15 results on '"J.-P. Lejeune"'
Search Results
2. From skeletal muscle to stem cells: an innovative and minimally-invasive process for multiple species
- Author
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J. Ceusters, J.-Ph. Lejeune, C. Sandersen, A. Niesten, L. Lagneaux, and D. Serteyn
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Medicine ,Science - Abstract
Abstract Bone marrow and adipose tissue represent the two most commonly exploited sources of adult mesenchymal stem cells for musculoskeletal applications. Unfortunately the sampling of bone marrow and fat tissue is invasive and does not always lead to a sufficient number of cells. The present study describes a novel sampling method based on microbiopsy of skeletal muscle in man, pigs, dogs and horses. The process includes explant of the sample, Percoll density gradient for isolation and subsequent culture of the cells. We further characterized the cells and identified their clonogenic and immunomodulatory capacities, their immune-phenotyping behavior and their capability to differentiate into chondroblasts, osteoblasts and adipocytes. In conclusion, this report describes a novel and easy-to-use technique of skeletal muscle-derived mesenchymal stem cell harvest, culture, characterization. This technique is transposable to a multitude of different animal species.
- Published
- 2017
- Full Text
- View/download PDF
3. Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age.
- Author
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M Robles, E Nouveau, C Gautier, L Mendoza, C Dubois, M Dahirel, B Lagofun, M-C Aubrière, J-P Lejeune, I Caudron, I Guenon, C Viguié, L Wimel, H Bouraima-Lelong, D Serteyn, A Couturier-Tarrade, and P Chavatte-Palmer
- Subjects
Medicine ,Science - Abstract
Obesity is a growing concern in horses. The effects of maternal obesity on maternal metabolism and low-grade inflammation during pregnancy, as well as offspring growth, metabolism, low-grade inflammation, testicular maturation and osteochondrotic lesions until 18 months of age were investigated.Twenty-four mares were used and separated into two groups at insemination according to body condition score (BCS): Normal (N, n = 10, BCS ≤4) and Obese (O, n = 14, BCS ≥4.25). BCS and plasma glucose, insulin, triglyceride, urea, non-esterified fatty acid, serum amyloid A (SAA), leptin and adiponectin concentrations were monitored throughout gestation. At 300 days of gestation, a Frequently Sampled Intravenous Glucose Tolerance Test (FSIGT) was performed. After parturition, foals' weight and size were monitored until 18 months of age with plasma SAA, leptin, adiponectin, triiodothyronine (T3), thyroxine (T4) and cortisol concentrations measured at regular intervals. At 6, 12 and 18 months of age, FSIGT and osteoarticular examinations were performed. Males were gelded at one year and expression of genes involved in testicular maturation analysed by RT-qPCR.Throughout the experiment, maternal BCS was higher in O versus N mares. During gestation, plasma urea and adiponectin were decreased and SAA and leptin increased in O versus N mares. O mares were also more insulin resistant than N mares with a higher glucose effectiveness. Postnatally, there was no difference in offspring growth between groups. Nevertheless, plasma SAA concentrations were increased in O versus N foals until 6 months, with O foals being consistently more insulin resistant with a higher glucose effectiveness. At 12 months of age, O foals were significantly more affected by osteochondrosis than N foals. All other parameters were not different between groups.In conclusion, maternal obesity altered metabolism and increased low-grade inflammation in both dams and foals. The risk of developing osteochondrosis at 12 months of age was also higher in foals born to obese dams.
