substitutes, and the usage of the turnkey mode. The problem is formulated with a mixed-integer programming model and solved using two novel heuristic algorithms: a product-based decomposition (PD_SCP) with profit-based criteria and a Lagrangian decomposition combined with the product-based decomposition (LD-SCP) method. Using the LD-SCP algorithm takes a long time but results in a great solution. Sensitivity analysis is conducted to investigate the impact of different parameters on production cost and total profit. [ABSTRACT FROM AUTHOR]

The redox performances of 1–10 wt% Na-modified Fe 2 O 3 /Al 2 O 3 oxygen carrier from seawater were investigated using syngas/air as reactive gases in the thermogravimetric analyzer (TGA) and lab-scaled semi-fluidized bed reactor (semi-FzBR). NaNO 3(aq) as the source of sodium dopants to prepare Na-contained solution was implemented by an air atmospheric pressure plasma jet (Air-APPJ) process, which can increase the feasibility of seawater. For the prepared samples, the materials properties, including crystalline phases, surface morphologies, surface areas, and attrition loss performances were well correlated with the Na contents. The results indicated that the poor reduction kinetics and attrition resistance were obtained with the Na adjunction over 5 wt%, attributing to the sintering issue on excessive phases of Na 2 (Al, Fe) 12 O 19 and Na(Al, Fe)O 2 solid solution in the samples. Therefore, the slight incorporation of Na content in the Fe 2 O 3 /Al 2 O 3 samples which improved the reduction rate was proved as the candidate oxygen carriers. Particularly, the Na content with 1 wt% in Fe 2 O 3 /Al 2 O 3 sample (Na1FA32) can significantly promote the reduction behavior, thermal stability, and attrition resistance as compared to the raw Fe 2 O 3 /Al 2 O 3 oxygen carrier. It is environmentally beneficial to use the Na1FA32 as oxygen carrier in a practical chemical looping combustion process. [ABSTRACT FROM AUTHOR]

The use of seawater as catalytic agents for hematite (Fe 2 O 3 ) as oxygen carrier in chemical looping combustion process is attractive, because of its abundance and low cost. Unfortunately, seawater itself with major NaCl compound under reactive species accompanying the volatilization of chlorine-containing gases probably lead to the corrosion on reactors during the combustion process. In this study, the feasibility evaluation of sodium dopants extracted from seawater as an effective catalytic agent via an air atmospheric pressure plasma jet (Air-APPJ) is performed, and as such it is combined with Fe 2 O 3 /Al 2 O 3 to assess any possible enhancement on the reduction kinetics. The sodium-contained solutions, NaNO 3(aq) and NaCl (aq) , as precursors are used to prepare the sodium dopants due to the evaporation-decomposition of water and dissolved salts via plasma discharge reaction. The sodium-modified Fe 2 O 3 /Al 2 O 3 oxygen carrier can significantly promote the efficiency of the carbon capture efficiency and CO 2 yield. Especially for the NaCl (aq) as precursor in an Air-APPJ system, the high carbon capture efficiency, CO 2 molar fraction and CO 2 yield around 0.96, 0.95 and 0.91 after fifty redox cycle for the sodium-modified Fe 2 O 3 /Al 2 O 3 oxygen carrier are achieved. It can be anticipated that the sodium-modified Fe 2 O 3 /Al 2 O 3 from seawater by an Air-APPJ system as an oxygen carrier candidate in a reversible CLC process would be notably attractive. [ABSTRACT FROM AUTHOR]

