Search

Your search keyword '"Iris N. Vos"' showing total 2 results
Start Over Author "Iris N. Vos" Search Limiters Full Text
2 results on '"Iris N. Vos"'

1. Anatomical Markers Associated With the Presence of Intracranial Aneurysms in Individuals Screened for Aneurysms

Author

Iris N. Vos, Rick J. van Tuijl, Liselore A. Mensing, Maud E. H. Ophelders, Mireille R. E. Velthuis, Nicolaas P. A. Zuithoff, Gabriel J. E. Rinkel, Hugo J. Kuijf, Jaco J. M. Zwanenburg, Irene C. van der Schaaf, Birgitta K. Velthuis, and Ynte M. Ruigrok

Subjects
arterial diameters, bifurcation angels, circle of Willis, imaging markers, intracranial aneurysms, magnetic resonance angiography, Neurology. Diseases of the nervous system, RC346-429, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Hemodynamic stress is linked to the development of intracranial aneurysms (IAs) and may be influenced by anatomic variation of intracranial arteries. We assessed diameters and bifurcation angles of intracranial arteries forming the circle of Willis in a cohort of individuals screened for the presence of IAs. Methods Individuals with and without IAs identified at screening with magnetic resonance angiography were compared. Diameters and bifurcation angles of the following arteries were measured using semiautomatic methods: A1 and A2 segments of the anterior cerebral artery, M1 and M2 segments of the middle cerebral artery, P1 segments of the posterior cerebral artery, posterior communicating artery (Pcom), internal carotid artery, vertebral artery, and basilar artery. We employed univariate general linear models to assess group differences. This included subgroup comparisons between individuals with IAs at specific locations and matched controls, and comparisons on group level between individuals with and without IAs, corrected for age and sex. Results In 94 of the 1049 individuals (9.0%) included, IAs were detected. Individuals with middle cerebral artery IAs had wider ipsilateral M2–M2 bifurcation angles compared with controls (121±25° versus 97±19°; P

Published
2024
Full Text
View/download PDF

2. Indirect frontocingulate structural connectivity predicts clinical response to accelerated rtms in major depressive disorder

Author

René M.H. Besseling, Albert P. Aldenkamp, Iris N. Vos, Alexander Leemans, Szabolcs David, Chris Baeken, Karen Caeyenberghs, Deborah C.W. Klooster, Electromagnetics for Care & Cure Lab (EM4C&C), Center for Care & Cure Technology Eindhoven, Electromagnetics, Video Coding & Architectures, Biomedical Engineering, Signal Processing Systems, EAISI Health, Brain, Body and Cognition, Clinical sciences, Neuroprotection & Neuromodulation, and Psychiatry

Subjects
Cingulate cortex, brain, medicine.medical_treatment, SDG 3 – Goede gezondheid en welzijn, computer.software_genre, Gyrus Cinguli, behavioral disciplines and activities, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, SDG 3 - Good Health and Well-being, Voxel, rTMS, Fractional anisotropy, Neural Pathways, mental disorders, medicine, Humans, Pharmacology (medical), Biological Psychiatry, Medicine(all), Depressive Disorder, Major, Cross-Over Studies, major depressive disorder, business.industry, medicine.disease, Prognosis, Transcranial Magnetic Stimulation, Frontal Lobe, Transcranial magnetic stimulation, Psychiatry and Mental health, Diffusion Magnetic Resonance Imaging, Treatment Outcome, Brain stimulation, Major depressive disorder, business, computer, Neuroscience, 030217 neurology & neurosurgery, Diffusion MRI, Tractography, Research Paper
Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD), but its clinical efficacy remains rather modest. One reason for this could be that the propagation of rTMS effects via structural connections from the stimulated area to deeper brain structures (such as the cingulate cortices) is suboptimal.Methods: We investigated whether structural connectivity — derived from diffusion MRI data — could serve as a biomarker to predict treatment response. We hypothesized that stronger structural connections between the patient-specific stimulation position in the left dorsolateral prefrontal cortex (dlPFC) and the cingulate cortices would predict better clinical outcomes. We applied accelerated intermittent theta burst stimulation (aiTBS) to the left dlPFC in 40 patients with MDD. We correlated baseline structural connectivity, quantified using various metrics (fractional anisotropy, mean diffusivity, tract density, tract volume and number of tracts), with changes in depression severity scores after aiTBS.Results: Exploratory results (p < 0.05) showed that structural connectivity between the patient-specific stimulation site and the caudal and posterior parts of the cingulate cortex had predictive potential for clinical response to aiTBS.Limitations: We used the diffusion tensor to perform tractography. A main limitation was that multiple fibre directions within voxels could not be resolved, which might have led to missing connections in some patients.Conclusion: Stronger structural frontocingular connections may be of essence to optimally benefit from left dlPFC rTMS treatment in MDD. Even though the results are promising, further investigation with larger numbers of patients, more advanced tractography algorithms and classic daily rTMS treatment paradigms is warranted.Clinical trial registration: http://clinicaltrials.gov/show/NCT01832805

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results