- Published
- 2018
- Full Text
- View/download PDF
4. Prise en charge des anomalies intracrâniennes de découverte fortuite
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N. Hadhoum, Didier Leys, J.-P. Lejeune, J P Pruvo, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Lille Inflammation Research International Center - U 995 (LIRIC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 (ONCO-THAI), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Pasteur de Lille, and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
- Subjects
03 medical and health sciences ,0302 clinical medicine ,[SDV]Life Sciences [q-bio] ,030212 general & internal medicine ,Neurology (clinical) ,030217 neurology & neurosurgery - Abstract
Resume La decouverte fortuite d’anomalies lors d’une exploration en imagerie par resonance magnetique (IRM) est observee 1 fois toutes les 37 IRM si l’on exclue les anomalies de la substance blanche, les infarctus silencieux et les micro-saignements. Cette proportion augmente avec l’injection de gadolinium, des sequences angiographiques, et l’âge des personnes. Les consequences sont parfois benefiques pour le patient lorsqu’elles permettent un traitement (par exemple d’une tumeur), ou la surveillance d’une lesion a risque evolutif (syndrome radiologique isole susceptible de representer un stade precoce de sclerose en plaques). Elles sont plus souvent deleteres par les consequences psychologiques et sociales qu’elles induisent, et les strategies therapeutiques auxquelles elles exposent, soient en traitant des anomalies qui ne devraient pas l’etre (par exemple certaines malformations arterioveineuses), ou en privant par exces de prudence le patient d’un traitement (thrombolyse intraveineuse en presence d’un anevrisme silencieux). Dans la plupart des cas l’incertitude prevaut et la decision necessite, en l’absence d’essais randomises, une analyse multidisciplinaire du risque spontane et du traitement, et la preference du patient. Un medecin qui demande la realisation d’une IRM doit avoir a l’esprit le risque de decouverte d’une anomalie fortuite qui ne rendra qu’exceptionnellement service au patient. Cette decouverte peut generer de l’anxiete chez les patients et leurs proches, et les exposer a des refus d’assurances, et une consommation excessive et souvent injustifiee de ressources medicales. Une telle eventualite doit etre anticipee, ce qui serait plus aise si l’acces a l’IRM etait reserve aux specialistes du sujet.
- Published
- 2019
5. Behavioral Disorders in Association with Posterior Callosal and Frontal Cerebral Infarction
- Author
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J. P. Lejeune and D. Caparros-Lefebvre
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Behavioral disorders were a prominent clinical feature after the surgical treatment of an anterior communicating artery aneurysm rupture in a 44-year-old man. Callosal apraxia was associated with an alien hand. The latter remained 1 year after surgery while diagonistic apraxia disappeared after 3 months. Other callosal signs included left agraphia, tactile anomia and auditory suppression. MRI revealed posterior callosal infarction and a right frontal infarct. The association of diagonistic apraxia and alien hand is rarely reported.
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- 1993
- Full Text
- View/download PDF
6. Subarachnoid hemorrhage in ten questions
- Author
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J P Lejeune, Jérôme Hodel, Catherine Oppenheim, Olivier Naggara, Rabih Aboukais, Xavier Leclerc, Denis Trystram, J.-F. Meder, J.P. Pruvo, Christine Rodriguez-Régent, and Myriam Edjlali
- Subjects
Male ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Contrast Media ,Hemorrhage ,Aneurysm, Ruptured ,Fluid-attenuated inversion recovery ,Sensitivity and Specificity ,Spinal Puncture ,Diagnosis, Differential ,Subarachnoid Hemorrhage, Traumatic ,Aneurysm ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Neurologic Examination ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Lumbar puncture ,Mortality rate ,General Medicine ,Middle Aged ,Subarachnoid Hemorrhage ,Image Enhancement ,medicine.disease ,Intracranial aneurysm ,Magnetic Resonance Imaging ,Cerebral Angiography ,Surgery ,Transcranial Doppler ,nervous system diseases ,Angiography ,Radiology ,Emergencies ,Artifacts ,Tomography, X-Ray Computed ,business ,Magnetic Resonance Angiography ,Cortical sulcus ,Hydrocephalus ,CT ,MRI - Abstract
Traumatic subarachnoid hemorrhage (SAH) has an annual incidence of 9 per 100 000 people. It is a rare but serious event, with an estimated mortality rate of 40% within the first 48hours. In 85% of cases, it is due to rupture of an intracranial aneurysm. In the early phase, during the first 24hours, cerebral CT, combined with intracranial CT angiography is recommended to make a positive diagnosis of SAH, to identify the cause and to investigate for an intracranial aneurysm. Cerebral MRI may be proposed if the patient's clinical condition allows it. FLAIR imaging is more sensitive than CT to demonstrate a subarachnoid hemorrhage and offers greater degrees of sensitivity for the diagnosis of restricted subarachnoid hemorrhage in cortical sulcus. A lumbar puncture should be performed if these investigations are normal while clinical suspicion is high.
