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Southeast Asia was known to the classical Islamic world as a region of trade and burgeoning local Muslim communities from the earliest decades of the Islamic era. By the 16th century direct diplomatic connections were established between the local communities and the Ottoman Caliphate and this significant historical relationship is crucial for understanding the dynamics between the Western and Eastern Islamic worlds. Relations persisted until the First World War, after which the Republic of Türkiye emerged as the successor to the Ottoman Empire and interactions were more limited until Malaysia's independence in 1957, after which a new phase of relations began, and by the 1990s, the relationship between Malaysia and Türkiye had rebounded. This study aims to explore the historical and contemporary relations between Turks and Malays based on primary sources, including Ottoman and Turkish archives, as well as Bahasa Melayu and English materials. [ABSTRACT FROM AUTHOR]

A vast number of studies have acknowledged the existence of Islamophobia, but few have attempted to deconstruct the concept. This study deconstructs Islamophobia into its constituent elements: hatred, hostility, and racism against Islam and Muslims. The study seeks to shed light on some methods applied by Prophet Muhammad (PBUH) in dealing with the roots of hatred, racism, and stereotypes. This can lead members of society to practice different forms of animosity between people based on religion, race, color, etc. In this context, the study confirms the depth of the prophetic biography and its ability to provide the modern world with systematic methods in dealing with its growing problems and challenges. Based on this biography, the study proposes solutions to the matter of Islamophobia, including the need for Muslims to interact with the regional and international societies from a standpoint of collaboration and engagement. This would be for the universal benefit of all societies and humanity in general. [ABSTRACT FROM AUTHOR]

The Japanese were the only colonial power that challenged British hegemony in Sabah, then known as “North Borneo”. In 1941 they attacked and defeated the British North Borneo Company (BNBC) and assumed governance of the land for the remainder of the war. Although their presence was temporary, it was enough to fundamentally alter the course of the history of Sabah. This paper explores the effects of the Japanese occupation during the years 1942 to 1963, concentrating on economic, political, and social progress. This includes two distinctive periods: the invasion and occupation (1942-1945) and over the longer term, including both positive and negative effects for local peoples. This study is important to understand the reasons for the transition of Sabah from a British Protectorate to a Crown Colony, set against its role in the framework of the Japanese “Greater East Asia Co-Prosperity Sphere”. Studies of the history of Sabah in general are lacking, particularly concerning the important years of British colonialism, the Japanese occupation, and the decolonization period. This study draws on archival and library resources to find that the Japanese occupation brought problems to certain parties and fields, alongside some tangible benefits for some groups. It is hoped that this study will open up historical understanding and investigation of the significance of Japanese influence in Sabah. [ABSTRACT FROM AUTHOR]

Prior to his renewed incumbency, as the fourth Prime Minister of Malaysia, Mahathir Mohamad (b. 1925) was able to remain in power for a more prolonged period compared to his predecessors. He was actively involved in galvanizing political action immediately after the independence of Malaysia and did not abandon active politics until his 2003 resignation. Under Mahathir's leadership and guidance, Malaysia made remarkable economic and political progress. He oversaw many innovations in the fledgling democracy and was able to develop the country due to his exceptional leadership qualities. His style and attitude towards engaging with problems, particularly his stance during the Asian Monetary Crisis in 1997, was highly criticized by some, and labelled as dictatorial. This stigma did not detract him from the path he considered right for Malaysia, and under his leadership he garnered worldwide appreciation for his national efforts and success in overcoming the economic crisis. Mahathir is undeniably an excellent case study as a prime minister, as well as a highly productive person. He contributed to a better understanding of modern Malaysia and his own tenure as PM in a series of books and articles. One of the significant aspects of his political heritage is his influential charisma and leadership. In all of his undertakings he has attracted both passionate support and hatred from friends and foes, but his political footsteps have always been certain and directed toward Malaysia's national wellbeing. Mahathir is a politician with sharp views on many issues and he was profoundly brave in verbalising them in the public arena, within Malaysia and internationally. His clear posture and speeches without fear made him a world-embracing political personality. This descriptive research study adopts a qualitative approach to analyse historical information, documents, memoirs and articles, and books to better understand the leadership of Mahathir. [ABSTRACT FROM AUTHOR]

