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12 results on '"Jager, Elise A."'

2. Verification of HE-based CTV in laryngeal and hypopharyngeal cancer using pan-cytokeratin

Author

Fysica Radiotherapie Research, Cancer, Pathologie Pathologen staf, Pathologie Groep Moelans, Onderzoek Radiotherapie, MS Radiotherapie, Klinische Fysica RT, Ligtenberg, Hans, Willems, Stefan M, Ruiter, Lilian N, Jager, Elise Anne, Terhaard, Chris H J, Raaijmakers, Cornelis P J, Philippens, Marielle E P, Fysica Radiotherapie Research, Cancer, Pathologie Pathologen staf, Pathologie Groep Moelans, Onderzoek Radiotherapie, MS Radiotherapie, Klinische Fysica RT, Ligtenberg, Hans, Willems, Stefan M, Ruiter, Lilian N, Jager, Elise Anne, Terhaard, Chris H J, Raaijmakers, Cornelis P J, and Philippens, Marielle E P

Published
2018

3. Validated guidelines for tumor delineation on magnetic resonance imaging for laryngeal and hypopharyngeal cancer

Author

Jager, Elise Anne, Ligtenberg, Hans, Caldas-Magalhaes, Joana, Schakel, Tim, Philippens, Marielle E., Pameijer, Frank A., Kasperts, Nicolien, Willems, Stefan M., Terhaard, Christiaan H., and Raaijmakers, Cornelis P.

Abstract

Background: Validation of magnetic resonance imaging (MRI) and development of guidelines for the delineation of the gross tumor volume (GTV) is of utmost importance to benefit from the visibility of anatomical details on MR images and to achieve an accurate GTV delineation. In the ideal situation, the GTV delineation corresponds to the histopathologically determined ‘true tumor volume’. Consequently, we developed guidelines for GTV delineation of laryngeal and hypopharyngeal tumors on MRI and determined the accuracy of the resulting delineation of the tumor outline on histopathology as gold standard. Material and methods: Twenty-seven patients with T3 or T4 laryngeal/hypopharyngeal cancer underwent a MRI scan before laryngectomy. Hematoxylin and eosin sections were obtained from surgical specimens and tumor was delineated by one pathologist. GTV was delineated on MR images by three independent observers in two sessions. The first session (del1) was performed according to clinical practice. In the second session (del2) guidelines were used. The reconstructed specimen was registered to the MR images for comparison of the delineated GTVs to the tumor on histopathology. Volumes and overlap parameters were analyzed. A target margin needed to assure tumor coverage was determined. Results: The median GTVs (del1: 19.4 cm3, del2: 15.8 cm3) were larger than the tumor volume on pathology (10.5 cm3). Comparable target margins were needed for both delineation sessions to assure tumor coverage. By adding these margins to the GTVs, the target volumes for del1 (median: 81.3 cm3) were significantly larger than for del2 (median: 64.2 cm3) (p ≤ 0.0001) with similar tumor coverage. Conclusions: In clinical radiotherapy practice, the delineated GTV on MRI is twice as large as the tumor volume. Validated delineation guidelines lead to a significant decrease in the overestimation of the tumor volume.

Published
2016
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5. Interobserver variation among pathologists for delineation of tumor on H&E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?

Author

Jager, Elise Anne, Willems, Stefan M., Schakel, Tim, Kooij, Nina, Slootweg, Pieter J., Philippens, Marielle E P, Caldas Magalhaes, Joana, Terhaard, Chris H. J., Raaijmakers, Cornelis P J, Jager, Elise Anne, Willems, Stefan M., Schakel, Tim, Kooij, Nina, Slootweg, Pieter J., Philippens, Marielle E P, Caldas Magalhaes, Joana, Terhaard, Chris H. J., and Raaijmakers, Cornelis P J