- Published
- 2015
- Full Text
- View/download PDF
7. Optic Nerve Sheath Meningocele: A Case Report
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O. Wavreille, E. Halimi, R. Rosenberg, I. Bouacha, J.-P. Lejeune, and S. Defoort-Dhellemmes
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Optic nerve sheath ,medicine.diagnostic_test ,business.industry ,Case Report ,Magnetic resonance imaging ,Anatomy ,Lesion ,Ophthalmology ,medicine.anatomical_structure ,Cerebrospinal fluid ,Optic nerve ,medicine ,Neurology (clinical) ,medicine.symptom ,business ,Orbit (anatomy) - Abstract
Isolated optic nerve sheath meningocele is a rare affection defined as the cystic enlargement of the optic nerve sheath filled with cerebrospinal fluid. We report the case of a 39-year-old woman presenting with bilateral meningocele uncovered during a routine examination for headache complaints. A 5-year follow-up validated the lesion’s clinical and imaging stability. Magnetic resonance imaging (MRI) is an essential tool in the diagnosis of this pathology, alongside characteristic symptoms indicating that the meningocele might have progressively expanded into the orbit. In this case we present a therapeutic approach based on pathophysiological hypotheses and review of the literature.
- Published
- 2013
8. Sstr2A: a relevant target for the delivery of genes into human glioblastoma cells using fiber-modified adenoviral vectors
- Author
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Jean-Claude D'Halluin, P Dournaud, E. Grellier, Anne Loyens, Morvane Colin, M Baroncini, J.C. Beauvillain, Dominique Demeyer, J P Lejeune, Z Csaba, Luc Buée, Séverine Bégard, Raphaëlle Caillierez, Ariane Sharif, Prévot, and Katia Lécolle
- Subjects
Coxsackie and Adenovirus Receptor-Like Membrane Protein ,Integrins ,Genetic Vectors ,Immunoblotting ,Molecular Sequence Data ,CHO Cells ,Biology ,medicine.disease_cause ,Adenoviridae ,Viral vector ,03 medical and health sciences ,Transduction (genetics) ,Cricetulus ,0302 clinical medicine ,Transduction, Genetic ,Cell Line, Tumor ,Cricetinae ,Tumor Cells, Cultured ,Genetics ,medicine ,Animals ,Humans ,Amino Acid Sequence ,Receptors, Somatostatin ,Receptor ,Molecular Biology ,030304 developmental biology ,Cell Nucleus ,0303 health sciences ,Microscopy, Confocal ,Brain Neoplasms ,Somatostatin receptor ,HEK 293 cells ,Genetic Therapy ,Endocytosis ,3. Good health ,HEK293 Cells ,Somatostatin ,Cell culture ,Immunology ,Cancer research ,Molecular Medicine ,Capsid Proteins ,Glioblastoma ,030217 neurology & neurosurgery - Abstract
Glioblastomas are the most aggressive of the brain tumors occurring in adults and children. Currently available chemotherapy prolongs the median survival time of patients by only 4 months. The low efficiency of current treatments is partly owing to the blood-brain barrier, which restricts the penetration of most drugs into the central nervous system. Locoregional treatment strategies thus become mandatory. In this context, viral tools are of great interest for the selective delivery of genes into tumoral cells. Gliomas express high levels of type 2 somatostatin receptors (sstr2A), pinpointing them as suitable targets for the improvement of transduction efficiency in these tumors. We designed a new adenoviral vector based on the introduction of the full-length somatostatin (SRIF (somatotropin release-inhibiting factor)) sequence into the HI loop of the HAdV fiber protein. We demonstrate that (i) HAdV-5-SRIF uptake into cells is mediated by sstr2A, (ii) our vector drives high levels of gene expression in cells expressing endogenous sstr2A, with up to 65-fold enhancement and (iii) low doses of HAdV-5-SRIF are sufficient to infect high-grade human primary glioblastoma cells. Adenoviral vectors targeting SRIF receptors might thus represent a promising therapeutic approach to brain tumors.