Chronic brain stimulation has become a promising physical therapy with increased efficacy and efficiency in the treatment of neurodegenerative diseases. The application of deep brain electrical stimulation (DBS) combined with manganese-enhanced magnetic resonance imaging (MEMRI) provides an unbiased representation of the functional anatomy, which shows the communication between areas of the brain responding to the therapy. However, it is challenging for the current system to provide a real-time high-resolution image because the incorporated MnCl 2 solution through microinjection usually results in image blurring or toxicity due to the uncontrollable diffusion of Mn 2+ . In this study, we developed a new type of conductive nanogel-based neural interface composed of amphiphilic chitosan-modified poly(3,4 -ethylenedioxythiophene) (PMSDT) that can exhibit biomimic structural/mechanical properties and ionic/electrical conductivity comparable to that of Au. More importantly, the PMSDT enables metal-ligand bonding with Mn 2+ ions, so that the system can release Mn 2+ ions rather than MnCl 2 solution directly and precisely controlled by electrical stimulation (ES) to achieve real-time high-resolution MEMRI. With the integration of PMSDT nanogel-based coating in polyimide-based microelectrode arrays, the post-implantation DBS enables frequency-dependent MR imaging in vivo , as well as small focal imaging in response to channel site-specific stimulation on the implant. The MR imaging of the implanted brain treated with 5-min electrical stimulation showed a thalamocortical neuronal pathway after 36 h, confirming the effective activation of a downstream neuronal circuit following DBS. By eliminating the susceptibility to artifact and toxicity, this system, in combination with a MR-compatible implant and a bio-compliant neural interface, provides a harmless and synchronic functional anatomy for DBS. The study demonstrates a model of MEMRI-functionalized DBS based on functional neural interface engineering and controllable delivery technology, which can be utilized in more detailed exploration of the functional anatomy in the treatment of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Sintered silver paste is widely used as the die-attachment material for power semiconductors. However, sintered silver joints encounter problems, such as severe coarsening of sintered pores and oxidation issues, in harsh high-temperature environments. These lead to the deterioration of the die-attachment joints. In this paper, a novel method of sintering silver joints is demonstrated, where silver–indium alloy paste is used to improve the reliability of sintered Ag joints. The silver–indium (Ag–In) alloy paste was fabricated through mechanical alloying using the ball-milling technique. The well-bonded sintered Ag–In alloy joints inhibited pore coarsening better than pure sintered Ag joints and significantly enhanced the mechanical properties at high operating temperatures. Lastly, an oxidation mechanism for the sintered joint was proposed, and strategies to prevent such high-temperature oxidation were discussed. [ABSTRACT FROM AUTHOR]

Simple Summary: Systemic therapy is current standard treatment for patients with hepatocellular carcinoma (HCC) with macrovascular invasion (MaVI). However, the outcome is poor. In the present study, we analyzed the outcome of patients treated with combined sorafenib, radiotherapy (RT), and transarterial chemoembolization (TACE) or sorafenib alone. The result showed superior overall survival in the combined modality group. Moreover, we conducted propensity score matching and multivariable analysis, showing that combined modality resulted in superior overall survival. Thus, we concluded adding TACE and RT to sorafenib might prolong survival in patients with HCC and MaVI. Background: Approximately 10–40% of hepatocellular carcinoma (HCC) patients have definite vascular invasion at the time of diagnosis. Without curative treatment options, these patients have an abysmal prognosis with a median survival of only a few months following systemic therapy. However, supportive evidence of combining multiple locoregional treatments with systemic therapy is limited. This study compared the outcomes of sorafenib alone versus multimodality therapy with sorafenib, radiotherapy (RT), and transarterial chemoembolization (TACE) in advanced HCC patients with macrovascular invasion (MaVI). Methods: The process took place over a nine-year period between March 2009 and October 2017, wherein 78 HCC patients with MaVI who underwent either sorafenib therapy alone (n = 49) or combined sorafenib/RT/TACE (n = 29) therapy were chosen for the retrospective study. We compared the overall survival (OS) between the two groups using the Cox regression hazard model and adjusted imbalances using propensity score matching (PSM). Results: At the last follow-up, 76 patients had died, with a median follow-up time of 4.8 months for all patients and 31 months for those who were alive. Patients treated with sorafenib/RT/TACE had superior OS compared to those treated with sorafenib alone, showing a median survival of 9.3 vs. 2.7 months and a one-year survival of 37.1% vs. 6.1% (p < 0.001). In the multivariable analysis, new diagnosis or recurrence of HCC and treatment modalities (sorafenib alone vs. sorafenib/RT/TACE) were independent prognostic factors for OS. Compared to patients treated with sorafenib alone, significantly better OS was further verified using PSM (p < 0.001) in patients who received multiple therapeutic modalities. Conclusion: Multimodality therapy with sorafenib/RT/TACE increased OS threefold versus sorafenib therapy alone in HCC patients with MaVI. This study offers promising benefits of combined locoregional and systemic therapy for advanced HCC in current patient management and prospective clinical trials. [ABSTRACT FROM AUTHOR]