Following their violent suppression of the Indian Revolution of 1857, the British founded and consolidated their secular empire in the Indian Subcontinent, which marginalized and bypassed religion as far as possible, particularly Islam, which had been the official religion of the Mughal ancien régime. Contemporaneous Ottoman efforts to counter European imperialism led to Sultan Abdul Hamid II's (r. 1876-1909) policy of pan-Islamism, particularly the call for Islamic unity against the Russian aggression against Turkey in 1877. It was at this critical juncture that some Indian Muslim scholars gallantly volunteered to counter this threat, and to preserve the Islamic faith and heritage worldwide, despite the severe problems faced by the Muslims in India itself. This study highlights the role of an eminent scholar in this movement, namely Allama Shibli Nu'mani (1857-1914), who in 1914 conceived the idea of founding the world-famous Islamic research institute Darul Musannefin Shibli Academy in his home town of Azamgarh, Uttar Pradesh, India. Shibli was very active and instrumental in collecting donations from the wealthy landowners (zamindars) among the Muslim elite in his hometown of Azamgarh for the Ottoman cause, raising 3,000 rupees, which was handed to Husain Hasib Afendi, the Ottoman Consul in Bombay in 1877. Furthermore, his eloquent poetry rallied Muslims across India to support the valour and heroism displayed in the jihad by Ghazi Usman Pasha against the Russians. Shibli travelled to Istanbul in 1892 and met with the Pasha, on whose efforts Tamgha-i Majidi (gold medal) was granted to Shibli on 13th Muharram, 1310/7th August, 1892. This article is based on Shibli's major works in Urdu, particularly his arousing eulogies (qasaid), Turkish archival reports, newspapers and magazines, and secondary sources in Urdu and English. [ABSTRACT FROM AUTHOR]

This paper studies waqf projects including schools, mosques, orphanages and housing built by Turkish aid agencies in Aceh province of Indonesia after the 2004 Aceh Tsunami following the Indian Ocean Earthquake. Such projects continue to be actively supported and to serve the Acehnese community, playing an important role with local organizations. Besides the Turkish Government, NGOs such as Turkish Foundation Institutions including the Turkish Red Crescent (Kızılay), Deniz Feneri and Humanitarian Relief Foundation (IHH) are the main groups considered in this study. The paper situates Turkish waqf in the long-term history of relations between Turkey and Aceh, dating from the mid-16th century, which was reinvigorated by Turkish solidarity following the 2004 tsunami. Essentially, the fact that there is a serious lack of literature on studies of these institutions and activities and their deeper cultural significance is the main rationale for presenting this work. The main purpose of this study is to examine the foundation and relief works from Turkey to Aceh after the shocking earthquake of 9.1 magnitude, which resulted in 126,741 deaths, 93,285 missing and massive destruction of property and infrastructure on 26th December 2004 in Aceh. [ABSTRACT FROM AUTHOR]

This study traces the history of the origin and development of Unani medicine in the Islamic world and its later blossoming in Persia. Based mainly on Arabic, Persian, Urdu and English sources, the study focuses on the intellectual legacy of the Muslims in the development of Unani medicine and their interest in the progress of medical sciences, when a number of classical works were produced by great Muslim scholars during this period that provide evidence of organized medical care that provided the basis for modern medicine as it emerged from the 17th century onwards in Europe. The early Muslim scholars' works were focused on the integration or Islamicisation of human knowledge in the areas of medical and health-care sciences as well as those who seek to understand the role of moral values and Maqaṣid al-Sharīʿah ('objectives of Sharīʿah) in medical and healthcare practices in a more comprehensive framework, exposing the dynamic contribution of Islamic civilization to medical progress that was later obscured in modernity by Western ideologies. [ABSTRACT FROM AUTHOR]

Muslim presence was manifest in the coastal regions of Southern India from the earliest days of Islam, as evidenced by the establishment of Arab trading settlements, with minor political impact prior to the conquests in Northern India from the beginning of the 8th century, which solidified the influence of Islam leading to tangible political and socio-cultural impacts in the region. The history of India furnishes an amazing picture of the syntheses of many divergent cultural trends which were gradually transformed by a process of mutual adjustment and assimilation. Islam played a significant role in this by contributing to India's multi-cultural and multi-religious ethos, embedding the subcontinent in the Arab-Islamic maritime civilization, stretching from southern Africa to China, particularly in connecting Africa as well as the great Turkic empires of Central Asia. It offers a pertinent example of the interaction of human minds and the effects of cultural and civilizational contacts on indigenous customs, religion, literature and arts. This paper examines the impact of Islam in the Indian Peninsula from three different angles: its political predominance, its intellectual and cultural impact, and finally, its influence on art and architecture. Based mainly on Arabic and Persian sources, the article focuses on the intellectual legacy, achievements and the role that the Indian Muslims played in the Indian subcontinent during the Delhi Sultanate, the first major Islamic political authority to govern large parts of South Asia. [ABSTRACT FROM AUTHOR]