- Published
- 2012
9. Effect of a 120 km endurance race on plasma and muscular neutrophil elastase and myeloperoxidase concentrations in horses
- Author
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A. G. Goachet, J. P. Lejeune, Audrey Fraipont, A. Mouithys-Mickalad, D. Votion, Justine Ceusters, G. de la Rebière de Pouyade, Ariane Niesten, Thierry Franck, Charlotte Sandersen, Didier Serteyn, Céline Robert, J. L. Leclerc, and E. Van Erck
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Elastase ,Physical exercise ,General Medicine ,Creatine ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Myeloperoxidase ,Neutrophil elastase ,Internal medicine ,Blood plasma ,Immunology ,biology.protein ,Absolute neutrophil count ,Medicine ,Creatine kinase ,business - Abstract
Summary Reasons for performing study: Intense physical exercise can induce the degranulation of neutrophils leading to an increase in plasma concentration of the neutrophil marker enzymes myeloperoxidase (MPO) and elastase (ELT). These enzymes have pro-oxidative and pro-inflammatory properties and may play a role in the exercised-induced muscular damage. Objectives: To measure MPO and ELT concentrations in plasma and muscles of endurance horses and to correlate them to the extent of exercise-induced muscular damage. Methods: Seven endurance horses qualified on 120 km races were tested in this study. Neutrophil count, serum creatine kinase (CK), plasmatic and muscular MPO and ELT concentrations were measured before and 2 h after a 120 km endurance race. Results: The race produced a significant increase of neutrophils, CK, and plasma MPO and ELT levels. A significant correlation was observed between the MPO and ELT values in plasma (r2= 0.92, P
- Published
- 2010
10. Age-dependent expression of osteochondrosis-related genes in equine leukocytes
- Author
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R. Bruno, Florian Noguier, Didier Serteyn, Charlotte Sandersen, J. P. Lejeune, David Piquemal, Luis Mendoza, and L. Vander Heyden
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General Veterinary ,MMP1 ,Apolipoprotein B ,biology ,business.industry ,Lameness ,Research ,Joint diseases ,Skeletal development ,Horse ,Inflammation ,Orthopaedics ,Bioinformatics ,medicine.disease ,Andrology ,Warmblood ,medicine ,Osteochondrosis ,biology.protein ,Horses ,medicine.symptom ,business ,Gene - Abstract
Introduction: Osteochondrosis (OC) is a developmental disease in horses which has a significant impact on the horse's welfare and performance. The early disturbance in the process of endochondral ossification progresses to inflammatory and repair processes in older horses. Previously, differentially expressed genes in leukocytes of OC-affected horses have been identified. The aim of the present study is to detect age-related changes in these differentially expressed genes. Materials and Methods: The expression of OC-related genes was analysed by real-time PCR and subsequent statistical analysis (ΔΔCT) in the leukocytes of 135 Belgian Warmblood horses divided into three different age groups: 30 months (n=38). Results: Relative expression of genes of horses less than 12 months of age showed significant induction of the genes MGAT4A, PRKCG, MHCI, ApoB, ApoB3G, B4GALT6 and a significantly lower expression of the genes OAS3. Horses of 18–24 months of age, showed a significantly higher expression of the genes TBC1D9, MGAT4A, IFIH1, MHCIIa and MMP1. Horses of more than 30 months of age showed a significantly higher expression of the genes MGAT4A, HP, SECTM1 compared with their age-matched control groups. Conclusions: The study demonstrates that OC-related genes are differentially expressed in horses of different ages compared with their age-matched controls. Some of the genes may be implicated in cell signalling and differentiation as well as carbohydrate and lipid metabolism and inflammation. However, the causal relationship between the differentially expressed genes and the development and progression of the OC lesions needs to be determined.
