Search

Your search keyword '"JUŠKAITĖ, VAIDA"' showing total 7 results
Start Over Author "JUŠKAITĖ, VAIDA" Search Limiters Full Text
7 results on '"JUŠKAITĖ, VAIDA"'

1. Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

Author

Juškaitė Vaida, Ramanauskienė Kristina, and Briedis Vitalis

Subjects
microemulsion, resveratrol, photostability, ha-cat cells, uvb, oxidative stress, Pharmaceutical industry, HD9665-9675
Abstract

Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed. Results of biopharmaceutical evaluation in vitro demonstrated that up to 60 % of resveratrol was released from microemulsions within 6 hours under a constant release rate profile. In vivo biological testing confirmed the ability of resveratrol to protect cells from oxidative stress and to increase cell viability. It was concluded that microemulsions might be considered in the development of UV light sensitive compounds.

Published
2017
Full Text
View/download PDF

2. Modelling, optimization and quality evaluation of topical microemulsions containing resveratrol

Author

Juškaitė, Vaida and Briedis, Vitalis

Subjects
615.451.23 [udc], Emulsions, chemistry, Stilbenes, administration&dosage, Drug design, Drug delivery systems, Drug stability
Abstract

[...]. The aim of the study. To formulate optimal and stable microemulsions, to apply them as carriers for resveratrol delivery into the skin and to evaluate their quality using physicochemical, biopharmaceutical and biological studies. The objectives of the study. 1. To model microemulsions using an experimental planning and to perform optimization of obtained formulations according to the selected critical parameters of the quality. 2. To evaluate the quality of optimal composition of microemulsions and to investigate their stability. 3. To apply selected stable microemulsions for incorporationn of aan active substance and to evaluate the quality and stability of formulated systems. 4. To investigate kinetics of resveratrol release from microemulsions and to evaluate its penetration into the skin ex vivo. 5. To evaluate the irritating effect of microemulsions containing resveratrol on the experimental animals skin in vivo. [...].

Published
2017

3. Formation and investigation of electrospun PLA materials with propolis extracts and silver nanoparticles for biomedical applications

Author

Adomavičiūtė, Erika, Pupkevičiūtė, Solveiga, Juškaitė, Vaida, Žilius, Modestas, Stanys, Sigitas, Pavilonis, Alvydas, Briedis, Vitalis, and Hindawi Publishing Corporation

Subjects
Silver| pharmacology, Coated materials, biocompatible| pharmacology, Silver| chemistry, Anti-bacterial agents| chemistry, technology, industry, and agriculture, Propolis| chemistry, Anti-bacterial agents| pharmacology, Wound healing| drug effects, Propolis| pharmacology
Abstract

An electrospun hydrophilic non-water-soluble biocompatible polylactic acid (PLA) nonwoven material was used as a delivery system for propolis ethanolic extract (PEE) and silver nanoparticles (AgNPs) that are known for their established antiseptic and antimicrobial activity. Combination of PEE and AgNPs in a single product should provide efficient antimicrobial protection and improved wound healing. Evaluations of PEE and AgNPs on morphology of electrospun materials, release kinetics of AgNPs and phenolic compounds, antibacterial properties, and cytotoxicity of electrospun PLAmaterials were performed. The presence of PEE or/and AgNPs resulted in densermats formed by thicker PLA fibers.Theaverage diameter of PLA microfibers was 168±29 nm.The average diameter of microfibers increased to 318 ± 40 and 370 ± 30nm when 10 wt% and 20 wt% ethanol were added, respectively. Addition of 10wt% or 20wt% PEE increased the diameter to 282 ± 25 and 371 ± 25 nm, respectively. Suspension of AgNPs also caused the formation of thicker microfibers with 254±25nm diameter. Electrospun PLA microfibers with PEE maintained viability of HaCaT cells. Testing of antimicrobial activity confirmed the ability of AgNPs containing PLA electrospun materials to inhibit the growth of microorganisms.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results