Published
2016

6. Validated guidelines for tumor delineation on magnetic resonance imaging for laryngeal and hypopharyngeal cancer

Author

Onderzoek Radiotherapie, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, MS Radiotherapie, Pathologie Pathologen staf, Jager, Elise Anne, Ligtenberg, Hans, Caldas Magalhaes, J, Schakel, Tim, Philippens, Marielle E, Pameijer, Frank A, Kasperts, Nicolien, Willems, Stefan M, Terhaard, CHJ, Raaijmakers, CPJ, Onderzoek Radiotherapie, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, MS Radiotherapie, Pathologie Pathologen staf, Jager, Elise Anne, Ligtenberg, Hans, Caldas Magalhaes, J, Schakel, Tim, Philippens, Marielle E, Pameijer, Frank A, Kasperts, Nicolien, Willems, Stefan M, Terhaard, CHJ, and Raaijmakers, CPJ

Published
2016

7. Interobserver variation among pathologists for delineation of tumor on H&E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?

Author

Onderzoek Radiotherapie, Pathologie Pathologen staf, Other research (not in main researchprogram), Cancer, Fysica Radiotherapie Research, Klinische Fysica RT, MS Radiotherapie, Jager, Elise Anne, Willems, Stefan M., Schakel, Tim, Kooij, Nina, Slootweg, Pieter J., Philippens, Marielle E P, Caldas Magalhaes, Joana, Terhaard, Chris H. J., Raaijmakers, Cornelis P J, Onderzoek Radiotherapie, Pathologie Pathologen staf, Other research (not in main researchprogram), Cancer, Fysica Radiotherapie Research, Klinische Fysica RT, MS Radiotherapie, Jager, Elise Anne, Willems, Stefan M., Schakel, Tim, Kooij, Nina, Slootweg, Pieter J., Philippens, Marielle E P, Caldas Magalhaes, Joana, Terhaard, Chris H. J., and Raaijmakers, Cornelis P J

Published
2016

9. The accuracy of target delineation in laryngeal and hypopharyngeal cancer

Author

Caldas Magalhaes, J, Kooij, Nina, Ligtenberg, Hans, Jager, Elise A., Schakel, Tim, Kasperts, Nicolien, Pameijer, Frank A., Terhaard, Chris H J, Janssen, Luuk M., Van Diest, Paul J., Philippens, Marielle E P, Raaijmakers, Cornelis P J, Caldas Magalhaes, J, Kooij, Nina, Ligtenberg, Hans, Jager, Elise A., Schakel, Tim, Kasperts, Nicolien, Pameijer, Frank A., Terhaard, Chris H J, Janssen, Luuk M., Van Diest, Paul J., Philippens, Marielle E P, and Raaijmakers, Cornelis P J

Published
2015

10. The accuracy of target delineation in laryngeal and hypopharyngeal cancer

Author

Fysica Radiotherapie Research, Pathologie, Cancer, MS Radiotherapie, MS Radiologie, MS KNO, Other research (not in main researchprogram), Klinische Fysica RT, Caldas Magalhaes, J, Kooij, Nina, Ligtenberg, Hans, Jager, Elise A., Schakel, Tim, Kasperts, Nicolien, Pameijer, Frank A., Terhaard, Chris H J, Janssen, Luuk M., Van Diest, Paul J., Philippens, Marielle E P, Raaijmakers, Cornelis P J, Fysica Radiotherapie Research, Pathologie, Cancer, MS Radiotherapie, MS Radiologie, MS KNO, Other research (not in main researchprogram), Klinische Fysica RT, Caldas Magalhaes, J, Kooij, Nina, Ligtenberg, Hans, Jager, Elise A., Schakel, Tim, Kasperts, Nicolien, Pameijer, Frank A., Terhaard, Chris H J, Janssen, Luuk M., Van Diest, Paul J., Philippens, Marielle E P, and Raaijmakers, Cornelis P J

Published
2015

11. GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation

Author

MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Cancer, MS Radiologie, Jager, Elise Anne, Kasperts, Nicolien, Caldas Magalhaes, Joana, Philippens, Marielle E. P., Pameijer, Frank A., Terhaard, Chris H. J., Raaijmakers, Cornelis P. J., MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Cancer, MS Radiologie, Jager, Elise Anne, Kasperts, Nicolien, Caldas Magalhaes, Joana, Philippens, Marielle E. P., Pameijer, Frank A., Terhaard, Chris H. J., and Raaijmakers, Cornelis P. J.

Published
2015

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