- Published
- 2015
11. New perspective for field measurement of cardiorespiratory parameters in exercising horses
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J. P. Lejeune, L. van der Heyden, Tatiana Art, E. Van Erck, D. Votion, Didier Serteyn, and Isabelle Caudron
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medicine.medical_specialty ,Equine ,business.industry ,Cellular respiration ,Cardiorespiratory fitness ,Submaximal exercise ,Oxygen uptake ,Blood chemistry ,Internal medicine ,Respiration ,Heart rate ,Cardiology ,Physical therapy ,Medicine ,Atp production ,business - Abstract
In the exercising horse, the oxygen delivery to the muscle enables the regeneration of high-energy phosphates (ATP) which are necessary for sustaining an effort and for subsequent recovery. For a fixed and constant level of submaximal exercise, the pulmonary oxygen uptake (VO2) reflects a balance between the energy required by the working muscles and ATP production via the aerobic metabolism. In horses performing
- Published
- 2006
12. RARE TUMOURS
- Author
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E. Panosyan, M. Gotesman, T. Kallay, S. Martinez, M. Bolaris, J. Lasky, F. Fouyssac, J.-C. Gentet, D. Frappaz, C. Piguet, S. Gorde-Grosjean, J. Grill, E. Schmitt, S. Pall-Kondolff, P. Chastagner, R. Dudley, M. Torok, D. Gallegos, A. Liu, M. Handler, T. Hankinson, K. Fukuoka, T. Yanagisawa, T. Suzuki, M. Shirahata, J.-i. Adachi, K. Mishima, T. Fujimaki, M. Matsutani, A. Sasaki, S. Wada, R. Nishikawa, M. Suzuki, A. Kondo, M. Miyajima, H. Arai, S. Morin, E. Uro-Coste, C. Munzer, M. Gambart, S. Puget, C. Miquel, C.-A. Maurage, C. Dufour, P. Leblond, N. Andre, J. Kanold, C. Icher, A.-a. I. Bertozzi, B. Diez, A. Muggeri, S. Cerrato, B. Calabrese, N. Arakaki, A. Marron, G. Sevlever, M. J. Fisher, B. C. Widemann, E. Dombi, P. Wolters, A. Cantor, A. Vinks, J. Parentesis, N. Ullrich, D. Gutmann, D. Viskochil, J. Tonsgard, B. Korf, R. Packer, B. Weiss, L. Marcus, A. Kim, A. Baldwin, P. Whitcomb, S. Martin, A. Gillespie, A. Doyle, C. Bulwer, H.-W. Gan, A. Ederies, M. Korbonits, M. Powell, O. Jeelani, T. Jacques, E. Stern, H. Spoudeas, M. Kimpo, J. Tang, C. L. Tan, T. T. Yeo, Q. T. Chong, V. Ruland, S. Hartung, U. Kordes, J. E. Wolff, W. Paulus, M. Hasselblatt, S. Patil, W. Zaky, S. Khatua, Y. Lassen-Ramshad, L. Christensen, N. Clausen, A. Bendel, W. Dobyns, J. Bennett, M. Reyes-Mugica, J. Petronio, M. Nikiforova, H. Mueller, E. Kirches, A. Korshunov, S. Pfister, C. Mawrin, M. Hemenway, N. Foreman, A. Kumar, S. Kalra, R. Acharya, N. Radhakrishnan, A. Sachdeva, B. Nimmervoll, D. Hadjadj, Y. Tong, A. A. Shelat, J. Low, G. Miller, C. F. Stewart, R. K. Guy, R. J. Gilbertson, T. Miwa, Y. Nonaka, S. Oi, H. Sasaki, K. Yoshida, R. Northup, L. Klesse, R. McNall-Knapp, M. Blagia, F. Romeo, S. Toscano, A. D'Agostino, L. Lafay-Cousin, G. Lindzon, E. Bouffet, M. Taylor, W. Hader, R. Nordal, C. Hawkins, N. Laperriere, S. Laughlin, H. Shash, P. McDonald, J. Wrogemann, A. Ahsanuddin, K. Matsuda, R. Soni, M. I. Vanan, K. Cohen, I. Taylor, F. Rodriguez, P. Burger, J. Yeh, S. Rao, B. Iskandar, B. A.- Kienitz, R. Bruce, L. Keller, S. Salamat, D. Puccetti, N. Patel, A. Hana, V. R. N. Gunness, C. Berthold, L. Bofferding, C. Neuhaeuser, E. Scalais, I. Kieffer, W. Feiden, N. Graf, H. Boecher-Schwarz, F. Hertel, O. Cruz, A. Morales, C. de Torres, A. Vicente, M. A. Gonzalez, M. Sunol, J. Mora, G. Garcia, A. Guillen, J. Muchart, M. Yankelevich, S. Sood, J. Diver, S. Savasan, J. Poulik, K. Bhambhani, A. Hochart, V. Gaillard, N.-X. Bonne, M. Baroncini, J.-P. Vannier, F. Dubrulle, J.-P. Lejeune, C. Vincent, A. Japp, M. Gessi, A. z. Muehlen, L. Klein-Hitpass, T. Pietsch, M. Sharma, R. Yadav, P. B. Malgulwar, P. Pathak, E. Sigamani, V. Suri, C. Sarkar, A. Jagdevan, M. Singh, B. S. Sharma, A. Garg, S. Bakhshi, M. Faruq, D. Doromal, C. J. Villafuerte, E. Tezcanli, M. Yilmaz, M. Sengoz, S. Peker, G. Dhall, N. Robison, A. Margol, A. Evans, M. Krieger, J. Finlay, T. Rosser, Y. Khakoo, C. Pratilas, A. Marghoob, M. Berger, T. Hollmann, M. Rosenblum, M. Mrugala, P. Giglio, C. Keene, M. Ferreira, D. Garcia, A. Weil, Z. Khatib, A. Diaz, T. Niazi, S. Bhatia, J. Ragheb, K. Rangan, F. Gilles, C. Morris, Y. Chen, V. Shetty, S. Elbabaa, M. Guzman, M. S. Abdel-Baki, S. Waguespack, J. Jones, S. Stapleton, D. Baskin, null M, and F. Okcu