The possibility of using electric arc furnace dust (EAFD) as regenerable sorbents to adsorptive hydrogen sulfide was studied. To avoid the releasing of zinc vapor and leaching of heavy metal matter, the addition of Al 2 O 3 was used as inert stabilizer to suppress the volatilization of zinc vapor and generate a more stable chemical forms in EAFD. The results of redox behavior and toxicity characteristic leaching procedure show that Al 2 O 3 are excellent stabilizers for EAFD of industrial waste. Multi-cycle tests of sulfidation/regeneration showed that the prepared EAFD/Al 2 O 3 sorbents can be regenerated and thus reused after the regeneration process. After ten sulfidation/regeneration cycles, the sulfur capacity of the tenth cycle remained approximately on a level of 79% of the sulfur capacity in the first cycle. The results based on the material characterization and sulfidation/regeneration performance evaluation showed that EAFD/Al 2 O 3 sorbent has desirable physical and chemical properties for the desulfurization of simulated syngas at high-Temperature range. Therefore, EAFD with addition of Al 2 O 3 has a potential utilization for the removal of hydrogen sulfide. [ABSTRACT FROM AUTHOR]

As a transmitter power amplifier (PA), the electrical output characteristics of gallium nitride (GaN) high electron mobility transistors (HEMTs) are closely related to the drain current versus drain voltage (${I}_{d}$ – ${V}_{d}$) characteristics. Any abnormalities in the ${I}_{d}$ – ${V}_{d}$ characteristics will seriously affect device performance. Therefore, many groups have investigated the kink effect of GaN HEMTs. One of the commonly used measurement methods of the kink effect is the ${I}_{d}$ – ${V}_{d}$ forward and reverse sweep. In this study, we used the same method for Al2O3/Si3N4–AlGaN/GaN metal–insulator–semiconductor HEMT (MIS HEMT) devices. We found that not only did the kink effect occurred but ${I}_{d}$ also increased abnormally during the reverse sweep and after a series of electrical measurements. At the end of the forward sweep, impact ionization caused by a high ${V}_{d}$ generated electron–hole pairs and some holes accumulated under the gate region, which caused the negative shift of the threshold voltage (${V}_{\text{Th}}$), leading to an abnormal increase in ${I}_{d}$ during the reverse sweep. [ABSTRACT FROM AUTHOR]

The use of scaled-down micro-bumps in miniaturized consumer electronic products has led to the easy realization of full intermetallic solder bumps owing to the completion of the wetting layer. However, the direct contact of the intermetallic compounds (IMCs) with the adhesion layer may pose serious reliability concerns. In this study, the terminal reaction of the Ti adhesion layer with Cu–Sn IMCs was investigated by aging the micro-bumps at 200 °C. Although all of the micro-bumps transformed into intermetallic structures after aging, they exhibited a strong attachment to the Ti adhesion layer, which differs significantly from the Cr system where spalling of IMCs occurred during the solid-state reaction. Moreover, the difference in the diffusion rates between Cu and Sn might have induced void formation during aging. These voids progressed to the center of the bump through the depleting Cu layer. However, they neither affected the attachment between the IMCs and the adhesion layer nor reduced the strength of the bumps. In conclusion, the IMCs demonstrated better adhesive behavior with the Ti adhesion layer when compared to Cr, which has been used in previous studies. [ABSTRACT FROM AUTHOR]

Abstract: This study fabricated hydrogenated diamond-like carbon/silver bioceramic films on glass substrates using radio frequency magnetron sputtering with a single silver target in an atmosphere of Ar/CH4 mixture. The effects of applied power on the composition and microstructure of bioceramic film were evaluated. A phase transformation, amorphous diamond-like carbon → nano-silver precipitation → nano-silver growth in the amorphous diamond-like carbon matrix was observed during sputtering. The film growth rate, surface roughness, silver content and size of silver nanoclusters in the films all increased with the silver target power due to the higher flux of sputtered silver species toward the substrate. [Copyright &y& Elsevier]