Two novel organoantimony(V) and two organobismuth(V) complexes of the type ML2 were synthesized, with L = acetylsalicylic acid (HL1) or 3-acetoxybenzoic acid (HL2) and M = triphenylantimony(V) (M1) or triphenylbismuth(V) (M2). Complexes, [M1(L1)2] (1), [M1(L2)2]·CHCl3 (2), [M2(L1)2], (3) and [M2(L2)2] (4), were characterized by elemental analysis, IR and NMR. Crystal structures of triphenylantimony(V) dicarboxylate complexes 1 and 2 were determined by single crystal X-ray diffraction. Structural analyses revealed that 1 and 2 adopt five-coordinated extremely distorted trigonal bipyramidal geometries, binding with three phenyl groups in the equatorial position and two deprotonated organic ligands (L) in the axial sites. The metal complexes, their metal salts and ligands were evaluated in vitro for their activities against Leishmania infantum and amazonensis promastigotes and Staphylococcus aureus and Pseudomonas aeruginosa bacteria. Both the metal complexes showed antileishmanial and antibacterial activities but the bismuth complexes were the most active. Intriguingly, complexation of organobismuth(V) salt reduced its activity against Leishmania, but increased it against bacteria. In vitro cytotoxic test of these complexes against murine macrophages showed that antimony(V) complexes were the least toxic. Considering the selectivity indexes, organoantimony(V) complexes emerge as the most promising antileishmanial agents and organobismuth(V) complex 3 as the best antibacterial agent. [ABSTRACT FROM AUTHOR]

Previous studies have shown that the association of the drug meglumine antimoniate (MA) with β-cyclodextrin can improve its bioavailability by the oral route. In this work, ribose and maltose were investigated for their ability to form mixed or association complexes with MA, release MA and modulate the serum levels of Sb after oral administration in mice. Analysis of the MA/ribose composition by high performance liquid chromatography coupled to mass spectrometry (LCMS-IT-TOF) revealed the presence of mixed meglumine-Sb-ribose and Sb-ribose complexes. Analysis of the MA/maltose composition suggested the formation of MA-maltose association compounds. Circular dichroism characterization of these compositions following dilution in water at 37 °C suggested a partial and slow dissociation of the association compounds. When the MA/ribose composition was administered orally and compared to MA, the serum concentration of Sb was significantly lower after 1 h and greater after 3 h. On the other hand, the MA/maltose composition showed similar serum Sb concentration after 1 h and higher level of Sb after 3 h, when compared to MA. In conclusion, the present study has demonstrated the formation of mixed or association complexes of MA with sugars, such as maltose and ribose, which promoted sustained serum level of Sb after oral administration. [ABSTRACT FROM AUTHOR]

The All-India Muslim League (AIML) was formed in 1906, with the primary aim to improve the educational and socioeconomic status of Muslims. Allama Shibli Nu'mani (1857-1914) put forward an argument in support of Muslims recovering from the political stupor into which they had fallen after the British suppression of the 1857 uprising. He encouraged Muslims to participate in democratic politics in India, departing from the educational focus of his mentor, Sir Saiyid Ahmad Khan (1817-1898). Shibli advanced a strong critique of the Muslim League's limited ambitions in comparison with the Indian National Congress (INC). His critique, notably in ironic and emotive poetry, signiicantly contributed to the national discussion pertaining to the Muslim League's reform and restructure. Based on Shibli's original writings, this paper analyses his critique of the Muslim League and his efforts to overhaul its structure and policies. It examines the response of the Muslim League to these critiques and studies the extent to which its structure and policies changed. [ABSTRACT FROM AUTHOR]

[Display omitted] • Leishmaniasis that affects nearly 0.7–1.3 million people annually, has so far limited and high toxic therapeutic options. • Novel coumarin-isatin hybrids have been synthesized and characterized. • Docking study reveals Spf-6 , Spf-8 and Spf-10 as the best lead molecules. • All the compounds were evaluated for their leishmanicidal potential. • Three compounds were highly active against L. tropica promastigotes and amastigotes. Leishmaniasis being one of the six major tropical diseases that affects nearly 0.7–1.3 million people annually, has so far limited and high toxic therapeutic options. Herein, we report the synthesis, in silico, and in vitro evaluations of novel coumarin-incorporated isatin hydrazones (Spf-1 – Spf-10) as highly potent and safe antileishmanial agents. Molecular docking was initially carried out to decipher the binding confirmation of lead molecules towards the active cavity of the target protein (Leishmanolysin gp63) of Leishmania tropica. Among all the docked compounds, only Spf-6 , Spf-8, and Spf-10 showed high binding affinities due to a pattern of strong conventional hydrogen bonds and hydrophobic π-interactions. The molecular dynamics simulations showed the stable pattern of such bonding and structure-based confirmation with a time scale of 50 ns towards the top compound (Spf-10) and protein. These analyses affirmed the high stability of the system. Three out of ten compounds evaluated for their antileishmanial activity against Leishmania tropica promastigotes and amastigotes were found to be active at micromolar concentrations (IC 50 range 0.1–4.13 μmol/L), and most importantly, they were also found to be highly biocompatible when screened for their toxicity in human erythrocytes. [ABSTRACT FROM AUTHOR]