- Subjects
Cancer Research ,Abstracts ,Oncology ,Neurology (clinical) - Published
- 2014
13. Behavioral disorders in association with posterior callosal and frontal cerebral infarction
- Author
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J P, Lejeune and D, Caparros-Lefebvre
- Abstract
Behavioral disorders were a prominent clinical feature after the surgical treatment of an anterior communicating artery aneurysm rupture in a 44-year-old man. Callosal apraxia was associated with an alien hand. The latter remained 1 year after surgery while diagonistic apraxia disappeared after 3 months. Other callosal signs included left agraphia, tactile anomia and auditory suppression. MRI revealed posterior callosal infarction and a right frontal infarct. The association of diagonistic apraxia and alien hand is rarely reported.
- Published
- 2014
14. Meningeal inflammatory pseudotumour: a case report
- Author
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L, Gollogly, B, Sadzot, J P, Lejeune, and M, Deprez
- Subjects
Adult ,Male ,Pseudotumor Cerebri ,Meningeal Neoplasms ,Humans ,Meningitis ,Dura Mater ,Magnetic Resonance Imaging - Abstract
We report the case of a meningeal inflammatory pseudotumour occurring in a 23-year-old male presenting with focal seizures and headaches. Brain imaging techniques showed a 3.5 cm left parietal meningeal tumour. Histology of the surgical specimen showed a dense lymphoid infiltrate permeating the dura mater and leptomeninges, consisting of a predominant polyclonal B cell population as confirmed by immunophenotyping and genotyping. Cultures of serum, CSF, and surgical specimen were negative and there was no serological evidence of a systemic dysimmune disease. The postoperative course was complicated by an episode of brain oedema resolving under steroid therapy. The patient, free from all medication, is asymptomatic at 3 years of follow-up. We discuss previously published cases and the nosology of intracranial inflammatory pseudotumours.
- Published
- 2001
15. Preoperative percutaneous injection of methyl methacrylate and N-butyl cyanoacrylate in vertebral hemangiomas
- Author
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A, Cotten, H, Deramond, B, Cortet, J P, Lejeune, X, Leclerc, P, Chastanet, and J, Clarisse
- Subjects
Male ,Spinal Neoplasms ,Enbucrilate ,Methylmethacrylate ,Middle Aged ,Combined Modality Therapy ,Embolization, Therapeutic ,Magnetic Resonance Imaging ,Journal Article ,Humans ,Methylmethacrylates ,Female ,Tomography, X-Ray Computed ,Spinal Cord Compression ,Aged ,Follow-Up Studies - Abstract
PURPOSE: To investigate the usefulness of preoperative percutaneous injections in vertebral hemangiomas. METHODS: Four patients presented with complicated vertebral hemangioma (spinal cord compression in three cases, intermittent spinal claudiction in one case). A three-part treatment was performed: initially, arterial embolization in three cases; 1 day later, percutaneous injections of methyl methacrylate into the vertebral body to strengthen it and of N-butyl cyanoacrylate into the posterior arch to optimize hemostasis during surgery; finally, the day after percutaneous injections, decompressive laminectomy and epidural hemangioma excision (when present). RESULTS: Laminectomy was performed with minimal blood loss. The epidural component present in three cases was excised without any difficulty. The follow-up (average, 20 months) showed no evidence of vertebral collapse. CONCLUSION: Percutaneous injections of methyl methacrylate and N-butyl cyanoacrylate might be useful before surgery for vertebral hemangiomas.
- Published
- 1996
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