This study investigates an improvement in memory characteristics through depositing an In2O3 layer as an oxygen ion reservoir in the switching layer (SL) of resistive random access memory (RRAM). The deposition of In2O3, denoted as Pt/HfO2/In2O3/TiN device, provides better memory characteristics including lower forming voltage (VF), set/reset voltage (VSET/VRESET), larger memory window, and higher resistances with higher uniformity at low resistance state (LRS) and high resistance state (HRS), compared to the devices without the In2O3 deposition, denoted as Pt/HfO2/TiN device. The conduction mechanisms, verified through fitting current–voltage (I - V) curves, are consistent with the results of a varied temperature I - V experiment. Finally, a physical model is proposed to explain our observations. [ABSTRACT FROM AUTHOR]

This article explains the difference in the reset processes between single RRAM and 1T1R RRAM structures. In the single RRAM, as the reset voltage increases, the off-state resistance increases. This is a normal RRAM operation. However, in the 1T1R structure, the reset voltage increases while the OFF-state resistance does not increase. This may be caused by either current or voltage being insufficient to switch the RRAM to its higher resistance state. The measurements of real voltage indicate that the insufficient voltage is in fact the main cause. For the 1T1R RRAM structure, if it is to be reset to a higher resistance state, it is best done by increasing the gate voltage to increase the OFF-state resistance. Therefore, we provide a method to reduce the misjudgment in the array, and it would be beneficial for the development of high-density memory. [ABSTRACT FROM AUTHOR]

This paper investigates material modifications induced by cosputtering indium-tin oxide (ITO) with gadolinium (Gd) at two different power levels. In addition, resistance switching (RS) properties were also verified for use as an insulator in resistive random access memory (RRAM). Comparison of scanning electron microscope (SEM) measurements for the two different cosputtering powers indicated significant changes of the ITO surface. Transparency was also verified by an N&K analyzer measurement, with results indicating a constant in transparency induced by the lower power Gd doping, indicating potential for transparent applications. Furthermore, the mole fraction ratio defined by X-ray photoelectron spectroscopy reveals a Gd2O3 peak, a likely reason for the ITO thin film becoming less conductive. This ITO/Gd:ITO/TiN RRAM can exhibit stable and robust RS characteristics at a lower forming voltage. In addition, lower operating voltages, including both SET and RESET voltages, can be obtained. Reliability tests including endurance and retention were carried out to confirm its RS stability. The RS mechanism of this ITO/Gd:ITO/TiN device was also investigated with the current–voltage (${I}$ – ${V}$) fitting method. Moreover, temperature effects were also applied to verify the high-resistance state (HRS) mechanism. Finally, a conduction model was proposed to clarify the RS characteristics and confirm that the ITO/Gd:ITO/TiN device is appropriate for data storage. [ABSTRACT FROM AUTHOR]

Abstract In this study, a facile co-electrodeposition method has been developed to co-deposit iridium oxide and human plasma proteins. We use a cyclic voltammetry (CV) approach for co-electrodeposition on indium tin oxide-coated glass substrates. We adjust the percentages of plasma proteins as 1%, 3%, 5% and 7% to obtain different film thicknesses. We also optimize the number of cycles to achieve the ideal thickness. Cyclic voltammetry, field emission scanning electron microscopy, and Fourier-transform infrared spectroscopy were used for characterizing the deposited film. The results show that the plasma proteins can be successfully co-deposited with iridium oxide. The incorporation of plasma proteins results in an increase in the roughness of the film. The thickness of the electrodeposited layer is dependent on the concentration of plasma proteins. [ABSTRACT FROM AUTHOR]