Corynebacterium pseudotuberculosis (Cp) is a pathogenic bacterium that causes caseous lymphadenitis (CLA), ulcerative lymphangitis, mastitis, and edematous to a broad spectrum of hosts, including ruminants, thereby threatening economic and dairy industries worldwide. Currently there is no effective drug or vaccine available against Cp. To identify new targets, we adopted a novel integrative strategy, which began with the prediction of the modelome (tridimensional protein structures for the proteome of an organism, generated through comparative modeling) for 15 previously sequenced C. pseudotuberculosis strains. This pan-modelomics approach identified a set of 331 conserved proteins having 95-100% intra-species sequence similarity. Next, we combined subtractive proteomics and modelomics to reveal a set of 10 Cp proteins, which may be essential for the bacteria. Of these, 4 proteins (tcsR, mtrA, nrdI, and ispH) were essential and non-host homologs (considering man, horse, cow and sheep as hosts) and satisfied all criteria of being putative targets. Additionally, we subjected these 4 proteins to virtual screening of a drug-like compound library. In all cases, molecules predicted to form favorable interactions and which showed high complementarity to the target were found among the top ranking compounds. The remaining 6 essential proteins (adk, gapA, glyA, fumC, gnd, and aspA) have homologs in the host proteomes. Their active site cavities were compared to the respective cavities in host proteins. We propose that some of these proteins can be selectively targeted using structure-based drug design approaches (SBDD). Our results facilitate the selection of C. pseudotuberculosis putative proteins for developing broad-spectrum novel drugs and vaccines. A few of the targets identified here have been validated in other microorganisms, suggesting that our modelome strategy is effective and can also be applicable to other pathogens. [ABSTRACT FROM AUTHOR]

The Actinobacteria, Corynebacterium pseudotuberculosis strain P54B96, a nonmotile, non-sporulating and a mesophile bacterium, was isolated from liver, lung and mediastinal lymph node lesions in an antelope from South Africa. This strain is interesting in the sense that it has been found together with non-tuberculous mycobacteria (NTMs) which could nevertheless play a role in the lesion formation. In this work, we describe a set of features of C. pseudotuberculosis P54B96, together with the details of the complete genome sequence and annotation. The genome comprises of 2.34 Mbp long, single circular genome with 2,084 protein-coding genes, 12 rRNA, 49 tRNA and 62 pseudogenes and a G+C content of 52.19%. The analysis of the genome sequence provides means to better understanding the molecular and genetic basis of virulence of this bacterium, enabling a detailed investigation of its pathogenesis. [ABSTRACT FROM AUTHOR]

Synergistic combinations of various antimicrobial agents are considered ideal strategies in combating clinical and multidrug resistant (MDR) infections. In this study, antibacterial potential of Jatropha curcas crude seed extracts, seed oil, commercially available antibiotics, and their combinations were investigated for their synergistic effect against clinical, MDR and ATCC bacterial strains by agar well diffusion assay. Methanolic extracts remained more active against Staphylococcus aureus (ATCC), with zone of inhibition (ZOI) of 21 mm, than clinical and methicillin-resistant S. aureus (MRSA) strains (ZOI range ~ 15.0–17.0 mm). Molecular docking demonstrated that beta-monolaurin from methanolic extract exhibited greater affinity conformation for UDP-N-acetylmuramoyl-tripeptide–d-alanyl-d-alanine (MurF) ligase's active pocket with binding energy of -7.3 kcal/mol. Moxifloxacin exhibited greater activity against Escherichia coli (ATCC) (ZOI ~ 50.0 mm), followed by ofloxacin against Pseudomonas chlororaphis (47.3 mm), moxifloxacin against P. monteilii (47 mm), P. aeruginosa (46.3 mm) and MRSA2 (46 mm) and ofloxacin against S. aureus (ATCC) strains (45.7 mm). Methanolic extract in combination with rifampicin showed the highest synergism against MRSA strains, A. baumannii, E. coli, E. faecalis, S. aureus, and P. aeruginosa, A. baumannii (MDR strain), P. chlororaphis, E. coli ATCC25922 and S. aureus ATCC25923. In combinations, moxifloxacin exhibited the highest antagonism. The methanolic, n-hexane, aqueous extracts and seed oil in various combinations with antibiotics showed 44.71, 32.94, 9.41 and 25.88% synergism, respectively. The current study showed that potency of antibiotics was improved when screened in combination with J. curcas seed's components, supporting the drug combination strategy to combat antibacterial resistance. [ABSTRACT FROM AUTHOR]