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A pandemic that is fast developing, the coronavirus epidemic is putting unprecedented pressure on healthcare systems. Children with renal disorders, including those undergoing renal transplantation, those with chronic kidney disease, and those with acute kidney damage necessitating dialysis, offer treatment issues due to COVID-19, particularly for those using long-term immunosuppressive medicines. The urgent requirement is for us to be ready to handle this vulnerable group of kids. This article's goals are to help caregivers and medical professionals manage children with renal illnesses, maintain patient well-being, and safeguard staff from infection. Setting:Participants and their data were drawn from an existing consent to contact database of the Infectious disease center of the Khorezm region. The candidates were 2 to 12 years of age, 20 women, and the ratio of male to female children was 67 % to 87 %. These individuals were receiving care (treatment and medication support) at different centers especially designated for Covid-19 infection in the Khorezm region and at different clinics in the Khorezm region. We retrieved the data from the infectious control center where all the data were collected from all centers of the Khorezm region. They can speak English or Russian, and agreed to be contacted for further research. Methods:A prospective study with Cohort study/guidelines from WHO for Covid-19 care and self-protection. A combined Cohort study of the COVID-19 survey was performed telephonically and personally for 15-20 minutes maximum, which included a discussion with doctors who attended and had any information about this syndrome. Research Focus:This researchis focusing ontheproblems of (MIS-C), which is a rare complication of COVID-19, but it can be serious or dangerous. The symptoms can overlap with infections and other illnesses. What are the circumstances and conditions of this disease, and what steps we can take to address them?

Coronavirus disease 2019 (COVID-19) has been declared a pandemic given its global spread. Children account for 1% of patients and are less likely to become seriously ill than adults; although preschool children and infants may have severe clinical manifestations. For two years, the damage to the organs of the urinary system in children with Covid-19 disease has been progressive in nature and today is one of the colossally urgent problems of medicine. Kidney pathology has a high risk of developing in children at different stages of Covid-19 compared to the general population .

While the covid-19 pandemic has affected the world, pediatric cases of covid-19 infections have been reported. this article analyzes bout clinical and Laboratory characteristics including Imaging characteristics also.All the data is based on published data from the m Center for infectious disease. Clinical data from 150 children's read covid-19 end almost 15 articles include for the quantitative analysis. Among these children, the children have fever was 41% to 95%, and cough37% to 87% which are the most common symptoms of these children. other issues showed infection and severe cases respectively were for 23%. The Jetta from theLaboratory Illustrated that tthat5% of the patients had lymphopenia. The dirty traffic data including the chest computed tomography demonstrated unilateral and bilateral lesions and ground glass opacity in almost32% to 34% end 28% respectively end normal approximately in 30% of children. this data shows us the children who were infected with covid-19 infection acquired a lot of other symptomatic infections but the overall rate of severe illness was low this data was collected from the original singer of the infection disease Hospital and other regions needed to determine. Even though six individuals had concomitant AKI that was not detected in this investigation, there were no complaints of vomiting or diarrhea, which is one of the signs of AKI. It's interesting to note that certain postmortem histopathological studies showed interaction with or damage to patients with COVID-19 whose renal tissue was not previously identified by regular testing (higher urea or creatinine values), suggesting the potential for subclinical AKI. Setting:Participants and their data were drawn from an existing consent to contact database of the Infectious disease center of the Khorezm region. The candidates were 2 to 12 years of age, 20 women, and the ratio of male to female children was 67 % to 87 %. These individuals were receiving care (treatment and medication support) at different centers especially designated for Covid-19 infection in the Khorezm region and at different clinics in the Khorezm region. We retrieved the data from the infectious control center where all the data were collected from all centers of the Khorezm region. They can speak English or Russian, and agreed to be contacted for further research. Methods:A prospective study with Cohort study/guidelines from WHO for Covid-19 care and self-protection. A combined Cohort study of the COVID-19 survey was performed telephonically and personally for 15-20 minutes maximum, which included a discussion with doctors who attended and had any information about this syndrome.

Although medically children are not at risk, but inthe ongoing COVID 19 pandemic has serious implications for children. New evidence donot clearly definerenal manifestations. Among the reasons for the lack of efficacy of the ongoing treatment of patients with renal complications, an incomplete understanding of its pathogenesis in children who have had a coronavirus infection plays a special role.Biochemical blood tests revealed the elevated blood and urine MC levels which in 1/5 of the patients with high parameters. Moderate proteinuria and transient macrohaematuria were observed in children in the COVID-19 group with renal complications. Children with moderate to severe ChKD with COVID-19 or with recurrent nephrotic syndrome are at risk of severe complications, including severe AKF or ChKF. This data indicates that the children with COVID-19 infection should be closely monitored for the development and progression of RF and special measures should be taken to prevent it.

Here we are elaborating the cases of a rare reaction of COVID-19 vaccine based on adenoviral (ChAdOx1) vector, the reactions include thrombocytopenia (low level of platelets count), rare type of blood clots, and ischemic strokes. The cases describe first a Pakistani 55 years old man who was hypertensive and diagnosed MI before 3 years, was on different medication, took first shot of vaccine (AZD1222) and felt little weakness including headache, after 3rd day of shot a greater elevation in blood pressure was seen, later he fell unconscious and later on computer tomography scan on head showed clots in right hemisphere with acute cerebral edema, the patient was completely paralyzed on the left size, in the blood reports there was a rapid decline in platelets count from 110000 to 65000 per uL, patient had 2 cardiac strokes events on 7th day of hospitalization with 2nd cardiac stroke he passed away, with CT scan it showed clots in both hemisphere , and blood reports showed platelet factor (PE-4) reactive antibody, here we took a reference of Danish 60 years old woman who was diagnosed with same kind of events after receiving same vaccine first shot, she passed away on 6th day of hospitalization. Her CT scan and MRI scan also showed acute cerebral edema, and blood reports revealed platelet factor (PF-4) reactive antibody, many countries also reported such cases, but no detailed information was provided. This can be novel immune response against specific type of vaccine, need to be evaluated further. Keywords: Thrombocytopenia, Hemorrhage, Stroke, antibodies, vector, vaccines