In this paper, vanadium oxide (VOx) was chosen for the resistive switching layer in a typical resistive random access memory (RRAM) structure. During negative forming bias, we found an initial selector property. This indicates the presence of metal–insulator-transition characteristics in the VOx layer even without an annealing process. In order to study this phenomenon, material analyses were conducted, with results indicating that there are V-O stretching bonds and an oxide/vanadium ratio of nearly 2.2 (${O}/{V} = {2.2}$). In addition, the experimental results of the dc sweeping test indicated that off-state current gradually decreased after each cycle, meaning that the selectivity characteristics in the VOx selector could be improved. Endurance performance of our experimental devices reached 108, sufficient for integration with RRAM devices in a 1S1R array. To further investigate this special phenomenon, current fitting analysis and simulation analyses were conducted. The results of the fitting analysis indicated that the conduction mechanism for off-state current was Schottky emission and the Schottky distance increased with increasing numbers of cycles. In other words, oxide ions migrate toward the filament at low negative voltage during dc sweeping, causing the formation of VOx. Furthermore, the results of thermal field simulation analysis indicated that there is a thermal concentration effect in and around the filament. Thus, oxide ions more easily migrate toward the vanadium filament when a stronger electrical field is present around the filament during dc sweeping cycles. Finally, stable vanadium selector characteristics are obtained and a conduction filament behavior model is proposed. [ABSTRACT FROM AUTHOR]

Background: We present the first comprehensive analysis of Mycobacterium tuberculosis (MTB) isolates circulating in southern Taiwan. In this 9-year population-based study, the TB situation in the Kaohsiung region was characterized by genotypic analysis of 421 MTB isolates. Methods: All 421 isolates of MTB were analyzed by spoligotyping and MIRU-VNTR typing. Drug-resistance patterns were also analyzed. Results: The percentage of EAI (East African-Indian) strains increased across sampling years (2000–2008) in southern Taiwan, whereas the proportion of Beijing lineages remained unchanged. Clustering was more frequent with EAI genotype infections (odds ratio = 3.6, p<0.0001) when compared to Beijing genotypes. Notably, MTB resistance to streptomycin (STR) had significantly increased over time, but resistance to other antibiotics, including multidrug resistance, had not. Three major genes (gidB, rpsL and rrs) implicated in STR resistance were sequenced and specific mutations identified. Conclusions: This study revealed that EAI strains were highly transmissible and that STR resistance has increased between 2000 and 2008 in Kaohsiung, Taiwan. [ABSTRACT FROM AUTHOR]

Although traditional 3D scaffolds or biomimetic hydrogels have been used for tissue engineering and regenerative medicine, soft tissue microenvironment usually has a highly anisotropic structure and a dynamically controllable deformation with various biomolecule distribution. In this study, we developed a hierarchical hybrid gelatin methacrylate-microcapsule hydrogel (HGMH) with Neurotrophin-3(NT-3)-loaded PLGA microcapsules to fabricate anisotropic structure with patterned NT-3 distribution (demonstrated as striped and triangular patterns) by dielectrophoresis (DEP). The HGMH provides a dynamic biomimetic sinuate-microwrinkles change with NT-3 spatial gradient and 2-stage time-dependent distribution, which was further simulated using a 3D finite element model. As demonstrated, in comparison with striped-patterned hydrogel, the triangular-patterned HGMH with highly anisotropic array of microcapsules exhibits remarkably spatial NT-3 gradient distributions that can not only guide neural stem cells (NSCs) migration but also facilitate spinal cord injury regeneration. This approach to construct hierarchical 4D hydrogel system via an electromicrofluidic platform demonstrates the potential for building various biomimetic soft scaffolds in vitro tailed to real soft tissues. [Display omitted] [ABSTRACT FROM AUTHOR]

A technique was proposed to concentrate the distribution of set voltages. After a plasma treatment, the stability of the high-resistive state (HRS) increased, and the distribution of set voltages was more concentrated at 0.8 V, with a sufficient HRS/LRS resistive ratio (∼100x). In addition, the surface of the TiN electrode became rougher, causing oxygen to enter the TiN electrode and form a TiON layer, which acts as an oxygen reservoir. The reservoir is confirmed and the conduction model is supported by both electrical and material analyses. We propose that the observed improvement is due to the difference in the TiN electrode surface. Image 1 • Applied the plasma treatment on electrode to stabilize set voltage. • Construct the physical model to explain abnormal current conduction. • Complete electrical and material analysis were performed in this work. [ABSTRACT FROM AUTHOR]